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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amitriptyline
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Accession:CHEBI:2666 term browser browse the term
Definition:An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Synonyms:exact_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine
 related_synonym: 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene;   10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine;   3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine;   3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine;   5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene;   5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene;   5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene;   Amitriptylin;   Formula=C20H23N;   InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3;   InChIKey=KRMDCWKBEZIMAB-UHFFFAOYSA-N;   SMILES=CN(C)CCC=C1c2ccccc2CCc2ccccc12
 xref: CAS:50-48-6;   DrugBank:DB00321;   Drug_Central:180;   HMDB:HMDB0014466;   KEGG:C06824;   KEGG:D07448;   LINCS:LSM-3190
 xref_mesh: MESH:D000639
 xref: PMID:15554244;   PMID:18359012;   PMID:24447704;   Patent:CN101780063;   Patent:WO2011089289;   Reaxys:2217885;   VSDB:2962;   Wikipedia:Amitriptyline


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amitriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Amitriptyline affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332 		JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP Amitriptyline results in decreased expression of ABAT mRNA CTD PMID:21820738 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Amitriptyline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport
increases transport
affects expression		 ISO
EXP		 ABCB1A protein affects the transport of Amitriptyline
ABCB1A protein results in increased transport of Amitriptyline; ABCB1A protein results in increased transport of Amitriptyline metabolite
Amitriptyline affects the expression of ABCB1 mRNA		 CTD PMID:10700657 PMID:12082591 PMID:18355885 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 decreases expression EXP Amitriptyline results in decreased expression of ABCD2 mRNA CTD PMID:22341215 NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP Amitriptyline results in decreased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP Amitriptyline results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression ISO Amitriptyline results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ache acetylcholinesterase decreases expression
increases activity		 EXP
ISO		 Amitriptyline results in decreased expression of ACHE mRNA
Amitriptyline results in increased activity of ACHE protein		 CTD PMID:21820738 PMID:29614332 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Amitriptyline affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression EXP Amitriptyline results in increased expression of ANKRD1 mRNA CTD PMID:22341215 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Ano3 anoctamin 3 decreases expression EXP Amitriptyline results in decreased expression of ANO3 mRNA CTD PMID:22341215 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Amitriptyline results in decreased expression of AP1S1 mRNA CTD PMID:17175557 PMID:17567588 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713 		JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Amitriptyline affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Arg1 arginase 1 increases expression EXP Amitriptyline results in increased expression of ARG1 mRNA CTD PMID:22341215 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Amitriptyline results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Amitriptyline results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Amitriptyline results in increased expression of ATF3 mRNA CTD PMID:22341215 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Amitriptyline affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G C1qa complement C1q A chain increases expression EXP Amitriptyline results in increased expression of C1QA mRNA CTD PMID:22341215 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qc complement C1q C chain increases expression EXP Amitriptyline results in increased expression of C1QC mRNA CTD PMID:22341215 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression EXP Amitriptyline results in increased expression of CACNA2D1 mRNA CTD PMID:22341215 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
Amitriptyline results in increased expression of CASP3 mRNA
Amitriptyline results in increased activity of CASP3 protein		 CTD PMID:16717317 PMID:19135049 PMID:19815060 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casr calcium-sensing receptor decreases expression EXP Amitriptyline results in decreased expression of CASR mRNA CTD PMID:22341215 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cat catalase decreases expression ISO Amitriptyline results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd74 CD74 molecule increases expression EXP Amitriptyline results in increased expression of CD74 mRNA CTD PMID:22341215 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Amitriptyline affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Amitriptyline affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chat choline O-acetyltransferase increases expression EXP Amitriptyline results in increased expression of CHAT mRNA CTD PMID:21820738 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression EXP Amitriptyline results in decreased expression of CHRNA3 mRNA CTD PMID:22341215 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit decreases expression
increases response to substance		 EXP
ISO		 Amitriptyline results in decreased expression of CHRNB2 mRNA
CHRNB2 protein results in increased susceptibility to Amitriptyline		 CTD PMID:21820738 PMID:21905669 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Amitriptyline affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033 		JBrowse link
G Cpne4 copine 4 decreases expression EXP Amitriptyline results in decreased expression of CPNE4 mRNA CTD PMID:22341215 NCBI chr 8:105,177,376...105,653,075
Ensembl chr 8:105,177,376...105,653,068 		JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Amitriptyline affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054 		JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Amitriptyline affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Amitriptyline results in increased expression of CSRP3 mRNA CTD PMID:22341215 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein] CTD PMID:28633109 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions		 ISO Amitriptyline results in increased metabolism of CYP1A2 protein; CYP1A2 protein results in increased metabolism of Amitriptyline
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline		 CTD PMID:18359012 PMID:23397584 PMID:27320963 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Amitriptyline affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Amitriptyline results in increased expression of CYP2B1 mRNA CTD PMID:10945841 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Amitriptyline affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Amitriptyline results in increased expression of CYP2B2 mRNA CTD PMID:10945841 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
increases metabolic processing		 ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CYP2C19 protein results in increased metabolism of Amitriptyline		 CTD PMID:23397584 PMID:27320963 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
increases metabolic processing		 ISO Amitriptyline results in decreased activity of CYP2D6 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
Amitriptyline results in increased metabolism of CYP2D6 protein; CYP2D6 protein results in increased metabolism of Amitriptyline		 CTD PMID:16044105 PMID:18359012 PMID:18359183 PMID:23397584 PMID:27320963 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions		 ISO Amitriptyline results in increased metabolism of CYP3A4 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline		 CTD PMID:18359012 PMID:23397584 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
affects expression		 EXP Amitriptyline results in increased expression of CYP3A23-3A1 mRNA
Amitriptyline affects the expression of CYP3A23-3A1 mRNA		 CTD PMID:10945841 PMID:18355885 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO Amitriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Amitriptyline affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506 		JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Amitriptyline affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Amitriptyline results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Des desmin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:23024785 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity EXP Amitriptyline results in decreased activity of DNMT1 protein
Amitriptyline decreases activity of Dnmt1 protein in astrocyte nucleus		 CTD
RGD		 PMID:19924110 PMID:22880885 RGD:9588218 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP Amitriptyline results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Amitriptyline results in increased expression of DRD3 mRNA CTD PMID:21820738 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Ecel1 endothelin converting enzyme-like 1 increases expression EXP Amitriptyline results in increased expression of ECEL1 mRNA CTD PMID:22341215 NCBI chr 9:87,819,516...87,829,154
Ensembl chr 9:87,816,718...87,826,675 		JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Amitriptyline affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Amitriptyline affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Amitriptyline affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Amitriptyline results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 increases expression EXP Amitriptyline results in increased expression of FLRT3 mRNA CTD PMID:22341215 NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Amitriptyline results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression
decreases expression		 EXP Amitriptyline results in increased expression of GABRA1 mRNA
Amitriptyline results in decreased expression of GABRA1 mRNA		 CTD PMID:21820738 PMID:22341215 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases expression EXP Amitriptyline results in increased expression of GABRA2 mRNA CTD PMID:21820738 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression EXP Amitriptyline results in increased expression of GABRA4 mRNA CTD PMID:21820738 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression EXP Amitriptyline results in increased expression of GABRB3 mRNA CTD PMID:21820738 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Amitriptyline results in increased expression of GADD45A mRNA CTD PMID:22341215 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gal galanin and GMAP prepropeptide increases expression EXP Amitriptyline results in increased expression of GAL mRNA CTD PMID:22341215 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gckr glucokinase regulator affects expression EXP Amitriptyline affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Amitriptyline results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Amitriptyline results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gls2 glutaminase 2 affects expression EXP Amitriptyline affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Amitriptyline affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Amitriptyline affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 decreases expression EXP Amitriptyline results in decreased expression of GRIK1 mRNA CTD PMID:22341215 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Amitriptyline results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hal histidine ammonia lyase affects expression EXP Amitriptyline affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701 		JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Amitriptyline affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Amitriptyline results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hoxd1 homeo box D1 decreases expression EXP Amitriptyline results in decreased expression of HOXD1 mRNA CTD PMID:22341215 NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769 		JBrowse link
G Hpn hepsin increases expression ISO Amitriptyline results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Hpse heparanase decreases expression EXP Amitriptyline results in decreased expression of HPSE mRNA CTD PMID:22341215 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010 		JBrowse link
G Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 decreases expression EXP Amitriptyline results in decreased expression of HS3ST2 mRNA CTD PMID:22341215 NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression EXP Amitriptyline results in increased expression of HTR1A protein CTD PMID:1589591 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D decreases expression EXP Amitriptyline results in decreased expression of HTR1D mRNA CTD PMID:22341215 NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Amitriptyline binds to HTR2C protein CTD PMID:18083778 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein] CTD PMID:28633109 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il33 interleukin 33 affects expression EXP Amitriptyline affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Amitriptyline results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Itgb6 integrin subunit beta 6 decreases expression EXP Amitriptyline results in decreased expression of ITGB6 mRNA CTD PMID:22341215 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases expression EXP Amitriptyline results in decreased expression of KCNA4 mRNA CTD PMID:22341215 NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Amitriptyline results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347 		JBrowse link
G Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 decreases expression EXP Amitriptyline results in decreased expression of KCNS1 mRNA CTD PMID:22341215 NCBI chr 3:152,835,642...152,843,032
Ensembl chr 3:152,835,644...152,842,960 		JBrowse link
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 decreases expression EXP Amitriptyline results in decreased expression of KCNS3 mRNA CTD PMID:22341215 NCBI chr 6:33,808,314...33,865,018
Ensembl chr 6:33,808,216...33,865,125 		JBrowse link
G Lox lysyl oxidase affects expression EXP Amitriptyline affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lss lanosterol synthase increases expression ISO Amitriptyline results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Amitriptyline affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072 		JBrowse link
G Manba mannosidase beta affects expression EXP Amitriptyline affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983 		JBrowse link
G Maoa monoamine oxidase A affects expression EXP Amitriptyline affects the expression of MAOA mRNA CTD PMID:21820738 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Amitriptyline affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350 		JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression EXP Amitriptyline results in increased expression of MMP16 mRNA CTD PMID:22341215 NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388 		JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Amitriptyline affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Amitriptyline affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein] CTD PMID:28633109 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nmb neuromedin B decreases expression EXP Amitriptyline results in decreased expression of NMB mRNA CTD PMID:22341215 NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190 		JBrowse link
G Nmur1 neuromedin U receptor 1 decreases expression EXP Amitriptyline results in decreased expression of NMUR1 mRNA CTD PMID:21820738 NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684 		JBrowse link
G Nog noggin decreases expression EXP Amitriptyline results in decreased expression of NOG mRNA CTD PMID:22341215 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:23024785 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Npy neuropeptide Y increases expression EXP Amitriptyline results in increased expression of NPY mRNA CTD PMID:22341215 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 increases expression EXP Amitriptyline results in increased expression of NPY5R mRNA CTD PMID:21820738 NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Amitriptyline results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects response to substance ISO NR3C1 protein affects the susceptibility to Amitriptyline CTD PMID:11226678 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Amitriptyline results in increased expression of NR3C2 mRNA CTD PMID:12393271 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Amitriptyline affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591 		JBrowse link
G Ntng1 netrin G1 decreases expression EXP Amitriptyline results in decreased expression of NTNG1 mRNA CTD PMID:22341215 NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Amitriptyline results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Oaf out at first homolog affects expression EXP Amitriptyline affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334 		JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression EXP Amitriptyline results in decreased expression of PATJ mRNA CTD PMID:22341215 NCBI chr 5:113,061,985...113,364,807
Ensembl chr 5:113,062,118...113,364,807 		JBrowse link
G Pc pyruvate carboxylase affects expression EXP Amitriptyline affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Amitriptyline affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Amitriptyline results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP Amitriptyline results in decreased expression of PLCD4 mRNA CTD PMID:22341215 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453 		JBrowse link
G Plpp4 phospholipid phosphatase 4 decreases expression EXP Amitriptyline results in decreased expression of PLPP4 mRNA CTD PMID:22341215 NCBI chr 1:183,829,794...183,959,319
Ensembl chr 1:183,830,409...183,959,319 		JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Amitriptyline affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prokr1 prokineticin receptor 1 decreases expression EXP Amitriptyline results in decreased expression of PROKR1 mRNA CTD PMID:21820738 NCBI chr 4:120,022,301...120,033,367
Ensembl chr 4:120,021,747...120,033,379 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein] CTD PMID:28633109 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression EXP Amitriptyline results in increased expression of RASD1 mRNA CTD PMID:22341215 NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Amitriptyline affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572 		JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Amitriptyline results in increased expression of REG3B mRNA CTD PMID:22341215 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Rnf112 ring finger protein 112 decreases expression EXP Amitriptyline results in decreased expression of RNF112 mRNA CTD PMID:22341215 NCBI chr10:46,121,146...46,126,691
Ensembl chr10:46,121,148...46,126,699 		JBrowse link
G RT1-Da RT1 class II, locus Da increases expression EXP Amitriptyline results in increased expression of RT1-DA mRNA CTD PMID:22341215 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression EXP Amitriptyline results in increased expression of RT1-DB1 mRNA CTD PMID:22341215 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Amitriptyline affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Amitriptyline results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 decreases expression EXP Amitriptyline results in decreased expression of SCN11A mRNA CTD PMID:22341215 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
G Sema6a semaphorin 6A increases expression EXP Amitriptyline results in increased expression of SEMA6A mRNA CTD PMID:22341215 NCBI chr18:40,050,623...40,171,954
Ensembl chr18:40,050,624...40,171,954 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Amitriptyline results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Amitriptyline affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:136,124,500...136,255,669
Ensembl chr 1:136,124,499...136,255,584 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity		 ISO Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
Amitriptyline results in decreased activity of SLC22A1 protein		 CTD PMID:30189235 PMID:31364238 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity		 ISO Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Amitriptyline results in decreased activity of SLC22A2 protein		 CTD PMID:21599003 PMID:23770354 PMID:28629854 PMID:30189235 PMID:31364238 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Amitriptyline results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium] CTD PMID:28629854 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Amitriptyline affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Amitriptyline affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Smagp small cell adhesion glycoprotein increases expression EXP Amitriptyline results in increased expression of SMAGP mRNA CTD PMID:22341215 NCBI chr 7:131,720,260...131,738,711
Ensembl chr 7:131,718,740...131,738,691 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
increases response to substance
decreases activity		 ISO [Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein
SMPD1 protein results in increased susceptibility to Amitriptyline
Amitriptyline results in decreased activity of SMPD1 protein		 CTD PMID:23770692 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Amitriptyline results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP Amitriptyline results in decreased expression of SORL1 mRNA CTD PMID:22341215 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Sox11 SRY-box transcription factor 11 increases expression EXP Amitriptyline results in increased expression of SOX11 mRNA CTD PMID:22341215 NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354 		JBrowse link
G Sprr1a small proline-rich protein 1A increases expression EXP Amitriptyline results in increased expression of SPRR1A mRNA CTD PMID:22341215 NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Sstr1 somatostatin receptor 1 decreases expression EXP Amitriptyline results in decreased expression of SSTR1 mRNA CTD PMID:21820738 NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802 		JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Amitriptyline affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945 		JBrowse link
G Stac2 SH3 and cysteine rich domain 2 increases expression EXP Amitriptyline results in increased expression of STAC2 mRNA CTD PMID:22341215 NCBI chr10:83,032,418...83,048,260
Ensembl chr10:83,032,417...83,048,260 		JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Amitriptyline affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443 		JBrowse link
G Stmn1 stathmin 1 affects expression EXP Amitriptyline affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Stmn4 stathmin 4 increases expression EXP Amitriptyline results in increased expression of STMN4 mRNA CTD PMID:22341215 NCBI chr15:40,541,305...40,559,253
Ensembl chr15:40,541,357...40,559,253 		JBrowse link
G Tagln transgelin decreases expression ISO Amitriptyline results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tex261 testis expressed 261 affects expression EXP Amitriptyline affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253 		JBrowse link
G Tgm1 transglutaminase 1 increases expression EXP Amitriptyline results in increased expression of TGM1 mRNA CTD PMID:22341215 NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523 		JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Amitriptyline affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642
Ensembl chr20:159,980,484...159,981,642 		JBrowse link
G Trh thyrotropin releasing hormone multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Amitriptyline inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium] CTD PMID:23264033 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Amitriptyline affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Amitriptyline affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Amitriptyline affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 affects expression EXP Amitriptyline affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein] CTD PMID:23024785 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Amitriptyline results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
nortriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
affects response to substance		 ISO ABCB1A protein results in increased transport of Nortriptyline; ABCB1A protein results in increased transport of Nortriptyline metabolite
ABCB1 exon SNP affects the susceptibility to Nortriptyline		 CTD PMID:10700657 PMID:12082591 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nortriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
increases activity		 ISO Nortriptyline results in decreased activity of CASP3 protein
Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein]		 CTD PMID:17686041 PMID:18174477 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cycs cytochrome c, somatic decreases secretion ISO Nortriptyline results in decreased secretion of CYCS protein CTD PMID:17686041 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP1A2 protein CTD PMID:18359012 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions		 ISO Nortriptyline results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases response to substance
increases hydroxylation
increases metabolic processing
multiple interactions		 ISO CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline
CYP2D6 protein results in increased hydroxylation of Nortriptyline
Nortriptyline results in increased metabolism of CYP2D6 protein
Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline]		 CTD PMID:11673748 PMID:17470523 PMID:18359012 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP3A4 protein CTD PMID:18359012 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Gnb3 G protein subunit beta 3 decreases response to substance
increases response to substance		 ISO GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline
GNB3 protein results in increased susceptibility to Nortriptyline		 CTD PMID:14604448 NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C decreases expression ISO Nortriptyline results in decreased expression of HTR2C protein CTD PMID:8131152 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Pf4 platelet factor 4 affects expression ISO Nortriptyline affects the expression of PF4 protein CTD PMID:10770450 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Ppbp pro-platelet basic protein affects expression ISO Nortriptyline affects the expression of PPBP protein CTD PMID:10770450 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nortriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 affects response to substance ISO SLC6A2 gene polymorphism affects the susceptibility to Nortriptyline CTD PMID:17018806 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects response to substance
decreases response to substance
increases response to substance		 ISO SLC6A4 polymorphism affects the susceptibility to Nortriptyline; SLC6A4 promoter polymorphism affects the susceptibility to Nortriptyline
SLC6A4 gene polymorphism results in decreased susceptibility to Nortriptyline
SLC6A4 protein results in increased susceptibility to Nortriptyline		 CTD PMID:14604448 PMID:17018806 PMID:21658141 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        xenobiotic 18749
          amitriptyline 189
            amitriptyline-d3 0
            nortriptyline 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19669
                        hydrogen molecular entity 19651
                          hydrides 19162
                            organic hydride 18712
                              organic fundamental parent 18712
                                hydrocarbon 18460
                                  cyclic hydrocarbon 17248
                                    arene 17229
                                      polycyclic arene 17053
                                        ortho-fused polycyclic arene 9850
                                          dibenzannulene 197
                                            dibenzo[a,d][7]annulene 197
                                              amitriptyline 189
                                                amitriptyline-d3 0
                                                nortriptyline 21
paths to the root