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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nortriptyline
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Accession:CHEBI:7640 term browser browse the term
Definition:An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Synonyms:exact_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine
 related_synonym: 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine;   3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine;   Ateben;   Avantyl;   Aventyl;   Formula=C19H21N;   InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3;   InChIKey=PHVGLTMQBUFIQQ-UHFFFAOYSA-N;   Noritren;   Psychostyl;   SMILES=CNCCC=C1c2ccccc2CCc2ccccc12;   Sensaval;   demethylamitriptyline;   desmethylamitriptyline;   nortriptylina;   nortriptylinum
 xref: Beilstein:2216786;   CAS:72-69-5;   DrugBank:DB00540;   Drug_Central:1971;   HMDB:HMDB0014680;   KEGG:C07274;   KEGG:D08288;   LINCS:LSM-4039
 xref_mesh: MESH:D009661
 xref: PDBeChem:21B;   PMID:10379421;   PMID:14561440;   PMID:17071817;   PMID:23280809;   PMID:24037379;   PMID:24368464;   PMID:25224004;   PMID:25480462;   PMID:25569864;   PMID:25592638;   PMID:25683584;   PMID:25707462;   PMID:25749306;   PMID:26086857;   PMID:26453560;   Patent:NL6408512;   Patent:US3442949;   Patent:US3922305;   Reaxys:2216786;   Wikipedia:Nortriptyline


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nortriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
affects response to substance
ISO ABCB1A protein results in increased transport of Nortriptyline; ABCB1A protein results in increased transport of Nortriptyline metabolite
ABCB1 exon SNP affects the susceptibility to Nortriptyline
CTD PMID:10700657 PMID:12082591 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nortriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Casp3 caspase 3 decreases activity
increases activity
multiple interactions
ISO Nortriptyline results in decreased activity of CASP3 protein
Nortriptyline results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein]
CTD PMID:17686041 PMID:18174477 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Cycs cytochrome c, somatic decreases secretion ISO Nortriptyline results in decreased secretion of CYCS protein CTD PMID:17686041 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP1A2 protein CTD PMID:18359012 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions
ISO Nortriptyline results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]
CTD PMID:15304522
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases response to substance
multiple interactions
increases metabolic processing
increases hydroxylation
ISO CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline
Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline]
Nortriptyline results in increased metabolism of CYP2D6 protein
CYP2D6 protein results in increased hydroxylation of Nortriptyline
CTD PMID:11673748 PMID:17470523 PMID:18359012 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP3A4 protein CTD PMID:18359012 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Gnb3 G protein subunit beta 3 decreases response to substance
increases response to substance
ISO GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline
GNB3 protein results in increased susceptibility to Nortriptyline
CTD PMID:14604448 NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C decreases expression ISO Nortriptyline results in decreased expression of HTR2C protein CTD PMID:8131152 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Pf4 platelet factor 4 affects expression ISO Nortriptyline affects the expression of PF4 protein CTD PMID:10770450 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Ppbp pro-platelet basic protein affects expression ISO Nortriptyline affects the expression of PPBP protein CTD PMID:10770450 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nortriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc6a2 solute carrier family 6 member 2 affects response to substance ISO SLC6A2 gene polymorphism affects the susceptibility to Nortriptyline CTD PMID:17018806 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects response to substance
increases response to substance
decreases response to substance
ISO SLC6A4 polymorphism affects the susceptibility to Nortriptyline; SLC6A4 promoter polymorphism affects the susceptibility to Nortriptyline
SLC6A4 protein results in increased susceptibility to Nortriptyline
SLC6A4 gene polymorphism results in decreased susceptibility to Nortriptyline
CTD PMID:14604448 PMID:17018806 PMID:21658141 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        xenobiotic 18442
          amitriptyline 191
            nortriptyline 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            organic hydride 18354
                              organic fundamental parent 18354
                                hydrocarbon 18065
                                  cyclic hydrocarbon 17077
                                    arene 17073
                                      polycyclic arene 16892
                                        ortho-fused polycyclic arene 9662
                                          dibenzannulene 199
                                            dibenzo[a,d][7]annulene 199
                                              amitriptyline 191
                                                nortriptyline 21
paths to the root