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ONTOLOGY REPORT - ANNOTATIONS


Term:nortriptyline
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Accession:CHEBI:7640 term browser browse the term
Definition:An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Synonyms:exact_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine
 related_synonym: 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine;   3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine;   Ateben;   Avantyl;   Aventyl;   Formula=C19H21N;   InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3;   InChIKey=PHVGLTMQBUFIQQ-UHFFFAOYSA-N;   Noritren;   Psychostyl;   SMILES=CNCCC=C1c2ccccc2CCc2ccccc12;   Sensaval;   demethylamitriptyline;   desmethylamitriptyline;   nortriptylina;   nortriptylinum
 xref: Beilstein:2216786 "ChemIDplus";   CAS:72-69-5 "ChemIDplus";   CAS:72-69-5 "KEGG COMPOUND";   CAS:72-69-5 "NIST Chemistry WebBook";   DrugBank:DB00540;   Drug_Central:1971 "DrugCentral";   HMDB:HMDB0014680;   KEGG:C07274;   KEGG:D08288;   LINCS:LSM-4039
 xref_mesh: MESH:D009661
 xref: PDBeChem:21B;   PMID:10379421 "Europe PMC";   PMID:14561440 "Europe PMC";   PMID:17071817 "Europe PMC";   PMID:23280809 "Europe PMC";   PMID:24037379 "Europe PMC";   PMID:24368464 "Europe PMC";   PMID:25224004 "Europe PMC";   PMID:25480462 "Europe PMC";   PMID:25569864 "Europe PMC";   PMID:25592638 "Europe PMC";   PMID:25683584 "Europe PMC";   PMID:25707462 "Europe PMC";   PMID:25749306 "Europe PMC";   PMID:26086857 "Europe PMC";   PMID:26453560 "Europe PMC";   Patent:NL6408512;   Patent:US3442949;   Patent:US3922305;   Reaxys:2216786 "Reaxys";   Wikipedia:Nortriptyline


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nortriptyline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Gnb3 G protein subunit beta 3 JBrowse link 4 157,352,558 157,359,237 RGD:6480464
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:6480464
G Ppbp pro-platelet basic protein JBrowse link 14 18,852,433 18,853,237 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc6a2 solute carrier family 6 member 2 JBrowse link 19 15,391,682 15,431,274 RGD:6480464
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        xenobiotic 18178
          amitriptyline 185
            nortriptyline 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            organic hydride 17528
                              organic fundamental parent 17528
                                hydrocarbon 16935
                                  cyclic hydrocarbon 15098
                                    arene 15085
                                      polycyclic arene 14519
                                        ortho-fused polycyclic arene 9542
                                          dibenzannulene 185
                                            dibenzo[a,d][7]annulene 185
                                              amitriptyline 185
                                                nortriptyline 20
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