Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzo[a,d][7]annulene
go back to main search page
Accession:CHEBI:35642 term browser browse the term
Definition:A dibenzannulene that has formula C15H12.
Synonyms:exact_synonym: 5H-dibenzo[a,d][7]annulene
 related_synonym: 5H-dibenzo[a,d]cycloheptene;   Formula=C15H12;   InChI=1S/C15H12/c1-3-7-14-11-15-8-4-2-6-13(15)10-9-12(14)5-1/h1-10H,11H2;   InChIKey=QPJORFLSOJAUNL-UHFFFAOYSA-N;   SMILES=C1c2ccccc2C=Cc2ccccc12


show annotations for term's descendants           Sort by:
 
amitriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Amitriptyline affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP Amitriptyline results in decreased expression of ABAT mRNA CTD PMID:21820738 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Amitriptyline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport
increases transport
affects expression
ISO
EXP
ABCB1A protein affects the transport of Amitriptyline
ABCB1A protein results in increased transport of Amitriptyline; ABCB1A protein results in increased transport of Amitriptyline metabolite
Amitriptyline affects the expression of ABCB1 mRNA
CTD PMID:10700657, PMID:12082591, PMID:18355885 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 decreases expression EXP Amitriptyline results in decreased expression of ABCD2 mRNA CTD PMID:22341215 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP Amitriptyline results in decreased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP Amitriptyline results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Ache acetylcholinesterase decreases expression
increases activity
EXP
ISO
Amitriptyline results in decreased expression of ACHE mRNA
Amitriptyline results in increased activity of ACHE protein
CTD PMID:21820738, PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Amitriptyline affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP Amitriptyline affects the expression of ALDH1A4 mRNA CTD PMID:18355885 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression EXP Amitriptyline results in increased expression of ANKRD1 mRNA CTD PMID:22341215 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Ano3 anoctamin 3 decreases expression EXP Amitriptyline results in decreased expression of ANO3 mRNA CTD PMID:22341215 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Amitriptyline results in decreased expression of AP1S1 mRNA CTD PMID:17175557, PMID:17567588 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Amitriptyline affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Arg1 arginase 1 increases expression EXP Amitriptyline results in increased expression of ARG1 mRNA CTD PMID:22341215 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Amitriptyline results in increased expression of ASAH1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Amitriptyline results in increased expression of ASNS mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Amitriptyline results in increased expression of ATF3 mRNA CTD PMID:22341215 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Amitriptyline affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G C1qa complement C1q A chain increases expression EXP Amitriptyline results in increased expression of C1QA mRNA CTD PMID:22341215 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qc complement C1q C chain increases expression EXP Amitriptyline results in increased expression of C1QC mRNA CTD PMID:22341215 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression EXP Amitriptyline results in increased expression of CACNA2D1 mRNA CTD PMID:22341215 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
Amitriptyline results in increased expression of CASP3 mRNA
Amitriptyline results in increased activity of CASP3 protein
CTD PMID:16717317, PMID:19135049, PMID:19815060 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casr calcium-sensing receptor decreases expression EXP Amitriptyline results in decreased expression of CASR mRNA CTD PMID:22341215 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cat catalase decreases expression ISO Amitriptyline results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd74 CD74 molecule increases expression EXP Amitriptyline results in increased expression of CD74 mRNA CTD PMID:22341215 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Amitriptyline affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Amitriptyline affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chat choline O-acetyltransferase increases expression EXP Amitriptyline results in increased expression of CHAT mRNA CTD PMID:21820738 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression EXP Amitriptyline results in decreased expression of CHRNA3 mRNA CTD PMID:22341215 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit decreases expression
increases response to substance
EXP
ISO
Amitriptyline results in decreased expression of CHRNB2 mRNA
CHRNB2 protein results in increased susceptibility to Amitriptyline
CTD PMID:21820738, PMID:21905669 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Amitriptyline affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:122,789,208...122,807,560
Ensembl chr 8:122,789,453...122,807,560
JBrowse link
G Cpne4 copine 4 decreases expression EXP Amitriptyline results in decreased expression of CPNE4 mRNA CTD PMID:22341215 NCBI chr 8:113,105,814...113,586,429
Ensembl chr 8:113,105,814...113,586,418
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Amitriptyline affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,655,038...3,774,887
Ensembl chr10:3,655,038...3,774,884
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Amitriptyline affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Amitriptyline results in increased expression of CSRP3 mRNA CTD PMID:22341215 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein] CTD PMID:28633109 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO Amitriptyline results in increased metabolism of CYP1A2 protein; CYP1A2 protein results in increased metabolism of Amitriptyline
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD PMID:18359012, PMID:23397584, PMID:27320963 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Amitriptyline affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Amitriptyline results in increased expression of CYP2B1 mRNA CTD PMID:10945841 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Amitriptyline affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Amitriptyline results in increased expression of CYP2B2 mRNA CTD PMID:10945841 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases metabolic processing
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CYP2C19 protein results in increased metabolism of Amitriptyline
CTD PMID:23397584, PMID:27320963 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
increases metabolic processing
ISO Amitriptyline results in decreased activity of CYP2D6 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
Amitriptyline results in increased metabolism of CYP2D6 protein; CYP2D6 protein results in increased metabolism of Amitriptyline
CTD PMID:16044105, PMID:18359012, PMID:18359183, PMID:23397584, PMID:27320963 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
affects expression
EXP Amitriptyline results in increased expression of CYP3A23-3A1 mRNA
Amitriptyline affects the expression of CYP3A23-3A1 mRNA
CTD PMID:10945841, PMID:18355885 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO Amitriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 affects expression EXP Amitriptyline affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Amitriptyline affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:90,532,153...90,587,542
Ensembl chr13:90,532,326...90,591,796
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Amitriptyline results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Des desmin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:23024785 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity EXP Amitriptyline results in decreased activity of DNMT1 protein CTD PMID:19924110 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP Amitriptyline results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Amitriptyline results in increased expression of DRD3 mRNA CTD PMID:21820738 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Ecel1 endothelin converting enzyme-like 1 increases expression EXP Amitriptyline results in increased expression of ECEL1 mRNA CTD PMID:22341215 NCBI chr 9:94,238,568...94,252,484
Ensembl chr 9:94,239,006...94,250,809
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Amitriptyline affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:143,679,656...143,701,452
Ensembl chr 7:143,679,617...143,701,452
JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Amitriptyline affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Amitriptyline affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Amitriptyline results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 increases expression EXP Amitriptyline results in increased expression of FLRT3 mRNA CTD PMID:22341215 NCBI chr 3:134,684,446...134,696,586
Ensembl chr 3:134,683,065...134,696,654
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression
decreases expression
EXP Amitriptyline results in increased expression of GABRA1 mRNA
Amitriptyline results in decreased expression of GABRA1 mRNA
CTD PMID:21820738, PMID:22341215 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases expression EXP Amitriptyline results in increased expression of GABRA2 mRNA CTD PMID:21820738 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression EXP Amitriptyline results in increased expression of GABRA4 mRNA CTD PMID:21820738 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression EXP Amitriptyline results in increased expression of GABRB3 mRNA CTD PMID:21820738 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Amitriptyline results in increased expression of GADD45A mRNA CTD PMID:22341215 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression EXP Amitriptyline results in increased expression of GAL mRNA CTD PMID:22341215 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gckr glucokinase regulator affects expression EXP Amitriptyline affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Amitriptyline results in increased expression of GDPD3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Amitriptyline results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gls2 glutaminase 2 affects expression EXP Amitriptyline affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:2,605,679...2,621,853
Ensembl chr 7:2,605,719...2,621,852
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Amitriptyline affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Amitriptyline affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 decreases expression EXP Amitriptyline results in decreased expression of GRIK1 mRNA CTD PMID:22341215 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Amitriptyline results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Amitriptyline affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Amitriptyline affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Amitriptyline results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hoxd1 homeo box D1 decreases expression EXP Amitriptyline results in decreased expression of HOXD1 mRNA CTD PMID:22341215 NCBI chr 3:61,685,619...61,687,758
Ensembl chr 3:61,685,619...61,687,758
JBrowse link
G Hpn hepsin increases expression ISO Amitriptyline results in increased expression of HPN mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hpse heparanase decreases expression EXP Amitriptyline results in decreased expression of HPSE mRNA CTD PMID:22341215 NCBI chr14:10,534,358...10,576,686
Ensembl chr14:10,534,423...10,575,224
JBrowse link
G Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 decreases expression EXP Amitriptyline results in decreased expression of HS3ST2 mRNA CTD PMID:22341215 NCBI chr 1:191,344,979...191,474,143
Ensembl chr 1:191,344,979...191,474,142
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression EXP Amitriptyline results in increased expression of HTR1A protein CTD PMID:1589591 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D decreases expression EXP Amitriptyline results in decreased expression of HTR1D mRNA CTD PMID:22341215 NCBI chr 5:154,780,958...154,801,505
Ensembl chr 5:154,800,226...154,801,350
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Amitriptyline binds to HTR2C protein CTD PMID:18083778 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein] CTD PMID:28633109 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il33 interleukin 33 affects expression EXP Amitriptyline affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Amitriptyline results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Itgb6 integrin subunit beta 6 decreases expression EXP Amitriptyline results in decreased expression of ITGB6 mRNA CTD PMID:22341215 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases expression EXP Amitriptyline results in decreased expression of KCNA4 mRNA CTD PMID:22341215 NCBI chr 3:98,293,295...98,300,763
Ensembl chr 3:98,297,554...98,300,680
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963, PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Amitriptyline results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 decreases expression EXP Amitriptyline results in decreased expression of KCNS1 mRNA CTD PMID:22341215 NCBI chr 3:160,554,423...160,561,820
Ensembl chr 3:160,554,425...160,561,741
JBrowse link
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 decreases expression EXP Amitriptyline results in decreased expression of KCNS3 mRNA CTD PMID:22341215 NCBI chr 6:36,764,040...36,819,810
Ensembl chr 6:36,764,044...36,819,821
JBrowse link
G Lox lysyl oxidase affects expression EXP Amitriptyline affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Lss lanosterol synthase increases expression ISO Amitriptyline results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Amitriptyline affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678
JBrowse link
G Manba mannosidase beta affects expression EXP Amitriptyline affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:240,668,213...240,760,264
Ensembl chr 2:240,668,195...240,760,261
JBrowse link
G Maoa monoamine oxidase A affects expression EXP Amitriptyline affects the expression of MAOA mRNA CTD PMID:21820738 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Amitriptyline affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:88,997,011...89,002,154
Ensembl chr10:88,997,399...89,002,152
JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression EXP Amitriptyline results in increased expression of MMP16 mRNA CTD PMID:22341215 NCBI chr 5:31,568,344...31,818,368
Ensembl chr 5:31,568,419...31,810,484
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Amitriptyline affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:3,344,870...3,350,929
Ensembl chr20:3,344,870...3,350,927
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Amitriptyline affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein] CTD PMID:28633109 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nmb neuromedin B decreases expression EXP Amitriptyline results in decreased expression of NMB mRNA CTD PMID:22341215 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nmur1 neuromedin U receptor 1 decreases expression EXP Amitriptyline results in decreased expression of NMUR1 mRNA CTD PMID:21820738 NCBI chr 9:93,402,871...93,407,264
Ensembl chr 9:93,403,314...93,404,883
JBrowse link
G Nog noggin decreases expression EXP Amitriptyline results in decreased expression of NOG mRNA CTD PMID:22341215 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:23024785 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Npy neuropeptide Y increases expression EXP Amitriptyline results in increased expression of NPY mRNA CTD PMID:22341215 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Npy5r neuropeptide Y receptor Y5 increases expression EXP Amitriptyline results in increased expression of NPY5R mRNA CTD PMID:21820738 NCBI chr16:24,796,685...24,805,730
Ensembl chr16:24,797,124...24,805,079
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Amitriptyline results in increased expression of NR0B2 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects response to substance ISO NR3C1 protein affects the susceptibility to Amitriptyline CTD PMID:11226678 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Amitriptyline results in increased expression of NR3C2 mRNA CTD PMID:12393271 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Amitriptyline affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Ntng1 netrin G1 decreases expression EXP Amitriptyline results in decreased expression of NTNG1 mRNA CTD PMID:22341215 NCBI chr 2:212,695,464...213,073,046
Ensembl chr 2:212,696,624...212,852,870
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Amitriptyline results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oaf out at first homolog affects expression EXP Amitriptyline affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression EXP Amitriptyline results in decreased expression of PATJ mRNA CTD PMID:22341215 NCBI chr 5:117,038,548...117,340,308
Ensembl chr 5:117,052,260...117,340,336
JBrowse link
G Pc pyruvate carboxylase affects expression EXP Amitriptyline affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Amitriptyline affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Amitriptyline results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP Amitriptyline results in decreased expression of PLCD4 mRNA CTD PMID:22341215 NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364
JBrowse link
G Plpp4 phospholipid phosphatase 4 decreases expression EXP Amitriptyline results in decreased expression of PLPP4 mRNA CTD PMID:22341215 NCBI chr 1:202,432,366...202,560,628
Ensembl chr 1:202,432,366...202,560,628
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Amitriptyline affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prokr1 prokineticin receptor 1 decreases expression EXP Amitriptyline results in decreased expression of PROKR1 mRNA CTD PMID:21820738 NCBI chr 4:119,375,790...119,386,551
Ensembl chr 4:119,375,778...119,386,590
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein] CTD PMID:28633109 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression EXP Amitriptyline results in increased expression of RASD1 mRNA CTD PMID:22341215 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Amitriptyline affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Amitriptyline results in increased expression of REG3B mRNA CTD PMID:22341215 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rnf112 ring finger protein 112 decreases expression EXP Amitriptyline results in decreased expression of RNF112 mRNA CTD PMID:22341215 NCBI chr10:47,719,034...47,726,050
Ensembl chr10:47,719,014...47,725,172
JBrowse link
G RT1-Da RT1 class II, locus Da increases expression EXP Amitriptyline results in increased expression of RT1-DA mRNA CTD PMID:22341215 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression EXP Amitriptyline results in increased expression of RT1-DB1 mRNA CTD PMID:22341215 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Amitriptyline affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Amitriptyline results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 decreases expression EXP Amitriptyline results in decreased expression of SCN11A mRNA CTD PMID:22341215 NCBI chr 8:128,450,793...128,527,510
Ensembl chr 8:128,450,801...128,521,109
JBrowse link
G Sema6a semaphorin 6A increases expression EXP Amitriptyline results in increased expression of SEMA6A mRNA CTD PMID:22341215 NCBI chr18:41,330,519...41,451,813
Ensembl chr18:41,333,551...41,389,510
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Amitriptyline results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Amitriptyline affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:144,069,641...144,200,402
Ensembl chr 1:144,069,638...144,200,397
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity
ISO Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
Amitriptyline results in decreased activity of SLC22A1 protein
CTD PMID:30189235, PMID:31364238 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity
ISO Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Amitriptyline results in decreased activity of SLC22A2 protein
CTD PMID:21599003, PMID:23770354, PMID:28629854, PMID:30189235, PMID:31364238 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Amitriptyline results in decreased expression of SLC2A3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium] CTD PMID:28629854 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Amitriptyline affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Amitriptyline affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Smagp small cell adhesion glycoprotein increases expression EXP Amitriptyline results in increased expression of SMAGP mRNA CTD PMID:22341215 NCBI chr 7:142,244,295...142,260,896
Ensembl chr 7:142,244,295...142,260,896
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
increases response to substance
decreases activity
ISO [Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein
SMPD1 protein results in increased susceptibility to Amitriptyline
Amitriptyline results in decreased activity of SMPD1 protein
CTD PMID:23770692 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Amitriptyline results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP Amitriptyline results in decreased expression of SORL1 mRNA CTD PMID:22341215 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Sox11 SRY-box transcription factor 11 increases expression EXP Amitriptyline results in increased expression of SOX11 mRNA CTD PMID:22341215 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983
JBrowse link
G Sprr1a small proline-rich protein 1A increases expression EXP Amitriptyline results in increased expression of SPRR1A mRNA CTD PMID:22341215 NCBI chr 2:192,669,143...192,671,059
Ensembl chr 2:192,669,143...192,671,059
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Sstr1 somatostatin receptor 1 decreases expression EXP Amitriptyline results in decreased expression of SSTR1 mRNA CTD PMID:21820738 NCBI chr 6:79,252,914...79,258,611
Ensembl chr 6:79,254,339...79,258,611
JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Amitriptyline affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Stac2 SH3 and cysteine rich domain 2 increases expression EXP Amitriptyline results in increased expression of STAC2 mRNA CTD PMID:22341215 NCBI chr10:85,988,367...86,004,209
Ensembl chr10:85,988,367...86,004,209
JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Amitriptyline affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:16,976,355...16,979,760
Ensembl chr14:16,976,356...16,979,760
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Amitriptyline affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Stmn4 stathmin 4 increases expression EXP Amitriptyline results in increased expression of STMN4 mRNA CTD PMID:22341215 NCBI chr15:43,007,901...43,025,852
Ensembl chr15:43,007,908...43,025,852
JBrowse link
G Tagln transgelin decreases expression ISO Amitriptyline results in decreased expression of TAGLN mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tex261 testis expressed 261 affects expression EXP Amitriptyline affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:115,446,830...115,454,035
Ensembl chr 4:115,448,708...115,453,659
JBrowse link
G Tgm1 transglutaminase 1 increases expression EXP Amitriptyline results in increased expression of TGM1 mRNA CTD PMID:22341215 NCBI chr15:34,378,136...34,393,150
Ensembl chr15:34,378,148...34,392,066
JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Amitriptyline affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:170,471,265...170,474,111
Ensembl chr 1:170,471,238...170,474,113
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Amitriptyline affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Amitriptyline affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Amitriptyline affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 affects expression EXP Amitriptyline affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein] CTD PMID:23024785 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Amitriptyline results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
cyclobenzaprine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
nortriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
affects response to substance
ISO ABCB1A protein results in increased transport of Nortriptyline; ABCB1A protein results in increased transport of Nortriptyline metabolite
ABCB1 exon SNP affects the susceptibility to Nortriptyline
CTD PMID:10700657, PMID:12082591 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nortriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Casp3 caspase 3 decreases activity
increases activity
multiple interactions
ISO Nortriptyline results in decreased activity of CASP3 protein
Nortriptyline results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein]
CTD PMID:17686041, PMID:18174477, PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cycs cytochrome c, somatic decreases secretion ISO Nortriptyline results in decreased secretion of CYCS protein CTD PMID:17686041 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP1A2 protein CTD PMID:18359012 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions
ISO Nortriptyline results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]
CTD PMID:15304522 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases response to substance
multiple interactions
increases metabolic processing
increases hydroxylation
ISO CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline
Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline]
Nortriptyline results in increased metabolism of CYP2D6 protein
CYP2D6 protein results in increased hydroxylation of Nortriptyline
CTD PMID:11673748, PMID:17470523, PMID:18359012 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gnb3 G protein subunit beta 3 decreases response to substance
increases response to substance
ISO GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline
GNB3 protein results in increased susceptibility to Nortriptyline
CTD PMID:14604448 NCBI chr 4:157,352,558...157,359,237
Ensembl chr 4:157,352,372...157,358,262
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C decreases expression ISO Nortriptyline results in decreased expression of HTR2C protein CTD PMID:8131152 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Pf4 platelet factor 4 affects expression ISO Nortriptyline affects the expression of PF4 protein CTD PMID:10770450 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Ppbp pro-platelet basic protein affects expression ISO Nortriptyline affects the expression of PPBP protein CTD PMID:10770450 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nortriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc6a2 solute carrier family 6 member 2 affects response to substance ISO SLC6A2 gene polymorphism affects the susceptibility to Nortriptyline CTD PMID:17018806 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects response to substance
increases response to substance
decreases response to substance
ISO SLC6A4 polymorphism affects the susceptibility to Nortriptyline; SLC6A4 promoter polymorphism affects the susceptibility to Nortriptyline
SLC6A4 protein results in increased susceptibility to Nortriptyline
SLC6A4 gene polymorphism results in decreased susceptibility to Nortriptyline
CTD PMID:14604448, PMID:17018806, PMID:21658141 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
protriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Protriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression ISO Protriptyline results in decreased expression of SLC6A2 protein CTD PMID:18923402 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            polycyclic arene 16889
              ortho-fused polycyclic arene 9650
                dibenzannulene 186
                  dibenzo[a,d][7]annulene 186
                    1-(2,4-dichloro-10,11-dihydrodibenzo[a,d][7]annulen-5-yl)imidazole + 0
                    amineptine + 0
                    amitriptyline + 186
                    cyclobenzaprine + 1
                    cyclobenzaprine hydrochloride 0
                    nortriptyline 20
                    protriptyline + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            organic hydride 18269
                              organic fundamental parent 18269
                                hydrocarbon 17988
                                  cyclic hydrocarbon 17075
                                    arene 17071
                                      polycyclic arene 16889
                                        ortho-fused polycyclic arene 9650
                                          dibenzannulene 186
                                            dibenzo[a,d][7]annulene 186
                                              1-(2,4-dichloro-10,11-dihydrodibenzo[a,d][7]annulen-5-yl)imidazole + 0
                                              amineptine + 0
                                              amitriptyline + 186
                                              cyclobenzaprine + 1
                                              cyclobenzaprine hydrochloride 0
                                              nortriptyline 20
                                              protriptyline + 2
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.