deoxy sugar - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	deoxy sugar	go back to main search page
Accession:	CHEBI:23639	browse the term
Definition:	Any sugar having a hydroxy group replaced with a hydrogen atom.
Synonyms:	related_synonym:	deoxy sugars; deoxysugar; deoxysugars

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Rat (146) Mouse (148) Human (148) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (146)

2-deoxy-D-glucose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases uptake
multiple interactions

A2M protein modified form results in increased uptake of Deoxyglucose
HSPA5 protein affects the reaction [A2M protein modified form results in increased uptake of Deoxyglucose]

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

multiple interactions

Deoxyglucose inhibits the reaction [ABCB1 protein results in increased export of Diazinon]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 9

multiple interactions

[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

actin-binding Rho activating protein

multiple interactions
increases uptake

CCG 1423 promotes the reaction [ABRA mutant form promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; CCG 1423 promotes the reaction [ABRA mutant form results in increased uptake of Deoxyglucose]; CCG 1423 promotes the reaction [INS1 protein promotes the reaction [ABRA mutant form results in increased uptake of Deoxyglucose]]; INS1 protein promotes the reaction [ABRA mutant form results in increased uptake of Deoxyglucose]

NCBI chr 7:72,970,187...72,974,255
Ensembl chr 7:72,970,186...72,974,255

G

adiponectin, C1Q and collagen domain containing

increases uptake
multiple interactions

ADIPOQ protein modified form results in increased uptake of Deoxyglucose
Indinavir inhibits the reaction [ADIPOQ protein modified form results in increased uptake of Deoxyglucose]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

agouti related neuropeptide

increases expression

Deoxyglucose results in increased expression of AGRP mRNA

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

adaptor related protein complex 5 subunit sigma 1

increases expression

Deoxyglucose results in increased expression of AP5S1 mRNA

NCBI chr 3:118,429,618...118,432,929
Ensembl chr 3:118,429,637...118,432,926

G

amyloid beta precursor protein

multiple interactions

[Sodium Azide co-treated with Deoxyglucose] affects the cleavage of and affects the localization of APP protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

autophagy related 3

multiple interactions

Deoxyglucose affects the reaction [demycarosyl-3D-digitoxosylmithramycin SK affects the expression of ATG3 mRNA]

NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224

G

autophagy related 4B, cysteine peptidase

multiple interactions

[demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] results in increased expression of ATG4B mRNA

NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103

G

autophagy related 7

multiple interactions

ATG7 protein inhibits the reaction [Deoxyglucose results in increased cleavage of CASP3 protein]; ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of DDIT3 protein]; ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]; ATG7 protein promotes the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein]

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

BCL2 associated X, apoptosis regulator

multiple interactions
decreases expression

Deoxyglucose promotes the reaction [arsenic trioxide results in increased localization of and results in increased activity of BAX protein]; Deoxyglucose results in increased localization of and results in increased activity of BAX protein
Deoxyglucose results in decreased expression of BAX mRNA

PMID:23041229 PMID:26079942

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

Deoxyglucose affects the reaction [demycarosyl-3D-digitoxosylmithramycin SK affects the expression of BCL2 mRNA]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases response to substance

BCL2L1 protein results in decreased susceptibility to Deoxyglucose

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

beclin 1

multiple interactions

[bafilomycin A co-treated with Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] results in decreased expression of BECN1 protein; [demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] results in increased expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BH3 interacting domain death agonist

multiple interactions

Deoxyglucose promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of BID protein]; Deoxyglucose results in increased cleavage of and results in increased activity of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

caspase 3

multiple interactions
increases activity
increases cleavage

ATG7 protein inhibits the reaction [Deoxyglucose results in increased cleavage of CASP3 protein]; Deoxyglucose promotes the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP3 protein]; Deoxyglucose results in increased cleavage of and results in increased activity of CASP3 protein
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]
Deoxyglucose results in increased activity of CASP3 protein
Corticosterone inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein]; GPX4 protein inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein]

PMID:10506188 PMID:15755911 PMID:20593179 PMID:23041229 PMID:29095437

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

[Deoxyglucose co-treated with Cisplatin] results in increased activity of CASP9 protein; Deoxyglucose promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]; Deoxyglucose results in increased cleavage of and results in increased activity of CASP9 protein

PMID:20138251 PMID:23041229

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cell migration inducing hyaluronidase 2

decreases expression

Deoxyglucose results in decreased expression of CEMIP2 mRNA

NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760

G

cholinergic receptor, muscarinic 3

affects response to substance

CHRM3 protein affects the susceptibility to Deoxyglucose

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

component of inhibitor of nuclear factor kappa B kinase complex

affects localization

Deoxyglucose analog affects the localization of CHUK protein

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cathepsin D

increases expression

Deoxyglucose results in increased expression of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cullin 7

multiple interactions

[INS1 protein co-treated with CUL7 mutant form] results in increased uptake of Deoxyglucose

NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of DDIT3 protein]; Mannose inhibits the reaction [Deoxyglucose results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

epidermal growth factor receptor

multiple interactions
increases import

AICA ribonucleotide inhibits the reaction [EGFR protein results in increased import of Deoxyglucose]
EGFR protein mutant form results in increased import of Deoxyglucose

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

Deoxyglucose results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

[Deoxyglucose co-treated with Quercetin] results in increased ubiquitination of ERBB2 protein; Deoxyglucose inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

ERBB receptor feedback inhibitor 1

decreases expression

Deoxyglucose results in decreased expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

family with sequence similarity 117, member A

decreases expression

Deoxyglucose results in decreased expression of FAM117A mRNA

NCBI chr10:80,281,411...80,325,345
Ensembl chr10:80,281,408...80,325,343

G

FXYD domain-containing ion transport regulator 2

multiple interactions
increases transport

Calcium inhibits the reaction [FXYD2 protein results in increased transport of Deoxyglucose]

NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203

G

G3BP stress granule assembly factor 1

multiple interactions

Deoxyglucose inhibits the reaction [G3BP1 protein results in increased abundance of Lactic Acid]; Deoxyglucose inhibits the reaction [G3BP1 protein results in increased expression of HK2 protein]; Deoxyglucose inhibits the reaction [G3BP1 protein results in increased expression of LDHA protein]; Deoxyglucose inhibits the reaction [G3BP1 protein results in increased expression of PKM protein]; Deoxyglucose inhibits the reaction [G3BP1 protein results in increased uptake of Glucose]

NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268

G

galanin receptor 1

increases expression

Deoxyglucose results in increased expression of GALR1 mRNA

PMID:9858361 PMID:9928191

NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577

G

glucagon

multiple interactions
increases secretion

Capsaicin inhibits the reaction [Deoxyglucose results in increased secretion of GCG protein]

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glutathione peroxidase 4

multiple interactions

GPX4 protein inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glycogen synthase kinase 3 beta

multiple interactions

Deoxyglucose inhibits the reaction [arsenic trioxide results in increased phosphorylation of GSK3B protein]; Deoxyglucose inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

H2A.X variant histone

decreases expression

Deoxyglucose results in decreased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hexokinase 2

multiple interactions

[Lactic Acid co-treated with Deoxyglucose] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HK2 protein]; Deoxyglucose inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HK2 protein]; Deoxyglucose inhibits the reaction [G3BP1 protein results in increased expression of HK2 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of HK2 protein]; Deoxyglucose results in decreased expression of and results in decreased activity of HK2 protein

PMID:32619556 PMID:34481905 PMID:35945655 PMID:36336208

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group AT-hook 2

multiple interactions

Deoxyglucose inhibits the reaction [HMGA2 protein results in decreased expression of COX4 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in decreased expression of ND1 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of HK2 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of MMP2 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of MMP9 protein]

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

heme oxygenase 1

multiple interactions

Deoxyglucose inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Deoxyglucose inhibits the reaction [Fenretinide results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein 90 alpha family class A member 1

multiple interactions

Deoxyglucose inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 beta family member 1

increases expression
multiple interactions

Deoxyglucose results in increased expression of HSP90B1 protein
4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSP90B1 protein]

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 mRNA]; 4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]; ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]; HSPA5 protein affects the reaction [A2M protein modified form results in increased uptake of Deoxyglucose]; HSPA5 protein affects the reaction [INS protein results in increased uptake of Deoxyglucose]; Mannose inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]; Oxygen deficiency inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]
Deoxyglucose results in increased expression of HSPA5 mRNA; Deoxyglucose results in increased expression of HSPA5 protein

PMID:20593179 PMID:25720493 PMID:31022492

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

HtrA serine peptidase 2

multiple interactions
decreases localization

Deoxyglucose promotes the reaction [arsenic trioxide results in decreased localization of HTRA2 protein]
Deoxyglucose results in decreased localization of HTRA2 protein

NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095

G

insulin-like growth factor 1 receptor

multiple interactions

Deoxyglucose results in increased phosphorylation of and results in increased activity of IGF1R protein

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 1 beta

decreases response to substance
multiple interactions

Deoxyglucose results in decreased susceptibility to IL1B protein
Deoxyglucose inhibits the reaction [bisphenol F results in increased secretion of IL1B protein]
Deoxyglucose inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]

PMID:21211511 PMID:34147605

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Deoxyglucose inhibits the reaction [bisphenol F results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions
increases uptake
increases transport
increases secretion
affects transport

4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS1 results in increased uptake of Deoxyglucose]]; CCG 1423 promotes the reaction [ABRA mutant form promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; CCG 1423 promotes the reaction [INS1 protein promotes the reaction [ABRA mutant form results in increased uptake of Deoxyglucose]]; CCG 1423 promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Diethylhexyl Phthalate inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Glucosamine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Glucosamine inhibits the reaction [INS1 results in increased uptake of Deoxyglucose]; Glucose inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; glyceryl 2-arachidonate promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; INS1 protein promotes the reaction [ABRA mutant form results in increased uptake of Deoxyglucose]; INS1 protein promotes the reaction [CCG 1423 results in increased uptake of Deoxyglucose]; mono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Quercetin inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; Quercetin inhibits the reaction [TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; Quercetin promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; SLC2A4 promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; ursodoxicoltaurine inhibits the reaction [Glucosamine inhibits the reaction [INS1 results in increased uptake of Deoxyglucose]]
[INS1 protein co-treated with CUL7 mutant form] results in increased uptake of Deoxyglucose; acetylaminophenylarsine oxide inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]; Apigenin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]]; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; Dimercaprol inhibits the reaction [p-aminophenylarsine oxide inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]]; dorsomorphin inhibits the reaction [Quercetin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; epigallocatechin gallate inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; fisetin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Genistein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Genistein inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; kaempferol inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Luteolin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; p-aminophenylarsine oxide inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]; Quercetin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Quercetin inhibits the reaction [TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Ro 31-8220 inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Silybin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; theaflavin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; tyrphostin 25 inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; Wortmannin inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]
INS1 protein results in increased uptake of Deoxyglucose; INS1 results in increased uptake of Deoxyglucose
Deoxyglucose results in increased secretion of INS1 protein
INS1 protein affects the transport of Deoxyglucose

PMID:1378463 PMID:1536656 PMID:1847587 PMID:1918056 PMID:2202293 More...

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

increases uptake
multiple interactions

INS protein results in increased uptake of Deoxyglucose; INS results in increased uptake of Deoxyglucose
METRNL protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]]
3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]; 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]; GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]; HSPA5 protein affects the reaction [INS protein results in increased uptake of Deoxyglucose]; Palmitates inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; Palmitic Acid inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; SLC2A1 protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]]; TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; Troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]; ursodoxicoltaurine inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]

PMID:2173694 PMID:16483873 PMID:20165829 PMID:21324916 PMID:25720493 More...

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

integrin subunit beta 1

decreases expression

Deoxyglucose analog results in decreased expression of ITGB1 protein

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

jade family PHD finger 2

increases expression

Deoxyglucose results in increased expression of JADE2 mRNA

NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

[Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein; Deoxyglucose inhibits the reaction [Glucose results in decreased activity of KCNH2 protein]; Deoxyglucose promotes the reaction [Glucose deficiency results in decreased activity of KCNH2 protein]; Pyruvic Acid inhibits the reaction [[Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein]
Deoxyglucose results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 11

multiple interactions

[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]

NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082

G

kelch-like family, member 42

increases expression

Deoxyglucose results in increased expression of KLHL42 mRNA

NCBI chr 4:179,999,655...180,027,283
Ensembl chr 4:180,004,580...180,027,283

G

lactate dehydrogenase A

multiple interactions

Deoxyglucose inhibits the reaction [G3BP1 protein results in increased expression of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

leptin

multiple interactions
decreases secretion

[Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein
Deoxyglucose results in decreased secretion of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

lipase H

decreases expression

Deoxyglucose results in decreased expression of LIPH mRNA

NCBI chr11:79,032,229...79,081,625
Ensembl chr11:79,033,312...79,081,625

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

Deoxyglucose affects the reaction [demycarosyl-3D-digitoxosylmithramycin SK affects the expression of MAP1LC3A mRNA]

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases prenylation

ATG7 protein promotes the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein]; Mannose inhibits the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein]; Oxygen deficiency inhibits the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions

arsenic trioxide inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK1 protein; PQ 401 inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

MAPK3 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose]
Arsenic Trioxide inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein; PQ 401 inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:11978788 PMID:23041229

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

methylphosphate capping enzyme

increases expression

Deoxyglucose results in increased expression of MEPCE mRNA

NCBI chr12:18,911,796...18,916,515
Ensembl chr12:18,911,796...18,916,514

G

meteorin-like, glial cell differentiation regulator

multiple interactions

METRNL protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]

NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869

G

matrix metallopeptidase 13

multiple interactions
decreases expression

Deoxyglucose inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Deoxyglucose inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
Deoxyglucose analog results in decreased expression of MMP13 protein

PMID:21211511 PMID:27931795

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

multiple interactions

Deoxyglucose inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
multiple interactions

Deoxyglucose analog results in decreased expression of MMP9 protein
Deoxyglucose inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in increased expression of MMP9 protein]

PMID:27931795 PMID:34481905

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions

Deoxyglucose inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of ND1 protein]; Deoxyglucose inhibits the reaction [HMGA2 protein results in decreased expression of ND1 protein]

NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

mechanistic target of rapamycin kinase

multiple interactions

Deoxyglucose results in decreased phosphorylation of and results in increased expression of MTOR protein; Deoxyglucose results in increased phosphorylation of and results in increased activity of MTOR protein

PMID:23041229 PMID:23363784

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MAX interactor 1, dimerization protein

decreases expression

Deoxyglucose results in decreased expression of MXI1 mRNA

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

myosin IE

decreases expression

Deoxyglucose results in decreased expression of MYO1E mRNA

NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression

[demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] affects the expression of NFKB1 mRNA
Deoxyglucose results in decreased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

multiple interactions

Deoxyglucose promotes the reaction [STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuropeptide Y

increases expression

Deoxyglucose results in increased expression of NPY mRNA

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

ornithine aminotransferase

multiple interactions

Deoxyglucose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Deoxyglucose inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Deoxyglucose inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]
Deoxyglucose results in increased cleavage of PARP1 protein

PMID:25246272 PMID:29095437

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pyruvate kinase M1/2

multiple interactions

Deoxyglucose inhibits the reaction [G3BP1 protein results in increased expression of PKM protein]

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

pro-melanin-concentrating hormone

increases expression

Deoxyglucose results in increased expression of PMCH mRNA

NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250

G

peroxisome proliferator activated receptor alpha

multiple interactions

PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

affects uptake
increases uptake

PPARG protein affects the uptake of Deoxyglucose
PPARG gene polymorphism results in increased uptake of Deoxyglucose

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 3 catalytic subunit alpha

decreases response to substance

PPP3CA protein results in decreased susceptibility to Deoxyglucose

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

PYM homolog 1, exon junction complex associated factor

increases expression

Deoxyglucose results in increased expression of PYM1 mRNA

NCBI chr 7:1,177,746...1,200,899
Ensembl chr 7:1,178,008...1,198,937

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

RAF1 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

ring finger protein 24

decreases expression

Deoxyglucose results in decreased expression of RNF24 mRNA

NCBI chr 3:118,520,459...118,575,213
Ensembl chr 3:118,525,349...118,541,080

G

ribosomal protein S6

decreases phosphorylation

Deoxyglucose results in decreased phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein
Deoxyglucose results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; oxophenylarsine inhibits the reaction [Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein]

PMID:16183647 PMID:23041229

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

serpin family B member 5

increases expression

Deoxyglucose analog results in increased expression of SERPINB5 protein

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756

G

solute carrier family 16 member 1

multiple interactions

[Lactic Acid co-treated with Deoxyglucose] promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC16A1 protein]

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 2 member 1

multiple interactions
increases uptake

[arsenite affects the localization of SLC2A1 protein] which results in increased uptake of Deoxyglucose
SLC2A1 protein results in increased uptake of Deoxyglucose
[Deoxyglucose results in increased abundance of Glucose] which affects the localization of SLC2A1 protein; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [[Deoxyglucose results in increased abundance of Glucose] which affects the localization of SLC2A1 protein]; SLC2A1 protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]

PMID:2173694 PMID:14511371 PMID:31398423

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 2

multiple interactions
increases transport

Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 3

increases transport
multiple interactions

SLC2A3 protein results in increased transport of Deoxyglucose
Cytochalasin B inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Galactose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 2 member 4

multiple interactions
increases uptake

2-chloro-5-nitrobenzanilide inhibits the reaction [mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]]; [arsenite affects the localization of SLC2A4 protein] which results in increased uptake of Deoxyglucose; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]; Plant Extracts promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]
[Indinavir results in decreased activity of SLC2A4 protein] inhibits the reaction [resveratrol results in increased uptake of Deoxyglucose]; SLC2A4 promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; SLC2A4 protein promotes the reaction [resveratrol results in increased uptake of Deoxyglucose]

PMID:14511371 PMID:18601907 PMID:19477051 PMID:20206685

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 2 member 8

increases uptake

SLC2A8 protein results in increased uptake of Deoxyglucose

NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464

G

small integral membrane protein 14

decreases expression

Deoxyglucose results in decreased expression of SMIM14 mRNA

NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760

G

superoxide dismutase 2

multiple interactions

Deoxyglucose inhibits the reaction [manganese chloride results in increased expression of SOD2 mRNA]; Deoxyglucose inhibits the reaction [manganese chloride results in increased expression of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sequestosome 1

multiple interactions

[bafilomycin A co-treated with Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] affects the expression of SQSTM1 protein; [bafilomycin A co-treated with Deoxyglucose] affects the expression of SQSTM1 protein; Deoxyglucose inhibits the reaction [demycarosyl-3D-digitoxosylmithramycin SK results in decreased expression of SQSTM1 mRNA]; Deoxyglucose promotes the reaction [demycarosyl-3D-digitoxosylmithramycin SK results in decreased expression of SQSTM1 mRNA]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

increases expression

Deoxyglucose results in increased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

SLIT-ROBO Rho GTPase activating protein 3

decreases expression

Deoxyglucose results in decreased expression of SRGAP3 mRNA

NCBI chr 4:145,839,369...146,070,556
Ensembl chr 4:145,840,078...146,070,575

G

serine/threonine kinase 11

decreases phosphorylation

Deoxyglucose results in decreased phosphorylation of STK11 protein

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

terminal nucleotidyltransferase 4B

decreases expression

Deoxyglucose results in decreased expression of TENT4B mRNA

NCBI chr19:18,807,616...18,868,969
Ensembl chr19:18,807,525...18,869,537

G

transmembrane and coiled-coil domain family 3

decreases expression

Deoxyglucose results in decreased expression of TMCC3 mRNA

NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926

G

transmembrane protein 250

increases expression

Deoxyglucose results in increased expression of TMEM250 mRNA

NCBI chr 3:8,962,657...8,966,349
Ensembl chr 3:8,962,657...8,966,349

G

transmembrane protein 87A

increases expression

Deoxyglucose results in increased expression of TMEM87A mRNA

NCBI chr 3:107,307,726...107,353,571
Ensembl chr 3:107,307,726...107,353,551

G

tumor necrosis factor

decreases expression
multiple interactions
decreases response to substance

Deoxyglucose results in decreased expression of TNF protein
Quercetin inhibits the reaction [TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
Deoxyglucose inhibits the reaction [bisphenol F results in increased secretion of TNF protein]; Quercetin inhibits the reaction [TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
Deoxyglucose results in decreased susceptibility to TNF protein
Deoxyglucose inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]

PMID:16483873 PMID:21211511 PMID:21778228 PMID:22713545 PMID:23439570 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

[Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] results in increased expression of TP53 mRNA; Deoxyglucose promotes the reaction [demycarosyl-3D-digitoxosylmithramycin SK results in increased expression of TP53 mRNA]; TP53 protein inhibits the reaction [Deoxyglucose results in decreased abundance of Adenosine Triphosphate]

PMID:21042727 PMID:26079942

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

X-linked inhibitor of apoptosis

multiple interactions

[arsenic trioxide co-treated with Deoxyglucose] results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

tyrosyl-tRNA synthetase 2

increases expression

Deoxyglucose results in increased expression of YARS2 mRNA

NCBI chr11:84,632,350...84,638,138
Ensembl chr11:84,624,369...84,638,125

G

YES proto-oncogene 1, Src family tyrosine kinase

decreases expression

Deoxyglucose results in decreased expression of YES1 mRNA

NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837

G

zinc finger and BTB domain containing 1

increases expression

Deoxyglucose results in increased expression of ZBTB1 mRNA

NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996

G

zinc finger protein X-linked

increases expression

Deoxyglucose results in increased expression of ZFX mRNA

NCBI chr X:58,804,690...58,853,155
Ensembl chr X:58,804,691...58,853,265

fucose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fucosyltransferase 8

multiple interactions

Fucose analog inhibits the reaction [Mersalyl results in decreased activity of FUT8 protein]; Fucose analog inhibits the reaction [p-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein]; Fucose analog inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]; Fucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein]

NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677

G

lactase

increases hydrolysis

LCT protein results in increased hydrolysis of Fucose

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

icariside II

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

baohuoside I results in decreased expression of ABCB11 mRNA; baohuoside I results in decreased expression of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

decreases expression

baohuoside I results in decreased expression of ABCC2 mRNA; baohuoside I results in decreased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

baohuoside I results in decreased phosphorylation of AKT1 protein
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT1 substrate 1

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]
baohuoside I results in decreased phosphorylation of AKT1S1 protein

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

alkaline phosphatase, biomineralization associated

increases expression
increases secretion

baohuoside I results in increased expression of ALPL mRNA
baohuoside I results in increased secretion of ALPL protein

PMID:17764702 PMID:35802278

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

increases expression

baohuoside I results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

baohuoside I results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

increases expression

baohuoside I results in increased expression of BGLAP mRNA

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

B-Raf proto-oncogene, serine/threonine kinase

decreases phosphorylation
multiple interactions

baohuoside I results in decreased phosphorylation of BRAF protein
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

caspase 3

increases cleavage
increases activity

baohuoside I results in increased cleavage of CASP3 protein
baohuoside I results in increased activity of CASP3 protein

PMID:19289254 PMID:22687635

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

baohuoside I results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
increases cleavage

baohuoside I results in increased activity of CASP9 protein
baohuoside I results in increased cleavage of CASP9 protein

PMID:19289254 PMID:22687635

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

collagen type I alpha 2 chain

increases expression

baohuoside I results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

cytochrome P450 family 7 subfamily A member 1

increases expression

baohuoside I results in increased expression of CYP7A1 mRNA; baohuoside I results in increased expression of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

epidermal growth factor

multiple interactions

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
baohuoside I results in decreased phosphorylation of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

estrogen receptor 1

multiple interactions

baohuoside I binds to and results in increased degradation of ESR1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [baohuoside I results in increased degradation of ESR1 protein]; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

glutamic-oxaloacetic transaminase 1

increases secretion

baohuoside I results in increased secretion of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases secretion

baohuoside I results in increased secretion of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glycogen synthase kinase 3 beta

decreases phosphorylation

baohuoside I results in decreased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]
baohuoside I results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
baohuoside I results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

marker of proliferation Ki-67

decreases expression

baohuoside I results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]
baohuoside I results in decreased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

nitric oxide synthase 2

decreases expression

baohuoside I results in decreased expression of NOS2

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
decreases expression

baohuoside I results in decreased expression of and results in decreased activity of and affects the localization of NR0B2 protein; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein]
baohuoside I results in decreased expression of NR0B2 mRNA; baohuoside I results in decreased expression of NR0B2 protein

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

baohuoside I results in decreased expression of NR1H4 mRNA; baohuoside I results in decreased expression of NR1H4 protein

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

baohuoside I results in increased cleavage of PARP1 protein
Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein]; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein]

PMID:19289254 PMID:22687635

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

3-phosphoinositide dependent protein kinase-1

decreases phosphorylation

baohuoside I results in decreased phosphorylation of PDPK1 protein

NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

baohuoside I results in decreased expression of PTGS2
[baohuoside I results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

solute carrier family 10 member 1

increases expression

baohuoside I results in increased expression of SLC10A1 protein
baohuoside I results in increased expression of SLC10A1 mRNA; baohuoside I results in increased expression of SLC10A1 protein

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier organic anion transporter family, member 1a4

decreases expression

baohuoside I results in decreased expression of SLCO1A1 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

TNF receptor superfamily member 11B

increases expression

baohuoside I results in increased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

decreases expression

baohuoside I results in decreased expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

vascular endothelial growth factor A

decreases expression

baohuoside I results in decreased expression of VEGFA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

phosphoramidon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

AKT serine/threonine kinase 1

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

endothelin converting enzyme 1

multiple interactions
decreases activity

EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of ECE1 protein]
phosphoramidon decreases activity of recombinant Ece1 protein in COS cells

CTD
RGD

PMID:11145282 PMID:16280098 PMID:8034569

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

endothelin 1

decreases expression
multiple interactions

phosphoramidon results in decreased expression of EDN1 protein
EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]

PMID:11145282 PMID:16280098 PMID:16391412

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

multiple interactions

phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

increases expression

phosphoramidon results in increased expression of EDNRB protein

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

epidermal growth factor receptor

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

intercellular adhesion molecule 1

multiple interactions

phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

Kell metallo-endopeptidase (Kell blood group)

multiple interactions

KEL protein alternative form binds to and affects the metabolism of phosphoramidon

NCBI chr 4:70,568,241...70,585,666
Ensembl chr 4:70,568,243...70,585,631

G

leptin

decreases expression

phosphoramidon results in decreased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen activated protein kinase 1

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

membrane metallo-endopeptidase

multiple interactions

phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein]

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

neurotensin

multiple interactions

phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

selectin L

multiple interactions

phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

tachykinin, precursor 1

multiple interactions

[TAC1 protein co-treated with phosphoramidon] results in increased uptake of Oxygen

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

rhamnose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ornithine aminotransferase

multiple interactions

Rhamnose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19838
chemical entity	19836
atom	19836
nonmetal atom	19774
oxygen atom	19518
oxygen molecular entity	19518
organooxygen compound	19168
carbohydrates and carbohydrate derivatives	15283
carbohydrate	15283
deoxy sugar	146
deoxy oligosaccharide +	0
deoxyheptose +	0
deoxyhexose +	146
deoxyketohexose +	0
deoxypentose +	0
Path 2
Term	Annotations
CHEBI ontology	19838
subatomic particle	19836
composite particle	19836
hadron	19836
baryon	19836
nucleon	19836
atomic nucleus	19836
atom	19836
main group element atom	19786
p-block element atom	19786
carbon group element atom	19734
carbon atom	19731
organic molecular entity	19731
heteroorganic entity	19488
organochalcogen compound	19251
organooxygen compound	19168
carbohydrates and carbohydrate derivatives	15283
carbohydrate	15283
deoxy sugar	146
deoxy oligosaccharide +	0
deoxyheptose +	0
deoxyhexose +	146
deoxyketohexose +	0
deoxypentose +	0

paths to the root