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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atg7
Name: autophagy related 7
Acc ID: CHEBI:15866
Term: 2-deoxy-D-glucose
Definition: A deoxyglucose that is D-glucose in which the hydroxy group at position 2 has been replaced by a hydrogen. It is an antimetabolite of glucose with antiviral activity, which acts by inhibiting the glycosylation of glycoproteins and glycolipids. Used as an antiherpes agent.
Chemical ID: MESH:D003847
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atg7multiple interactionsISORGD:13124816480464CTDATG7 protein inhibits the reaction [Deoxyglucose results in increased cleavage of CASP3 protein] ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of DDIT3 protein] ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein] ATG7 protein promotes the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein]

PMID:20593179
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