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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrate ester
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Accession:CHEBI:51080 term browser browse the term
Definition:Any member of the class of nitrates resulting from the esterification of nitric acid with an alcohol.
Synonyms:related_synonym: nitrate esters
 xref: Wikipedia:Nitrate_ester


show annotations for term's descendants           Sort by:
isosorbide dinitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Isosorbide Dinitrate results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA CTD PMID:15719745 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases response to substance ISO G6PD protein results in decreased susceptibility to Isosorbide Dinitrate CTD PMID:6401899 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNA; [Isosorbide Dinitrate co-treated with Plant Preparations] results in increased expression of NOS3 mRNA CTD PMID:15719745 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
isosorbide mononitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 multiple interactions EXP isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein] CTD PMID:8738301 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
nicorandil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP Nicorandil inhibits the reaction [Methotrexate results in decreased expression of ABCB1A protein] CTD PMID:32666843 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 increases activity ISO Nicorandil results in increased activity of ABCC9 protein CTD PMID:22622455 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein] CTD PMID:22622455 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Alb albumin multiple interactions ISO Nicorandil inhibits the reaction [Folic Acid results in decreased expression of ALB protein] CTD PMID:33404076 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 Nicorandil inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
Nicorandil inhibits the reaction [Folic Acid results in increased expression of BAX protein]		 CTD PMID:31376360 PMID:33404076 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:31376360 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Nicorandil inhibits the reaction [Folic Acid results in increased expression of CASP3 protein] CTD PMID:33404076 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:31376360 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 PMID:14499179 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:31376360 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP Nicorandil results in decreased expression of HMOX1 protein CTD PMID:22622455 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Nicorandil inhibits the reaction [Methotrexate results in increased expression of IL1B protein] CTD PMID:31376360 PMID:32666843 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Nicorandil inhibits the reaction [Folic Acid results in increased expression of IL6 protein] CTD PMID:33404076 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of MPO protein] CTD PMID:31376360 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein] CTD PMID:31376360 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of NFKB1 protein] CTD PMID:31376360 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Nicorandil inhibits the reaction [Folic Acid results in increased expression of NOS2 protein] CTD PMID:33404076 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO
EXP		 Nicorandil inhibits the reaction [Folic Acid results in decreased expression of NOS3 protein]
Nicorandil inhibits the reaction [Methotrexate results in decreased expression of NOS3 protein]		 CTD PMID:32666843 PMID:33404076 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Nicorandil results in increased expression of SOD2 protein CTD PMID:22622455 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TLR4 protein] CTD PMID:31376360 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Nicorandil inhibits the reaction [Methotrexate results in increased expression of TNF protein]
Nicorandil inhibits the reaction [Folic Acid results in increased expression of TNF protein]		 CTD PMID:31376360 PMID:32666843 PMID:33404076 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Nicorandil inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:32666843 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
decreases expression		 ISO
EXP		 Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein]
Nicorandil results in decreased expression of XDH protein		 CTD PMID:22622455 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
nitroflurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 decreases expression ISO nitroflurbiprofen results in decreased expression of CASP1 mRNA CTD PMID:15081244 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] CTD PMID:16491094 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:16491094 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:16491094 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 ISO
EXP		 nitroflurbiprofen results in decreased expression of NOS2 mRNA
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:8528547 PMID:15081244 PMID:16491094 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity		 ISO
EXP		 nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
nitroflurbiprofen results in decreased activity of RELA protein		 CTD PMID:12716482 PMID:16491094 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:12716482 PMID:16491094 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 increases expression EXP Nitroglycerin results in increased expression of ACAT1 mRNA CTD PMID:12102619 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Actb actin, beta decreases expression EXP Nitroglycerin results in decreased expression of ACTB mRNA CTD PMID:12102619 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression EXP Nitroglycerin results in decreased expression of ALDH1A1 mRNA CTD PMID:12102619 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
decreases activity
increases response to substance
decreases expression
affects metabolic processing
affects response to substance		 ISO
EXP		 [1-aminocyclopropanol analog results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]; ALDH2 protein affects the reaction [Nitroglycerin results in decreased abundance of Cyclic GMP]
ALDH2 protein affects the reaction [Ascorbic Acid deficiency results in decreased susceptibility to Nitroglycerin]
ALDH2 protein results in increased susceptibility to Nitroglycerin
Nitroglycerin results in decreased expression of ALDH2 mRNA; Nitroglycerin results in decreased expression of ALDH2 protein
ALDH2 protein affects the metabolism of and results in increased activity of Nitroglycerin; ALDH2 protein affects the reaction [Nitroglycerin results in increased abundance of Reactive Oxygen Species]; Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]
ALDH2 protein affects the metabolism of Nitroglycerin
ALDH2 gene polymorphism affects the susceptibility to Nitroglycerin; ALDH2 protein affects the susceptibility to Nitroglycerin; ALDH2 protein polymorphism affects the susceptibility to Nitroglycerin		 CTD PMID:15331769 PMID:16440063 PMID:17092343 PMID:17493633 PMID:17541025 More... NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Nitroglycerin results in decreased expression of ALOX15 mRNA CTD PMID:12102619 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 increases expression EXP Nitroglycerin results in increased expression of AP2M1 mRNA CTD PMID:12102619 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Nitroglycerin results in increased expression of APEX1 mRNA CTD PMID:12102619 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression EXP Nitroglycerin results in decreased expression of APOA1 mRNA CTD PMID:12102619 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Arl2 ARF like GTPase 2 increases expression EXP Nitroglycerin results in increased expression of ARL2 mRNA CTD PMID:12102619 NCBI chr 1:203,434,129...203,446,156
Ensembl chr 1:203,434,129...203,446,119 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression EXP Nitroglycerin results in decreased expression of ATP5F1A mRNA CTD PMID:12102619 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G B2m beta-2 microglobulin affects expression ISO Nitroglycerin affects the expression of B2M protein CTD PMID:8350464 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression EXP Nitroglycerin results in decreased expression of BCKDHB mRNA CTD PMID:12102619 NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Nitroglycerin results in decreased expression of BCL2 protein CTD PMID:17678976 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C3 complement C3 increases expression ISO Nitroglycerin results in increased expression of C3 protein alternative form CTD PMID:10884648 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases expression
affects expression		 EXP
ISO		 Capsaicin inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Dexamethasone inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]
Nitroglycerin results in increased expression of CALCA mRNA; Nitroglycerin results in increased expression of CALCA protein
Nitroglycerin affects the expression of CALCA protein		 CTD PMID:11919648 PMID:14659530 PMID:14729435 PMID:19121572 PMID:36924863 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Calm2 calmodulin 2 increases expression EXP Nitroglycerin results in increased expression of CALM2 mRNA CTD PMID:12102619 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Capn2 calpain 2 decreases expression EXP Nitroglycerin results in decreased expression of CAPN2 mRNA CTD PMID:12102619 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Nitroglycerin results in increased cleavage of and results in increased activity of CASP1 protein CTD PMID:12105852 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions		 ISO Nitroglycerin results in decreased expression of CASP3 protein modified form
Nitroglycerin results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:12105852 PMID:17322376 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Nitroglycerin results in increased expression of and results in increased activity of CAT protein CTD PMID:12860443 PMID:14732477 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex increases expression EXP Nitroglycerin results in increased expression of CD3D mRNA CTD PMID:12102619 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809 		JBrowse link
G Cd5 Cd5 molecule decreases expression EXP Nitroglycerin results in decreased expression of CD5 mRNA CTD PMID:12102619 NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313 		JBrowse link
G Cd53 Cd53 molecule decreases expression EXP Nitroglycerin results in decreased expression of CD53 mRNA CTD PMID:12102619 NCBI chr 2:194,352,139...194,399,668
Ensembl chr 2:194,352,139...194,399,657 		JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone increases expression EXP Nitroglycerin results in increased expression of CDC37 mRNA CTD PMID:12102619 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Nitroglycerin results in increased expression of CDKN1B mRNA CTD PMID:12102619 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Celf2 CUGBP, Elav-like family member 2 increases expression EXP Nitroglycerin results in increased expression of CELF2 mRNA CTD PMID:12102619 NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333 		JBrowse link
G Ckb creatine kinase B decreases expression EXP Nitroglycerin results in decreased expression of CKB mRNA CTD PMID:12102619 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Clu clusterin decreases expression EXP Nitroglycerin results in decreased expression of CLU mRNA CTD PMID:12102619 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Nitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein] CTD PMID:16775503 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cp ceruloplasmin decreases expression EXP Nitroglycerin results in decreased expression of CP mRNA CTD PMID:12102619 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression EXP Nitroglycerin results in decreased expression of CRIP2 mRNA CTD PMID:12102619 NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases localization		 ISO 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Nitroglycerin results in increased degradation of CTNNB1 protein]; Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Nitroglycerin results in decreased phosphorylation of and results in increased nitrosation of and results in increased degradation of and results in decreased activity of CTNNB1 protein; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein] CTD PMID:17030184 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsd cathepsin D decreases expression EXP Nitroglycerin results in decreased expression of CTSD mRNA CTD PMID:12102619 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
increases expression
decreases response to substance		 ISO
EXP		 CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]; Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
Nitroglycerin results in decreased expression of CYBB mRNA
CYBB gene mutant form results in decreased susceptibility to Nitroglycerin		 CTD PMID:16633368 PMID:17493633 PMID:18522491 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Nitroglycerin results in decreased expression of CYP11B2 mRNA CTD PMID:12102619 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression
decreases expression 		EXP Vitamin E inhibits the reaction [nitroglycerine decreases Cyp1a2 protein expression in rat heart]
nitroglycerin decreased expression of Cyp1a2 protein in thoracic aorta of rats		 RGD PMID:16520233 PMID:12688525 RGD:401900296, RGD:401900656 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 decreases expression EXP Nitroglycerin results in decreased expression of CYP2B15 mRNA CTD PMID:12102619 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Nitroglycerin results in increased expression of CYP2E1 mRNA CTD PMID:12102619 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Nitroglycerin results in decreased expression of DHCR7 mRNA CTD PMID:12102619 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 decreases expression EXP Nitroglycerin results in decreased expression of DYNC1I1 mRNA CTD PMID:12102619 NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression EXP Nitroglycerin results in decreased expression of DYRK1A mRNA CTD PMID:12102619 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Edn1 endothelin 1 decreases expression
increases expression
multiple interactions		 ISO
EXP		 Nitroglycerin results in decreased expression of EDN1 mRNA
Nitroglycerin results in increased expression of EDN1 protein
Nitroglycerin results in decreased expression of EDN1 mRNA; Nitroglycerin results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]		 CTD PMID:11751199 PMID:12206003 PMID:12901495 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Elane elastase, neutrophil expressed increases expression ISO Nitroglycerin results in increased expression of ELANE protein CTD PMID:10884648 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Eln elastin increases expression EXP Nitroglycerin results in increased expression of ELN mRNA CTD PMID:12187120 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Faah fatty acid amide hydrolase increases activity
multiple interactions		 EXP Nitroglycerin results in increased activity of FAAH protein
Nitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]		 CTD PMID:19515121 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Nitroglycerin results in increased expression of and results in increased localization of FAS protein CTD PMID:12105852 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression EXP Nitroglycerin results in increased expression of FGFR2 mRNA CTD PMID:12102619 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Nitroglycerin results in decreased expression of FMO1 mRNA CTD PMID:12102619 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO
EXP		 Nitroglycerin results in increased expression of FOS protein
Nitroglycerin results in increased expression of FOS mRNA; Nitroglycerin results in increased expression of FOS protein
anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of FOS mRNA]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of FOS mRNA]		 CTD PMID:7552308 PMID:10426492 PMID:16897600 PMID:18761334 PMID:19121572 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator decreases expression EXP Nitroglycerin results in decreased expression of GCHFR mRNA CTD PMID:12102619 NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080 		JBrowse link
G Gnb3 G protein subunit beta 3 affects response to substance ISO GNB3 protein affects the susceptibility to Nitroglycerin CTD PMID:14586390 NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173 		JBrowse link
G Gng7 G protein subunit gamma 7 decreases expression EXP Nitroglycerin results in decreased expression of GNG7 mRNA CTD PMID:12102619 NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Nitroglycerin inhibits the reaction [cupric nitrilotriacetate results in increased activity of GPT protein] CTD PMID:36305384 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance ISO GPX1 gene mutant form results in decreased susceptibility to Nitroglycerin CTD PMID:24296279 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Nitroglycerin results in decreased expression of GRK6 mRNA CTD PMID:12102619 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
G Grn granulin precursor decreases expression EXP Nitroglycerin results in decreased expression of GRN mRNA CTD PMID:12102619 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gsn gelsolin increases expression EXP Nitroglycerin results in increased expression of GSN mRNA CTD PMID:12187120 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Nitroglycerin results in decreased expression of GSTA2 mRNA CTD PMID:12102619 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects metabolic processing EXP GSTA3 protein affects the metabolism of Nitroglycerin CTD PMID:8968379 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects metabolic processing EXP GSTM2 protein affects the metabolism of Nitroglycerin CTD PMID:8968379 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gtf3c1 general transcription factor IIIC subunit 1 increases expression EXP Nitroglycerin results in increased expression of GTF3C1 mRNA CTD PMID:12102619 NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 increases expression EXP Nitroglycerin results in increased expression of GUCY1A1 mRNA; Nitroglycerin results in increased expression of GUCY1A1 protein CTD PMID:11331261 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 increases expression ISO
EXP		 Nitroglycerin results in increased expression of GUCY1B1 protein
Nitroglycerin results in increased expression of GUCY1B1 mRNA; Nitroglycerin results in increased expression of GUCY1B1 protein		 CTD PMID:11331261 PMID:11742226 PMID:17541025 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Nitroglycerin results in increased expression of HBB mRNA CTD PMID:12187120 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hdc histidine decarboxylase decreases expression EXP Nitroglycerin results in decreased expression of HDC mRNA CTD PMID:12102619 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Nitroglycerin results in increased expression of HMOX1 mRNA
[Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein		 CTD PMID:17092343 PMID:17470570 PMID:17541025 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpn hepsin increases expression EXP Nitroglycerin results in increased expression of HPN mRNA CTD PMID:12102619 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Iapp islet amyloid polypeptide increases expression EXP Nitroglycerin results in increased expression of IAPP mRNA CTD PMID:12102619 NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression EXP Nitroglycerin results in increased expression of ID2 mRNA CTD PMID:12102619 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases expression EXP Nitroglycerin results in decreased expression of IDO1 protein CTD PMID:28659861 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP Nitroglycerin results in increased expression of IL1B protein
rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of IL1B protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of IL1B protein]		 CTD PMID:11701602 PMID:36924863 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression ISO
EXP		 Nitroglycerin results in increased expression of IL6 mRNA; Nitroglycerin results in increased expression of IL6 protein CTD PMID:11701602 PMID:17470570 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jtb jumping translocation breakpoint increases expression EXP Nitroglycerin results in increased expression of JTB mRNA CTD PMID:12102619 NCBI chr 2:175,685,392...175,689,609
Ensembl chr 2:175,684,993...175,690,108 		JBrowse link
G Kmo kynurenine 3-monooxygenase decreases expression EXP Nitroglycerin results in decreased expression of KMO protein CTD PMID:28659861 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Kng2 kininogen 2 decreases expression EXP Nitroglycerin results in decreased expression of KNG2 mRNA CTD PMID:12102619 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Kynu kynureninase decreases expression EXP Nitroglycerin results in decreased expression of KYNU protein CTD PMID:28659861 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488 		JBrowse link
G Maob monoamine oxidase B increases expression EXP Nitroglycerin results in increased expression of MAOB mRNA CTD PMID:12102619 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase decreases expression EXP Nitroglycerin results in decreased expression of MECR mRNA CTD PMID:12102619 NCBI chr 5:144,029,684...144,056,373
Ensembl chr 5:144,029,731...144,055,863 		JBrowse link
G Mgll monoglyceride lipase multiple interactions
increases activity		 EXP Nitroglycerin promotes the reaction [MGLL protein results in increased chemical synthesis of Glycerol]; Nitroglycerin promotes the reaction [MGLL protein results in increased degradation of 2-oleoylglycerol]
Nitroglycerin results in increased activity of MGLL protein		 CTD PMID:19515121 NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO Nitroglycerin results in increased expression of MMP2 mRNA CTD PMID:12084592 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO Nitroglycerin results in increased expression of MMP7 mRNA CTD PMID:12084592 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression		 ISO Nitroglycerin results in increased activity of MMP9 protein
Nitroglycerin results in increased expression of MMP9 mRNA		 CTD PMID:12084592 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase decreases activity EXP Nitroglycerin results in decreased activity of MPO protein CTD PMID:8869312 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression EXP Nitroglycerin results in increased expression of MXI1 mRNA CTD PMID:12102619 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681 		JBrowse link
G Myo9b myosin IXb decreases expression EXP Nitroglycerin results in decreased expression of MYO9B mRNA CTD PMID:12102619 NCBI chr16:17,945,379...18,030,114
Ensembl chr16:17,945,448...18,030,126 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 increases expression EXP Nitroglycerin results in increased expression of NCAM1 mRNA CTD PMID:12102619 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases response to substance
multiple interactions		 ISO NCF1 gene mutant form results in decreased susceptibility to Nitroglycerin
NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]		 CTD PMID:18522491 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 decreases expression EXP Nitroglycerin results in decreased expression of NDUFA5 mRNA CTD PMID:12102619 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598 		JBrowse link
G Nkx2-1 NK2 homeobox 1 decreases expression EXP Nitroglycerin results in decreased expression of NKX2-1 mRNA CTD PMID:12102619 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Nnat neuronatin increases expression EXP Nitroglycerin results in increased expression of NNAT mRNA CTD PMID:12102619 NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression		 EXP acetylsalicylic acid lysinate inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]; Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein] CTD PMID:14510930 PMID:15154853 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
increases expression		 ISO
EXP		 Nitroglycerin results in decreased expression of NOS2 mRNA
NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]
Nitroglycerin results in increased expression of NOS2 mRNA; Nitroglycerin results in increased expression of NOS2 protein
Nitroglycerin results in decreased expression of NOS2 protein		 CTD PMID:11701602 PMID:12206003 PMID:14729435 PMID:14732477 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression		 EXP [Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]
Nitroglycerin results in increased expression of NOS3 mRNA; Nitroglycerin results in increased expression of NOS3 protein		 CTD PMID:10625313 PMID:12860443 PMID:14732477 PMID:17541025 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox1 NADPH oxidase 1 decreases expression EXP Nitroglycerin results in decreased expression of NOX1 mRNA CTD PMID:17493633 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox4 NADPH oxidase 4 decreases expression EXP Nitroglycerin results in decreased expression of NOX4 mRNA CTD PMID:17493633 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Npy neuropeptide Y increases expression EXP Nitroglycerin results in increased expression of NPY protein CTD PMID:10426492 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase increases expression EXP Nitroglycerin results in increased expression of PAICS mRNA CTD PMID:12102619 NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO Nitroglycerin results in decreased expression of PARP1 protein alternative form CTD PMID:17322376 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor decreases expression EXP Nitroglycerin results in decreased expression of PCSK1N mRNA CTD PMID:12102619 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566 		JBrowse link
G Pde1a phosphodiesterase 1A increases expression
multiple interactions		 EXP Nitroglycerin results in increased expression of PDE1A mRNA; Nitroglycerin results in increased expression of PDE1A protein
PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP]		 CTD PMID:11696475 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde2a phosphodiesterase 2A increases expression EXP Nitroglycerin results in increased expression of PDE2A mRNA CTD PMID:12102619 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pla2g1b phospholipase A2 group IB increases expression EXP Nitroglycerin results in increased expression of PLA2G1B mRNA CTD PMID:12102619 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Nitroglycerin results in increased expression of PLAUR mRNA CTD PMID:12102619 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression EXP Nitroglycerin results in decreased expression of PMP22 mRNA CTD PMID:12102619 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Polr1b RNA polymerase I subunit B increases expression EXP Nitroglycerin results in increased expression of POLR1B mRNA CTD PMID:12102619 NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Nitroglycerin results in decreased expression of PPP2CB mRNA CTD PMID:12102619 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression EXP Nitroglycerin results in decreased expression of PRKG1 protein CTD PMID:11331261 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Ptgds prostaglandin D2 synthase increases expression EXP Nitroglycerin results in increased expression of PTGDS mRNA CTD PMID:12102619 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R increases expression EXP Nitroglycerin results in increased expression of PTPRR mRNA CTD PMID:12102619 NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603 		JBrowse link
G Rab40c Rab40c, member RAS oncogene family increases expression EXP Nitroglycerin results in increased expression of RAB40C mRNA CTD PMID:12187120 NCBI chr10:14,900,926...14,936,153
Ensembl chr10:14,900,929...14,936,557 		JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Nitroglycerin results in increased expression of REG3B mRNA CTD PMID:12102619 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases localization
increases expression
multiple interactions		 EXP Nitroglycerin results in increased localization of RELA protein
Nitroglycerin results in increased expression of RELA mRNA
Atorvastatin inhibits the reaction [Nitroglycerin results in increased localization of RELA protein]; Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein]; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of RELA mRNA]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of RELA mRNA]		 CTD PMID:19733216 PMID:36924863 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases activity ISO Nitroglycerin results in increased activity of REN protein CTD PMID:9527094 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP Nitroglycerin results in increased expression of RGS8 mRNA CTD PMID:12102619 NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807 		JBrowse link
G Rheb Ras homolog, mTORC1 binding decreases expression EXP Nitroglycerin results in decreased expression of RHEB mRNA CTD PMID:12102619 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160 		JBrowse link
G Rpl6 ribosomal protein L6 decreases expression EXP Nitroglycerin results in decreased expression of RPL6 mRNA CTD PMID:12102619 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921 		JBrowse link
G Rps3a ribosomal protein S3a increases expression EXP Nitroglycerin results in increased expression of RPS3A mRNA CTD PMID:12102619 NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression EXP Nitroglycerin results in decreased expression of SCGB1A1 mRNA CTD PMID:12102619 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610 		JBrowse link
G Sdc4 syndecan 4 decreases expression EXP Nitroglycerin results in decreased expression of SDC4 mRNA CTD PMID:12102619 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Serpina3n serpin family A member 3N decreases expression EXP Nitroglycerin results in decreased expression of SERPINA3N mRNA CTD PMID:12102619 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 increases expression EXP Nitroglycerin results in increased expression of SHANK2 mRNA CTD PMID:12102619 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression EXP Nitroglycerin results in increased expression of SLC4A4 mRNA CTD PMID:12102619 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883 		JBrowse link
G Snn stannin decreases expression EXP Nitroglycerin results in decreased expression of SNN mRNA CTD PMID:12102619 NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021 		JBrowse link
G Snrk SNF related kinase increases expression EXP Nitroglycerin results in increased expression of SNRK mRNA CTD PMID:12102619 NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Nitroglycerin results in increased expression of and results in increased activity of SOD2 protein CTD PMID:12860443 PMID:14732477 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Nitroglycerin results in increased expression of STAT3 mRNA CTD PMID:12102619 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Syk spleen associated tyrosine kinase increases expression EXP Nitroglycerin results in increased expression of SYK mRNA CTD PMID:12102619 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Syn2 synapsin II increases expression EXP Nitroglycerin results in increased expression of SYN2 mRNA CTD PMID:12102619 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192 		JBrowse link
G Tac1 tachykinin, precursor 1 affects expression EXP Nitroglycerin affects the expression of TAC1 protein CTD PMID:18197882 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tcf4 transcription factor 4 multiple interactions ISO Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]] CTD PMID:17030184 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases expression EXP Nitroglycerin results in decreased expression of TDO2 protein CTD PMID:28659861 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression EXP Nitroglycerin results in decreased expression of THY1 mRNA CTD PMID:12102619 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tmpo thymopoietin increases expression EXP Nitroglycerin results in increased expression of TMPO mRNA CTD PMID:12102619 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 Nitroglycerin results in decreased expression of TNF protein
Capsaicin inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]		 CTD PMID:10884648 PMID:11744139 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 decreases expression EXP Nitroglycerin results in decreased expression of TNFRSF8 mRNA CTD PMID:12102619 NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421 		JBrowse link
G Umod uromodulin increases expression EXP Nitroglycerin results in increased expression of UMOD mRNA CTD PMID:12102619 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO
EXP		 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]
Nitroglycerin results in decreased phosphorylation of VASP protein
Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]		 CTD PMID:11331261 PMID:14551241 PMID:15331769 PMID:17541025 PMID:17868048 More... NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Vtn vitronectin increases expression EXP Nitroglycerin results in increased expression of VTN mRNA CTD PMID:12102619 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta decreases expression EXP Nitroglycerin results in decreased expression of YWHAZ mRNA CTD PMID:12102619 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668 		JBrowse link
pentaerythritol tetranitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
increases metabolic processing
increases response to substance		 ISO
EXP		 [ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide; [ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol
ALDH2 protein affects the metabolism of and results in increased activity of Pentaerythritol Tetranitrate
ALDH2 protein results in increased susceptibility to Pentaerythritol Tetranitrate		 CTD PMID:15331769 PMID:21156756 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Pentaerythritol Tetranitrate results in increased expression of FTH1 mRNA CTD PMID:17641250 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity		 ISO
EXP		 Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA
Pentaerythritol Tetranitrate results in increased activity of HMOX1 protein
Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA; Pentaerythritol Tetranitrate results in increased expression of HMOX1 protein		 CTD PMID:17092343 PMID:17541025 PMID:17641250 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Pentaerythritol Tetranitrate results in increased expression of NOS3 protein CTD PMID:17541025 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
increases phosphorylation		 EXP Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein] CTD PMID:15331769 PMID:17541025 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
pentrinitrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO [ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol CTD PMID:21156756 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        reagent 18070
          nitric acid 210
            nitrates 203
              nitrate ester 157
                aminoethyl nitrate + 0
                clonitrate 0
                erythrityl tetranitrate 0
                isosorbide dinitrate 4
                isosorbide mononitrate 1
                naproxcinod 0
                nicorandil 25
                nitroflurbiprofen 7
                nitroglycerol + 139
                nitrosulindac 0
                pentaerythritol nitrate + 5
                pentrinitrol 1
                propatylnitrate 0
                trolnitrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      chalcogen 19586
                        oxygen atom 19558
                          oxygen molecular entity 19558
                            hydroxides 19365
                              oxoacid 18801
                                pnictogen oxoacid 14982
                                  nitrogen oxoacid 283
                                    nitric acid 210
                                      nitrates 203
                                        nitrate ester 157
                                          aminoethyl nitrate + 0
                                          clonitrate 0
                                          erythrityl tetranitrate 0
                                          isosorbide dinitrate 4
                                          isosorbide mononitrate 1
                                          naproxcinod 0
                                          nicorandil 25
                                          nitroflurbiprofen 7
                                          nitroglycerol + 139
                                          nitrosulindac 0
                                          pentaerythritol nitrate + 5
                                          pentrinitrol 1
                                          propatylnitrate 0
                                          trolnitrate 0
paths to the root