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Gene: Grk6 (G protein-coupled receptor kinase 6) Rattus norvegicus
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Symbol: Grk6
Name: G protein-coupled receptor kinase 6
Description: Exhibits G protein-coupled receptor kinase activity. Involved in several processes, including cellular response to lipopolysaccharide; desensitization of G protein-coupled receptor signaling pathway; and negative regulation of anion channel activity. Localizes to the cytosol and plasma membrane. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; corticotropin-releasing hormone signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH (S)-amphetamine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: g protein-coupled receptor kinase GRK6; G-protein coupled receptor kinase 6; Gprk6
Orthologs:
Homo sapiens (human) : GRK6 (G protein-coupled receptor kinase 6)  HGNC  Alliance
Mus musculus (house mouse) : Grk6 (G protein-coupled receptor kinase 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk6 (G protein-coupled receptor kinase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK6 (G protein-coupled receptor kinase 6)
Canis lupus familiaris (dog) : GRK6 (G protein-coupled receptor kinase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk6 (G protein-coupled receptor kinase 6)
Sus scrofa (pig) : GRK6 (G protein-coupled receptor kinase 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0179,705,917 - 9,721,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01711,814,901 - 11,830,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,220,992 - 15,236,617 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11715,221,263 - 15,236,617 (-)NCBI
Celera179,255,527 - 9,271,204 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Grk6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61986
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.