Grk6 (G protein-coupled receptor kinase 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Grk6 (G protein-coupled receptor kinase 6) Rattus norvegicus
Analyze
Symbol: Grk6
Name: G protein-coupled receptor kinase 6
RGD ID: 61986
Description: Enables G protein-coupled receptor kinase activity. Involved in several processes, including cellular response to lipopolysaccharide; desensitization of G protein-coupled receptor signaling pathway; and negative regulation of anion channel activity. Predicted to be located in membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; corticotropin-releasing hormone signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: g protein-coupled receptor kinase GRK6; G-protein coupled receptor kinase 6; Gprk6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,182,160 - 9,198,380 (-)NCBIGRCr8
mRatBN7.2179,177,018 - 9,192,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,177,019 - 9,192,644 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,193,134 - 9,208,842 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,723,188 - 10,738,879 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,189,522 - 9,205,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,705,917 - 9,721,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,703,453 - 9,721,574 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,814,901 - 11,830,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,220,992 - 15,236,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,221,263 - 15,236,617 (-)NCBI
Celera179,255,527 - 9,271,204 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
capsaicin  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
disodium selenite  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
finasteride  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
haloperidol  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nitroglycerin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pirinixic acid  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
membrane  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7.
2. Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. Ahmed MR, etal., Sci Transl Med. 2010 Apr 21;2(28):28ra28.
3. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
4. Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. Ferrer-Alcón M, etal., Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):114-22. doi: 10.1016/j.molbrainres.2003.11.009.
5. Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6). Fraga S, etal., Cell Physiol Biochem. 2006;18(6):347-60.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Authentically phosphorylated alpha-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease. Sato H, etal., J Neurosci. 2011 Nov 16;31(46):16884-94.
19. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
20. Endogenous G protein-coupled receptor kinase 6 triggers homologous beta-adrenergic receptor desensitization in primary uterine smooth muscle cells. Simon V, etal., Endocrinology 2003 Jul;144(7):3058-66.
21. Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat. Sun B, etal., J Mol Histol. 2013 Jun;44(3):259-70. doi: 10.1007/s10735-013-9486-7. Epub 2013 Jan 29.
22. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26.
23. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
24. The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons. Willets JM, etal., J Neurochem. 2007 Dec;103(6):2268-80. Epub 2007 Oct 1.
Additional References at PubMed
PMID:8889548   PMID:9316417   PMID:9387888   PMID:10446210   PMID:14766980   PMID:19946888   PMID:20038610   PMID:22979934   PMID:23583200   PMID:23979726   PMID:26174132   PMID:27145805  
PMID:28106155   PMID:32484026   PMID:35349212  


Genomics

Comparative Map Data
Grk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,182,160 - 9,198,380 (-)NCBIGRCr8
mRatBN7.2179,177,018 - 9,192,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,177,019 - 9,192,644 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,193,134 - 9,208,842 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,723,188 - 10,738,879 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,189,522 - 9,205,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,705,917 - 9,721,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,703,453 - 9,721,574 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,814,901 - 11,830,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,220,992 - 15,236,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,221,263 - 15,236,617 (-)NCBI
Celera179,255,527 - 9,271,204 (-)NCBICelera
Cytogenetic Map17p14NCBI
GRK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,425,523 - 177,442,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,403,204 - 177,442,901 (+)EnsemblGRCh38hg38GRCh38
GRCh375176,853,677 - 176,869,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,786,293 - 176,802,456 (+)NCBINCBI36Build 36hg18NCBI36
Build 345176,786,293 - 176,802,437NCBI
Celera5171,631,577 - 171,647,739 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,774,137 - 171,790,304 (+)NCBIHuRef
CHM1_15176,287,084 - 176,303,247 (+)NCBICHM1_1
T2T-CHM13v2.05177,968,774 - 177,986,142 (+)NCBIT2T-CHM13v2.0
Grk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,592,865 - 55,608,740 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,592,885 - 55,608,740 (+)EnsemblGRCm39 Ensembl
GRCm381355,445,072 - 55,460,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,445,072 - 55,460,927 (+)EnsemblGRCm38mm10GRCm38
MGSCv371355,546,695 - 55,562,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,455,083 - 55,470,548 (+)NCBIMGSCv36mm8
Celera1356,499,490 - 56,514,953 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
Grk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,665,260 - 29,684,207 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,665,534 - 29,684,225 (+)NCBIChiLan1.0ChiLan1.0
GRK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,487,574 - 172,527,513 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,627,113 - 170,667,053 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,704,978 - 172,744,907 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,790,665 - 179,807,473 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,790,662 - 179,807,410 (+)Ensemblpanpan1.1panPan2
GRK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,927,470 - 35,943,218 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,913,472 - 35,943,221 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,894,854 - 35,910,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,293,886 - 36,309,656 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,293,889 - 36,309,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,119,132 - 36,134,901 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,305,102 - 36,320,864 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,814,574 - 36,830,339 (-)NCBIUU_Cfam_GSD_1.0
Grk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,681,758 - 122,697,463 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,706,665 - 1,722,370 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365971,706,671 - 1,722,370 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,508,979 - 80,527,210 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,496,105 - 80,527,208 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GRK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,437,056 - 79,454,213 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,437,078 - 79,453,113 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,628,695 - 10,645,867 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473312,633,565 - 12,661,284 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grk6
69 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:45
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000047958
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
RH141163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,177,171 - 9,177,366 (+)MAPPERmRatBN7.2
Rnor_6.0179,706,071 - 9,706,265NCBIRnor6.0
Rnor_5.01711,815,055 - 11,815,249UniSTSRnor5.0
RGSC_v3.41715,221,146 - 15,221,340UniSTSRGSC3.4
Celera179,255,681 - 9,255,875UniSTS
RH 3.4 Map1777.9UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001112712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001112713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF040750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ205012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB724577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV795758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EX488847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000047958   ⟹   ENSRNOP00000050134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,178,480 - 9,192,644 (-)Ensembl
Rnor_6.0 Ensembl179,707,379 - 9,721,542 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079063   ⟹   ENSRNOP00000073781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,177,019 - 9,188,805 (-)Ensembl
Rnor_6.0 Ensembl179,703,453 - 9,721,574 (-)Ensembl
RefSeq Acc Id: NM_001112712   ⟹   NP_001106183
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,182,160 - 9,197,954 (-)NCBI
mRatBN7.2179,177,018 - 9,192,813 (-)NCBI
Rnor_6.0179,705,917 - 9,721,542 (-)NCBI
Rnor_5.01711,814,901 - 11,830,762 (-)NCBI
RGSC_v3.41715,220,992 - 15,236,617 (-)RGD
Celera179,255,527 - 9,271,204 (-)RGD
Sequence:
RefSeq Acc Id: NM_001112713   ⟹   NP_001106184
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,183,622 - 9,197,785 (-)NCBI
mRatBN7.2179,178,480 - 9,192,644 (-)NCBI
Rnor_6.0179,707,379 - 9,721,542 (-)NCBI
Rnor_5.01711,814,901 - 11,830,762 (-)NCBI
RGSC_v3.41715,220,992 - 15,236,617 (-)RGD
Celera179,256,989 - 9,271,204 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031657   ⟹   NP_113845
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,182,160 - 9,197,954 (-)NCBI
mRatBN7.2179,177,018 - 9,192,813 (-)NCBI
Rnor_6.0179,705,917 - 9,721,542 (-)NCBI
Rnor_5.01711,814,901 - 11,830,762 (-)NCBI
RGSC_v3.41715,220,992 - 15,236,617 (-)RGD
Celera179,255,527 - 9,271,204 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096033   ⟹   XP_038951961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,182,185 - 9,191,580 (-)NCBI
mRatBN7.2179,177,036 - 9,186,438 (-)NCBI
RefSeq Acc Id: XM_063276716   ⟹   XP_063132786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,182,185 - 9,198,380 (-)NCBI
RefSeq Acc Id: NP_113845   ⟸   NM_031657
- Peptide Label: isoform a
- UniProtKB: P97549 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106183   ⟸   NM_001112712
- Peptide Label: isoform c
- UniProtKB: P97548 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106184   ⟸   NM_001112713
- Peptide Label: isoform b
- UniProtKB: F1LNP2 (UniProtKB/TrEMBL),   Q792R1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073781   ⟸   ENSRNOT00000079063
Ensembl Acc Id: ENSRNOP00000050134   ⟸   ENSRNOT00000047958
RefSeq Acc Id: XP_038951961   ⟸   XM_039096033
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132786   ⟸   XM_063276716
- Peptide Label: isoform X1
- UniProtKB: P97549 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97711-F1-model_v2 AlphaFold P97711 1-576 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700306
Promoter ID:EPDNEW_R10828
Type:initiation region
Name:Grk6_1
Description:G protein-coupled receptor kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,721,671 - 9,721,731EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61986 AgrOrtholog
BioCyc Gene G2FUF-10205 BioCyc
Ensembl Genes ENSRNOG00000014615 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047958 ENTREZGENE
  ENSRNOT00000079063 ENTREZGENE
  ENSRNOT00000171946 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  6.10.250.2260 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  GPCR_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
NCBI Gene 59076 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR KINASE 6 UniProtKB/Swiss-Prot
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
PhenoGen Grk6 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014615 RatGTEx
SMART RGS UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2K6E5_RAT UniProtKB/TrEMBL
  F1LNP2 ENTREZGENE, UniProtKB/TrEMBL
  GRK6_RAT UniProtKB/Swiss-Prot
  P97548 ENTREZGENE, UniProtKB/TrEMBL
  P97549 ENTREZGENE, UniProtKB/TrEMBL
  P97711 ENTREZGENE
  Q792R1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Grk6  G protein-coupled receptor kinase 6  Gprk6  G protein-coupled receptor kinase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gprk6  G protein-coupled receptor kinase 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference