|
|
| G
|
Acp5
|
acid phosphatase 5, tartrate resistant
|
increases expression
|
EXP
|
Nitric Acid results in increased expression of ACP5 protein
|
CTD |
PMID:16436523 |
|
NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929
|
|
| G
|
Bglap
|
bone gamma-carboxyglutamate protein
|
increases expression
|
EXP
|
Nitric Acid results in increased expression of BGLAP protein
|
CTD |
PMID:16436523 |
|
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
|
|
| G
|
Ca1
|
carbonic anhydrase 1
|
decreases activity
|
ISO
|
Nitric Acid results in decreased activity of CA1 protein
|
CTD |
PMID:15664814 |
|
NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454
|
|
| G
|
Ca4
|
carbonic anhydrase 4
|
decreases activity
|
ISO
|
Nitric Acid results in decreased activity of CA4 protein
|
CTD |
PMID:15664814 |
|
NCBI chr10:70,325,102...70,333,916
Ensembl chr10:70,325,358...70,333,916
|
|
| G
|
Ca5a
|
carbonic anhydrase 5A
|
decreases activity
|
ISO
|
Nitric Acid results in decreased activity of CA5A protein
|
CTD |
PMID:15664814 |
|
NCBI chr19:66,881,678...66,911,486
Ensembl chr19:66,881,693...66,911,486
|
|
| G
|
Ca9
|
carbonic anhydrase 9
|
decreases activity
|
ISO
|
Nitric Acid results in decreased activity of CA9 protein
|
CTD |
PMID:15664814 |
|
NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626
|
|
| G
|
Car2
|
carbonic anhydrase 2
|
decreases activity
|
ISO
|
Nitric Acid results in decreased activity of CA2 protein
|
CTD |
PMID:15664814 |
|
NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064
|
|
|
|
| G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
3-aminobenzamide inhibits the reaction [[oxyhyponitrite results in increased abundance of nitroxyl] which results in increased activity of CASP3 protein]; [oxyhyponitrite results in increased abundance of nitroxyl] which results in increased activity of CASP3 protein
|
CTD |
PMID:11744336 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
| G
|
Gpc1
|
glypican 1
|
multiple interactions
|
ISO
|
nitroxyl affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]
|
CTD |
PMID:12732622 |
|
NCBI chr 9:100,843,645...100,871,458
Ensembl chr 9:100,843,645...100,879,933
|
|
|
|
| G
|
Agt
|
angiotensinogen
|
increases abundance
|
ISO
|
AGT protein modified form results in increased abundance of Peroxynitrous Acid
|
CTD |
PMID:12606818 |
|
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
|
|
| G
|
Agtr2
|
angiotensin II receptor, type 2
|
multiple interactions
|
EXP
|
[Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid
|
CTD |
PMID:23824088 |
|
NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745
|
|
| G
|
Akt1
|
AKT serine/threonine kinase 1
|
increases phosphorylation multiple interactions
|
EXP
|
Peroxynitrous Acid results in increased phosphorylation of AKT1 protein BDNF protein promotes the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Catechin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Peroxynitrous Acid promotes the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:17302912 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
| G
|
Alb
|
albumin
|
multiple interactions increases glycation
|
ISO
|
[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein; pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein] Peroxynitrous Acid results in increased glycation of ALB protein modified form
|
CTD |
PMID:12196478 |
|
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
|
|
| G
|
Alox5
|
arachidonate 5-lipoxygenase
|
decreases activity multiple interactions
|
EXP
|
Peroxynitrous Acid results in decreased activity of ALOX5 protein Peroxynitrous Acid results in increased nitrosation of and affects the expression of ALOX5 protein; zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]
|
CTD |
PMID:11561080 PMID:12388339 |
|
NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126
|
|
| G
|
Apaf1
|
apoptotic peptidase activating factor 1
|
multiple interactions increases expression
|
EXP
|
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]
|
CTD |
PMID:20869986 |
|
NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772
|
|
| G
|
Bad
|
BCL2-associated agonist of cell death
|
multiple interactions
|
ISO
|
[N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased susceptibility to Peroxynitrous Acid] which results in increased phosphorylation of BAD protein; [PARP1 protein results in decreased susceptibility to Peroxynitrous Acid] which results in decreased phosphorylation of BAD protein
|
CTD |
PMID:18239155 |
|
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
|
|
| G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions increases expression
|
EXP
|
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein] Peroxynitrous Acid results in increased expression of BAX mRNA; Peroxynitrous Acid results in increased expression of BAX protein
|
CTD |
PMID:20869986 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
| G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression multiple interactions
|
EXP
|
Peroxynitrous Acid results in decreased expression of BCL2 mRNA; Peroxynitrous Acid results in decreased expression of BCL2 protein Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]
|
CTD |
PMID:20869986 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
| G
|
Bdnf
|
brain-derived neurotrophic factor
|
multiple interactions
|
EXP
|
BDNF protein promotes the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Peroxynitrous Acid promotes the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:17302912 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
|
|
| G
|
Bnip3
|
BCL2 interacting protein 3
|
increases expression
|
ISO
|
Peroxynitrous Acid results in increased expression of BNIP3 protein
|
CTD |
PMID:16002567 |
|
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962
|
|
| G
|
Cacna1c
|
calcium voltage-gated channel subunit alpha1 C
|
multiple interactions increases metabolic processing
|
ISO
|
[linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein; [Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form] which results in decreased phosphorylation of CREB1 protein; Peroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]
|
CTD |
PMID:17551092 PMID:20128810 |
|
NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762
|
|
| G
|
Casp3
|
caspase 3
|
multiple interactions increases expression increases activity decreases activity
|
ISO EXP
|
[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; demethoxycurcumin inhibits the reaction [Peroxynitrous Acid results in increased activity of CASP3 protein] Peroxynitrous Acid results in increased expression of CASP3 mRNA Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein Peroxynitrous Acid results in decreased activity of CASP3 protein
|
CTD |
PMID:9441900 PMID:19188863 PMID:20869986 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
| G
|
Casp9
|
caspase 9
|
multiple interactions increases expression
|
EXP
|
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]; Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein
|
CTD |
PMID:20869986 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
| G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Peroxynitrous Acid]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Peroxynitrous Acid]
|
CTD |
PMID:15855331 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
| G
|
Cbs
|
cystathionine beta synthase
|
decreases activity multiple interactions
|
ISO
|
Peroxynitrous Acid results in decreased activity of CBS protein 4-hydroxyphenylacetic acid inhibits the reaction [Peroxynitrous Acid results in decreased activity of CBS protein]
|
CTD |
PMID:19733148 |
|
NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066
|
|
| G
|
Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions
|
ISO
|
[Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form] which results in decreased phosphorylation of CREB1 protein; Peroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein] Peroxynitrous Acid inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]
|
CTD |
PMID:20128810 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
|
|
| G
|
Fgfr1
|
Fibroblast growth factor receptor 1
|
affects response to substance
|
EXP
|
FGFR1 protein alternative form affects the susceptibility to Peroxynitrous Acid
|
CTD |
PMID:12573278 |
|
NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855
|
|
| G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]; Peroxynitrous Acid affects the localization of and affects the activity of FOS protein; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]
|
CTD |
PMID:14572605 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
| G
|
Gnai2
|
G protein subunit alpha i2
|
multiple interactions decreases expression
|
EXP
|
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein]
|
CTD |
PMID:18055527 |
|
NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622
|
|
| G
|
Gnai3
|
G protein subunit alpha i3
|
multiple interactions decreases expression
|
EXP
|
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]
|
CTD |
PMID:18055527 |
|
NCBI chr 2:198,430,920...198,468,874
|
|
| G
|
Gpx1
|
glutathione peroxidase 1
|
affects response to substance increases abundance multiple interactions
|
ISO
|
GPX1 protein affects the susceptibility to Peroxynitrous Acid GPX1 gene mutant form results in increased abundance of Peroxynitrous Acid [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Peroxynitrous Acid
|
CTD |
PMID:16636302 PMID:24296279 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
|
|
| G
|
Gsr
|
glutathione-disulfide reductase
|
multiple interactions decreases activity
|
ISO
|
hydroquinone inhibits the reaction [Peroxynitrous Acid results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Peroxynitrous Acid results in decreased activity of GSR protein]
|
CTD |
PMID:15831208 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
|
|
| G
|
Gsta2
|
glutathione S-transferase alpha 2
|
increases expression
|
EXP
|
Peroxynitrous Acid results in increased expression of GSTA2; Peroxynitrous Acid results in increased expression of GSTA2 mRNA; Peroxynitrous Acid results in increased expression of GSTA2 protein
|
CTD |
PMID:12446173 PMID:15357004 |
|
NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092
|
|
| G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
EXP
|
[5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride results in decreased abundance of Peroxynitrous Acid] inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]
|
CTD |
PMID:21397656 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
| G
|
Mapk1
|
mitogen activated protein kinase 1
|
decreases phosphorylation
|
EXP
|
Peroxynitrous Acid results in decreased phosphorylation of MAPK1 protein
|
CTD |
PMID:18055527 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
| G
|
Mapk3
|
mitogen activated protein kinase 3
|
decreases phosphorylation
|
EXP
|
Peroxynitrous Acid results in decreased phosphorylation of MAPK3 protein
|
CTD |
PMID:18055527 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
| G
|
Mgst1
|
microsomal glutathione S-transferase 1
|
multiple interactions increases activity
|
EXP
|
[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Peroxynitrous Acid promotes the reaction [MGST1 protein binds to MGST1 protein]; sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein] Peroxynitrous Acid results in increased activity of MGST1 protein
|
CTD |
PMID:16386761 |
|
NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875
|
|
| G
|
Nat1
|
N-acetyltransferase 1
|
decreases activity
|
ISO
|
Peroxynitrous Acid results in decreased activity of NAT1 protein
|
CTD |
PMID:14672957 PMID:15644493 |
|
NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527
|
|
| G
|
Nat2
|
N-acetyltransferase 2
|
decreases activity multiple interactions
|
ISO
|
Peroxynitrous Acid results in decreased activity of NAT2 protein [Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid
|
CTD |
PMID:15644493 PMID:19248797 |
|
NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304
|
|
| G
|
Ngf
|
nerve growth factor
|
multiple interactions
|
EXP
|
[Methamphetamine co-treated with NGF protein] affects the abundance of Peroxynitrous Acid
|
CTD |
PMID:12105096 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
|
|
| G
|
Noa1
|
nitric oxide associated 1
|
multiple interactions
|
EXP
|
[Tamoxifen results in increased activity of NOA1 protein] which results in increased abundance of Peroxynitrous Acid
|
CTD |
PMID:17283165 |
|
NCBI chr14:31,189,570...31,205,600
Ensembl chr14:31,188,978...31,205,599
|
|
| G
|
Nos2
|
nitric oxide synthase 2
|
affects abundance multiple interactions
|
ISO
|
NOS2 protein affects the abundance of Peroxynitrous Acid [Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Peroxynitrous Acid
|
CTD |
PMID:11919077 PMID:15694688 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
| G
|
Nos3
|
nitric oxide synthase 3
|
multiple interactions
|
ISO
|
Peroxynitrous Acid results in increased nitrosation of and results in decreased activity of NOS3 protein; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Peroxynitrous Acid] which results in increased metabolism of NOS3 protein]
|
CTD |
PMID:11509453 PMID:12489993 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
|
|
| G
|
Npr3
|
natriuretic peptide receptor 3
|
decreases expression
|
EXP
|
Peroxynitrous Acid results in decreased expression of NPR3 protein
|
CTD |
PMID:18055527 |
|
NCBI chr 2:62,592,557...62,660,497
Ensembl chr 2:62,597,668...62,660,066
|
|
| G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
multiple interactions increases activity
|
ISO
|
[PARP1 protein results in decreased susceptibility to Peroxynitrous Acid] which results in decreased phosphorylation of BAD protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Peroxynitrous Acid results in increased activity of PARP1 protein]
|
CTD |
PMID:18239155 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
|
|
| G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
affects expression
|
EXP
|
Peroxynitrous Acid affects the expression of PPARGC1A protein
|
CTD |
PMID:24563852 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
|
|
| G
|
Pten
|
phosphatase and tensin homolog
|
increases oxidation
|
EXP
|
Peroxynitrous Acid results in increased oxidation of PTEN protein
|
CTD |
PMID:17302912 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
|
|
| G
|
Rcan1
|
regulator of calcineurin 1
|
increases phosphorylation
|
ISO
|
Peroxynitrous Acid results in increased phosphorylation of RCAN1 protein
|
CTD |
PMID:12927602 |
|
NCBI chr11:45,108,123...45,188,065
Ensembl chr11:45,108,124...45,118,236
|
|
| G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions affects localization
|
ISO
|
ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] Peroxynitrous Acid affects the localization of RELA protein
|
CTD |
PMID:14572605 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
| G
|
Smpd1
|
sphingomyelin phosphodiesterase 1
|
increases activity
|
ISO
|
Peroxynitrous Acid results in increased activity of SMPD1 protein
|
CTD |
PMID:17498692 |
|
NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614
|
|
| G
|
Sod1
|
superoxide dismutase 1
|
decreases abundance multiple interactions
|
ISO
|
SOD1 protein results in decreased abundance of Peroxynitrous Acid [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Peroxynitrous Acid [Peroxynitrous Acid co-treated with Bicarbonates] results in decreased activity of SOD1 protein; [Peroxynitrous Acid co-treated with Bicarbonates] results in increased metabolism of SOD1 protein; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Peroxynitrous Acid] which results in increased metabolism of NOS3 protein]; SOD1 protein inhibits the reaction [Nitric Oxide results in increased abundance of Peroxynitrous Acid]
|
CTD |
PMID:11451436 PMID:12489993 PMID:16636302 PMID:21443684 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
|
|
| G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions increases expression
|
ISO
|
SOD2 protein affects the susceptibility to [alatrofloxacin results in increased abundance of Peroxynitrous Acid] Peroxynitrous Acid results in increased expression of SOD2 mRNA Acetylcysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Peroxynitrous Acid]; Cysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Peroxynitrous Acid]
|
CTD |
PMID:9741582 PMID:15855331 PMID:20655887 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
| G
|
Sod3
|
superoxide dismutase 3
|
multiple interactions
|
ISO
|
[Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Peroxynitrous Acid
|
CTD |
PMID:23884884 |
|
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125
|
|
| G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP
|
Peroxynitrous Acid inhibits the reaction [TNF protein results in decreased export of Potassium]
|
CTD |
PMID:17337591 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
| G
|
Uqcrc2
|
ubiquinol cytochrome c reductase core protein 2
|
affects expression
|
EXP
|
Peroxynitrous Acid affects the expression of UQCRC2 protein
|
CTD |
PMID:24563852 |
|
NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946
|
|
| G
|
Vdac1
|
voltage-dependent anion channel 1
|
multiple interactions
|
EXP
|
Peroxynitrous Acid promotes the reaction [VDAC1 protein modified form binds to VDAC1 protein modified form]; Peroxynitrous Acid results in increased metabolism of and results in increased activity of VDAC1 protein; resveratrol inhibits the reaction [Peroxynitrous Acid results in increased metabolism of VDAC1 protein]
|
CTD |
PMID:22709907 |
|
NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541
|
|