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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrogen oxoacid
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Accession:CHEBI:33455 term browser browse the term
Synonyms:related_synonym: nitrogen oxoacids;   oxoacids of nitrogen



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isobutyl nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf1 fibroblast growth factor 1 increases expression ISO isobutyl nitrite results in increased expression of FGF1 mRNA CTD PMID:16288974 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf4 fibroblast growth factor 4 increases expression ISO isobutyl nitrite results in increased expression of FGF4 mRNA CTD PMID:16288974 NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isobutyl nitrite results in increased expression of HMOX1 mRNA CTD PMID:16288974 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO isobutyl nitrite results in increased expression of HSPA4 mRNA CTD PMID:16288974 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Pf4 platelet factor 4 increases expression ISO isobutyl nitrite results in increased expression of PF4 mRNA CTD PMID:16288974 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Smad7 SMAD family member 7 increases expression ISO isobutyl nitrite results in increased expression of SMAD7 mRNA CTD PMID:16288974 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO isobutyl nitrite results in increased expression of VEGFA mRNA CTD PMID:16288974 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO isobutyl nitrite results in increased expression of VEGFD mRNA CTD PMID:16288974 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295
JBrowse link
isosorbide dinitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions ISO [Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA CTD PMID:15719745 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases response to substance ISO G6PD protein results in decreased susceptibility to Isosorbide Dinitrate CTD PMID:6401899 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNA; [Isosorbide Dinitrate co-treated with Plant Preparations] results in increased expression of NOS3 mRNA CTD PMID:15719745 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
isosorbide mononitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 multiple interactions EXP isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein] CTD PMID:8738301 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
JBrowse link
nicorandil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 increases activity ISO Nicorandil results in increased activity of ABCC9 protein CTD PMID:22622455 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Agt angiotensinogen multiple interactions ISO Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein] CTD PMID:22622455 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:31376360 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:31376360 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:31376360 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ctsd cathepsin D multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 PMID:14499179 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:31376360 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP Nicorandil results in decreased expression of HMOX1 protein CTD PMID:22622455 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:31376360 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of MPO protein] CTD PMID:31376360 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein] CTD PMID:31376360 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of NFKB1 protein] CTD PMID:31376360 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Nicorandil results in increased expression of SOD2 protein CTD PMID:22622455 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TLR4 protein] CTD PMID:31376360 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:31376360 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
decreases expression
ISO
EXP
Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein]
Nicorandil results in decreased expression of XDH protein
CTD PMID:22622455 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
nitrates term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy4 adenylate cyclase 4 decreases expression EXP Nitrates results in decreased expression of ADCY4 mRNA CTD PMID:30022042 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108
JBrowse link
G Adcy9 adenylate cyclase 9 increases expression EXP Nitrates results in increased expression of ADCY9 mRNA CTD PMID:30022042 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Adm adrenomedullin affects abundance ISO ADM protein affects the abundance of Nitrates CTD PMID:15370692 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Atm ATM serine/threonine kinase increases expression EXP Nitrates results in increased expression of ATM mRNA CTD PMID:30022042 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bcl10 BCL10, immune signaling adaptor increases expression EXP Nitrates results in increased expression of BCL10 mRNA CTD PMID:30022042 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Nitrates results in decreased expression of BMP4 mRNA CTD PMID:30022042 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Card10 caspase recruitment domain family, member 10 decreases expression EXP Nitrates results in decreased expression of CARD10 mRNA CTD PMID:30022042 NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224
JBrowse link
G Casp1 caspase 1 increases expression EXP Nitrates results in increased expression of CASP1 mRNA CTD PMID:30022042 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp4 caspase 4 increases expression EXP Nitrates results in increased expression of CASP4 mRNA CTD PMID:30022042 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp6 caspase 6 increases expression EXP Nitrates results in increased expression of CASP6 mRNA CTD PMID:30022042 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Nitrates results in decreased activity of CFTR protein CTD PMID:15286085 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Nitrates results in increased expression of CNTF mRNA CTD PMID:30022042 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression EXP Nitrates results in decreased expression of CSF2 mRNA CTD PMID:30022042 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression EXP Nitrates results in decreased expression of HTR1A mRNA CTD PMID:30022042 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP Nitrates results in decreased expression of HTR2A mRNA CTD PMID:30022042 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C decreases expression EXP Nitrates results in decreased expression of HTR2C mRNA CTD PMID:30022042 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A decreases expression EXP Nitrates results in decreased expression of HTR3A mRNA CTD PMID:30022042 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B decreases expression EXP Nitrates results in decreased expression of HTR3B mRNA CTD PMID:30022042 NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444
JBrowse link
G Htr5b 5-hydroxytryptamine (serotonin) receptor 5B increases expression EXP Nitrates results in increased expression of HTR5B mRNA CTD PMID:30022042 NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835
JBrowse link
G Il1b interleukin 1 beta increases abundance
multiple interactions
ISO IL1B protein results in increased abundance of Nitrates
[Asbestos, Crocidolite co-treated with IL1B protein] results in increased abundance of Nitrates; [Asbestos, Serpentine co-treated with IL1B protein] results in increased abundance of Nitrates
CTD PMID:8904084 PMID:9698594 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression EXP Nitrates results in increased expression of IRAK4 mRNA CTD PMID:30022042 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837
JBrowse link
G Irf7 interferon regulatory factor 7 increases expression EXP Nitrates results in increased expression of IRF7 mRNA CTD PMID:30022042 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Kl Klotho decreases expression EXP Nitrates results in decreased expression of KL mRNA CTD PMID:30022042 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 increases expression EXP Nitrates results in increased expression of MAP4K4 mRNA CTD PMID:30022042 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698
JBrowse link
G Ngf nerve growth factor increases expression EXP Nitrates results in increased expression of NGF mRNA CTD PMID:30022042 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
NOS2 gene mutant form inhibits the reaction [SFTPD gene mutant form results in increased abundance of Nitrates]
[[Particulate Matter results in increased abundance of Nitrates] which results in decreased methylation of NOS2 promoter] which results in increased abundance of Nitric Oxide; [Particulate Matter results in increased abundance of Nitrates] which results in decreased methylation of NOS2 promoter
[[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrates
CTD PMID:17566059 PMID:24465666 PMID:26372312 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrates CTD PMID:17566059 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression EXP Nitrates results in decreased expression of OAS3 mRNA CTD PMID:30022042 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta increases expression EXP Nitrates results in increased expression of PIK3C2B mRNA CTD PMID:30022042 NCBI chr13:44,494,673...44,555,663
Ensembl chr13:44,495,050...44,555,612
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression EXP Nitrates results in increased expression of PIK3CG mRNA CTD PMID:30022042 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Plcb2 phospholipase C, beta 2 decreases expression EXP Nitrates results in decreased expression of PLCB2 mRNA CTD PMID:30022042 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302
JBrowse link
G Plch2 phospholipase C, eta 2 increases expression EXP Nitrates results in increased expression of PLCH2 mRNA CTD PMID:30022042 NCBI chr 5:165,544,209...165,613,769
Ensembl chr 5:165,544,200...165,602,356
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases expression EXP Nitrates results in decreased expression of PRKACB mRNA CTD PMID:30022042 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Ptx3 pentraxin 3 decreases expression EXP Nitrates results in decreased expression of PTX3 mRNA CTD PMID:30022042 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Rhog ras homolog family member G increases expression EXP Nitrates results in increased expression of RHOG mRNA CTD PMID:30022042 NCBI chr 1:156,618,713...156,630,710
Ensembl chr 1:156,615,349...156,631,257
JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 increases expression EXP Nitrates results in increased expression of S1PR5 mRNA CTD PMID:30022042 NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions EXP Nitrates results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Nitrates results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Nitrates results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816
JBrowse link
G Sftpd surfactant protein D multiple interactions
increases abundance
ISO NOS2 gene mutant form inhibits the reaction [SFTPD gene mutant form results in increased abundance of Nitrates] CTD PMID:24465666 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Nitrates results in increased expression of TGFB1 mRNA CTD PMID:30022042 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP Nitrates results in decreased expression of TGFB2 mRNA CTD PMID:30022042 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tlr3 toll-like receptor 3 increases expression EXP Nitrates results in increased expression of TLR3 mRNA CTD PMID:30022042 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr7 toll-like receptor 7 increases expression EXP Nitrates results in increased expression of TLR7 mRNA CTD PMID:30022042 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754
JBrowse link
G Tlr8 toll-like receptor 8 increases expression EXP Nitrates results in increased expression of TLR8 mRNA CTD PMID:30022042 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [Endotoxins results in increased abundance of Nitrates] CTD PMID:15659313 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A increases expression EXP Nitrates results in increased expression of TNFRSF11A mRNA CTD PMID:30022042 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Nitrates results in increased expression of TNFRSF1A mRNA CTD PMID:30022042 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression EXP Nitrates results in increased expression of TRADD mRNA CTD PMID:30022042 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases expression ISO Nitrates results in increased expression of TSHB protein CTD PMID:20439182 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N decreases expression EXP Nitrates results in decreased expression of UBE2N mRNA CTD PMID:30022042 NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
JBrowse link
nitric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant increases expression EXP Nitric Acid results in increased expression of ACP5 protein CTD PMID:16436523 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Nitric Acid results in increased expression of BGLAP protein CTD PMID:16436523 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Ca4 carbonic anhydrase 4 decreases activity ISO Nitric Acid results in decreased activity of CA4 protein CTD PMID:15664814 NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
JBrowse link
G Ca5a carbonic anhydrase 5A decreases activity ISO Nitric Acid results in decreased activity of CA5A protein CTD PMID:15664814 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity ISO Nitric Acid results in decreased activity of CA9 protein CTD PMID:15664814 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Nitric Acid results in decreased activity of CA1 protein CTD PMID:15664814 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Nitric Acid results in decreased activity of CA2 protein CTD PMID:15664814 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
nitrites term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance EXP AGT protein modified form results in increased abundance of Nitrites CTD PMID:28299329 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ak1 adenylate kinase 1 multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of AK1 protein CTD PMID:22892143 NCBI chr 3:15,912,431...15,923,045 JBrowse link
G Cp ceruloplasmin increases abundance
multiple interactions
ISO
EXP
CP protein results in increased abundance of Nitrites
SN50 peptide inhibits the reaction [CP protein results in increased abundance of Nitrites]
SB 203580 inhibits the reaction [CP protein results in increased abundance of Nitrites]
CTD PMID:17727827 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cs citrate synthase multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of CS protein CTD PMID:22892143 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP [Gentamicins results in increased expression of EDNRB protein] which results in increased abundance of Nitrites CTD PMID:15200423 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Epo erythropoietin increases abundance
multiple interactions
ISO EPO protein results in increased abundance of Nitrites
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased abundance of Nitrites]
CTD PMID:23384249 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fcer2 Fc epsilon receptor II affects chemical synthesis ISO FCER2 protein affects the chemical synthesis of Nitrites CTD PMID:11500085 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO HMOX1 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] CTD PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions
increases abundance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [Lipopolysaccharides co-treated with IFNG] results in increased abundance of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]
2,2'-dihydroxychalcone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; aristolochic acid I inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites]; carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; Industrial Waste inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; plumbagin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; pyrrolidine dithiocarbamic acid inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; sulforaphane inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [sulforaphane inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; Tosyllysine Chloromethyl Ketone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
CTD PMID:7532384 PMID:9918806 PMID:10532951 PMID:10903806 PMID:10967106 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases secretion
increases chemical synthesis
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; 8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased secretion of Nitrites]; Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Glucosamine inhibits the reaction [IL1B results in increased abundance of Nitrites]
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; Thiopental promotes the reaction [IL1B protein results in increased abundance of Nitrites]
IL1B protein results in increased abundance of Nitrites; IL1B results in increased abundance of Nitrites
CTD PMID:8904084 PMID:9436821 PMID:10532951 PMID:10903806 PMID:10967106 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites] CTD PMID:9918806 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Lpo lactoperoxidase multiple interactions ISO [LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Nitrites CTD PMID:22434701 NCBI chr10:72,606,944...72,626,535
Ensembl chr10:72,606,944...72,626,535
JBrowse link
G Mst1r macrophage stimulating 1 receptor multiple interactions ISO MST1R protein affects the reaction [nickel sulfate results in increased abundance of Nitrites] CTD PMID:11751209 NCBI chr 8:108,596,100...108,611,389
Ensembl chr 8:108,597,299...108,612,455
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP
NFE2L2 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
[Nitrites co-treated with Oxygen deficiency] results in increased expression of NFE2L2 mRNA
CTD PMID:22892143 PMID:23942037 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
[linsidomine results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites; [Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]] which results in decreased chemical synthesis of Nitrites
[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites; [[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrites; [Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [Oxidopamine results in increased expression of NOS2 protein] which results in increased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [testosterone enanthate results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]
[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; [Zymosan results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; Atenolol inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Carvedilol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dronabinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; ganglioside, GD1a analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1a inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; Hydrolyzable Tannins inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Leukotriene B4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Leukotriene C4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]; neurostatin inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Prazosin inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; protocatechuic acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; trisialoganglioside GT1 analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; trisialoganglioside GT1 inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ZM 230487 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]
CTD PMID:7532384 PMID:8700141 PMID:11405284 PMID:11454666 PMID:17566059 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO
EXP
[NOS3 intron polymorphism co-treated with Methylmercury Compounds] results in decreased abundance of Nitrites
[[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrites
CTD PMID:17566059 PMID:22134029 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions ISO NT5E protein affects the reaction [nimesulide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of Nitrites]] CTD PMID:27188793 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [GW 7647 binds to and results in increased activity of PPARA protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites] CTD PMID:17891158 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased expression of and results in decreased acetylation of PPARGC1A protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA; PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]; splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA; P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA] CTD PMID:22892143 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites] which results in increased chemical synthesis of Nitrogen Dioxide; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites; Nitrites promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide] CTD PMID:19243126 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased expression of TFAM mRNA CTD PMID:22892143 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites] CTD PMID:19573522 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
ISO
EXP
5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; TNF protein promotes the reaction [Endotoxins results in increased abundance of Nitrites]
TNF protein results in increased abundance of Nitrites
[Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]; Triglycerides inhibits the reaction [TNF protein affects the abundance of Nitrites]
CTD PMID:7532384 PMID:9918806 PMID:15659313 PMID:16140881 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
nitroflurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 decreases expression ISO nitroflurbiprofen results in decreased expression of CASP1 mRNA CTD PMID:15081244 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] CTD PMID:16491094 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:16491094 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:16491094 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
nitroflurbiprofen results in decreased expression of NOS2 mRNA
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:8528547 PMID:15081244 PMID:16491094 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
nitroflurbiprofen results in decreased activity of RELA protein
CTD PMID:12716482 PMID:16491094 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:12716482 PMID:16491094 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 increases expression EXP Nitroglycerin results in increased expression of ACAT1 mRNA CTD PMID:12102619 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Actb actin, beta decreases expression EXP Nitroglycerin results in decreased expression of ACTB mRNA CTD PMID:12102619 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression EXP Nitroglycerin results in decreased expression of ALDH1A1 mRNA CTD PMID:12102619 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
decreases activity
increases response to substance
decreases expression
affects metabolic processing
affects response to substance
ISO
EXP
[1-aminocyclopropanol analog results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]; ALDH2 protein affects the reaction [Nitroglycerin results in decreased abundance of Cyclic GMP]
ALDH2 protein affects the reaction [Ascorbic Acid deficiency results in decreased susceptibility to Nitroglycerin]
ALDH2 protein results in increased susceptibility to Nitroglycerin
Nitroglycerin results in decreased expression of ALDH2 mRNA; Nitroglycerin results in decreased expression of ALDH2 protein
ALDH2 protein affects the metabolism of and results in increased activity of Nitroglycerin; ALDH2 protein affects the reaction [Nitroglycerin results in increased abundance of Reactive Oxygen Species]; Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]
ALDH2 protein affects the metabolism of Nitroglycerin
ALDH2 gene polymorphism affects the susceptibility to Nitroglycerin; ALDH2 protein affects the susceptibility to Nitroglycerin; ALDH2 protein polymorphism affects the susceptibility to Nitroglycerin
CTD PMID:15331769 PMID:16440063 PMID:17092343 PMID:17493633 PMID:17541025 More... NCBI chr12:34,949,549...34,982,527 JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Nitroglycerin results in decreased expression of ALOX15 mRNA CTD PMID:12102619 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 increases expression EXP Nitroglycerin results in increased expression of AP2M1 mRNA CTD PMID:12102619 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Nitroglycerin results in increased expression of APEX1 mRNA CTD PMID:12102619 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression EXP Nitroglycerin results in decreased expression of APOA1 mRNA CTD PMID:12102619 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Arl2 ADP-ribosylation factor like GTPase 2 increases expression EXP Nitroglycerin results in increased expression of ARL2 mRNA CTD PMID:12102619 NCBI chr 1:203,434,129...203,446,156
Ensembl chr 1:203,434,129...203,446,119
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression EXP Nitroglycerin results in decreased expression of ATP5F1A mRNA CTD PMID:12102619 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G B2m beta-2 microglobulin affects expression ISO Nitroglycerin affects the expression of B2M protein CTD PMID:8350464 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression EXP Nitroglycerin results in decreased expression of BCKDHB mRNA CTD PMID:12102619 NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Nitroglycerin results in decreased expression of BCL2 protein CTD PMID:17678976 NCBI chr13:22,689,783...22,853,920 JBrowse link
G C3 complement C3 increases expression ISO Nitroglycerin results in increased expression of C3 protein alternative form CTD PMID:10884648 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases expression
affects expression
EXP
ISO
Capsaicin inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Dexamethasone inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]
Nitroglycerin results in increased expression of CALCA mRNA; Nitroglycerin results in increased expression of CALCA protein
Nitroglycerin affects the expression of CALCA protein
CTD PMID:11919648 PMID:14659530 PMID:14729435 PMID:19121572 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calm2 calmodulin 2 increases expression EXP Nitroglycerin results in increased expression of CALM2 mRNA CTD PMID:12102619 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Capn2 calpain 2 decreases expression EXP Nitroglycerin results in decreased expression of CAPN2 mRNA CTD PMID:12102619 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Nitroglycerin results in increased cleavage of and results in increased activity of CASP1 protein CTD PMID:12105852 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
ISO Nitroglycerin results in decreased expression of CASP3 protein modified form
Nitroglycerin results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:12105852 PMID:17322376 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Nitroglycerin results in increased expression of and results in increased activity of CAT protein CTD PMID:12860443 PMID:14732477 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd3d CD3d molecule increases expression EXP Nitroglycerin results in increased expression of CD3D mRNA CTD PMID:12102619 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
JBrowse link
G Cd5 Cd5 molecule decreases expression EXP Nitroglycerin results in decreased expression of CD5 mRNA CTD PMID:12102619 NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
JBrowse link
G Cd53 Cd53 molecule decreases expression EXP Nitroglycerin results in decreased expression of CD53 mRNA CTD PMID:12102619 NCBI chr 2:194,352,139...194,399,668
Ensembl chr 2:194,352,139...194,399,657
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone increases expression EXP Nitroglycerin results in increased expression of CDC37 mRNA CTD PMID:12102619 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Nitroglycerin results in increased expression of CDKN1B mRNA CTD PMID:12102619 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Celf2 CUGBP, Elav-like family member 2 increases expression EXP Nitroglycerin results in increased expression of CELF2 mRNA CTD PMID:12102619 NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333
JBrowse link
G Ckb creatine kinase B decreases expression EXP Nitroglycerin results in decreased expression of CKB mRNA CTD PMID:12102619 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Clu clusterin decreases expression EXP Nitroglycerin results in decreased expression of CLU mRNA CTD PMID:12102619 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Nitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein] CTD PMID:16775503 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cp ceruloplasmin decreases expression EXP Nitroglycerin results in decreased expression of CP mRNA CTD PMID:12102619 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression EXP Nitroglycerin results in decreased expression of CRIP2 mRNA CTD PMID:12102619 NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases localization
ISO 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Nitroglycerin results in increased degradation of CTNNB1 protein]; Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Nitroglycerin results in decreased phosphorylation of and results in increased nitrosation of and results in increased degradation of and results in decreased activity of CTNNB1 protein; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein] CTD PMID:17030184 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsd cathepsin D decreases expression EXP Nitroglycerin results in decreased expression of CTSD mRNA CTD PMID:12102619 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
increases expression
decreases response to substance
ISO
EXP
CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]; Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
Nitroglycerin results in decreased expression of CYBB mRNA
CYBB gene mutant form results in decreased susceptibility to Nitroglycerin
CTD PMID:16633368 PMID:17493633 PMID:18522491 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Nitroglycerin results in decreased expression of CYP11B2 mRNA CTD PMID:12102619 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 decreases expression EXP Nitroglycerin results in decreased expression of CYP2B15 mRNA CTD PMID:12102619 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Nitroglycerin results in increased expression of CYP2E1 mRNA CTD PMID:12102619 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Defb4 defensin beta 4 decreases expression EXP Nitroglycerin results in decreased expression of DEFB4 mRNA CTD PMID:12102619 NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Nitroglycerin results in decreased expression of DHCR7 mRNA CTD PMID:12102619 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 decreases expression EXP Nitroglycerin results in decreased expression of DYNC1I1 mRNA CTD PMID:12102619 NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression EXP Nitroglycerin results in decreased expression of DYRK1A mRNA CTD PMID:12102619 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
JBrowse link
G Edn1 endothelin 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Nitroglycerin results in decreased expression of EDN1 mRNA
Nitroglycerin results in increased expression of EDN1 protein
Nitroglycerin results in decreased expression of EDN1 mRNA; Nitroglycerin results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
CTD PMID:11751199 PMID:12206003 PMID:12901495 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Elane elastase, neutrophil expressed increases expression ISO Nitroglycerin results in increased expression of ELANE protein CTD PMID:10884648 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Eln elastin increases expression EXP Nitroglycerin results in increased expression of ELN mRNA CTD PMID:12187120 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Faah fatty acid amide hydrolase increases activity
multiple interactions
EXP Nitroglycerin results in increased activity of FAAH protein
Nitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]
CTD PMID:19515121 NCBI chr 5:129,479,774...129,499,018 JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Nitroglycerin results in increased expression of and results in increased localization of FAS protein CTD PMID:12105852 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression EXP Nitroglycerin results in increased expression of FGFR2 mRNA CTD PMID:12102619 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Nitroglycerin results in decreased expression of FMO1 mRNA CTD PMID:12102619 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
Nitroglycerin results in increased expression of FOS protein
anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]
CTD PMID:7552308 PMID:10426492 PMID:16897600 PMID:18761334 PMID:19121572 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator decreases expression EXP Nitroglycerin results in decreased expression of GCHFR mRNA CTD PMID:12102619 NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080
JBrowse link
G Gnb3 G protein subunit beta 3 affects response to substance ISO GNB3 protein affects the susceptibility to Nitroglycerin CTD PMID:14586390 NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
JBrowse link
G Gng7 G protein subunit gamma 7 decreases expression EXP Nitroglycerin results in decreased expression of GNG7 mRNA CTD PMID:12102619 NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance ISO GPX1 gene mutant form results in decreased susceptibility to Nitroglycerin CTD PMID:24296279 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Nitroglycerin results in decreased expression of GRK6 mRNA CTD PMID:12102619 NCBI chr17:9,177,018...9,192,644
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Grn granulin precursor decreases expression EXP Nitroglycerin results in decreased expression of GRN mRNA CTD PMID:12102619 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Gsn gelsolin increases expression EXP Nitroglycerin results in increased expression of GSN mRNA CTD PMID:12187120 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Nitroglycerin results in decreased expression of GSTA2 mRNA CTD PMID:12102619 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects metabolic processing EXP GSTA3 protein affects the metabolism of Nitroglycerin CTD PMID:8968379 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects metabolic processing EXP GSTM2 protein affects the metabolism of Nitroglycerin CTD PMID:8968379 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gtf3c1 general transcription factor IIIC subunit 1 increases expression EXP Nitroglycerin results in increased expression of GTF3C1 mRNA CTD PMID:12102619 NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 increases expression EXP Nitroglycerin results in increased expression of GUCY1A1 mRNA; Nitroglycerin results in increased expression of GUCY1A1 protein CTD PMID:11331261 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 increases expression ISO
EXP
Nitroglycerin results in increased expression of GUCY1B1 protein
Nitroglycerin results in increased expression of GUCY1B1 mRNA; Nitroglycerin results in increased expression of GUCY1B1 protein
CTD PMID:11331261 PMID:11742226 PMID:17541025 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Nitroglycerin results in increased expression of HBB mRNA CTD PMID:12187120 NCBI chr 1:158,250,421...158,251,832 JBrowse link
G Hdc histidine decarboxylase decreases expression EXP Nitroglycerin results in decreased expression of HDC mRNA CTD PMID:12102619 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Nitroglycerin results in increased expression of HMOX1 mRNA
[Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein
CTD PMID:17092343 PMID:17470570 PMID:17541025 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpn hepsin increases expression EXP Nitroglycerin results in increased expression of HPN mRNA CTD PMID:12102619 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Iapp islet amyloid polypeptide increases expression EXP Nitroglycerin results in increased expression of IAPP mRNA CTD PMID:12102619 NCBI chr 4:175,237,013...175,244,373
Ensembl chr 4:175,237,115...175,242,920
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression EXP Nitroglycerin results in increased expression of ID2 mRNA CTD PMID:12102619 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases expression EXP Nitroglycerin results in decreased expression of IDO1 protein CTD PMID:28659861 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Nitroglycerin results in increased expression of IL1B protein CTD PMID:11701602 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression ISO
EXP
Nitroglycerin results in increased expression of IL6 mRNA; Nitroglycerin results in increased expression of IL6 protein CTD PMID:11701602 PMID:17470570 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jtb jumping translocation breakpoint increases expression EXP Nitroglycerin results in increased expression of JTB mRNA CTD PMID:12102619 NCBI chr 2:175,685,392...175,689,609
Ensembl chr 2:175,684,993...175,690,108
JBrowse link
G Kmo kynurenine 3-monooxygenase decreases expression EXP Nitroglycerin results in decreased expression of KMO protein CTD PMID:28659861 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Kng2 kininogen 2 decreases expression EXP Nitroglycerin results in decreased expression of KNG2 mRNA CTD PMID:12102619 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Kynu kynureninase decreases expression EXP Nitroglycerin results in decreased expression of KYNU protein CTD PMID:28659861 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G Maob monoamine oxidase B increases expression EXP Nitroglycerin results in increased expression of MAOB mRNA CTD PMID:12102619 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase decreases expression EXP Nitroglycerin results in decreased expression of MECR mRNA CTD PMID:12102619 NCBI chr 5:144,029,684...144,056,373
Ensembl chr 5:144,029,731...144,055,863
JBrowse link
G Mgll monoglyceride lipase multiple interactions
increases activity
EXP Nitroglycerin promotes the reaction [MGLL protein results in increased chemical synthesis of Glycerol]; Nitroglycerin promotes the reaction [MGLL protein results in increased degradation of 2-oleoylglycerol]
Nitroglycerin results in increased activity of MGLL protein
CTD PMID:19515121 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO Nitroglycerin results in increased expression of MMP2 mRNA CTD PMID:12084592 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO Nitroglycerin results in increased expression of MMP7 mRNA CTD PMID:12084592 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression
ISO Nitroglycerin results in increased activity of MMP9 protein
Nitroglycerin results in increased expression of MMP9 mRNA
CTD PMID:12084592 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase decreases activity EXP Nitroglycerin results in decreased activity of MPO protein CTD PMID:8869312 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression EXP Nitroglycerin results in increased expression of MXI1 mRNA CTD PMID:12102619 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
JBrowse link
G Myo9b myosin IXb decreases expression EXP Nitroglycerin results in decreased expression of MYO9B mRNA CTD PMID:12102619 NCBI chr16:17,945,379...18,030,114
Ensembl chr16:17,945,448...18,030,126
JBrowse link
G Ncam1 neural cell adhesion molecule 1 increases expression EXP Nitroglycerin results in increased expression of NCAM1 mRNA CTD PMID:12102619 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases response to substance
multiple interactions
ISO NCF1 gene mutant form results in decreased susceptibility to Nitroglycerin
NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]
CTD PMID:18522491 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 decreases expression EXP Nitroglycerin results in decreased expression of NDUFA5 mRNA CTD PMID:12102619 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Nkx2-1 NK2 homeobox 1 decreases expression EXP Nitroglycerin results in decreased expression of NKX2-1 mRNA CTD PMID:12102619 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
JBrowse link
G Nnat neuronatin increases expression EXP Nitroglycerin results in increased expression of NNAT mRNA CTD PMID:12102619 NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
EXP acetylsalicylic acid lysinate inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]; Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein] CTD PMID:14510930 PMID:15154853 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
increases expression
ISO
EXP
Nitroglycerin results in decreased expression of NOS2 mRNA
NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]
Nitroglycerin results in increased expression of NOS2 mRNA; Nitroglycerin results in increased expression of NOS2 protein
Nitroglycerin results in decreased expression of NOS2 protein
CTD PMID:11701602 PMID:12206003 PMID:14729435 PMID:14732477 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
EXP [Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]
Nitroglycerin results in increased expression of NOS3 mRNA; Nitroglycerin results in increased expression of NOS3 protein
CTD PMID:10625313 PMID:12860443 PMID:14732477 PMID:17541025 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox1 NADPH oxidase 1 decreases expression EXP Nitroglycerin results in decreased expression of NOX1 mRNA CTD PMID:17493633 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 decreases expression EXP Nitroglycerin results in decreased expression of NOX4 mRNA CTD PMID:17493633 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Npy neuropeptide Y increases expression EXP Nitroglycerin results in increased expression of NPY protein CTD PMID:10426492 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase increases expression EXP Nitroglycerin results in increased expression of PAICS mRNA CTD PMID:12102619 NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO Nitroglycerin results in decreased expression of PARP1 protein alternative form CTD PMID:17322376 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor decreases expression EXP Nitroglycerin results in decreased expression of PCSK1N mRNA CTD PMID:12102619 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566
JBrowse link
G Pde1a phosphodiesterase 1A increases expression
multiple interactions
EXP Nitroglycerin results in increased expression of PDE1A mRNA; Nitroglycerin results in increased expression of PDE1A protein
PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP]
CTD PMID:11696475 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
JBrowse link
G Pde2a phosphodiesterase 2A increases expression EXP Nitroglycerin results in increased expression of PDE2A mRNA CTD PMID:12102619 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
JBrowse link
G Pla2g1b phospholipase A2 group IB increases expression EXP Nitroglycerin results in increased expression of PLA2G1B mRNA CTD PMID:12102619 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Nitroglycerin results in increased expression of PLAUR mRNA CTD PMID:12102619 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression EXP Nitroglycerin results in decreased expression of PMP22 mRNA CTD PMID:12102619 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Polr1b RNA polymerase I subunit B increases expression EXP Nitroglycerin results in increased expression of POLR1B mRNA CTD PMID:12102619 NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Nitroglycerin results in decreased expression of PPP2CB mRNA CTD PMID:12102619 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression EXP Nitroglycerin results in decreased expression of PRKG1 protein CTD PMID:11331261 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Ptgds prostaglandin D2 synthase increases expression EXP Nitroglycerin results in increased expression of PTGDS mRNA CTD PMID:12102619 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R increases expression EXP Nitroglycerin results in increased expression of PTPRR mRNA CTD PMID:12102619 NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603
JBrowse link
G Rab40c Rab40c, member RAS oncogene family increases expression EXP Nitroglycerin results in increased expression of RAB40C mRNA CTD PMID:12187120 NCBI chr10:14,900,926...14,936,165
Ensembl chr10:14,900,929...14,936,557
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Nitroglycerin results in increased expression of REG3B mRNA CTD PMID:12102619 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases localization
multiple interactions
EXP Nitroglycerin results in increased localization of RELA protein
Atorvastatin inhibits the reaction [Nitroglycerin results in increased localization of RELA protein]
CTD PMID:19733216 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin increases activity ISO Nitroglycerin results in increased activity of REN protein CTD PMID:9527094 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP Nitroglycerin results in increased expression of RGS8 mRNA CTD PMID:12102619 NCBI chr13:65,804,703...65,848,953
Ensembl chr13:65,804,797...65,846,807
JBrowse link
G Rheb Ras homolog, mTORC1 binding decreases expression EXP Nitroglycerin results in decreased expression of RHEB mRNA CTD PMID:12102619 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Rpl6 ribosomal protein L6 decreases expression EXP Nitroglycerin results in decreased expression of RPL6 mRNA CTD PMID:12102619 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
JBrowse link
G Rps3a ribosomal protein S3a increases expression EXP Nitroglycerin results in increased expression of RPS3A mRNA CTD PMID:12102619 NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression EXP Nitroglycerin results in decreased expression of SCGB1A1 mRNA CTD PMID:12102619 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
JBrowse link
G Sdc4 syndecan 4 decreases expression EXP Nitroglycerin results in decreased expression of SDC4 mRNA CTD PMID:12102619 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N decreases expression EXP Nitroglycerin results in decreased expression of SERPINA3N mRNA CTD PMID:12102619 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 increases expression EXP Nitroglycerin results in increased expression of SHANK2 mRNA CTD PMID:12102619 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression EXP Nitroglycerin results in increased expression of SLC4A4 mRNA CTD PMID:12102619 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
JBrowse link
G Snn stannin decreases expression EXP Nitroglycerin results in decreased expression of SNN mRNA CTD PMID:12102619 NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021
JBrowse link
G Snrk SNF related kinase increases expression EXP Nitroglycerin results in increased expression of SNRK mRNA CTD PMID:12102619 NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Nitroglycerin results in increased expression of and results in increased activity of SOD2 protein CTD PMID:12860443 PMID:14732477 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Nitroglycerin results in increased expression of STAT3 mRNA CTD PMID:12102619 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Syk spleen associated tyrosine kinase increases expression EXP Nitroglycerin results in increased expression of SYK mRNA CTD PMID:12102619 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Syn2 synapsin II increases expression EXP Nitroglycerin results in increased expression of SYN2 mRNA CTD PMID:12102619 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
JBrowse link
G Tac1 tachykinin, precursor 1 affects expression EXP Nitroglycerin affects the expression of TAC1 protein CTD PMID:18197882 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tcf4 transcription factor 4 multiple interactions ISO Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]] CTD PMID:17030184 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases expression EXP Nitroglycerin results in decreased expression of TDO2 protein CTD PMID:28659861 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression EXP Nitroglycerin results in decreased expression of THY1 mRNA CTD PMID:12102619 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Tmpo thymopoietin increases expression EXP Nitroglycerin results in increased expression of TMPO mRNA CTD PMID:12102619 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
Nitroglycerin results in decreased expression of TNF protein
Capsaicin inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]
CTD PMID:10884648 PMID:11744139 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 decreases expression EXP Nitroglycerin results in decreased expression of TNFRSF8 mRNA CTD PMID:12102619 NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421
JBrowse link
G Umod uromodulin increases expression EXP Nitroglycerin results in increased expression of UMOD mRNA CTD PMID:12102619 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]
Nitroglycerin results in decreased phosphorylation of VASP protein
Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]
CTD PMID:11331261 PMID:14551241 PMID:15331769 PMID:17541025 PMID:17868048 More... NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vtn vitronectin increases expression EXP Nitroglycerin results in increased expression of VTN mRNA CTD PMID:12102619 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta decreases expression EXP Nitroglycerin results in decreased expression of YWHAZ mRNA CTD PMID:12102619 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
JBrowse link
nitroxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO 3-aminobenzamide inhibits the reaction [[oxyhyponitrite results in increased abundance of nitroxyl] which results in increased activity of CASP3 protein]; [oxyhyponitrite results in increased abundance of nitroxyl] which results in increased activity of CASP3 protein CTD PMID:11744336 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Gpc1 glypican 1 multiple interactions ISO nitroxyl affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]] CTD PMID:12732622 NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047
JBrowse link
pentaerythritol tetranitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
increases metabolic processing
increases response to substance
ISO
EXP
[ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide; [ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol
ALDH2 protein affects the metabolism of and results in increased activity of Pentaerythritol Tetranitrate
ALDH2 protein results in increased susceptibility to Pentaerythritol Tetranitrate
CTD PMID:15331769 PMID:21156756 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Pentaerythritol Tetranitrate results in increased expression of FTH1 mRNA CTD PMID:17641250 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity
ISO
EXP
Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA
Pentaerythritol Tetranitrate results in increased activity of HMOX1 protein
Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA; Pentaerythritol Tetranitrate results in increased expression of HMOX1 protein
CTD PMID:17092343 PMID:17541025 PMID:17641250 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Pentaerythritol Tetranitrate results in increased expression of NOS3 protein CTD PMID:17541025 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
increases phosphorylation
EXP Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein] CTD PMID:15331769 PMID:17541025 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
pentrinitrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO [ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol CTD PMID:21156756 NCBI chr12:34,949,549...34,982,527 JBrowse link
peroxynitrous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance ISO AGT protein modified form results in increased abundance of Peroxynitrous Acid CTD PMID:12606818 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid CTD PMID:23824088 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP Peroxynitrous Acid results in increased phosphorylation of AKT1 protein
BDNF protein promotes the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Catechin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Peroxynitrous Acid promotes the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]
CTD PMID:17302912 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions
increases glycation
ISO [Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein; pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]
Peroxynitrous Acid results in increased glycation of ALB protein modified form
CTD PMID:12196478 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity
multiple interactions
EXP Peroxynitrous Acid results in decreased activity of ALOX5 protein
Peroxynitrous Acid results in increased nitrosation of and affects the expression of ALOX5 protein; zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]
CTD PMID:11561080 PMID:12388339 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA] CTD PMID:20869986 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased susceptibility to Peroxynitrous Acid] which results in increased phosphorylation of BAD protein; [PARP1 protein results in decreased susceptibility to Peroxynitrous Acid] which results in decreased phosphorylation of BAD protein CTD PMID:18239155 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]
Peroxynitrous Acid results in increased expression of BAX mRNA; Peroxynitrous Acid results in increased expression of BAX protein
CTD PMID:20869986 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Peroxynitrous Acid results in decreased expression of BCL2 mRNA; Peroxynitrous Acid results in decreased expression of BCL2 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]
CTD PMID:20869986 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP BDNF protein promotes the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Peroxynitrous Acid promotes the reaction [BDNF protein results in increased phosphorylation of AKT1 protein] CTD PMID:17302912 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Peroxynitrous Acid results in increased expression of BNIP3 protein CTD PMID:16002567 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions
increases metabolic processing
ISO [linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein; [Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form] which results in decreased phosphorylation of CREB1 protein; Peroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein] CTD PMID:17551092 PMID:20128810 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
decreases activity
ISO
EXP
[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; demethoxycurcumin inhibits the reaction [Peroxynitrous Acid results in increased activity of CASP3 protein]
Peroxynitrous Acid results in increased expression of CASP3 mRNA
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein
Peroxynitrous Acid results in decreased activity of CASP3 protein
CTD PMID:9441900 PMID:19188863 PMID:20869986 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]; Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:20869986 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Peroxynitrous Acid]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Peroxynitrous Acid] CTD PMID:15855331 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbs cystathionine beta synthase decreases activity
multiple interactions
ISO Peroxynitrous Acid results in decreased activity of CBS protein
4-hydroxyphenylacetic acid inhibits the reaction [Peroxynitrous Acid results in decreased activity of CBS protein]
CTD PMID:19733148 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form] which results in decreased phosphorylation of CREB1 protein; Peroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]
Peroxynitrous Acid inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]
CTD PMID:20128810 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects response to substance EXP FGFR1 protein alternative form affects the susceptibility to Peroxynitrous Acid CTD PMID:12573278 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]; Peroxynitrous Acid affects the localization of and affects the activity of FOS protein; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions
decreases expression
EXP manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein] CTD PMID:18055527 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions
decreases expression
EXP manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein] CTD PMID:18055527 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Gpx1 glutathione peroxidase 1 affects response to substance
increases abundance
multiple interactions
ISO GPX1 protein affects the susceptibility to Peroxynitrous Acid
GPX1 gene mutant form results in increased abundance of Peroxynitrous Acid
[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Peroxynitrous Acid
CTD PMID:16636302 PMID:24296279 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
ISO hydroquinone inhibits the reaction [Peroxynitrous Acid results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Peroxynitrous Acid results in decreased activity of GSR protein] CTD PMID:15831208 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Peroxynitrous Acid results in increased expression of GSTA2; Peroxynitrous Acid results in increased expression of GSTA2 mRNA; Peroxynitrous Acid results in increased expression of GSTA2 protein CTD PMID:12446173 PMID:15357004 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride results in decreased abundance of Peroxynitrous Acid] inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein] CTD PMID:21397656 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Peroxynitrous Acid results in decreased phosphorylation of MAPK1 protein CTD PMID:18055527 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Peroxynitrous Acid results in decreased phosphorylation of MAPK3 protein CTD PMID:18055527 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions
increases activity
EXP [Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Peroxynitrous Acid promotes the reaction [MGST1 protein binds to MGST1 protein]; sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]
Peroxynitrous Acid results in increased activity of MGST1 protein
CTD PMID:16386761 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO Peroxynitrous Acid results in decreased activity of NAT1 protein CTD PMID:14672957 PMID:15644493 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 decreases activity
multiple interactions
ISO Peroxynitrous Acid results in decreased activity of NAT2 protein
[Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid
CTD PMID:15644493 PMID:19248797 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Ngf nerve growth factor multiple interactions EXP [Methamphetamine co-treated with NGF protein] affects the abundance of Peroxynitrous Acid CTD PMID:12105096 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Noa1 nitric oxide associated 1 multiple interactions EXP [Tamoxifen results in increased activity of NOA1 protein] which results in increased abundance of Peroxynitrous Acid CTD PMID:17283165 NCBI chr14:30,835,012...30,851,296
Ensembl chr14:30,835,247...30,851,293
JBrowse link
G Nos2 nitric oxide synthase 2 affects abundance
multiple interactions
ISO NOS2 protein affects the abundance of Peroxynitrous Acid
[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Peroxynitrous Acid
CTD PMID:11919077 PMID:15694688 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Peroxynitrous Acid results in increased nitrosation of and results in decreased activity of NOS3 protein; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Peroxynitrous Acid] which results in increased metabolism of NOS3 protein] CTD PMID:11509453 PMID:12489993 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Npr3 natriuretic peptide receptor 3 decreases expression EXP Peroxynitrous Acid results in decreased expression of NPR3 protein CTD PMID:18055527 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
ISO [PARP1 protein results in decreased susceptibility to Peroxynitrous Acid] which results in decreased phosphorylation of BAD protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Peroxynitrous Acid results in increased activity of PARP1 protein] CTD PMID:18239155 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha affects expression EXP Peroxynitrous Acid affects the expression of PPARGC1A protein CTD PMID:24563852 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Pten phosphatase and tensin homolog increases oxidation EXP Peroxynitrous Acid results in increased oxidation of PTEN protein CTD PMID:17302912 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rcan1 regulator of calcineurin 1 increases phosphorylation ISO Peroxynitrous Acid results in increased phosphorylation of RCAN1 protein CTD PMID:12927602 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]
Peroxynitrous Acid affects the localization of RELA protein
CTD PMID:14572605 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases activity ISO Peroxynitrous Acid results in increased activity of SMPD1 protein CTD PMID:17498692 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Sod1 superoxide dismutase 1 decreases abundance
multiple interactions
ISO SOD1 protein results in decreased abundance of Peroxynitrous Acid
[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Peroxynitrous Acid
[Peroxynitrous Acid co-treated with Bicarbonates] results in decreased activity of SOD1 protein; [Peroxynitrous Acid co-treated with Bicarbonates] results in increased metabolism of SOD1 protein; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Peroxynitrous Acid] which results in increased metabolism of NOS3 protein]; SOD1 protein inhibits the reaction [Nitric Oxide results in increased abundance of Peroxynitrous Acid]
CTD PMID:11451436 PMID:12489993 PMID:16636302 PMID:21443684 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO SOD2 protein affects the susceptibility to [alatrofloxacin results in increased abundance of Peroxynitrous Acid]
Peroxynitrous Acid results in increased expression of SOD2 mRNA
Acetylcysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Peroxynitrous Acid]; Cysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Peroxynitrous Acid]
CTD PMID:9741582 PMID:15855331 PMID:20655887 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Peroxynitrous Acid CTD PMID:23884884 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Peroxynitrous Acid inhibits the reaction [TNF protein results in decreased export of Potassium] CTD PMID:17337591 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 affects expression EXP Peroxynitrous Acid affects the expression of UQCRC2 protein CTD PMID:24563852 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP Peroxynitrous Acid promotes the reaction [VDAC1 protein modified form binds to VDAC1 protein modified form]; Peroxynitrous Acid results in increased metabolism of and results in increased activity of VDAC1 protein; resveratrol inhibits the reaction [Peroxynitrous Acid results in increased metabolism of VDAC1 protein] CTD PMID:22709907 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
sodium nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO [Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein
CTD PMID:12414318 PMID:26231821 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acp1 acid phosphatase 1 increases activity ISO Sodium Nitrite results in increased activity of ACP1 protein CTD PMID:26231821 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]
CTD PMID:28266762 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity ISO Sodium Nitrite results in increased activity of AMPD3 protein CTD PMID:26231821 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]
CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]
CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]
CTD PMID:28833918 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity
increases activity
ISO Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein
CTD PMID:26231821 PMID:31476334 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Sodium Nitrite results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Crp C-reactive protein multiple interactions
increases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein] CTD PMID:28266762 PMID:28833918 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Sodium Nitrite results in decreased activity of G6PD protein CTD PMID:26231821 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Sodium Nitrite results in decreased activity of GSR protein CTD PMID:26231821 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Sodium Nitrite results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]
CTD PMID:28000380 PMID:28266762 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
ISO Sodium Nitrite results in increased expression of IL1B mRNA
Sodium Nitrite results in increased secretion of IL1B protein
CTD PMID:16581224 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Sodium Nitrite results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions
ISO
EXP
Sodium Nitrite results in increased secretion of IL6 protein
Sodium Nitrite results in increased expression of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]
CTD PMID:16581224 PMID:28266762 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ldhb lactate dehydrogenase B increases activity ISO Sodium Nitrite results in increased activity of LDHB protein CTD PMID:26231821 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Sodium Nitrite results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sodium Nitrite results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]
CTD PMID:28000380 PMID:28266762 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Sodium Nitrite results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]
CTD PMID:28266762 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO
EXP
Sodium Nitrite results in increased expression of TNF mRNA
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
Sodium Nitrite results in increased secretion of TNF protein
CTD PMID:16581224 PMID:28266762 PMID:28833918 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]
CTD PMID:28266762 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              nitrogen oxoacid 276
                azinic acid + 0
                azonic acid + 0
                hyponitrous acid 0
                nitric acid + 205
                nitrous acid + 58
                nitroxyl 2
                peroxynitric acid 0
                peroxynitrous acid 47
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19450
                        oxygen atom 19423
                          oxygen molecular entity 19423
                            hydroxides 19158
                              oxoacid 18472
                                pnictogen oxoacid 10733
                                  nitrogen oxoacid 276
                                    azinic acid + 0
                                    azonic acid + 0
                                    hyponitrous acid 0
                                    nitric acid + 205
                                    nitrous acid + 58
                                    nitroxyl 2
                                    peroxynitric acid 0
                                    peroxynitrous acid 47
paths to the root