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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrogen oxoacid
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Accession:CHEBI:33455 term browser browse the term
Synonyms:related_synonym: nitrogen oxoacids;   oxoacids of nitrogen


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isobutyl nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf1 fibroblast growth factor 1 increases expression ISO isobutyl nitrite results in increased expression of FGF1 mRNA CTD PMID:16288974 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf4 fibroblast growth factor 4 increases expression ISO isobutyl nitrite results in increased expression of FGF4 mRNA CTD PMID:16288974 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isobutyl nitrite results in increased expression of HMOX1 mRNA CTD PMID:16288974 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO isobutyl nitrite results in increased expression of HSPA4 mRNA CTD PMID:16288974 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Pf4 platelet factor 4 increases expression ISO isobutyl nitrite results in increased expression of PF4 mRNA CTD PMID:16288974 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Smad7 SMAD family member 7 increases expression ISO isobutyl nitrite results in increased expression of SMAD7 mRNA CTD PMID:16288974 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO isobutyl nitrite results in increased expression of VEGFA mRNA CTD PMID:16288974 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO isobutyl nitrite results in increased expression of VEGFD mRNA CTD PMID:16288974 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
isosorbide dinitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions ISO [Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA CTD PMID:15719745 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases response to substance ISO G6PD protein results in decreased susceptibility to Isosorbide Dinitrate CTD PMID:6401899 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNA; [Isosorbide Dinitrate co-treated with Plant Preparations] results in increased expression of NOS3 mRNA CTD PMID:15719745 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
isosorbide mononitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 multiple interactions EXP isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein] CTD PMID:8738301 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
nicorandil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 increases activity ISO Nicorandil results in increased activity of ABCC9 protein CTD PMID:22622455 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Agt angiotensinogen multiple interactions ISO Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein] CTD PMID:22622455 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:31376360 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:31376360 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:31376360 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ctsd cathepsin D multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:11829124 PMID:14499179 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 PMID:14499179 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:31376360 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP Nicorandil results in decreased expression of HMOX1 protein CTD PMID:22622455 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:31376360 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of MPO protein] CTD PMID:31376360 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein] CTD PMID:31376360 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of NFKB1 protein] CTD PMID:31376360 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Nicorandil results in increased expression of SOD2 protein CTD PMID:22622455 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TLR4 protein] CTD PMID:31376360 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:31376360 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
decreases expression
ISO
EXP
Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein]
Nicorandil results in decreased expression of XDH protein
CTD PMID:22622455 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
nitrates term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy4 adenylate cyclase 4 decreases expression EXP Nitrates results in decreased expression of ADCY4 mRNA CTD PMID:30022042 NCBI chr15:34,453,917...34,469,779
Ensembl chr15:34,453,915...34,469,746
JBrowse link
G Adcy9 adenylate cyclase 9 increases expression EXP Nitrates results in increased expression of ADCY9 mRNA CTD PMID:30022042 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Adm adrenomedullin affects abundance ISO ADM protein affects the abundance of Nitrates CTD PMID:15370692 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Atm ATM serine/threonine kinase increases expression EXP Nitrates results in increased expression of ATM mRNA CTD PMID:30022042 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bcl10 BCL10, immune signaling adaptor increases expression EXP Nitrates results in increased expression of BCL10 mRNA CTD PMID:30022042 NCBI chr 2:251,805,392...251,814,957
Ensembl chr 2:251,805,392...251,814,957
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Nitrates results in decreased expression of BMP4 mRNA CTD PMID:30022042 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Card10 caspase recruitment domain family, member 10 decreases expression EXP Nitrates results in decreased expression of CARD10 mRNA CTD PMID:30022042 NCBI chr 7:119,998,639...120,028,632
Ensembl chr 7:119,999,472...120,027,026
JBrowse link
G Casp1 caspase 1 increases expression EXP Nitrates results in increased expression of CASP1 mRNA CTD PMID:30022042 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp4 caspase 4 increases expression EXP Nitrates results in increased expression of CASP4 mRNA CTD PMID:30022042 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp6 caspase 6 increases expression EXP Nitrates results in increased expression of CASP6 mRNA CTD PMID:30022042 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Nitrates results in decreased activity of CFTR protein CTD PMID:15286085 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Nitrates results in increased expression of CNTF mRNA CTD PMID:30022042 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression EXP Nitrates results in decreased expression of CSF2 mRNA CTD PMID:30022042 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression EXP Nitrates results in decreased expression of HTR1A mRNA CTD PMID:30022042 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP Nitrates results in decreased expression of HTR2A mRNA CTD PMID:30022042 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C decreases expression EXP Nitrates results in decreased expression of HTR2C mRNA CTD PMID:30022042 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A decreases expression EXP Nitrates results in decreased expression of HTR3A mRNA CTD PMID:30022042 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B decreases expression EXP Nitrates results in decreased expression of HTR3B mRNA CTD PMID:30022042 NCBI chr 8:53,247,881...53,278,170
Ensembl chr 8:53,248,705...53,277,859
JBrowse link
G Il1b interleukin 1 beta increases abundance
multiple interactions
ISO IL1B protein results in increased abundance of Nitrates
[Asbestos, Crocidolite co-treated with IL1B protein] results in increased abundance of Nitrates; [Asbestos, Serpentine co-treated with IL1B protein] results in increased abundance of Nitrates
CTD PMID:8904084 PMID:9698594 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression EXP Nitrates results in increased expression of IRAK4 mRNA CTD PMID:30022042 NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652
JBrowse link
G Irf7 interferon regulatory factor 7 increases expression EXP Nitrates results in increased expression of IRF7 mRNA CTD PMID:30022042 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Kl Klotho decreases expression EXP Nitrates results in decreased expression of KL mRNA CTD PMID:30022042 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 increases expression EXP Nitrates results in increased expression of MAP4K4 mRNA CTD PMID:30022042 NCBI chr 9:46,657,444...46,782,545
Ensembl chr 9:46,657,575...46,782,545
JBrowse link
G Ngf nerve growth factor increases expression EXP Nitrates results in increased expression of NGF mRNA CTD PMID:30022042 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
NOS2 gene mutant form inhibits the reaction [SFTPD gene mutant form results in increased abundance of Nitrates]
[[Particulate Matter results in increased abundance of Nitrates] which results in decreased methylation of NOS2 promoter] which results in increased abundance of Nitric Oxide; [Particulate Matter results in increased abundance of Nitrates] which results in decreased methylation of NOS2 promoter
[[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrates
CTD PMID:17566059 PMID:24465666 PMID:26372312 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrates CTD PMID:17566059 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression EXP Nitrates results in decreased expression of OAS3 mRNA CTD PMID:30022042 NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta increases expression EXP Nitrates results in increased expression of PIK3C2B mRNA CTD PMID:30022042 NCBI chr13:49,848,939...49,909,404
Ensembl chr13:49,850,189...49,911,202
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression EXP Nitrates results in increased expression of PIK3CG mRNA CTD PMID:30022042 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Plcb2 phospholipase C, beta 2 decreases expression EXP Nitrates results in decreased expression of PLCB2 mRNA CTD PMID:30022042 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Plch2 phospholipase C, eta 2 increases expression EXP Nitrates results in increased expression of PLCH2 mRNA CTD PMID:30022042 NCBI chr 5:172,386,400...172,455,965
Ensembl chr 5:172,388,598...172,424,081
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases expression EXP Nitrates results in decreased expression of PRKACB mRNA CTD PMID:30022042 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Ptx3 pentraxin 3 decreases expression EXP Nitrates results in decreased expression of PTX3 mRNA CTD PMID:30022042 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Rhog ras homolog family member G increases expression EXP Nitrates results in increased expression of RHOG mRNA CTD PMID:30022042 NCBI chr 1:167,336,147...167,347,720
Ensembl chr 1:167,335,248...167,347,671
JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 increases expression EXP Nitrates results in increased expression of S1PR5 mRNA CTD PMID:30022042 NCBI chr 8:22,268,635...22,273,708
Ensembl chr 8:22,268,657...22,270,647
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions EXP Nitrates results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions EXP Nitrates results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions EXP Nitrates results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] CTD PMID:16027156 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Sftpd surfactant protein D multiple interactions
increases abundance
ISO NOS2 gene mutant form inhibits the reaction [SFTPD gene mutant form results in increased abundance of Nitrates] CTD PMID:24465666 NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Nitrates results in increased expression of TGFB1 mRNA CTD PMID:30022042 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP Nitrates results in decreased expression of TGFB2 mRNA CTD PMID:30022042 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tlr3 toll-like receptor 3 increases expression EXP Nitrates results in increased expression of TLR3 mRNA CTD PMID:30022042 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr7 toll-like receptor 7 increases expression EXP Nitrates results in increased expression of TLR7 mRNA CTD PMID:30022042 NCBI chr  X:28,486,836...28,513,004
Ensembl chr  X:28,486,869...28,512,957
JBrowse link
G Tlr8 toll-like receptor 8 increases expression EXP Nitrates results in increased expression of TLR8 mRNA CTD PMID:30022042 NCBI chr  X:28,539,158...28,562,803
Ensembl chr  X:28,539,158...28,562,803
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [Endotoxins results in increased abundance of Nitrates] CTD PMID:15659313 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A increases expression EXP Nitrates results in increased expression of TNFRSF11A mRNA CTD PMID:30022042 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Nitrates results in increased expression of TNFRSF1A mRNA CTD PMID:30022042 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression EXP Nitrates results in increased expression of TRADD mRNA CTD PMID:30022042 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases expression ISO Nitrates results in increased expression of TSHB protein CTD PMID:20439182 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N decreases expression EXP Nitrates results in decreased expression of UBE2N mRNA CTD PMID:30022042 NCBI chr 7:36,610,147...36,640,190
Ensembl chr 7:36,610,147...36,640,189
JBrowse link
nitric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant increases expression EXP Nitric Acid results in increased expression of ACP5 protein CTD PMID:16436523 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Nitric Acid results in increased expression of BGLAP protein CTD PMID:16436523 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Ca4 carbonic anhydrase 4 decreases activity ISO Nitric Acid results in decreased activity of CA4 protein CTD PMID:15664814 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067
JBrowse link
G Ca5a carbonic anhydrase 5A decreases activity ISO Nitric Acid results in decreased activity of CA5A protein CTD PMID:15664814 NCBI chr19:54,731,829...54,761,697
Ensembl chr19:54,731,859...54,761,670
JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity ISO Nitric Acid results in decreased activity of CA9 protein CTD PMID:15664814 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Nitric Acid results in decreased activity of CA1 protein CTD PMID:15664814 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Nitric Acid results in decreased activity of CA2 protein CTD PMID:15664814 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
nitrites term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance EXP AGT protein modified form results in increased abundance of Nitrites CTD PMID:28299329 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ak1 adenylate kinase 1 multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of AK1 protein CTD PMID:22892143 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Cp ceruloplasmin increases abundance
multiple interactions
ISO
EXP
CP protein results in increased abundance of Nitrites
SN50 peptide inhibits the reaction [CP protein results in increased abundance of Nitrites]
SB 203580 inhibits the reaction [CP protein results in increased abundance of Nitrites]
CTD PMID:17727827 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cs citrate synthase multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of CS protein CTD PMID:22892143 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP [Gentamicins results in increased expression of EDNRB protein] which results in increased abundance of Nitrites CTD PMID:15200423 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Epo erythropoietin increases abundance
multiple interactions
ISO EPO protein results in increased abundance of Nitrites
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased abundance of Nitrites]
CTD PMID:23384249 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fcer2 Fc fragment of IgE receptor II affects chemical synthesis ISO FCER2 protein affects the chemical synthesis of Nitrites CTD PMID:11500085 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO HMOX1 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] CTD PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions
increases abundance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [Lipopolysaccharides co-treated with IFNG] results in increased abundance of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; sulforafan inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]
2,2'-dihydroxychalcone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; aristolochic acid I inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites]; carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; Industrial Waste inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; plumbagin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; pyrrolidine dithiocarbamic acid inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; sulforafan inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; sulforafan inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [sulforafan inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; Tosyllysine Chloromethyl Ketone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
CTD PMID:7532384 PMID:9918806 PMID:10532951 PMID:10903806 PMID:10967106 PMID:12845421 PMID:17727827 PMID:19071154 PMID:19457078 PMID:21396992 PMID:23942037 PMID:24412304 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases secretion
increases chemical synthesis
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; 8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased secretion of Nitrites]; Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Glucosamine inhibits the reaction [IL1B results in increased abundance of Nitrites]
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; sulforafan inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; Thiopental promotes the reaction [IL1B protein results in increased abundance of Nitrites]
IL1B protein results in increased abundance of Nitrites; IL1B results in increased abundance of Nitrites
CTD PMID:8904084 PMID:9436821 PMID:10532951 PMID:10903806 PMID:10967106 PMID:17605605 PMID:18077487 PMID:19071154 PMID:21954917 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites] CTD PMID:9918806 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Lpo lactoperoxidase multiple interactions ISO [LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Nitrites CTD PMID:22434701 NCBI chr10:75,100,385...75,120,247
Ensembl chr10:75,100,385...75,120,247
JBrowse link
G Mst1r macrophage stimulating 1 receptor multiple interactions ISO MST1R protein affects the reaction [nickel sulfate results in increased abundance of Nitrites] CTD PMID:11751209 NCBI chr 8:116,686,601...116,700,132
Ensembl chr 8:116,686,601...116,700,132
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
NFE2L2 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
[Nitrites co-treated with Oxygen deficiency] results in increased expression of NFE2L2 mRNA
CTD PMID:22892143 PMID:23942037 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
[linsidomine results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites; [Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]] which results in decreased chemical synthesis of Nitrites
[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites; [[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrites; [Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [Oxidopamine results in increased expression of NOS2 protein] which results in increased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [testosterone enanthate results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]
[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; [Zymosan results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; Atenolol inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Carvedilol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dronabinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; ganglioside, GD1a analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1a inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; Hydrolyzable Tannins inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Leukotriene B4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Leukotriene C4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]; neurostatin inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Prazosin inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; protocatechuic acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; trisialoganglioside GT1 analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; trisialoganglioside GT1 inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ZM 230487 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]
CTD PMID:7532384 PMID:8700141 PMID:11405284 PMID:11454666 PMID:17566059 PMID:19439816 PMID:20026373 PMID:20463352 PMID:21397656 PMID:21401295 PMID:23174672 PMID:31202640 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO
EXP
[NOS3 intron polymorphism co-treated with Methylmercury Compounds] results in decreased abundance of Nitrites
[[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrites
CTD PMID:17566059 PMID:22134029 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions ISO NT5E protein affects the reaction [nimesulide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of Nitrites]] CTD PMID:27188793 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [GW 7647 binds to and results in increased activity of PPARA protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites] CTD PMID:17891158 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased expression of and results in decreased acetylation of PPARGC1A protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA; PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]; splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA; P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA] CTD PMID:22892143 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites] which results in increased chemical synthesis of Nitrogen Dioxide; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites; Nitrites promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide] CTD PMID:19243126 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased expression of TFAM mRNA CTD PMID:22892143 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites] CTD PMID:19573522 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
ISO
EXP
5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; TNF protein promotes the reaction [Endotoxins results in increased abundance of Nitrites]
TNF protein results in increased abundance of Nitrites
[Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]; Triglycerides inhibits the reaction [TNF protein affects the abundance of Nitrites]
CTD PMID:7532384 PMID:9918806 PMID:15659313 PMID:16140881 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
nitroflurbiprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 decreases expression ISO nitroflurbiprofen results in decreased expression of CASP1 mRNA CTD PMID:15081244 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA] CTD PMID:16491094 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:16491094 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:16491094 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
nitroflurbiprofen results in decreased expression of NOS2 mRNA
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:8528547 PMID:15081244 PMID:16491094 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
nitroflurbiprofen results in decreased activity of RELA protein
CTD PMID:12716482 PMID:16491094 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
nitroflurbiprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]
nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:12716482 PMID:16491094 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 increases expression EXP Nitroglycerin results in increased expression of ACAT1 mRNA CTD PMID:12102619 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Actb actin, beta decreases expression EXP Nitroglycerin results in decreased expression of ACTB mRNA CTD PMID:12102619 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression EXP Nitroglycerin results in decreased expression of ALDH1A1 mRNA CTD PMID:12102619 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
decreases activity
increases response to substance
decreases expression
affects metabolic processing
affects response to substance
ISO
EXP
[1-aminocyclopropanol analog results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]; ALDH2 protein affects the reaction [Nitroglycerin results in decreased abundance of Cyclic GMP]
ALDH2 protein affects the reaction [Ascorbic Acid deficiency results in decreased susceptibility to Nitroglycerin]
ALDH2 protein results in increased susceptibility to Nitroglycerin
Nitroglycerin results in decreased expression of ALDH2 mRNA; Nitroglycerin results in decreased expression of ALDH2 protein
ALDH2 protein affects the metabolism of and results in increased activity of Nitroglycerin; ALDH2 protein affects the reaction [Nitroglycerin results in increased abundance of Reactive Oxygen Species]; Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]
ALDH2 protein affects the metabolism of Nitroglycerin
ALDH2 gene polymorphism affects the susceptibility to Nitroglycerin; ALDH2 protein affects the susceptibility to Nitroglycerin; ALDH2 protein polymorphism affects the susceptibility to Nitroglycerin
CTD PMID:15331769 PMID:16440063 PMID:17092343 PMID:17493633 PMID:17541025 PMID:17585900 PMID:17967228 PMID:18272654 PMID:19576883 PMID:21156756 PMID:23194305 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Nitroglycerin results in decreased expression of ALOX15 mRNA CTD PMID:12102619 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 increases expression EXP Nitroglycerin results in increased expression of AP2M1 mRNA CTD PMID:12102619 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Nitroglycerin results in increased expression of APEX1 mRNA CTD PMID:12102619 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression EXP Nitroglycerin results in decreased expression of APOA1 mRNA CTD PMID:12102619 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Arl2 ADP-ribosylation factor like GTPase 2 increases expression EXP Nitroglycerin results in increased expression of ARL2 mRNA CTD PMID:12102619 NCBI chr 1:221,504,150...221,516,191
Ensembl chr 1:221,504,170...221,516,110
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression EXP Nitroglycerin results in decreased expression of ATP5F1A mRNA CTD PMID:12102619 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G B2m beta-2 microglobulin affects expression ISO Nitroglycerin affects the expression of B2M protein CTD PMID:8350464 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression EXP Nitroglycerin results in decreased expression of BCKDHB mRNA CTD PMID:12102619 NCBI chr 8:91,464,229...91,656,134
Ensembl chr 8:91,464,229...91,656,134
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Nitroglycerin results in decreased expression of BCL2 protein CTD PMID:17678976 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C3 complement C3 increases expression ISO Nitroglycerin results in increased expression of C3 protein alternative form CTD PMID:10884648 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases expression
affects expression
EXP
ISO
Capsaicin inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Dexamethasone inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]
Nitroglycerin results in increased expression of CALCA mRNA; Nitroglycerin results in increased expression of CALCA protein
Nitroglycerin affects the expression of CALCA protein
CTD PMID:11919648 PMID:14659530 PMID:14729435 PMID:19121572 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calm2 calmodulin 2 increases expression EXP Nitroglycerin results in increased expression of CALM2 mRNA CTD PMID:12102619 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Capn2 calpain 2 decreases expression EXP Nitroglycerin results in decreased expression of CAPN2 mRNA CTD PMID:12102619 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Nitroglycerin results in increased cleavage of and results in increased activity of CASP1 protein CTD PMID:12105852 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
ISO Nitroglycerin results in decreased expression of CASP3 protein modified form
Nitroglycerin results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:12105852 PMID:17322376 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP Nitroglycerin results in increased expression of and results in increased activity of CAT protein CTD PMID:12860443 PMID:14732477 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd3d CD3d molecule increases expression EXP Nitroglycerin results in increased expression of CD3D mRNA CTD PMID:12102619 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
JBrowse link
G Cd5 Cd5 molecule decreases expression EXP Nitroglycerin results in decreased expression of CD5 mRNA CTD PMID:12102619 NCBI chr 1:226,770,912...226,791,861
Ensembl chr 1:226,770,744...226,791,879
JBrowse link
G Cd53 Cd53 molecule decreases expression EXP Nitroglycerin results in decreased expression of CD53 mRNA CTD PMID:12102619 NCBI chr 2:209,489,279...209,537,098
Ensembl chr 2:209,489,279...209,537,087
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone increases expression EXP Nitroglycerin results in increased expression of CDC37 mRNA CTD PMID:12102619 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Nitroglycerin results in increased expression of CDKN1B mRNA CTD PMID:12102619 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Celf2 CUGBP, Elav-like family member 2 increases expression EXP Nitroglycerin results in increased expression of CELF2 mRNA CTD PMID:12102619 NCBI chr17:75,259,269...75,660,154
Ensembl chr17:75,352,389...75,654,951
JBrowse link
G Ckb creatine kinase B decreases expression EXP Nitroglycerin results in decreased expression of CKB mRNA CTD PMID:12102619 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Clu clusterin decreases expression EXP Nitroglycerin results in decreased expression of CLU mRNA CTD PMID:12102619 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Nitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein] CTD PMID:16775503 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cp ceruloplasmin decreases expression EXP Nitroglycerin results in decreased expression of CP mRNA CTD PMID:12102619 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression EXP Nitroglycerin results in decreased expression of CRIP2 mRNA CTD PMID:12102619 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases localization
ISO 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Nitroglycerin results in increased degradation of CTNNB1 protein]; Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Nitroglycerin results in decreased phosphorylation of and results in increased nitrosation of and results in increased degradation of and results in decreased activity of CTNNB1 protein; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein] CTD PMID:17030184 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsd cathepsin D decreases expression EXP Nitroglycerin results in decreased expression of CTSD mRNA CTD PMID:12102619 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
increases expression
decreases response to substance
ISO
EXP
CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]; Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
Nitroglycerin results in decreased expression of CYBB mRNA
CYBB gene mutant form results in decreased susceptibility to Nitroglycerin
CTD PMID:16633368 PMID:17493633 PMID:18522491 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Nitroglycerin results in decreased expression of CYP11B2 mRNA CTD PMID:12102619 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 decreases expression EXP Nitroglycerin results in decreased expression of CYP2B15 mRNA CTD PMID:12102619 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Nitroglycerin results in increased expression of CYP2E1 mRNA CTD PMID:12102619 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Defb4 defensin beta 4 decreases expression EXP Nitroglycerin results in decreased expression of DEFB4 mRNA CTD PMID:12102619 NCBI chr16:75,634,598...75,637,789
Ensembl chr16:75,634,598...75,637,789
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Nitroglycerin results in decreased expression of DHCR7 mRNA CTD PMID:12102619 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 decreases expression EXP Nitroglycerin results in decreased expression of DYNC1I1 mRNA CTD PMID:12102619 NCBI chr 4:30,807,755...31,121,097
Ensembl chr 4:30,807,879...31,121,090
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression EXP Nitroglycerin results in decreased expression of DYRK1A mRNA CTD PMID:12102619 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G Edn1 endothelin 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Nitroglycerin results in decreased expression of EDN1 mRNA
Nitroglycerin results in increased expression of EDN1 protein
Nitroglycerin results in decreased expression of EDN1 mRNA; Nitroglycerin results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
CTD PMID:11751199 PMID:12206003 PMID:12901495 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Elane elastase, neutrophil expressed increases expression ISO Nitroglycerin results in increased expression of ELANE protein CTD PMID:10884648 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Eln elastin increases expression EXP Nitroglycerin results in increased expression of ELN mRNA CTD PMID:12187120 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Faah fatty acid amide hydrolase increases activity
multiple interactions
EXP Nitroglycerin results in increased activity of FAAH protein
Nitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]
CTD PMID:19515121 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Nitroglycerin results in increased expression of and results in increased localization of FAS protein CTD PMID:12105852 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression EXP Nitroglycerin results in increased expression of FGFR2 mRNA CTD PMID:12102619 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Nitroglycerin results in decreased expression of FMO1 mRNA CTD PMID:12102619 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
Nitroglycerin results in increased expression of FOS protein
anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]
CTD PMID:7552308 PMID:10426492 PMID:16897600 PMID:18761334 PMID:19121572 PMID:19489890 PMID:19515121 PMID:25290014 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator decreases expression EXP Nitroglycerin results in decreased expression of GCHFR mRNA CTD PMID:12102619 NCBI chr 3:110,975,923...110,979,957
Ensembl chr 3:110,975,923...110,979,957
JBrowse link
G Gnb3 G protein subunit beta 3 affects response to substance ISO GNB3 protein affects the susceptibility to Nitroglycerin CTD PMID:14586390 NCBI chr 4:157,352,558...157,359,237
Ensembl chr 4:157,352,372...157,358,262
JBrowse link
G Gng7 G protein subunit gamma 7 decreases expression EXP Nitroglycerin results in decreased expression of GNG7 mRNA CTD PMID:12102619 NCBI chr 7:11,565,740...11,629,519
Ensembl chr 7:11,582,984...11,628,929
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance ISO GPX1 gene mutant form results in decreased susceptibility to Nitroglycerin CTD PMID:24296279 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Nitroglycerin results in decreased expression of GRK6 mRNA CTD PMID:12102619 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Grn granulin precursor decreases expression EXP Nitroglycerin results in decreased expression of GRN mRNA CTD PMID:12102619 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsn gelsolin increases expression EXP Nitroglycerin results in increased expression of GSN mRNA CTD PMID:12187120 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP Nitroglycerin results in decreased expression of GSTA2 mRNA CTD PMID:12102619 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects metabolic processing EXP GSTA3 protein affects the metabolism of Nitroglycerin CTD PMID:8968379 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects metabolic processing EXP GSTM2 protein affects the metabolism of Nitroglycerin CTD PMID:8968379 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gtf3c1 general transcription factor IIIC subunit 1 increases expression EXP Nitroglycerin results in increased expression of GTF3C1 mRNA CTD PMID:12102619 NCBI chr 1:197,032,473...197,098,676
Ensembl chr 1:197,032,474...197,098,649
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 increases expression EXP Nitroglycerin results in increased expression of GUCY1A1 mRNA; Nitroglycerin results in increased expression of GUCY1A1 protein CTD PMID:11331261 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 increases expression ISO
EXP
Nitroglycerin results in increased expression of GUCY1B1 protein
Nitroglycerin results in increased expression of GUCY1B1 mRNA; Nitroglycerin results in increased expression of GUCY1B1 protein
CTD PMID:11331261 PMID:11742226 PMID:17541025 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Nitroglycerin results in increased expression of HBB mRNA CTD PMID:12187120 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hdc histidine decarboxylase decreases expression EXP Nitroglycerin results in decreased expression of HDC mRNA CTD PMID:12102619 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Nitroglycerin results in increased expression of HMOX1 mRNA
[Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein
CTD PMID:17092343 PMID:17470570 PMID:17541025 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpn hepsin increases expression EXP Nitroglycerin results in increased expression of HPN mRNA CTD PMID:12102619 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Iapp islet amyloid polypeptide increases expression EXP Nitroglycerin results in increased expression of IAPP mRNA CTD PMID:12102619 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression EXP Nitroglycerin results in increased expression of ID2 mRNA CTD PMID:12102619 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases expression EXP Nitroglycerin results in decreased expression of IDO1 protein CTD PMID:28659861 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Nitroglycerin results in increased expression of IL1B protein CTD PMID:11701602 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO
EXP
Nitroglycerin results in increased expression of IL6 mRNA; Nitroglycerin results in increased expression of IL6 protein CTD PMID:11701602 PMID:17470570 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jtb jumping translocation breakpoint increases expression EXP Nitroglycerin results in increased expression of JTB mRNA CTD PMID:12102619 NCBI chr 2:189,591,707...189,595,926
Ensembl chr 2:189,591,780...189,596,421
JBrowse link
G Kmo kynurenine 3-monooxygenase decreases expression EXP Nitroglycerin results in decreased expression of KMO protein CTD PMID:28659861 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Kng2 kininogen 2 decreases expression EXP Nitroglycerin results in decreased expression of KNG2 mRNA CTD PMID:12102619 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kynu kynureninase decreases expression EXP Nitroglycerin results in decreased expression of KYNU protein CTD PMID:28659861 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Maob monoamine oxidase B increases expression EXP Nitroglycerin results in increased expression of MAOB mRNA CTD PMID:12102619 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase decreases expression EXP Nitroglycerin results in decreased expression of MECR mRNA CTD PMID:12102619 NCBI chr 5:150,001,281...150,027,407
Ensembl chr 5:150,001,281...150,027,049
JBrowse link
G Mgll monoglyceride lipase multiple interactions
increases activity
EXP Nitroglycerin promotes the reaction [MGLL protein results in increased chemical synthesis of Glycerol]; Nitroglycerin promotes the reaction [MGLL protein results in increased degradation of 2-oleoylglycerol]
Nitroglycerin results in increased activity of MGLL protein
CTD PMID:19515121 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO Nitroglycerin results in increased expression of MMP2 mRNA CTD PMID:12084592 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO Nitroglycerin results in increased expression of MMP7 mRNA CTD PMID:12084592 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
increases expression
ISO Nitroglycerin results in increased activity of MMP9 protein
Nitroglycerin results in increased expression of MMP9 mRNA
CTD PMID:12084592 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase decreases activity EXP Nitroglycerin results in decreased activity of MPO protein CTD PMID:8869312 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression EXP Nitroglycerin results in increased expression of MXI1 mRNA CTD PMID:12102619 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Myo9b myosin IXb decreases expression EXP Nitroglycerin results in decreased expression of MYO9B mRNA CTD PMID:12102619 NCBI chr16:19,669,373...19,754,065
Ensembl chr16:19,669,411...19,754,069
JBrowse link
G Ncam1 neural cell adhesion molecule 1 increases expression EXP Nitroglycerin results in increased expression of NCAM1 mRNA CTD PMID:12102619 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases response to substance
multiple interactions
ISO NCF1 gene mutant form results in decreased susceptibility to Nitroglycerin
NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]
CTD PMID:18522491 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 decreases expression EXP Nitroglycerin results in decreased expression of NDUFA5 mRNA CTD PMID:12102619 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
JBrowse link
G Nkx2-1 NK2 homeobox 1 decreases expression EXP Nitroglycerin results in decreased expression of NKX2-1 mRNA CTD PMID:12102619 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286
JBrowse link
G Nnat neuronatin increases expression EXP Nitroglycerin results in increased expression of NNAT mRNA CTD PMID:12102619 NCBI chr 3:154,043,873...154,046,334
Ensembl chr 3:154,043,873...154,046,330
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
EXP acetylsalicylic acid lysinate inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]; Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein] CTD PMID:14510930 PMID:15154853 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
increases expression
ISO
EXP
Nitroglycerin results in decreased expression of NOS2 mRNA
NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]
Nitroglycerin results in increased expression of NOS2 mRNA; Nitroglycerin results in increased expression of NOS2 protein
Nitroglycerin results in decreased expression of NOS2 protein
CTD PMID:11701602 PMID:12206003 PMID:14729435 PMID:14732477 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
EXP [Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]
Nitroglycerin results in increased expression of NOS3 mRNA; Nitroglycerin results in increased expression of NOS3 protein
CTD PMID:10625313 PMID:12860443 PMID:14732477 PMID:17541025 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 decreases expression EXP Nitroglycerin results in decreased expression of NOX1 mRNA CTD PMID:17493633 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 decreases expression EXP Nitroglycerin results in decreased expression of NOX4 mRNA CTD PMID:17493633 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Npy neuropeptide Y increases expression EXP Nitroglycerin results in increased expression of NPY protein CTD PMID:10426492 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase increases expression EXP Nitroglycerin results in increased expression of PAICS mRNA CTD PMID:12102619 NCBI chr14:33,563,884...33,580,944
Ensembl chr14:33,563,886...33,580,566
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO Nitroglycerin results in decreased expression of PARP1 protein alternative form CTD PMID:17322376 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor decreases expression EXP Nitroglycerin results in decreased expression of PCSK1N mRNA CTD PMID:12102619 NCBI chr  X:15,324,263...15,327,705 JBrowse link
G Pde1a phosphodiesterase 1A increases expression
multiple interactions
EXP Nitroglycerin results in increased expression of PDE1A mRNA; Nitroglycerin results in increased expression of PDE1A protein
PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP]
CTD PMID:11696475 NCBI chr 3:66,803,247...67,263,658
Ensembl chr 3:66,803,247...66,885,094
JBrowse link
G Pde2a phosphodiesterase 2A increases expression EXP Nitroglycerin results in increased expression of PDE2A mRNA CTD PMID:12102619 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pla2g1b phospholipase A2 group IB increases expression EXP Nitroglycerin results in increased expression of PLA2G1B mRNA CTD PMID:12102619 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Nitroglycerin results in increased expression of PLAUR mRNA CTD PMID:12102619 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression EXP Nitroglycerin results in decreased expression of PMP22 mRNA CTD PMID:12102619 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Polr1b RNA polymerase I subunit B increases expression EXP Nitroglycerin results in increased expression of POLR1B mRNA CTD PMID:12102619 NCBI chr 3:121,632,043...121,656,506
Ensembl chr 3:121,632,043...121,656,506
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Nitroglycerin results in decreased expression of PPP2CB mRNA CTD PMID:12102619 NCBI chr16:62,273,276...62,294,767
Ensembl chr16:62,273,276...62,294,769
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression EXP Nitroglycerin results in decreased expression of PRKG1 protein CTD PMID:11331261 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Ptgds prostaglandin D2 synthase increases expression EXP Nitroglycerin results in increased expression of PTGDS mRNA CTD PMID:12102619 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R increases expression EXP Nitroglycerin results in increased expression of PTPRR mRNA CTD PMID:12102619 NCBI chr 7:59,039,717...59,325,925
Ensembl chr 7:59,039,720...59,325,947
JBrowse link
G Rab40c Rab40c, member RAS oncogene family increases expression EXP Nitroglycerin results in increased expression of RAB40C mRNA CTD PMID:12187120 NCBI chr10:15,247,913...15,283,111
Ensembl chr10:15,247,914...15,282,951
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Nitroglycerin results in increased expression of REG3B mRNA CTD PMID:12102619 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases localization
multiple interactions
EXP Nitroglycerin results in increased localization of RELA protein
Atorvastatin inhibits the reaction [Nitroglycerin results in increased localization of RELA protein]
CTD PMID:19733216 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases activity ISO Nitroglycerin results in increased activity of REN protein CTD PMID:9527094 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP Nitroglycerin results in increased expression of RGS8 mRNA CTD PMID:12102619 NCBI chr13:71,086,654...71,141,820
Ensembl chr13:71,086,745...71,141,075
JBrowse link
G Rheb Ras homolog, mTORC1 binding decreases expression EXP Nitroglycerin results in decreased expression of RHEB mRNA CTD PMID:12102619 NCBI chr 4:6,827,429...6,873,384
Ensembl chr 4:6,827,429...6,873,383
JBrowse link
G Rpl6 ribosomal protein L6 decreases expression EXP Nitroglycerin results in decreased expression of RPL6 mRNA CTD PMID:12102619 NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
JBrowse link
G Rps3a ribosomal protein S3a increases expression EXP Nitroglycerin results in increased expression of RPS3A mRNA CTD PMID:12102619 NCBI chr 2:185,440,477...185,444,846
Ensembl chr 2:185,440,291...185,444,897
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression EXP Nitroglycerin results in decreased expression of SCGB1A1 mRNA CTD PMID:12102619 NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
JBrowse link
G Sdc4 syndecan 4 decreases expression EXP Nitroglycerin results in decreased expression of SDC4 mRNA CTD PMID:12102619 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N decreases expression EXP Nitroglycerin results in decreased expression of SERPINA3N mRNA CTD PMID:12102619 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 increases expression EXP Nitroglycerin results in increased expression of SHANK2 mRNA CTD PMID:12102619 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763
JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression EXP Nitroglycerin results in increased expression of SLC4A4 mRNA CTD PMID:12102619 NCBI chr14:20,476,258...20,817,042
Ensembl chr14:20,479,323...20,920,286
JBrowse link
G Snn stannin decreases expression EXP Nitroglycerin results in decreased expression of SNN mRNA CTD PMID:12102619 NCBI chr10:4,635,897...4,644,570
Ensembl chr10:4,635,898...4,644,570
JBrowse link
G Snrk SNF related kinase increases expression EXP Nitroglycerin results in increased expression of SNRK mRNA CTD PMID:12102619 NCBI chr 8:130,749,806...130,805,225
Ensembl chr 8:130,749,838...130,803,597
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Nitroglycerin results in increased expression of and results in increased activity of SOD2 protein CTD PMID:12860443 PMID:14732477 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Nitroglycerin results in increased expression of STAT3 mRNA CTD PMID:12102619 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Syk spleen associated tyrosine kinase increases expression EXP Nitroglycerin results in increased expression of SYK mRNA CTD PMID:12102619 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Syn2 synapsin II increases expression EXP Nitroglycerin results in increased expression of SYN2 mRNA CTD PMID:12102619 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096
JBrowse link
G Tac1 tachykinin, precursor 1 affects expression EXP Nitroglycerin affects the expression of TAC1 protein CTD PMID:18197882 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tcf4 transcription factor 4 multiple interactions ISO Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]] CTD PMID:17030184 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases expression EXP Nitroglycerin results in decreased expression of TDO2 protein CTD PMID:28659861 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression EXP Nitroglycerin results in decreased expression of THY1 mRNA CTD PMID:12102619 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tmpo thymopoietin increases expression EXP Nitroglycerin results in increased expression of TMPO mRNA CTD PMID:12102619 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
Nitroglycerin results in decreased expression of TNF protein
Capsaicin inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]
CTD PMID:10884648 PMID:11744139 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 decreases expression EXP Nitroglycerin results in decreased expression of TNFRSF8 mRNA CTD PMID:12102619 NCBI chr 5:163,186,349...163,231,578
Ensembl chr 5:163,186,349...163,231,578
JBrowse link
G Umod uromodulin increases expression EXP Nitroglycerin results in increased expression of UMOD mRNA CTD PMID:12102619 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]
Nitroglycerin results in decreased phosphorylation of VASP protein
Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]
CTD PMID:11331261 PMID:14551241 PMID:15331769 PMID:17541025 PMID:17868048 PMID:20129490 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link
G Vtn vitronectin increases expression EXP Nitroglycerin results in increased expression of VTN mRNA CTD PMID:12102619 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta decreases expression EXP Nitroglycerin results in decreased expression of YWHAZ mRNA CTD PMID:12102619 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link
nitroxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO 3-aminobenzamide inhibits the reaction [[oxyhyponitrite results in increased abundance of nitroxyl] which results in increased activity of CASP3 protein]; [oxyhyponitrite results in increased abundance of nitroxyl] which results in increased activity of CASP3 protein CTD PMID:11744336 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Gpc1 glypican 1 multiple interactions ISO nitroxyl affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]] CTD PMID:12732622 NCBI chr 9:99,998,275...100,026,818
Ensembl chr 9:99,998,275...100,026,818
JBrowse link
pentaerythritol tetranitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
increases metabolic processing
increases response to substance
ISO
EXP
[ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide; [ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol
ALDH2 protein affects the metabolism of and results in increased activity of Pentaerythritol Tetranitrate
ALDH2 protein results in increased susceptibility to Pentaerythritol Tetranitrate
CTD PMID:15331769 PMID:21156756 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Pentaerythritol Tetranitrate results in increased expression of FTH1 mRNA CTD PMID:17641250 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity
ISO
EXP
Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA
Pentaerythritol Tetranitrate results in increased activity of HMOX1 protein
Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA; Pentaerythritol Tetranitrate results in increased expression of HMOX1 protein
CTD PMID:17092343 PMID:17541025 PMID:17641250 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Pentaerythritol Tetranitrate results in increased expression of NOS3 protein CTD PMID:17541025 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
increases phosphorylation
EXP Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein] CTD PMID:15331769 PMID:17541025 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link
pentrinitrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO [ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol CTD PMID:21156756 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
peroxynitrous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance ISO AGT protein modified form results in increased abundance of Peroxynitrous Acid CTD PMID:12606818 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Mevinphos results in increased activity of AGTR2 protein] which results in increased abundance of Peroxynitrous Acid CTD PMID:23824088 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP Peroxynitrous Acid results in increased phosphorylation of AKT1 protein
BDNF protein promotes the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Catechin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Peroxynitrous Acid promotes the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]
CTD PMID:17302912 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions
increases glycation
ISO [Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein; pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]
Peroxynitrous Acid results in increased glycation of ALB protein modified form
CTD PMID:12196478 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity
multiple interactions
EXP Peroxynitrous Acid results in decreased activity of ALOX5 protein
Peroxynitrous Acid results in increased nitrosation of and affects the expression of ALOX5 protein; zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]
CTD PMID:11561080 PMID:12388339 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA] CTD PMID:20869986 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased susceptibility to Peroxynitrous Acid] which results in increased phosphorylation of BAD protein; [PARP1 protein results in decreased susceptibility to Peroxynitrous Acid] which results in decreased phosphorylation of BAD protein CTD PMID:18239155 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]
Peroxynitrous Acid results in increased expression of BAX mRNA; Peroxynitrous Acid results in increased expression of BAX protein
CTD PMID:20869986 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Peroxynitrous Acid results in decreased expression of BCL2 mRNA; Peroxynitrous Acid results in decreased expression of BCL2 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]
CTD PMID:20869986 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP BDNF protein promotes the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Peroxynitrous Acid promotes the reaction [BDNF protein results in increased phosphorylation of AKT1 protein] CTD PMID:17302912 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Peroxynitrous Acid results in increased expression of BNIP3 protein CTD PMID:16002567 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions
increases metabolic processing
ISO [linsidomine co-treated with Peroxynitrous Acid] results in increased nitrosation of CACNA1C protein; [Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form] which results in decreased phosphorylation of CREB1 protein; Peroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein] CTD PMID:17551092 PMID:20128810 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
decreases activity
ISO
EXP
[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; demethoxycurcumin inhibits the reaction [Peroxynitrous Acid results in increased activity of CASP3 protein]
Peroxynitrous Acid results in increased expression of CASP3 mRNA
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein
Peroxynitrous Acid results in decreased activity of CASP3 protein
CTD PMID:9441900 PMID:19188863 PMID:20869986 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]; Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:20869986 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Peroxynitrous Acid]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Peroxynitrous Acid] CTD PMID:15855331 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbs cystathionine beta synthase decreases activity
multiple interactions
ISO Peroxynitrous Acid results in decreased activity of CBS protein
4-hydroxyphenylacetic acid inhibits the reaction [Peroxynitrous Acid results in decreased activity of CBS protein]
CTD PMID:19733148 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [Peroxynitrous Acid results in increased metabolism of CACNA1C protein alternative form] which results in decreased phosphorylation of CREB1 protein; Peroxynitrous Acid inhibits the reaction [[Potassium Chloride co-treated with CACNA1C protein alternative form] results in increased phosphorylation of CREB1 protein]
Peroxynitrous Acid inhibits the reaction [Potassium Chloride results in increased phosphorylation of CREB1 protein]
CTD PMID:20128810 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects response to substance EXP FGFR1 protein alternative form affects the susceptibility to Peroxynitrous Acid CTD PMID:12573278 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]; Peroxynitrous Acid affects the localization of and affects the activity of FOS protein; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions
decreases expression
EXP manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein] CTD PMID:18055527 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions
decreases expression
EXP manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein] CTD PMID:18055527 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gpx1 glutathione peroxidase 1 affects response to substance
increases abundance
multiple interactions
ISO GPX1 protein affects the susceptibility to Peroxynitrous Acid
GPX1 gene mutant form results in increased abundance of Peroxynitrous Acid
[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Peroxynitrous Acid
CTD PMID:16636302 PMID:24296279 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
ISO hydroquinone inhibits the reaction [Peroxynitrous Acid results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Peroxynitrous Acid results in decreased activity of GSR protein] CTD PMID:15831208 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Peroxynitrous Acid results in increased expression of GSTA2; Peroxynitrous Acid results in increased expression of GSTA2 mRNA; Peroxynitrous Acid results in increased expression of GSTA2 protein CTD PMID:12446173 PMID:15357004 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride results in decreased abundance of Peroxynitrous Acid] inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein] CTD PMID:21397656 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP Peroxynitrous Acid results in decreased phosphorylation of MAPK1 protein CTD PMID:18055527 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP Peroxynitrous Acid results in decreased phosphorylation of MAPK3 protein CTD PMID:18055527 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions
increases activity
EXP [Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Peroxynitrous Acid promotes the reaction [MGST1 protein binds to MGST1 protein]; sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]
Peroxynitrous Acid results in increased activity of MGST1 protein
CTD PMID:16386761 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO Peroxynitrous Acid results in decreased activity of NAT1 protein CTD PMID:14672957 PMID:15644493 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 decreases activity
multiple interactions
ISO Peroxynitrous Acid results in decreased activity of NAT2 protein
[Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid
CTD PMID:15644493 PMID:19248797 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Ngf nerve growth factor multiple interactions EXP [Methamphetamine co-treated with NGF protein] affects the abundance of Peroxynitrous Acid CTD PMID:12105096 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Noa1 nitric oxide associated 1 multiple interactions EXP [Tamoxifen results in increased activity of NOA1 protein] which results in increased abundance of Peroxynitrous Acid CTD PMID:17283165 NCBI chr14:33,107,868...33,124,172
Ensembl chr14:33,108,024...33,124,171
JBrowse link
G Nos2 nitric oxide synthase 2 affects abundance
multiple interactions
ISO NOS2 protein affects the abundance of Peroxynitrous Acid
[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Peroxynitrous Acid
CTD PMID:11919077 PMID:15694688 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Peroxynitrous Acid results in increased nitrosation of and results in decreased activity of NOS3 protein; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Peroxynitrous Acid] which results in increased metabolism of NOS3 protein] CTD PMID:11509453 PMID:12489993 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npr3 natriuretic peptide receptor 3 decreases expression EXP Peroxynitrous Acid results in decreased expression of NPR3 protein CTD PMID:18055527 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
ISO [PARP1 protein results in decreased susceptibility to Peroxynitrous Acid] which results in decreased phosphorylation of BAD protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Peroxynitrous Acid results in increased activity of PARP1 protein] CTD PMID:18239155 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha affects expression EXP Peroxynitrous Acid affects the expression of PPARGC1A protein CTD PMID:24563852 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Pten phosphatase and tensin homolog increases oxidation EXP Peroxynitrous Acid results in increased oxidation of PTEN protein CTD PMID:17302912 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rcan1 regulator of calcineurin 1 increases phosphorylation ISO Peroxynitrous Acid results in increased phosphorylation of RCAN1 protein CTD PMID:12927602 NCBI chr11:32,539,689...32,620,274
Ensembl chr11:32,539,683...32,550,539
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]; Selenomethionine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]
Peroxynitrous Acid affects the localization of RELA protein
CTD PMID:14572605 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases activity ISO Peroxynitrous Acid results in increased activity of SMPD1 protein CTD PMID:17498692 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Sod1 superoxide dismutase 1 decreases abundance
multiple interactions
ISO SOD1 protein results in decreased abundance of Peroxynitrous Acid
[GPX1 protein co-treated with SOD1 protein] affects the susceptibility to Peroxynitrous Acid
[Peroxynitrous Acid co-treated with Bicarbonates] results in decreased activity of SOD1 protein; [Peroxynitrous Acid co-treated with Bicarbonates] results in increased metabolism of SOD1 protein; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Peroxynitrous Acid] which results in increased metabolism of NOS3 protein]; SOD1 protein inhibits the reaction [Nitric Oxide results in increased abundance of Peroxynitrous Acid]
CTD PMID:11451436 PMID:12489993 PMID:16636302 PMID:21443684 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO SOD2 protein affects the susceptibility to [alatrofloxacin results in increased abundance of Peroxynitrous Acid]
Peroxynitrous Acid results in increased expression of SOD2 mRNA
Acetylcysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Peroxynitrous Acid]; Cysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Peroxynitrous Acid]
CTD PMID:9741582 PMID:15855331 PMID:20655887 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Peroxynitrous Acid CTD PMID:23884884 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Peroxynitrous Acid inhibits the reaction [TNF protein results in decreased export of Potassium] CTD PMID:17337591 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 affects expression EXP Peroxynitrous Acid affects the expression of UQCRC2 protein CTD PMID:24563852 NCBI chr 1:190,555,177...190,585,741
Ensembl chr 1:190,555,177...190,585,734
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP Peroxynitrous Acid promotes the reaction [VDAC1 protein modified form binds to VDAC1 protein modified form]; Peroxynitrous Acid results in increased metabolism of and results in increased activity of VDAC1 protein; resveratrol inhibits the reaction [Peroxynitrous Acid results in increased metabolism of VDAC1 protein] CTD PMID:22709907 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
sodium nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO [Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein
CTD PMID:12414318 PMID:26231821 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acp1 acid phosphatase 1 increases activity ISO Sodium Nitrite results in increased activity of ACP1 protein CTD PMID:26231821 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]
CTD PMID:28266762 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity ISO Sodium Nitrite results in increased activity of AMPD3 protein CTD PMID:26231821 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]
CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]
CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]
CTD PMID:28833918 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases activity
increases activity
ISO Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein
CTD PMID:26231821 PMID:31476334 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Sodium Nitrite results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Crp C-reactive protein multiple interactions
increases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein] CTD PMID:28266762 PMID:28833918 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Sodium Nitrite results in decreased activity of G6PD protein CTD PMID:26231821 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Sodium Nitrite results in decreased activity of GSR protein CTD PMID:26231821 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Sodium Nitrite results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]
CTD PMID:28000380 PMID:28266762 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
ISO Sodium Nitrite results in increased expression of IL1B mRNA
Sodium Nitrite results in increased secretion of IL1B protein
CTD PMID:16581224 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Sodium Nitrite results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions
ISO
EXP
Sodium Nitrite results in increased secretion of IL6 protein
Sodium Nitrite results in increased expression of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]
CTD PMID:16581224 PMID:28266762 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ldhb lactate dehydrogenase B increases activity ISO Sodium Nitrite results in increased activity of LDHB protein CTD PMID:26231821 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Sodium Nitrite results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sodium Nitrite results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]
CTD PMID:28000380 PMID:28266762 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Sodium Nitrite results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]
CTD PMID:28266762 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO
EXP
Sodium Nitrite results in increased expression of TNF mRNA
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
Sodium Nitrite results in increased secretion of TNF protein
CTD PMID:16581224 PMID:28266762 PMID:28833918 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]
CTD PMID:28266762 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          nitrogen atom 18613
            nitrogen molecular entity 18613
              nitrogen oxoacid 275
                azinic acid + 0
                azonic acid + 0
                hyponitrous acid 0
                nitric acid + 204
                nitrous acid + 58
                nitroxyl 2
                peroxynitric acid 0
                peroxynitrous acid 47
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      chalcogen 19425
                        oxygen atom 19387
                          oxygen molecular entity 19387
                            hydroxides 19113
                              oxoacid 18243
                                pnictogen oxoacid 10293
                                  nitrogen oxoacid 275
                                    azinic acid + 0
                                    azonic acid + 0
                                    hyponitrous acid 0
                                    nitric acid + 204
                                    nitrous acid + 58
                                    nitroxyl 2
                                    peroxynitric acid 0
                                    peroxynitrous acid 47
paths to the root