Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naproxcinod
go back to main search page
Accession:CHEBI:76254 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation of the carboxy group of naproxen with the hydroxy group of 4-(nitrooxy)butanol. A cyclooxygenase-inhibiting nitric oxide donator that is metabolised to naproxen and a nitric oxide donating moiety, effective in treatment of osteoarthritis.
Synonyms:exact_synonym: 4-(nitrooxy)butyl (2S)-2-(6-methoxy-2-naphthyl)propanoate
 related_synonym: (S)-2-(6-Methoxy-2-naphthyl)propanoic acid 4-nitrooxybutyl ester;   AZD 3582;   AZD3582;   Formula=C18H21NO6;   HCT 3012;   InChI=1S/C18H21NO6/c1-13(18(20)24-9-3-4-10-25-19(21)22)14-5-6-16-12-17(23-2)8-7-15(16)11-14/h5-8,11-13H,3-4,9-10H2,1-2H3/t13-/m0/s1;   InChIKey=AKFJWRDCWYYTIG-ZDUSSCGKSA-N;   Naproxen-N-butyl nitrate;   Nitronaproxen;   SMILES=COc1ccc2cc(ccc2c1)[C@H](C)C(=O)OCCCCO[N+]([O-])=O;   naproxcinodum
 xref: CAS:163133-43-5;   Drug_Central:4674;   KEGG:D09568;   PMID:16784252;   PMID:17596112;   PMID:19392579;   PMID:19393822;   PMID:19411388;   PMID:19446261;   PMID:19557204;   PMID:19733721;   PMID:19798455;   PMID:20202489;   PMID:20677266;   PMID:20722026;   PMID:20828790;   PMID:21272053;   PMID:21275896;   PMID:21371681;   PMID:21439116;   PMID:21542252;   PMID:21545399;   PMID:21756233;   PMID:22425883;   PMID:22852285;   PMID:22870450;   PMID:23060406;   Patent:US2008269323;   Patent:WO2009000723;   Patent:WO2012152438;   Reaxys:8432594;   Wikipedia:Naproxcinod



show annotations for term's descendants           Sort by:

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19863
    role 19835
      application 19677
        pro-agent 11550
          prodrug 11311
            naproxcinod 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19863
    subatomic particle 19861
      composite particle 19861
        hadron 19861
          baryon 19861
            nucleon 19861
              atomic nucleus 19861
                atom 19861
                  main group element atom 19807
                    p-block element atom 19807
                      carbon group element atom 19748
                        carbon atom 19744
                          organic molecular entity 19744
                            organic molecule 19695
                              organic cyclic compound 19506
                                carbocyclic compound 18593
                                  carbopolycyclic compound 17186
                                    carbobicyclic compound 5885
                                      naphthalenes 3851
                                        alkyloxynaphthalene 114
                                          methoxynaphthalene 114
                                            naproxen 110
                                              naproxcinod 0
paths to the root