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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naproxcinod
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Accession:CHEBI:76254 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation of the carboxy group of naproxen with the hydroxy group of 4-(nitrooxy)butanol. A cyclooxygenase-inhibiting nitric oxide donator that is metabolised to naproxen and a nitric oxide donating moiety, effective in treatment of osteoarthritis.
Synonyms:exact_synonym: 4-(nitrooxy)butyl (2S)-2-(6-methoxy-2-naphthyl)propanoate
 related_synonym: (S)-2-(6-Methoxy-2-naphthyl)propanoic acid 4-nitrooxybutyl ester;   AZD 3582;   AZD3582;   Formula=C18H21NO6;   HCT 3012;   InChI=1S/C18H21NO6/c1-13(18(20)24-9-3-4-10-25-19(21)22)14-5-6-16-12-17(23-2)8-7-15(16)11-14/h5-8,11-13H,3-4,9-10H2,1-2H3/t13-/m0/s1;   InChIKey=AKFJWRDCWYYTIG-ZDUSSCGKSA-N;   Naproxen-N-butyl nitrate;   Nitronaproxen;   SMILES=COc1ccc2cc(ccc2c1)[C@H](C)C(=O)OCCCCO[N+]([O-])=O;   naproxcinodum
 xref: CAS:163133-43-5;   Drug_Central:4674;   KEGG:D09568;   PMID:16784252;   PMID:17596112;   PMID:19392579;   PMID:19393822;   PMID:19411388;   PMID:19446261;   PMID:19557204;   PMID:19733721;   PMID:19798455;   PMID:20202489;   PMID:20677266;   PMID:20722026;   PMID:20828790;   PMID:21272053;   PMID:21275896;   PMID:21371681;   PMID:21439116;   PMID:21542252;   PMID:21545399;   PMID:21756233;   PMID:22425883;   PMID:22852285;   PMID:22870450;   PMID:23060406;   Patent:US2008269323;   Patent:WO2009000723;   Patent:WO2012152438;   Reaxys:8432594;   Wikipedia:Naproxcinod



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Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      application 19465
        pro-agent 10117
          prodrug 9921
            naproxcinod 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic molecule 19506
                              organic cyclic compound 19324
                                carbocyclic compound 18435
                                  carbopolycyclic compound 17112
                                    carbobicyclic compound 5853
                                      naphthalenes 3811
                                        alkyloxynaphthalene 111
                                          methoxynaphthalene 111
                                            naproxen 108
                                              naproxcinod 0
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