Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naproxcinod
go back to main search page
Accession:CHEBI:76254 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation of the carboxy group of naproxen with the hydroxy group of 4-(nitrooxy)butanol. A cyclooxygenase-inhibiting nitric oxide donator that is metabolised to naproxen and a nitric oxide donating moiety, effective in treatment of osteoarthritis.
Synonyms:exact_synonym: 4-(nitrooxy)butyl (2S)-2-(6-methoxy-2-naphthyl)propanoate
 related_synonym: (S)-2-(6-Methoxy-2-naphthyl)propanoic acid 4-nitrooxybutyl ester;   AZD 3582;   AZD3582;   Formula=C18H21NO6;   HCT 3012;   InChI=1S/C18H21NO6/c1-13(18(20)24-9-3-4-10-25-19(21)22)14-5-6-16-12-17(23-2)8-7-15(16)11-14/h5-8,11-13H,3-4,9-10H2,1-2H3/t13-/m0/s1;   InChIKey=AKFJWRDCWYYTIG-ZDUSSCGKSA-N;   Naproxen-N-butyl nitrate;   Nitronaproxen;   SMILES=COc1ccc2cc(ccc2c1)[C@H](C)C(=O)OCCCCO[N+]([O-])=O;   naproxcinodum
 xref: CAS:163133-43-5;   Drug_Central:4674;   KEGG:D09568;   PMID:16784252;   PMID:17596112;   PMID:19392579;   PMID:19393822;   PMID:19411388;   PMID:19446261;   PMID:19557204;   PMID:19733721;   PMID:19798455;   PMID:20202489;   PMID:20677266;   PMID:20722026;   PMID:20828790;   PMID:21272053;   PMID:21275896;   PMID:21371681;   PMID:21439116;   PMID:21542252;   PMID:21545399;   PMID:21756233;   PMID:22425883;   PMID:22852285;   PMID:22870450;   PMID:23060406;   Patent:US2008269323;   Patent:WO2009000723;   Patent:WO2012152438;   Reaxys:8432594;   Wikipedia:Naproxcinod


show annotations for term's descendants           Sort by:
 

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      application 19412
        pro-agent 8890
          prodrug 8645
            naproxcinod 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19337
                                carbocyclic compound 18300
                                  carbopolycyclic compound 17049
                                    carbobicyclic compound 5818
                                      naphthalenes 3759
                                        alkyloxynaphthalene 111
                                          methoxynaphthalene 111
                                            naproxen 107
                                              naproxcinod 0
paths to the root