CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: nicorandil
Accession: CHEBI:31905
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Definition: A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris.
Synonyms: exact_synonym: 2-[(pyridin-3-ylcarbonyl)amino]ethyl nitrate
related_synonym: 2-nicotinamidoethyl nitrate; Adancor; Formula=C8H9N3O4; Ikorel; InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12); InChIKey=LBHIOVVIQHSOQN-UHFFFAOYSA-N; N-(2-hydroxyethyl)nicotinamide nitrate; Perisalol; SG 75; SMILES=[O-][N+](=O)OCCNC(=O)c1cccnc1; Sigmart; nicorandilum
xref: CAS:65141-46-0; Drug_Central:1919; KEGG:C13280; KEGG:D01810; LINCS:LSM-6009
xref_mesh: MESH:D020108
xref: PMID:23841868; PMID:23845070; PMID:24685703; PMID:24837014; PMID:24952900; PMID:25319832; Patent:DE2714713; Patent:US4200640; Wikipedia:Nicorandil
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Abcc9
ATP binding cassette subfamily C member 9
increases activity
ISO
Nicorandil results in increased activity of ABCC9 protein
CTD
PMID:22622455
NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
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Agt
angiotensinogen
multiple interactions
ISO
Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein]
CTD
PMID:22622455
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Alb
albumin
multiple interactions
ISO
Nicorandil inhibits the reaction [Folic Acid results in decreased expression of ALB protein]
CTD
PMID:33404076
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP ISO
Nicorandil inhibits the reaction [Doxorubicin results in increased expression of BAX protein] Nicorandil inhibits the reaction [Folic Acid results in increased expression of BAX protein]
CTD
PMID:31376360 PMID:33404076
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
CTD
PMID:31376360
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
Nicorandil inhibits the reaction [Folic Acid results in increased expression of CASP3 protein]
CTD
PMID:33404076
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]
CTD
PMID:31376360
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ctsd
cathepsin D
multiple interactions
EXP
[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
CTD
PMID:11829124 PMID:14499179
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Gal
galanin and GMAP prepropeptide
multiple interactions
EXP
[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein]
CTD
PMID:11829124 PMID:14499179
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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Gusb
glucuronidase, beta
multiple interactions
EXP
[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]
CTD
PMID:11829124 PMID:14499179
NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
EXP
Nicorandil inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein]
CTD
PMID:31376360
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Hmox1
heme oxygenase 1
decreases expression
EXP
Nicorandil results in decreased expression of HMOX1 protein
CTD
PMID:22622455
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il1b
interleukin 1 beta
multiple interactions
EXP
Nicorandil inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]
CTD
PMID:31376360
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
Nicorandil inhibits the reaction [Folic Acid results in increased expression of IL6 protein]
CTD
PMID:33404076
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mpo
myeloperoxidase
multiple interactions
EXP
Nicorandil inhibits the reaction [Doxorubicin results in increased expression of MPO protein]
CTD
PMID:31376360
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]
CTD
PMID:31376360
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
EXP
Nicorandil inhibits the reaction [Doxorubicin results in increased expression of NFKB1 protein]
CTD
PMID:31376360
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
Nicorandil inhibits the reaction [Folic Acid results in increased expression of NOS2 protein]
CTD
PMID:33404076
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
multiple interactions
ISO
Nicorandil inhibits the reaction [Folic Acid results in decreased expression of NOS3 protein]
CTD
PMID:33404076
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Sod2
superoxide dismutase 2
increases expression
EXP
Nicorandil results in increased expression of SOD2 protein
CTD
PMID:22622455
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Tlr4
toll-like receptor 4
multiple interactions
EXP
Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TLR4 protein]
CTD
PMID:31376360
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
multiple interactions
EXP ISO
Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TNF protein] Nicorandil inhibits the reaction [Folic Acid results in increased expression of TNF protein]
CTD
PMID:31376360 PMID:33404076
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Xdh
xanthine dehydrogenase
multiple interactions decreases expression
ISO EXP
Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein] Nicorandil results in decreased expression of XDH protein
CTD
PMID:22622455
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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