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ONTOLOGY REPORT - ANNOTATIONS


Term:nicorandil
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Accession:CHEBI:31905 term browser browse the term
Definition:A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris.
Synonyms:exact_synonym: 2-[(pyridin-3-ylcarbonyl)amino]ethyl nitrate
 related_synonym: 2-nicotinamidoethyl nitrate;   Adancor;   Formula=C8H9N3O4;   Ikorel;   InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12);   InChIKey=LBHIOVVIQHSOQN-UHFFFAOYSA-N;   N-(2-hydroxyethyl)nicotinamide nitrate;   Perisalol;   SG 75;   SMILES=[O-][N+](=O)OCCNC(=O)c1cccnc1;   Sigmart;   nicorandilum
 xref: CAS:65141-46-0 "ChemIDplus";   CAS:65141-46-0 "KEGG COMPOUND";   Drug_Central:1919 "DrugCentral";   KEGG:C13280;   KEGG:D01810;   LINCS:LSM-6009
 xref_mesh: MESH:D020108
 xref: PMID:23841868 "Europe PMC";   PMID:23845070 "Europe PMC";   PMID:24685703 "Europe PMC";   PMID:24837014 "Europe PMC";   PMID:24952900 "Europe PMC";   PMID:25319832 "Europe PMC";   Patent:DE2714713;   Patent:US4200640;   Wikipedia:Nicorandil


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nicorandil term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc9 ATP binding cassette subfamily C member 9 JBrowse link 4 176,806,098 176,928,540 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Gal galanin and GMAP prepropeptide JBrowse link 1 218,653,059 218,657,922 RGD:6480464
G Gusb glucuronidase, beta JBrowse link 12 30,202,066 30,215,583 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      chemical role 19114
        antioxidant 14059
          nicotinamide 126
            nicorandil 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic acid 17908
                                        carboacyl group 16930
                                          univalent carboacyl group 16930
                                            carbamoyl group 16610
                                              carboxamide 16610
                                                pyridinecarboxamide 262
                                                  nicotinamide 126
                                                    nicorandil 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.