Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isosorbide dinitrate
go back to main search page
Accession:CHEBI:6061 term browser browse the term
Definition:A glucitol derivative that has formula C6H8N2O8.
Synonyms:exact_synonym: 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol
 related_synonym: 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate;   Carvasin;   Cedocard Retard;   D-Isosorbide dinitrate;   Dianhydrosorbitol 2,5-dinitrate;   Dinitroisosorbide;   Dinitrosorbide;   Flindix;   Formula=C6H8N2O8;   InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1;   InChIKey=MOYKHGMNXAOIAT-JGWLITMVSA-N;   Isoket;   Isorbid;   Isordil;   Isosorbide 2,5-dinitrate;   Nitrosorbide;   SMILES=[H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@H]2O[N+]([O-])=O;   Sorbide nitrate;   Sorbidilat;   Sorbidnitrate;   dinitrato de isosorbida;   isosorbidi dinitras
 xref: Beilstein:88225;   CAS:87-33-2;   DrugBank:DB00883;   Drug_Central:1505;   KEGG:C07456;   KEGG:D00516
 xref_mesh: MESH:D007548



show annotations for term's descendants           Sort by:
 
isosorbide dinitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Isosorbide Dinitrate results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA CTD PMID:15719745 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases response to substance ISO G6PD protein results in decreased susceptibility to Isosorbide Dinitrate CTD PMID:6401899 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNA; [Isosorbide Dinitrate co-treated with Plant Preparations] results in increased expression of NOS3 mRNA CTD PMID:15719745 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19703
    role 19678
      chemical role 19323
        donor 18703
          nitric oxide donor 2772
            isosorbide dinitrate 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19703
    subatomic particle 19702
      composite particle 19702
        hadron 19702
          baryon 19702
            nucleon 19702
              atomic nucleus 19702
                atom 19702
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19595
                        carbon atom 19592
                          organic molecular entity 19592
                            heteroorganic entity 19337
                              organochalcogen compound 19132
                                organooxygen compound 19040
                                  carbohydrates and carbohydrate derivatives 13973
                                    carbohydrate 13973
                                      alditol 1906
                                        hexitol 115
                                          glucitol 28
                                            glucitol derivative 5
                                              isosorbide dinitrate 4
paths to the root