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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isosorbide dinitrate
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Accession:CHEBI:6061 term browser browse the term
Definition:A glucitol derivative that has formula C6H8N2O8.
Synonyms:exact_synonym: 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol
 related_synonym: 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate;   Carvasin;   Cedocard Retard;   D-Isosorbide dinitrate;   Dianhydrosorbitol 2,5-dinitrate;   Dinitroisosorbide;   Dinitrosorbide;   Flindix;   Formula=C6H8N2O8;   InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1;   InChIKey=MOYKHGMNXAOIAT-JGWLITMVSA-N;   Isoket;   Isorbid;   Isordil;   Isosorbide 2,5-dinitrate;   Nitrosorbide;   SMILES=[H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@H]2O[N+]([O-])=O;   Sorbide nitrate;   Sorbidilat;   Sorbidnitrate;   dinitrato de isosorbida;   isosorbidi dinitras
 xref: Beilstein:88225;   CAS:87-33-2;   DrugBank:DB00883;   Drug_Central:1505;   KEGG:C07456;   KEGG:D00516
 xref_mesh: MESH:D007548


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isosorbide dinitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions ISO [Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA CTD PMID:15719745 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases response to substance ISO G6PD protein results in decreased susceptibility to Isosorbide Dinitrate CTD PMID:6401899 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNA; [Isosorbide Dinitrate co-treated with Plant Preparations] results in increased expression of NOS3 mRNA CTD PMID:15719745 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      chemical role 19262
        donor 18486
          nitric oxide donor 2762
            isosorbide dinitrate 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            heteroorganic entity 19207
                              organochalcogen compound 18958
                                organooxygen compound 18886
                                  carbohydrates and carbohydrate derivatives 12347
                                    carbohydrate 12347
                                      alditol 1893
                                        hexitol 113
                                          glucitol 25
                                            glucitol derivative 4
                                              isosorbide dinitrate 3
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