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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Saccharomyces cerevisiae metabolite
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Accession:CHEBI:75772 term browser browse the term
Definition:Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
Synonyms:related_synonym: S. cerevisiae metabolite;   S. cerevisiae metabolites;   S. cerevisiae secondary metabolite;   S. cerevisiae secondary metabolites;   Saccharomyces cerevisiae metabolites;   Saccharomyces cerevisiae secondary metabolites;   baker's yeast metabolite;   baker's yeast metabolites;   baker's yeast secondary metabolite;   baker's yeast secondary metabolites
 alt_id: CHEBI:76949;   CHEBI:76951


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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions		 EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
1-stearoyl-2-arachidonoylphosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
3'-CMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
3-isobutyl-1-methyl-7H-xanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603 		JBrowse link
acyclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin decreases activity EXP Acyclovir results in decreased activity of AVP protein CTD PMID:2724137 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883 		JBrowse link
amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Amlodipine results in increased expression of REN protein CTD PMID:10218729 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G SCT secretin multiple interactions EXP Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] CTD PMID:3562434
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DES desmin decreases expression EXP benazepril results in decreased expression of DES mRNA CTD PMID:20137276 NCBI chr37:25,933,525...25,939,910
Ensembl chr37:25,933,455...25,940,985 		JBrowse link
Butyrylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis
multiple interactions		 EXP BCHE protein results in increased hydrolysis of butyrylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]		 CTD PMID:4631366 PMID:4985882 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
butyrylthiocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis EXP BCHE protein results in increased hydrolysis of Butyrylthiocholine CTD PMID:22407886 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
carmustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MGMT O-6-methylguanine-DNA methyltransferase decreases response to substance
multiple interactions		 EXP MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine
MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]		 CTD PMID:14617759 PMID:15053863 NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380 		JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases expression EXP Cilazapril results in decreased expression of AGT protein CTD PMID:2419701 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G REN renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2419701 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 increases expression EXP Clofibrate results in increased expression of ACAA2 mRNA CTD PMID:19952500 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain increases expression EXP Clofibrate results in increased expression of ACADVL protein CTD PMID:19952500 NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990 		JBrowse link
G AGXT alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression EXP Clofibrate results in decreased expression of AGXT protein CTD PMID:19952500 NCBI chr25:50,968,291...50,976,089 JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Clofibrate results in decreased expression of AHCY protein CTD PMID:19952500 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767 		JBrowse link
G ASL argininosuccinate lyase increases expression EXP Clofibrate results in increased expression of ASL protein CTD PMID:19952500 NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424 		JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression EXP Clofibrate results in decreased expression of ASS1 protein CTD PMID:19952500 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 increases expression EXP Clofibrate results in increased expression of CPS1 protein CTD PMID:19952500 NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697 		JBrowse link
G CPT2 carnitine palmitoyltransferase 2 increases expression EXP Clofibrate results in increased expression of CPT2 mRNA CTD PMID:19952500 NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression EXP Clofibrate results in decreased expression of CYP1A2 mRNA CTD PMID:19952500 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 decreases expression EXP Clofibrate results in decreased expression of CYP2A13 mRNA CTD PMID:19952500 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350 		JBrowse link
G CYP2B6 cytochrome P450 2B11 decreases expression EXP Clofibrate results in decreased expression of CYP2B6 mRNA CTD PMID:19952500 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
G CYP2C18 cytochrome P450 2C21 decreases expression EXP Clofibrate results in decreased expression of CYP2C18 mRNA CTD PMID:19952500 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression EXP Clofibrate results in increased expression of CYP2E1 protein CTD PMID:19952500 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
G CYP3A12 cytochrome P-450 3A12 decreases expression EXP Clofibrate results in decreased expression of CYP3A12 mRNA CTD PMID:19952500
G CYP3A26 cytochrome P450 3A26 decreases expression EXP Clofibrate results in decreased expression of CYP3A26 mRNA CTD PMID:19952500 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352 		JBrowse link
G CYP4A37 cytochrome P450 4A37 increases expression EXP Clofibrate results in increased expression of CYP4A11 mRNA CTD PMID:19952500 NCBI chr15:13,604,130...13,623,797 JBrowse link
G DLST dihydrolipoamide S-succinyltransferase increases expression EXP Clofibrate results in increased expression of DLST protein CTD PMID:19952500 NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999 		JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 increases expression EXP Clofibrate results in increased expression of ECHS1 protein CTD PMID:19952500 NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167 		JBrowse link
G GDI1 GDP dissociation inhibitor 1 increases expression EXP Clofibrate results in increased expression of GDI1 protein CTD PMID:19952500 NCBI chr  X:122,141,633...122,146,724
Ensembl chr  X:122,141,566...122,146,824 		JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases expression EXP Clofibrate results in decreased expression of GSTA4 mRNA CTD PMID:19952500 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200 		JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP Clofibrate results in decreased expression of GSTK1 mRNA CTD PMID:19952500 NCBI chr16:6,411,678...6,416,135 JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Clofibrate results in decreased expression of GSTO1 mRNA CTD PMID:19952500 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880 		JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase increases expression EXP Clofibrate results in increased expression of HADH mRNA CTD PMID:19952500 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clofibrate results in increased expression of HSPD1 protein CTD PMID:19952500 NCBI chr37:7,010,421...7,025,912 JBrowse link
G KRT1 keratin 1 increases expression EXP Clofibrate results in increased expression of KRT1 protein CTD PMID:19952500 NCBI chr27:2,422,150...2,427,160 JBrowse link
G KRT18 keratin 18 decreases expression EXP Clofibrate results in decreased expression of KRT18 protein CTD PMID:19952500 NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368 		JBrowse link
G LOC474938 glutathione S-transferase A2 decreases expression EXP Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein CTD PMID:19952500 NCBI chr12:20,349,133...20,365,023 JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Clofibrate results in increased expression of MGST1 mRNA CTD PMID:19952500 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778 		JBrowse link
G PC pyruvate carboxylase increases expression EXP Clofibrate results in increased expression of PC protein CTD PMID:19952500 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669 		JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial increases expression EXP Clofibrate results in increased expression of PCK2 protein CTD PMID:19952500 NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865 		JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP Clofibrate results in decreased expression of PRDX6 protein CTD PMID:19952500 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754 		JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Clofibrate results in decreased expression of SELENBP1 protein CTD PMID:19952500 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 decreases expression EXP Clofibrate results in decreased expression of SHMT1 protein CTD PMID:19952500 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166 		JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases expression EXP Clofibrate results in decreased expression of UGP2 protein CTD PMID:19952500 NCBI chr10:63,532,366...63,598,362
Ensembl chr10:63,533,171...63,597,452 		JBrowse link
G UQCRC1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP Clofibrate results in increased expression of UQCRC1 protein CTD PMID:19952500 NCBI chr20:40,507,767...40,515,854
Ensembl chr20:40,506,907...40,520,110 		JBrowse link
G UROC1 urocanate hydratase 1 decreases expression EXP Clofibrate results in decreased expression of UROC1 protein CTD PMID:19952500 NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141 		JBrowse link
cytidine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
D-glucitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Sorbitol results in increased phosphorylation of MAPK1 protein CTD PMID:12639917 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Sorbitol results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
D-mannitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Mannitol results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C18 cytochrome P450 2C21 increases hydroxylation EXP CYP2C19 protein results in increased hydroxylation of Diclofenac CTD PMID:15677349 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587 		JBrowse link
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
dihexadecanoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 multiple interactions
increases activity		 EXP dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
dimyristoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dimyristoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dioleoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
dioxygen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL8 protein] CTD PMID:18339021 NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP2 protein] CTD PMID:18339021 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP9 protein] CTD PMID:18339021 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
etoposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Etoposide CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Glyburide results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 EXP Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]		 CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases activity		 EXP Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] CTD PMID:16682413 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCT secretin increases abundance
multiple interactions		 EXP SCT protein results in increased abundance of Bicarbonates
[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates; Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]		 CTD PMID:3562434
iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
loratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Loratadine results in increased activity of CASP3 protein CTD PMID:20570632 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
metamizole sodium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Dipyrone results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
nicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions		 EXP Niacinamide results in increased expression of PPARG protein
Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]		 CTD PMID:22539994 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G RUNX2 RUNX family transcription factor 2 increases acetylation
multiple interactions
decreases expression		 EXP Niacinamide results in increased acetylation of RUNX2 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]		 CTD PMID:22539994 NCBI chr12:13,723,535...13,842,565
Ensembl chr12:13,628,539...13,840,785
Ensembl chr12:13,628,539...13,840,785 		JBrowse link
G SIRT1 sirtuin 1 decreases expression
multiple interactions		 EXP Niacinamide results in decreased expression of SIRT1 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]		 CTD PMID:22539994 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases activity EXP Nitroglycerin results in decreased activity of REN protein CTD PMID:8640982 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]
ochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 protein		 CTD PMID:33543323 NCBI chr26:38,700,434...38,714,915
Ensembl chr26:38,700,480...38,711,753 		JBrowse link
G B9D2 B9 domain containing 2 increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of TGFB1 mRNA; ochratoxin A results in increased expression of TGFB1 protein
CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]		 CTD PMID:33543323 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G CASP4 caspase 4, apoptosis-related cysteine peptidase increases cleavage
multiple interactions
increases expression		 EXP ochratoxin A results in increased cleavage of CASP1 protein
CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]		 CTD PMID:33543323 NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736 		JBrowse link
G GSDMD gasdermin D multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]
ochratoxin A results in increased expression of GSDMD mRNA; ochratoxin A results in increased expression of GSDMD protein		 CTD PMID:33543323 NCBI chr13:37,221,219...37,226,912
Ensembl chr13:37,193,022...37,228,360 		JBrowse link
G IL18 interleukin 18 multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA] CTD PMID:33543323 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]
ochratoxin A results in increased expression of IL1B mRNA; ochratoxin A results in increased expression of IL1B protein		 CTD PMID:33543323 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 increases secretion
increases expression		 EXP ochratoxin A results in increased secretion of IL6 protein
ochratoxin A results in increased expression of IL6 mRNA		 CTD PMID:33543323 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions
increases expression		 EXP N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]
ochratoxin A results in increased expression of NLRP3 mRNA; ochratoxin A results in increased expression of NLRP3 protein		 CTD PMID:33543323 NCBI chr 8:251,776...313,290
Ensembl chr 8:253,407...313,059 		JBrowse link
G PYCARD PYD and CARD domain containing increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of PYCARD mRNA; ochratoxin A results in increased expression of PYCARD protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]		 CTD PMID:33543323 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240 		JBrowse link
G TNF tumor necrosis factor increases secretion
increases expression		 EXP ochratoxin A results in increased secretion of TNF protein
ochratoxin A results in increased expression of TNF mRNA		 CTD PMID:33543323 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G VIM vimentin multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of VIM protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]
ochratoxin A results in increased expression of VIM mRNA; ochratoxin A results in increased expression of VIM protein		 CTD PMID:33543323 NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466 		JBrowse link
phenylglyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 increases reduction EXP DHRS4 protein results in increased reduction of phenylglyoxylic acid CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
phosphatidylinositol 3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
potassium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP [INS protein co-treated with Glucose] results in decreased abundance of Potassium CTD PMID:140932 PMID:1013176 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP [KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP [KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478 		JBrowse link
prochloraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Ritonavir results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
saquinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Saquinavir CTD PMID:12702717 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740 		JBrowse link
sodium arsenite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSR glutathione-disulfide reductase multiple interactions
decreases activity		 EXP [monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:18163546 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752 		JBrowse link
G HSP70 heat shock protein 70 increases expression
multiple interactions		 EXP sodium arsenite results in increased expression of HSP70 protein
carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]; leucinostatin A promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]		 CTD PMID:31940135 NCBI chr12:1,285,282...1,287,670 JBrowse link
sodium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions
affects response to substance		 EXP INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins]; Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]
INS protein affects the susceptibility to Sodium		 CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
sodium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression
multiple interactions		 EXP Sodium Chloride results in increased expression of CLDN4 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]		 CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Sodium Chloride results in increased expression of JUN protein
pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]		 CTD PMID:23816505 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP Sodium Chloride results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]		 CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP Sodium Chloride results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]		 CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Sodium Chloride results in increased expression of SOD2 protein CTD PMID:22718889 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
G SP1 Sp1 transcription factor multiple interactions
increases expression		 EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] CTD PMID:23816505 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226 		JBrowse link
succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis
multiple interactions		 EXP BCHE protein results in increased hydrolysis of Succinylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]		 CTD PMID:4985882 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
taurocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of Taurocholic Acid CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G SCT secretin multiple interactions EXP Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] CTD PMID:3562434
urea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Urea results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Urea results in increased expression of SOD2 protein CTD PMID:22718889 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
UTP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions
increases activity		 EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:1618819 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609 		JBrowse link
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  CHEBI ontology 503
    role 503
      biological role 503
        biochemical role 460
          metabolite 451
            eukaryotic metabolite 429
              fungal metabolite 94
                Saccharomyces cerevisiae metabolite 92
                  (1->3)-beta-D-glucan + 0
                  (1->6)-beta-D-glucan 0
                  (1s,4s)-prephenate(2-) 0
                  (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate(3-) 0
                  (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone 0
                  (2E)-3-(methoxycarbonyl)pent-2-enedioate(2-) 0
                  (2R,3R)-2,3-dihydroxy-3-methylpentanoate 0
                  (2R,3S)-3-isopropylmalate(2-) 0
                  (2S)-2-isopropyl-3-oxosuccinate(2-) 0
                  (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate 0
                  (4R)-N-(2,3-dihydroxytetracosanoyl)-4-hydroxysphinganine + 0
                  (5S,6S)-dihydroxy-(7E,9E,11Z,14Z)-icosatetraenoic acid 0
                  (6R)-5,10-methenyltetrahydrofolate + 0
                  (6S)-5-formyltetrahydrofolate(2-) 0
                  (6S)-5-methyltetrahydrofolate(2-) + 0
                  (N(omega)-L-arginino)succinate(1-) 0
                  (R)-2,3-dihydroxy-3-methylbutanoate 0
                  (R)-4'-phosphopantothenic acid 0
                  (R)-5-diphosphonatomevalonate(4-) 0
                  (R)-5-phosphonatomevalonate(3-) 0
                  (R)-S-lactoylglutathionate(1-) 0
                  (R)-S-lactoylglutathione 0
                  (R)-acetoin 0
                  (R)-carnitine + 0
                  (R)-lactate + 0
                  (R)-mevalonate + 0
                  (R)-pantoate 0
                  (R)-pantolactone 0
                  (R)-pantothenate 0
                  (R)-phenylacetylcarbinol + 0
                  (R,R)-butane-2,3-diol 0
                  (S)-2,3-epoxysqualene 0
                  (S)-2-acetyl-2-hydroxybutanoate 0
                  (S)-3-hydroxydecanoyl-CoA 0
                  (S)-3-hydroxyhexacosanoyl-CoA 0
                  (S)-3-hydroxylauroyl-CoA 0
                  (S)-3-hydroxypalmitoyl-CoA 0
                  (S)-3-hydroxytetradecanoyl-CoA 0
                  (S)-3-methyl-2-oxovalerate 0
                  (S)-dihydroorotate 0
                  (S)-dihydroorotic acid 0
                  (S)-lactaldehyde 0
                  (S)-lactate + 0
                  (S)-malate(2-) + 0
                  1-(2-carboxylatophenylamino)-1-deoxy-D-ribulose 5-phosphate(3-) 0
                  1-(5-phospho-D-ribosyl)-ATP(6-) + 0
                  1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide(4-) 0
                  1-(5-phosphonato-beta-D-ribosyl)-5'-AMP(4-) 0
                  1-(sn-glycero-3-O-phosphonato)-1D-myo-inositol 0
                  1-C-(indol-3-yl)glycerol 3-phosphate(2-) 0
                  1-methylnicotinamide + 0
                  1-pyrroline-3-hydroxy-5-carboxylate 0
                  1-pyrroline-5-carboxylate + 0
                  10-formyltetrahydrofolate(2-) + 0
                  14-demethyllanosterol + 0
                  1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-) 0
                  1D-myo-inositol 1,4,5,6-tetrakisphosphate(8-) 0
                  1D-myo-inositol 1,4,5-trisphosphate(6-) 0
                  1D-myo-inositol 1-phosphate(2-) 0
                  1D-myo-inositol 3-phosphate(2-) 0
                  2',3'-cyclic AMP(1-) 0
                  2'-deoxyadenosine + 0
                  2'-deoxycytidine + 0
                  2'-deoxycytosine 5'-monophosphate(2-) + 0
                  2'-deoxyguanosine + 0
                  2'-deoxyguanosine 5'-monophosphate(2-) + 0
                  2'-deoxyinosine 0
                  2'-deoxyinosine-5'-diphosphate 0
                  2'-deoxyuridine + 0
                  2,3-bisphosphonato-D-glycerate(5-) 0
                  2,5-diamino-4-hydroxy-6-(5-phosphonatoribosylamino)pyrimidine(3-) 0
                  2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone 0
                  2-(3-amino-3-carboxypropyl)-L-histidine + 0
                  2-[3-carboxylato-3-(methylammonio)propyl]-L-histidine dizwitterion + 0
                  2-acetamido-5-oxopentanoate 0
                  2-acetyllactate 0
                  2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + 0
                  2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol 0
                  2-dehydropantoate 0
                  2-deoxy-D-ribofuranose 0
                  2-deoxy-D-ribose + 0
                  2-deoxy-D-ribose 5-phosphate(2-) 0
                  2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone 0
                  2-formamido-N(1)-(5-O-phosphonato-D-ribosyl)acetamidine + 0
                  2-furoate 0
                  2-furoic acid + 0
                  2-hexaprenyl-6-methoxy-1,4-benzoquinone 0
                  2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone 0
                  2-hexaprenyl-6-methoxyphenol 0
                  2-hydroxy-3-oxobutyl phosphate + 0
                  2-hydroxyhexadecanal + 0
                  2-isopropylmalate(2-) + 0
                  2-isopropylmaleate(2-) 0
                  2-methylbutan-1-ol + 0
                  2-methylbutanal + 0
                  2-methylbutyl acetate 0
                  2-methylcitrate(3-) + 0
                  2-oxoadipate(2-) 0
                  2-oxobutanoate 0
                  2-oxoglutarate(2-) 0
                  2-phenylethanol + 0
                  2-phospho-D-glyceric acid 0
                  2-phosphonato-D-glycerate(3-) 0
                  2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) 0
                  2-trans,6-trans-farnesyl diphosphate(3-) 0
                  3',5'-cyclic AMP(1-) 0
                  3',5'-cyclic CMP(1-) 0
                  3',5'-cyclic GMP + 0
                  3',5'-cyclic GMP(1-) + 0
                  3',5'-cyclic IMP 0
                  3',5'-cyclic dAMP 0
                  3'-dephospho-CoA(2-) 0
                  3'-phosphonato-5'-adenylyl sulfate(4-) 0
                  3-(4-hydroxyphenyl)pyruvate 0
                  3-(imidazol-4-yl)-2-oxopropyl phosphate(2-) 0
                  3-(indol-3-yl)pyruvate 0
                  3-(indol-3-yl)pyruvic acid 0
                  3-amino-4-iodopyridine 0
                  3-ammoniopropanal 0
                  3-dehydro-4-methylzymosterol + 0
                  3-dehydroquinate 0
                  3-dehydroshikimate 0
                  3-dehydrosphinganinium(1+) + 0
                  3-demethylubiquinone-6 0
                  3-hexaprenyl-4,5-dihydroxybenzoate 0
                  3-hexaprenyl-4-hydroxy-5-methoxybenzoate 0
                  3-hexaprenyl-4-hydroxybenzoic acid 0
                  3-hydroxy-2-isopropyl-4-methoxy-4-oxobutanoate 0
                  3-hydroxy-3-methylglutaryl-CoA + 0
                  3-hydroxy-L-kynurenine 0
                  3-hydroxyanthranilate 0
                  3-hydroxydocosanoyl-CoA + 0
                  3-hydroxyicosanoyl-CoA + 0
                  3-hydroxyoctadecanoyl-CoA + 0
                  3-hydroxytetracosanoyl-CoA 0
                  3-mercaptohexanol + 0
                  3-mercaptohexyl acetate 0
                  3-methyl-2-oxobutanoate 0
                  3-methyl-2-oxobutanoic acid 0
                  3-methylbutanal 0
                  3-methylthiopropanol + 0
                  3-oxodecanoyl-CoA 0
                  3-oxodocosanoyl-CoA 0
                  3-oxohexacosanoyl-CoA 0
                  3-oxoicosanoyl-CoA 0
                  3-oxolauroyl-CoA 0
                  3-oxooctadecanoyl-CoA 0
                  3-oxopalmitoyl-CoA(4-) 0
                  3-oxotetracosanoyl-CoA 0
                  3-oxotetradecanoyl-CoA 0
                  3-phosphonato-D-glyceroyl phosphate(4-) 0
                  3-phosphonatooxypyruvate(3-) 0
                  3-phosphonatoshikimate(3-) 0
                  4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol 0
                  4,5-bis(diphospho)-1D-myo-inositol tetrakisphosphate 0
                  4-(phosphonatooxy)-L-threonine(2-) 0
                  4-amino-2-methyl-5-diphosphonatooxymethylpyrimidine(3-) 0
                  4-amino-2-methyl-5-phosphonatooxymethylpyrimidine(2-) 0
                  4-amino-4-deoxychorismate(2-) 0
                  4-amino-5-hydroxymethyl-2-methylpyrimidine 0
                  4-aminobenzoate + 0
                  4-ammoniobutanal 0
                  4-diphospho-1D-myo-inositol pentakisphosphate 0
                  4-formylzymosterol + 0
                  4-guanidiniumylbutanamide(1+) 0
                  4-guanidinobutanoic acid 0
                  4-hydroxy-2-oxoglutarate(2-) + 0
                  4-hydroxy-L-threonine 0
                  4-hydroxybenzoate + 0
                  4-hydroxybenzoyl-CoA(4-) 0
                  4-hydroxymethylzymosterol + 0
                  4-mercapto-4-methylpentan-2-one 0
                  4-methyl-2-oxopentanoate 0
                  4-methyl-5-(2-phosphonatooxyethyl)thiazole(2-) 0
                  4-methylthio-2-oxobutanoate + 0
                  4-oxobutanoate 0
                  4-phospho-L-aspartate 0
                  4alpha-methylzymosterol + 0
                  4beta-methylzymosterol-4alpha-carboxylic acid 0
                  5'-S-methyl-5'-thioadenosine 0
                  5'-adenylyl sulfate(2-) 0
                  5'-xanthylate(2-) 0
                  5,10-methylenetetrahydrofolate(2-) + 0
                  5,6,7,8-tetrahydrofolic acid + 0
                  5,6,7,8-tetrahydrofolyl-L-glutamic acid 0
                  5,6-bis(diphospho)-1D-myo-inositol tetrakisphosphate 0
                  5-(2-hydroxyethyl)-4-methylthiazole 0
                  5-(methylsulfanyl)-2,3-dioxopentyl phosphate(2-) 0
                  5-O-(1-carboxylatovinyl)-3-phosphonatoshikimate 0
                  5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) 0
                  5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(4-) 0
                  5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-) + 0
                  5-amino-1-(5-phosphonato-D-ribosyl)imidazol-3-ium 0
                  5-amino-1-(5-phosphonato-D-ribosyl)imidazole-4-carboxylate 0
                  5-amino-6-(5-phosphoribitylamino)uracil(2-) 0
                  5-amino-6-(D-ribitylamino)uracil 0
                  5-aminolevulinic acid + 0
                  5-diphospho-1D-myo-inositol pentakisphosphate(13-) 0
                  5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-) 0
                  5-hydroxyfuran-2-carboxylic acid 0
                  5-methyltetrahydropteroyltri-L-glutamate(4-) 0
                  5-phospho-beta-D-ribosylaminium(1-) 0
                  6,7-dimethyl-8-(1-D-ribityl)lumazine(1-) 0
                  6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-) + 0
                  6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + 0
                  6-(alpha-D-glucosaminyl)-O-acyl-1-phosphatidyl-1D-myo-inositol 0
                  6-O-[alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol 0
                  6-O-\{2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl\}-O-acyl-1-phosphatidyl-1D-myo-inositol 0
                  6-O-\{alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl\}-O-acyl-1-phosphatidyl-1D-myo-inositol 0
                  6-O-\{alpha-D-mannosyl-(1->6)-2-O-[(2-aminoethyl)phosphoryl]-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl\}-O-acyl-1-phosphatidyl-1D-myo-inositol 0
                  6-O-phosphonato-D-glucono-1,5-lactone(2-) 0
                  6-[6-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-2-(2-aminoethylphosphoryl)-alpha-mannosyl-(1->6)-alpha-2-(2-aminoethylphosphoryl)mannosyl-(1->4)-alpha-glucosaminyl]-O-acyl-1-phosphatidyl-1D-myo-inositol + 0
                  6-diphospho-1D-myo-inositol pentakisphosphate 0
                  7,8-diaminononanoate 0
                  7,8-dihydroneopterin + 0
                  7,8-dihydroneopterin 3'-phosphate(2-) 0
                  7,8-dihydroneopterin 3'-triphosphate(4-) 0
                  7,8-dihydropteroate + 0
                  7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate 0
                  8-amino-7-oxononanoic acid 0
                  9H-xanthine + 0
                  A-factor 0
                  ADP-D-ribose(2-) + 0
                  AICA ribonucleotide 0
                  Ala-tRNA(Ala) 0
                  Arg-tRNA(Arg) 0
                  Asn-tRNA(Asn) 0
                  Asp-tRNA(Asp) 0
                  CDP(3-) + 0
                  CDP-choline 0
                  CDP-ethanolamine(1-) 0
                  CTP(4-) + 0
                  Cys-tRNA(Cys) 0
                  D-arabinono-1,4-lactone 0
                  D-arabinose + 0
                  D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate(2-) 0
                  D-erythrose 4-phosphate(2-) 0
                  D-fructose + 0
                  D-fructose 6-phosphate(2-) 0
                  D-galactose + 0
                  D-glucitol + 2
                  D-glucopyranose + 1
                  D-glyceraldehyde + 0
                  D-histidinate(1-) 0
                  D-histidinate(2-) 0
                  D-histidine + 0
                  D-histidinium(1+) + 0
                  D-histidinium(2+) 0
                  D-isoleucinate 0
                  D-isoleucine + 0
                  D-isoleucinium 0
                  D-leucinate 0
                  D-leucine + 0
                  D-leucinium 0
                  D-mannose + 0
                  D-methioninate 0
                  D-methioninium 0
                  D-threoninate 0
                  D-threonine + 0
                  D-threoninium 0
                  D-xylulose + 0
                  D-xylulose 5-phosphate(2-) + 0
                  Delta(6)-trans,Delta(8)-cis-leukotriene B4 0
                  FAD(3-) 0
                  FADH2(2-) + 0
                  FMN(3-) + 0
                  FMNH2(2-) 0
                  GDP(3-) + 0
                  GDP-alpha-D-mannose(2-) 0
                  GDP-mannose + 0
                  GTP(3-) + 0
                  Gln-tRNA(Gln) 0
                  Glu-tRNA(Glu) 0
                  Gly-tRNA(Gly) 0
                  His-tRNA(His) 0
                  IDP(3-) 0
                  IMP(2-) + 0
                  ITP(4-) 0
                  Ile-tRNA(Ile) 0
                  Ins-1-P-6-Man-1-6-Ins-1-P-Cer(d18:0/2-OH-26:0) 0
                  Ins-1-P-6-Man-1-6-Ins-1-P-Cer(d18:0/26:0) + 0
                  Ins-1-P-6-Man-1-6-Ins-1-P-Cer(t18:0/2,3-OH-26:0) 0
                  Ins-1-P-6-Man-1-6-Ins-1-P-Cer(t18:0/26:0) 0
                  Ins-1-P-6-Man-beta1-3-Ins-1-P-Cer(t18:0/2-OH-26:0) 0
                  Ins-1-P-6-Man-beta1-6-Ins-1-P-Cer(d18:0/2-OH-24:0) 0
                  Ins-1-P-6-Man-beta1-6-Ins-1-P-Cer(d18:0/24:0) 0
                  Ins-1-P-6-Man-beta1-6-Ins-1-P-Cer(t18:0/2,3-OH-24:0) 0
                  Ins-1-P-6-Man-beta1-6-Ins-1-P-Cer(t18:0/2-OH-24:0) 0
                  Ins-1-P-6-Man-beta1-6-Ins-1-P-Cer(t18:0/24:0) 0
                  Ins-1-P-Cer(d18:0/2-OH-24:0) + 0
                  Ins-1-P-Cer(d18:0/2-OH-26:0) + 0
                  Ins-1-P-Cer(d18:0/24:0) + 0
                  Ins-1-P-Cer(d18:0/26:0) + 0
                  Ins-1-P-Cer(t18:0/2,3-OH-24:0) + 0
                  Ins-1-P-Cer(t18:0/2,3-OH-26:0) + 0
                  Ins-1-P-Cer(t18:0/2-OH-24:0) + 0
                  Ins-1-P-Cer(t18:0/2-OH-26:0) + 0
                  Ins-1-P-Cer(t18:0/24:0) + 0
                  Ins-1-P-Cer(t18:0/26:0) + 0
                  L-2-amino-3-oxobutanoic acid 0
                  L-2-aminoadipate(1-) 0
                  L-3-oxoalaninate 0
                  L-4-hydroxyglutamic semialdehyde 0
                  L-allothreonine 0
                  L-allysine + 0
                  L-arabinitol + 0
                  L-arabinose + 0
                  L-argininium(1+) + 0
                  L-asparagine + 1
                  L-aspartic 4-semialdehyde 0
                  L-citrulline + 0
                  L-cystathionine 0
                  L-cysteinylglycine + 0
                  L-cysteinylglycine zwitterion 0
                  L-cystine + 0
                  L-gamma-glutamyl phosphate(2-) 0
                  L-gamma-glutamyl-L-cysteinate(1-) 0
                  L-gamma-glutamyl-L-cysteine + 0
                  L-glucitol 0
                  L-glutamate(1-) + 0
                  L-glutamic 5-semialdehyde + 0
                  L-glutamine + 0
                  L-histidinate(1-) 0
                  L-histidinate(2-) 0
                  L-histidine + 0
                  L-histidinium(1+) + 0
                  L-histidinium(2+) 0
                  L-histidinol + 0
                  L-histidinol phosphate(1-) 0
                  L-histidinol(1+) 0
                  L-homoserine + 0
                  L-isoleucinate 0
                  L-isoleucine + 0
                  L-isoleucinium + 0
                  L-kynurenine + 0
                  L-leucinate + 0
                  L-leucine + 0
                  L-leucinium + 0
                  L-lysinate 0
                  L-lysine + 0
                  L-lysinium(1+) + 0
                  L-lysinium(2+) + 0
                  L-methioninate + 0
                  L-methioninium + 0
                  L-phenylalaninate + 0
                  L-phenylalanine + 11
                  L-phenylalaninium + 0
                  L-proline + 0
                  L-saccharopinate(1-) 0
                  L-saccharopine 0
                  L-serine + 0
                  L-sorbose + 0
                  L-threoninate 0
                  L-threonine + 0
                  L-threoninium + 0
                  L-tryptophan + 0
                  L-valine + 2
                  Leu-tRNA(Leu) 0
                  Lys-tRNA(Lys) 0
                  Man-1-6-Ins-1-P-Cer(d18:0/2-OH-26:0) + 0
                  Man-1-6-Ins-1-P-Cer(d18:0/26:0) + 0
                  Man-1-6-Ins-1-P-Cer(t18:0/2,3-OH-26:0) + 0
                  Man-1-6-Ins-1-P-Cer(t18:0/2-OH-26:0) 0
                  Man-1-6-Ins-1-P-Cer(t18:0/26:0) + 0
                  Man-beta1-6-Ins-1-P-Cer(d18:0/2-OH-24:0) + 0
                  Man-beta1-6-Ins-1-P-Cer(d18:0/24:0) + 0
                  Man-beta1-6-Ins-1-P-Cer(t18:0/2,3-OH-24:0) + 0
                  Man-beta1-6-Ins-1-P-Cer(t18:0/2-OH-24:0) + 0
                  Man-beta1-6-Ins-1-P-Cer(t18:0/24:0) + 0
                  Met-tRNA(Met) 0
                  N(1)-(5-phospho-D-ribosyl)glycinamide(1-) + 0
                  N(1)-acetylspermidinium(2+) 0
                  N(1)-acetylsperminium(3+) 0
                  N(2)-acetyl-L-ornithine 0
                  N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide(2-) + 0
                  N(6)-(1,2-dicarboxylatoethyl)-AMP(4-) 0
                  N(pros)-methyl-L-histidine + 0
                  N,N'-diacetylchitobiosyldiphosphodolichol 0
                  N,N'-diformyldityrosine 0
                  N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 0
                  N-(2-hydroxyhexacosanoyl)sphinganine + 0
                  N-(2-hydroxyhexacosanyl)-(4R)-phytosphingosine 0
                  N-(2-hydroxytetracosanoyl)phytosphingosine + 0
                  N-(2-hydroxytetracosanoyl)sphinganine + 0
                  N-(5-phosphonato-beta-D-ribosyl)anthranilate 0
                  N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-) 0
                  N-acetyl-D-glucosamine 6-phosphate + 0
                  N-acetyl-D-glucosamine 6-phosphate(2-) + 0
                  N-acetyl-L-alanine + 0
                  N-acetyl-L-gamma-glutamyl phosphate(3-) 0
                  N-acetyl-L-glutamate(2-) + 0
                  N-acetyl-L-glutamic acid 0
                  N-acetyl-alpha-D-glucosamine 1-phosphate 0
                  N-acetylputrescinium 0
                  N-carbamoyl-L-aspartate(2-) 0
                  N-carbamoylaspartic acid + 0
                  N-formyl-L-kynurenine + 0
                  N-formyl-L-tyrosine 0
                  N-hexacosanoylphytosphingosine + 0
                  N-hexacosanoylsphinganine + 0
                  N-ribosylnicotinamide 0
                  N-tetracosanoylphytosphingosine + 0
                  N-tetracosanoylsphinganine + 0
                  NAD(1-) + 0
                  NADH(2-) + 0
                  NADP(3-) 0
                  NADPH(4-) + 0
                  NMN(-) 0
                  O-acetyl-L-carnitine 0
                  O-acetyl-L-homoserine 0
                  O-acetyl-L-serine + 0
                  O-phospho-L-serine + 0
                  O-phosphonato-L-homoserine(2-) 0
                  O-phosphonato-L-serine(2-) + 0
                  O-phosphonatoethanaminium(1-) 0
                  O-succinyl-L-homoserinate(1-) 0
                  O-succinyl-L-homoserine 0
                  P(1),P(4)-bis(5'-adenosyl) tetraphosphate(4-) 0
                  P(1),P(4)-bis(5'-guanosyl) tetraphosphate(4-) 0
                  P(1)-(5'-adenosyl),P(4)-(5'-guanosyl) tetraphosphate 0
                  Phe-tRNA(Phe) 0
                  Pro-tRNA(Pro) 0
                  S(8)-aminomethyldihydrolipoamide 0
                  S(8)-aminomethyldihydrolipoylprotein 0
                  S(8)-succinyldihydrolipoamide 0
                  S-adenosyl-4-methylthio-2-oxobutanoate 0
                  S-adenosyl-L-methionine + 0
                  S-adenosylmethioninaminium 0
                  S-formylglutathionate(1-) 0
                  S-formylglutathione 0
                  S-methyl-5-thio-D-ribulose 1-phosphate(2-) 0
                  S-methyl-5-thio-alpha-D-ribose 1-phosphate(2-) 0
                  S-methyl-L-methionine 0
                  SAICAR(4-) 0
                  Ser-tRNA(Ser) 0
                  Thr-tRNA(Thr) 0
                  Trp-tRNA(Trp) 0
                  Tyr-tRNA(Tyr) 0
                  UDP(3-) 0
                  UDP-D-galactose(2-) + 0
                  UDP-D-glucose(2-) 0
                  UDP-N-acetyl-alpha-D-glucosamine(2-) 0
                  UTP(4-) + 0
                  Val-tRNA(Val) 0
                  WHWLQLKPGQPMY 0
                  YIIKGLFWDPAC + 0
                  YIIKGVFWDPAC + 0
                  acetaldehyde + 0
                  acetate + 0
                  acetoacetyl-CoA(4-) 0
                  acetyl-CoA(4-) 0
                  acetyl-[acyl-carrier protein] 0
                  acyl-carrier protein + 0
                  adenine + 0
                  adenosine 2'-phosphate 0
                  adenosine 3',5'-bismonophosphate(4-) 0
                  aldehydo-D-galacturonate 0
                  aldehydo-D-xylose + 0
                  allantoate 0
                  allantoin + 0
                  alpha,alpha-trehalose + 0
                  alpha,alpha-trehalose 6-phosphate(2-) 0
                  alpha-D-galactose 1-phosphate(2-) 0
                  alpha-D-glucosamine 1-phosphate(1-) 0
                  alpha-D-glucosamine 6-phosphate 0
                  alpha-D-mannosyl-beta-D-mannosyldiacetylchitobiosyldiphosphodolichol 0
                  alpha-D-ribose 1-phosphate(2-) 0
                  ammonioacetaldehyde 0
                  ammonioacetone 0
                  ammonium + 5
                  anthranilate + 0
                  beta-D-fructofuranose 2,6-bisphosphate(4-) 0
                  beta-D-mannosyldiacetylchitobiosyldiphosphodolichol 0
                  biotin + 0
                  biotinate + 0
                  biotinyl-5'-AMP(1-) 0
                  but-1-ene-1,2,4-tricarboxylate 0
                  butane-2,3-dione 0
                  carbamoyl phosphate(2-) 0
                  carbon dioxide 0
                  carboxyacetyl-[acyl-carrier protein] 0
                  cerotate + 0
                  chitin 0
                  chitosan 0
                  cholesta-5,7-dien-3beta,25-diol 0
                  choline + 1
                  choline alfoscerate 0
                  choline phosphate(1-) 0
                  chorismate(2-) + 0
                  chorismic acid + 0
                  cis-aconitate(3-) 0
                  coenzyme A(4-) + 0
                  coproporphyrinogen III(4-) 0
                  cytidine + 0
                  cytidine 5'-monophosphate(2-) + 0
                  cytosine + 1
                  dADP(3-) 0
                  dATP(4-) 0
                  dCDP(3-) + 0
                  dCTP(3-) 0
                  dGDP(3-) 0
                  dGTP 0
                  dGTP(3-) 0
                  dITP(4-) 0
                  dTDP(3-) 0
                  dTTP(3-) 0
                  dUDP(3-) 0
                  dUMP(2-) + 0
                  dUTP(3-) 0
                  deamido-NAD(+) + 0
                  decanoate + 0
                  decanoyl-CoA(4-) + 0
                  decaprenyl diphosphate + 0
                  dehydro-D-arabinono-1,4-lactone(1-) 0
                  delta-tocotrienol 0
                  dethiobiotin(1-) 0
                  diglyceride + 0
                  dihydrofolate(2-) 0
                  dihydrolipoamide + 0
                  dihydrolipoylprotein 0
                  dihydromonacolin L acid + 0
                  dihydroxyacetone + 0
                  dihydroxyacetone phosphate 0
                  dioxygen + 3
                  diphosphate(3-) + 0
                  docosaprenyl diphosphate 0
                  dodecanoate + 0
                  dodecaprenyl diphosphate + 0
                  dolichol + 0
                  dolichyl D-mannosyl phosphate + 0
                  dolichyl phosphate + 0
                  episterol + 0
                  episteryl oleate 0
                  episteryl palmitoleate 0
                  ergosta-5,7,22,24(28)-tetraen-3beta-ol 0
                  ergosta-5,7,24(28)-trien-3beta-ol 0
                  ergosterol + 0
                  ergosteryl 3-beta-D-glucoside 0
                  ergosteryl oleate 0
                  ergosteryl palmitoleate 0
                  erythro-4-hydroxy-L-glutamic acid 0
                  ethanol + 41
                  ethanolaminium(1+) + 0
                  ethoxide + 0
                  ethyl (2R)-lactate + 0
                  ethyl (2S)-lactate + 0
                  ethyl acetate 0
                  fMet-tRNA(fMet) 0
                  fecosterol + 0
                  fecosteryl oleate 0
                  fecosteryl palmitoleate 0
                  ferricytochrome c + 0
                  ferrocytochrome c + 0
                  ferroheme b(2-) 0
                  folate(2-) 0
                  formaldehyde + 0
                  formate + 0
                  fumarate(2-) + 0
                  gamma-Glu-Ala 0
                  gamma-Glu-Ala(1-) 0
                  gamma-aminobutyric acid + 0
                  geranyl diphosphate(3-) 0
                  glutathionate(1-) + 0
                  glutathione disulfide(2-) 0
                  glyceraldehyde 3-phosphate(2-) 0
                  glycerol + 3
                  glycerone phosphate(2-) 0
                  glycogen 0
                  glyoxylate + 0
                  glyoxylic acid + 1
                  guanine + 2
                  guanosine 5'-monophosphate(2-) + 0
                  heme a + 0
                  heme o + 0
                  henicosaprenyl diphosphate 0
                  heptadecaprenyl diphosphate 0
                  heptaprenyl diphosphate + 0
                  hexacosanoyl-CoA + 0
                  hexadec-2-enoyl-CoA + 0
                  hexadecanal + 0
                  hexadecanoate + 0
                  hexadecaprenyl diphosphate 0
                  hexaprenyl diphosphate + 0
                  homocitrate(3-) 0
                  homocysteine zwitterion 0
                  homoisocitrate(3-) + 0
                  hydrogen peroxide + 6
                  hydrogencarbonate + 1
                  hydrogenphosphate + 0
                  hydrogensulfite + 0
                  hydrosulfide + 0
                  icosaprenyl diphosphate 0
                  indol-3-ylacetaldehyde 0
                  indole-3-acetate 0
                  inosine + 0
                  iron(2+) + 0
                  isoamyl acetate 0
                  isoamylol + 0
                  isobutanol + 0
                  isobutyl acetate 0
                  isobutyraldehyde + 0
                  isocitrate(3-) + 0
                  isopentenyl diphosphate(3-) 0
                  itaconate(2-) 0
                  itaconyl-CoA(5-) 0
                  keto-D-fructose 1,6-bisphosphate 0
                  keto-phenylpyruvate 0
                  kynurenic acid + 0
                  lanosterol + 0
                  lanosteryl oleate 0
                  lanosteryl palmitoleate 0
                  lauroyl-CoA(4-) + 0
                  leukotriene A4(1-) 0
                  leukotriene B4(1-) 0
                  lipoamide + 0
                  lipoylprotein 0
                  malonyl-CoA(5-) 0
                  maltose + 0
                  mannan + 0
                  mannitol + 1
                  mannose-(1D-myo-inositol 1-phosphate)2 0
                  mannose-1D-myo-inositol 1-phosphate 0
                  melibiose + 0
                  methanethiol + 0
                  methionine + 0
                  methylglyoxal + 0
                  myo-inositol + 0
                  myo-inositol 1,3,4,5,6-pentakisphosphate(10-) 0
                  myo-inositol hexakisphosphate(12-) 0
                  myristoyl-CoA(4-) + 0
                  nicotinamide + 3
                  nicotinate + 0
                  nicotinate D-ribonucleotide(2-) 0
                  nonadecaprenyl diphosphate 0
                  nonaprenyl 4-hydroxybenzoate 0
                  nonaprenyl diphosphate + 0
                  octadecanoate + 0
                  octadecaprenyl diphosphate 0
                  octanoate + 0
                  octanoyl-CoA(4-) + 0
                  octanoyl-[acyl-carrier protein] 0
                  octaprenyl diphosphate + 0
                  oleate + 0
                  oleoyl-CoA(4-) 0
                  ornithinium(1+) + 0
                  orotate + 0
                  orotidine 5'-phosphate(3-) 0
                  oxaloacetate(2-) 0
                  palmitoleate + 0
                  palmitoleoyl-CoA(4-) + 0
                  palmitoyl-CoA(4-) 0
                  pantetheine 4'-phosphate(2-) + 0
                  pectin + 0
                  pentadecaprenyl diphosphate 0
                  pentaprenyl diphosphate + 0
                  phenethyl acetate 0
                  phenylacetaldehyde + 0
                  phenylacetate + 0
                  phenylacetic acid + 5
                  phytosphingosine + 0
                  phytosphingosine 1-phosphate + 0
                  pimeloyl-CoA(5-) 0
                  polysulfur 0
                  porphobilinogen(1-) 0
                  potassium atom + 3
                  precorrin-2(7-) 0
                  prenyl diphosphate(3-) 0
                  preuroporphyrinogen(8-) 0
                  prop-2-yn-1-ol + 0
                  propionyl-CoA(4-) + 0
                  propyl decanoate 0
                  protoporphyrinate 0
                  protoporphyrinogen(2-) 0
                  pseudouridine 5'-phosphate(2-) 0
                  pyridoxal + 1
                  pyridoxal 5'-phosphate + 1
                  pyridoxal 5'-phosphate(2-) 0
                  pyridoxal hydrochloride 0
                  pyridoxamine + 0
                  pyridoxamine 5'-phosphate 0
                  pyridoxamine 5'-phosphate(1-) 0
                  pyridoxamine dihydrochloride 0
                  pyridoxamine hydrochloride 0
                  pyridoxaminium(1+) + 0
                  pyridoxine + 0
                  pyridoxine 5'-phosphate(2-) 0
                  quinaldic acid 0
                  quinolinate(2-) 0
                  raffinose + 0
                  riboflavin(1-) + 0
                  sedoheptulose 1,7-bisphosphate(4-) 0
                  sedoheptulose 7-phosphate(2-) 0
                  shikimate + 0
                  shikimic acid + 0
                  siroheme(8-) 0
                  sirohydrochlorin(8-) 0
                  sn-glycerol 3-phosphate(2-) 0
                  sodium atom + 12
                  sodium glyoxylate 0
                  sodium orotate 0
                  sphinganine 1-phosphate(1-) 0
                  sphinganine(1+) + 0
                  squalene + 0
                  stearoyl-CoA(4-) 0
                  succinate(2-) + 0
                  succinyl-CoA(5-) 0
                  sucrose + 0
                  sulfate + 0
                  tRNA(Ala) + 0
                  tRNA(Arg) + 0
                  tRNA(Asn) + 0
                  tRNA(Asp) + 0
                  tRNA(Cys) + 0
                  tRNA(Gln) + 0
                  tRNA(Glu) + 0
                  tRNA(Gly) + 0
                  tRNA(His) + 0
                  tRNA(Ile) + 0
                  tRNA(Leu) + 0
                  tRNA(Lys) + 0
                  tRNA(Met) + 0
                  tRNA(Phe) + 0
                  tRNA(Pro) + 0
                  tRNA(Ser) + 0
                  tRNA(Thr) + 0
                  tRNA(Trp) + 0
                  tRNA(Tyr) + 0
                  tRNA(Val) + 0
                  taurine + 1
                  taurocholate + 0
                  tetracosanoate + 0
                  tetracosanoyl-CoA 0
                  tetradecanoate + 0
                  tetradecaprenyl diphosphate + 0
                  tetrahydropteroyltri-L-glutamate(4-) 0
                  thiamine(1+) + 0
                  thiamine(1+) diphosphate(1-) 0
                  thiamine(1+) monophosphate + 0
                  thiamine(1+) triphosphate(4-) 0
                  thioredoxin disulfide 0
                  thioredoxin dithiol 0
                  trans-2-hexacosenoyl-CoA 0
                  trans-2-octadecenoyl-CoA 0
                  trans-dec-2-enoyl-CoA(4-) 0
                  trans-dodec-2-enoyl-CoA(4-) 0
                  trans-tetradec-2-enoyl-CoA(4-) 0
                  tridecaprenyl diphosphate + 0
                  trimethylenediaminium 0
                  tryptophol + 0
                  ubiquinol-6 0
                  ubiquinone-6 0
                  undecaprenyl diphosphate + 0
                  uracil + 1
                  urea + 9
                  urea-1-carboxylate 0
                  ureidoglycolic acid + 0
                  uridine 5'-monophosphate(2-) + 0
                  uroporphyrinogen III(8-) 0
                  water + 2
                  xylitol + 0
                  zymosterol + 0
                  zymosterol intermediate 1c 0
                  zymosterol intermediate 2 0
                  zymosteryl oleate 0
                  zymosteryl palmitoleate 0
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