CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 2'-deoxyadenosine
Accession: CHEBI:17256
browse the term
Definition: A purine 2'-deoxyribonucleoside having adenine as the nucleobase.
Synonyms: related_synonym: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol; 5-(6-AMINO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL; 9-(2-Deoxy-beta-D-erythro-pentofuranosyl)adenine; 9-(2-deoxy-beta-D-ribofuranosyl)-9H-purin-6-amine; Deoxyadenosine; Formula=C10H13N5O3; InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1; InChIKey=OLXZPDWKRNYJJZ-RRKCRQDMSA-N; SMILES=Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1; adenine deoxyribonucleoside; adenyldeoxyriboside; dA
alt_id: CHEBI:14112; CHEBI:19234; CHEBI:39863; CHEBI:40535; CHEBI:40560; CHEBI:4405
xref: Beilstein:91015; CAS:958-09-8; Gmelin:283189; HMDB:HMDB0000101; KEGG:C00559; KNApSAcK:C00019281
xref_mesh: MESH:C058118
xref: MetaCyc:DEOXYADENOSINE; PDBeChem:3D1; PMID:14253484; PMID:18508186; PMID:24144081; PMID:8171392; PMID:9869364; Reaxys:91015; Wikipedia:Deoxyadenosine
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
ISO
2'-deoxyadenosine results in decreased expression of CDKN1A mRNA
CTD
PMID:24211769
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
G
Polb
DNA polymerase beta
multiple interactions
ISO
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLB protein
CTD
PMID:26098310
NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271
G
Poli
DNA polymerase iota
multiple interactions
ISO
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein; POLN protein inhibits the reaction [[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein]
CTD
PMID:26098310
NCBI chr18:65,749,107...65,768,805
Ensembl chr18:65,748,908...65,768,781
G
Polk
DNA polymerase kappa
multiple interactions
ISO
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLK protein
CTD
PMID:26098310
NCBI chr 2:27,305,718...27,364,906
Ensembl chr 2:27,305,728...27,364,906
G
Poln
DNA polymerase nu
multiple interactions
ISO
[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLN protein; POLN protein inhibits the reaction [[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein]
CTD
PMID:26098310
NCBI chr14:81,837,764...82,037,999
Ensembl chr14:81,858,737...82,037,747
G
Slc29a1
solute carrier family 29 member 1
multiple interactions
ISO
2'-deoxyadenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
CTD
PMID:11085929
NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
G
Slc29a2
solute carrier family 29 member 2
multiple interactions
ISO
2'-deoxyadenosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]
CTD
PMID:11085929
NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189 Ensembl chr 1:220,400,855...220,407,189
G
Neil1
nei-like DNA glycosylase 1
affects metabolic processing
ISO
NEIL1 protein affects the metabolism of 8,5'-cyclo-2'-deoxyadenosine
CTD
PMID:20067321
NCBI chr 8:61,817,258...61,824,023
Ensembl chr 8:61,817,258...61,823,102
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all