CYP2A13 (cytochrome P450 family 2 subfamily A polypeptide 13) - Rat Genome Database

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Gene: CYP2A13 (cytochrome P450 family 2 subfamily A polypeptide 13) Canis lupus familiaris
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Symbol: CYP2A13
Name: cytochrome P450 family 2 subfamily A polypeptide 13
RGD ID: 12180515
Description: ENCODES a protein that exhibits oxidoreductase activity (ortholog); steroid hydroxylase activity (ortholog); INVOLVED IN cellular response to cadmium ion (ortholog); coumarin metabolic process (ortholog); heme metabolic process (ortholog); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); lung adenocarcinoma (ortholog); Neoplastic Cell Transformation (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); INTERACTS WITH clofibrate; phenobarbital
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Rat
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,932,246 - 112,938,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,931,985 - 112,938,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,334,931 - 112,340,932 (-)NCBI
ROS_Cfam_1.01113,530,545 - 113,536,550 (-)NCBI
ROS_Cfam_1.0 Ensembl1113,529,888 - 113,536,652 (-)Ensembl
UMICH_Zoey_3.11113,090,324 - 113,096,328 (-)NCBI
UNSW_CanFamBas_1.01112,722,239 - 112,728,251 (-)NCBI
UU_Cfam_GSD_1.01113,716,309 - 113,722,322 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
CYP2A13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,932,246 - 112,938,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,931,985 - 112,938,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,334,931 - 112,340,932 (-)NCBI
ROS_Cfam_1.01113,530,545 - 113,536,550 (-)NCBI
ROS_Cfam_1.0 Ensembl1113,529,888 - 113,536,652 (-)Ensembl
UMICH_Zoey_3.11113,090,324 - 113,096,328 (-)NCBI
UNSW_CanFamBas_1.01112,722,239 - 112,728,251 (-)NCBI
UU_Cfam_GSD_1.01113,716,309 - 113,722,322 (-)NCBI
CYP2A13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,088,451 - 41,096,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1941,088,451 - 41,096,195 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,594,356 - 41,602,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,286,208 - 46,293,939 (+)NCBINCBI36hg18NCBI36
Build 341946,286,207 - 46,293,939NCBI
Celera1938,394,537 - 38,402,261 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,026,475 - 38,034,212 (+)NCBIHuRef
CHM1_11941,594,072 - 41,601,816 (+)NCBICHM1_1
T2T-CHM13v2.01943,909,356 - 43,917,084 (+)NCBI
Cyp2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,231,611 - 82,244,887 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl182,231,611 - 82,244,887 (+)Ensembl
Rnor_6.0183,711,223 - 83,725,222 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,925,733 - 84,938,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,006,828 - 82,020,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,084,938 - 82,098,390 (+)NCBI
Celera176,649,089 - 76,662,287 (+)NCBICelera
Cytogenetic Map1q21NCBI
CYP2A19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,056,578 - 49,064,107 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,056,579 - 49,064,111 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,872,084 - 44,877,470 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1 1 1
Medium 7 5 5 7 6
Low 4 4 4 2 3
Below cutoff 1 5 10 6 2 6 10 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008163   ⟹   ENSCAFP00000007561
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1112,931,985 - 112,938,350 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063697   ⟹   ENSCAFP00000061037
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1112,931,985 - 112,938,248 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845005096   ⟹   ENSCAFP00845004053
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1113,529,888 - 113,536,576 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845005106   ⟹   ENSCAFP00845004063
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1113,529,888 - 113,536,550 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845005117   ⟹   ENSCAFP00845004072
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1113,530,105 - 113,536,652 (-)Ensembl
RefSeq Acc Id: NM_001037345   ⟹   NP_001032422
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11112,932,246 - 112,938,248 (-)NCBI
Dog10K_Boxer_Tasha1112,334,931 - 112,340,932 (-)NCBI
ROS_Cfam_1.01113,530,545 - 113,536,550 (-)NCBI
UMICH_Zoey_3.11113,090,324 - 113,096,328 (-)NCBI
UNSW_CanFamBas_1.01112,722,239 - 112,728,251 (-)NCBI
UU_Cfam_GSD_1.01113,716,309 - 113,722,322 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032422 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT44551 (Get FASTA)   NCBI Sequence Viewer  
  AAT44552 (Get FASTA)   NCBI Sequence Viewer  
  ABB43280 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001032422   ⟸   NM_001037345
- UniProtKB: Q307K8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000061037   ⟸   ENSCAFT00000063697
RefSeq Acc Id: ENSCAFP00000007561   ⟸   ENSCAFT00000008163
RefSeq Acc Id: ENSCAFP00845004063   ⟸   ENSCAFT00845005106
RefSeq Acc Id: ENSCAFP00845004053   ⟸   ENSCAFT00845005096
RefSeq Acc Id: ENSCAFP00845004072   ⟸   ENSCAFT00845005117

Promoters
RGD ID:13682290
Promoter ID:EPDNEW_C359
Type:multiple initiation site
Name:CYP2A13_1
Description:cytochrome P450 family 2 subfamily A polypeptide 13
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11112,938,274 - 112,938,334EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 112933083 112933084 G T snv Australian Shepherd (AU178), Standard Poodle (SRS932143), Basenji (BJ003), Siberian Husky (SY046), Basenji (BJ004), Basenji (BJ006), Miniature Bullterrier (BT007), Bullterrier (BT012), Great Dane (DD116), German Shepherd/Mixed breed (DS032), Leonberger (LB1919), Malinois (MA008), Mixed Breed (MI016), Portuguese Wolf (SRS661492), Pembroke Welsh Corgi (SRS732551), Basenji (BJ001)
1 112934380 112934381 C T snv French Bulldog (FB065), Chinese indigenous dogs (YJ6), Weimaraner (WE006), Poodle (PL116), Malinois (MA008), Pomeranian (ZS14_2), Australian Cattle dog (AC046), Alpine Dachsbracke (AD009), Alaskan Malamute (AM007), Berger Blanc Suisse (BB011), German Shepherd (DS043), German Shepherd (DS051), German Shepherd (DS053), German Shepherd (DS064), French Bulldog (FB046), Golden Retriever (GR0855), Golden Retriever (GR0860), German Shepherd (GS1), German Shepherd (GS10), German Shepherd (GS2), German Shepherd (GS4), German Shepherd (GS6), German Shepherd (GS7), German Shepherd (GS8), German Wirehaired (GW004), Kunming Dog (KM10), Kunming Dog (KM2), Kunming Dog (KM3), Kunming Dog (KM4), Kunming Dog (KM5), Kunming Dog (KM6), Kunming Dog (KM7), Kunming Dog (KM9), Leonberger (LB111), Malinois (MA324), Norwich Terrier (NW152), Norwich Terrier (NW206), Norwich Terrier (NW255)
1 112936343 112936344 A T snv Bavarian Hound (BG064)
1 112937751 112937752 G T snv Doberman Pinscher (DO263), Doberman Pinscher (DO159), Lagotto Romagnolo (LR390)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032339 Ensembl
  ENSCAFG00845002875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845004053 ENTREZGENE
  ENSCAFP00845004053.1 UniProtKB/TrEMBL
  ENSCAFP00845004063.1 UniProtKB/TrEMBL
  ENSCAFP00845004072.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845005096 ENTREZGENE
  ENSCAFT00845005096.1 UniProtKB/TrEMBL
  ENSCAFT00845005106.1 UniProtKB/TrEMBL
  ENSCAFT00845005117.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2A-like UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report cfa:484494 UniProtKB/TrEMBL
NCBI Gene CYP2A13 ENTREZGENE
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP2A UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8I3MMS0_CANLF UniProtKB/TrEMBL
  A0A8I3RSH6_CANLF UniProtKB/TrEMBL
  Q307K8 ENTREZGENE, UniProtKB/TrEMBL
  Q6JDL9_CANLF UniProtKB/TrEMBL
  Q6JDM0_CANLF UniProtKB/TrEMBL