PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma) - Rat Genome Database

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Gene: PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma) Canis lupus familiaris
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Symbol: PIK3CG
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
RGD ID: 12399201
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); protein serine kinase activity (ortholog); INVOLVED IN behavioral response to pain (ortholog); cellular response to cAMP (ortholog); G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; insulin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog); phosphatidylinositol 3-kinase complex (ortholog); INTERACTS WITH (R)-noradrenaline; clonidine; clonidine (amino form)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase, catalytic, gamma polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11813,576,966 - 13,611,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,570,999 - 13,611,141 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,224,877 - 13,259,686 (-)NCBI
ROS_Cfam_1.01813,848,210 - 13,882,893 (-)NCBI
ROS_Cfam_1.0 Ensembl1813,847,825 - 13,882,854 (-)Ensembl
UMICH_Zoey_3.11813,664,384 - 13,696,319 (-)NCBI
UNSW_CanFamBas_1.01813,582,574 - 13,617,381 (-)NCBI
UU_Cfam_GSD_1.01813,862,587 - 13,897,681 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:20157769  


Genomics

Comparative Map Data
PIK3CG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11813,576,966 - 13,611,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,570,999 - 13,611,141 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1813,224,877 - 13,259,686 (-)NCBI
ROS_Cfam_1.01813,848,210 - 13,882,893 (-)NCBI
ROS_Cfam_1.0 Ensembl1813,847,825 - 13,882,854 (-)Ensembl
UMICH_Zoey_3.11813,664,384 - 13,696,319 (-)NCBI
UNSW_CanFamBas_1.01813,582,574 - 13,617,381 (-)NCBI
UU_Cfam_GSD_1.01813,862,587 - 13,897,681 (-)NCBI
PIK3CG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387106,865,282 - 106,908,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7106,865,278 - 106,908,980 (+)EnsemblGRCh38hg38GRCh38
GRCh377106,505,727 - 106,549,425 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367106,293,160 - 106,334,828 (+)NCBINCBI36hg18NCBI36
Build 347106,099,874 - 106,141,543NCBI
Celera7101,311,222 - 101,352,879 (+)NCBI
Cytogenetic Map7q22.3NCBI
HuRef7100,864,687 - 100,906,376 (+)NCBIHuRef
CHM1_17106,439,450 - 106,481,120 (+)NCBICHM1_1
T2T-CHM13v2.07108,181,318 - 108,225,014 (+)NCBI
CRA_TCAGchr7v27105,867,019 - 105,908,676 (+)NCBI
Pik3cg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,223,128 - 32,258,675 (-)NCBIGRCm39mm39
GRCm39 Ensembl1232,223,472 - 32,258,658 (-)Ensembl
GRCm381232,173,397 - 32,208,677 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,173,473 - 32,208,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,858,262 - 32,893,514 (-)NCBIGRCm37mm9NCBIm37
MGSCv361232,760,883 - 32,793,717 (-)NCBImm8
Celera1233,627,107 - 33,665,676 (-)NCBICelera
Cytogenetic Map12A3NCBI
Pik3cg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2648,766,778 - 48,802,098 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl648,766,864 - 48,802,043 (-)Ensembl
Rnor_6.0651,465,696 - 51,501,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,465,908 - 51,498,337 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,106,730 - 61,142,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4650,441,892 - 50,476,931 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1650,447,918 - 50,480,237 (-)NCBI
Celera647,971,127 - 48,004,061 (-)NCBICelera
Cytogenetic Map6q16NCBI
Pik3cg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541011,402,520 - 11,437,422 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541011,402,476 - 11,433,335 (+)NCBIChiLan1.0ChiLan1.0
PIK3CG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17111,569,947 - 111,611,614 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7111,570,148 - 111,611,614 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0798,841,974 - 98,885,446 (+)NCBIMhudiblu_PPA_v0panPan3
Pik3cg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,959,678 - 55,990,585 (-)NCBI
SpeTri2.0NW_00493647917,084,006 - 17,112,264 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,698,207 - 106,745,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,698,200 - 106,748,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29117,537,774 - 117,572,944 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,781,812 - 75,823,404 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2175,784,648 - 75,825,496 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604228,038,017 - 28,081,732 (-)NCBIVero_WHO_p1.0
Pik3cg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473922,737,270 - 22,772,589 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473922,737,376 - 22,772,696 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 1
Low 5 22 6 2 6 6 12 8 9 6
Below cutoff 5 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005630959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038423803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038453995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038500158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038562714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038562715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038562716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038626822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038626823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038626824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_540385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000006384   ⟹   ENSCAFP00000005911
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1813,579,615 - 13,608,284 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000064500   ⟹   ENSCAFP00000061634
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1813,570,999 - 13,608,284 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000089087   ⟹   ENSCAFP00000055617
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1813,587,554 - 13,611,141 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845047056   ⟹   ENSCAFP00845036928
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1813,847,825 - 13,882,854 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845047153   ⟹   ENSCAFP00845037003
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1813,847,825 - 13,879,725 (-)Ensembl
RefSeq Acc Id: XM_005630959   ⟹   XP_005631016
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11813,576,966 - 13,611,748 (-)NCBI
Dog10K_Boxer_Tasha1813,224,877 - 13,259,686 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038423801   ⟹   XP_038279729
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01813,848,210 - 13,882,720 (-)NCBI
RefSeq Acc Id: XM_038423802   ⟹   XP_038279730
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01813,848,210 - 13,882,893 (-)NCBI
RefSeq Acc Id: XM_038423803   ⟹   XP_038279731
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01813,848,210 - 13,882,666 (-)NCBI
RefSeq Acc Id: XM_038453995   ⟹   XP_038309923
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1813,224,877 - 13,259,513 (-)NCBI
RefSeq Acc Id: XM_038500158   ⟹   XP_038356086
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11813,664,384 - 13,696,319 (-)NCBI
RefSeq Acc Id: XM_038562714   ⟹   XP_038418642
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01813,862,587 - 13,897,508 (-)NCBI
RefSeq Acc Id: XM_038562715   ⟹   XP_038418643
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01813,862,587 - 13,897,681 (-)NCBI
RefSeq Acc Id: XM_038562716   ⟹   XP_038418644
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01813,862,587 - 13,897,454 (-)NCBI
RefSeq Acc Id: XM_038626822   ⟹   XP_038482750
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01813,582,574 - 13,617,208 (-)NCBI
RefSeq Acc Id: XM_038626823   ⟹   XP_038482751
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01813,582,574 - 13,617,381 (-)NCBI
RefSeq Acc Id: XM_038626824   ⟹   XP_038482752
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01813,582,574 - 13,617,154 (-)NCBI
RefSeq Acc Id: XM_540385   ⟹   XP_540385
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11813,576,966 - 13,611,275 (-)NCBI
Dog10K_Boxer_Tasha1813,224,877 - 13,259,459 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005631016   ⟸   XM_005630959
- Peptide Label: isoform X2
- UniProtKB: E2RCV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_540385   ⟸   XM_540385
- Peptide Label: isoform X2
- UniProtKB: E2RCV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000061634   ⟸   ENSCAFT00000064500
RefSeq Acc Id: ENSCAFP00000005911   ⟸   ENSCAFT00000006384
RefSeq Acc Id: ENSCAFP00000055617   ⟸   ENSCAFT00000089087
RefSeq Acc Id: XP_038356086   ⟸   XM_038500158
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038482751   ⟸   XM_038626823
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038482750   ⟸   XM_038626822
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038482752   ⟸   XM_038626824
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038279730   ⟸   XM_038423802
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038279729   ⟸   XM_038423801
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038279731   ⟸   XM_038423803
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038309923   ⟸   XM_038453995
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038418643   ⟸   XM_038562715
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038418642   ⟸   XM_038562714
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038418644   ⟸   XM_038562716
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845037003   ⟸   ENSCAFT00845047153
RefSeq Acc Id: ENSCAFP00845036928   ⟸   ENSCAFT00845047056
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
18 13607349 13607350 G T snv Chinese indigenous dogs (YJ2)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003977 Ensembl
  ENSCAFG00030020245 UniProtKB/TrEMBL
  ENSCAFG00845026701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030032432.1 UniProtKB/TrEMBL
  ENSCAFP00030032495.1 UniProtKB/TrEMBL
  ENSCAFP00845036928 ENTREZGENE
  ENSCAFP00845036928.1 UniProtKB/TrEMBL
  ENSCAFP00845037003.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030037180.1 UniProtKB/TrEMBL
  ENSCAFT00030037252.1 UniProtKB/TrEMBL
  ENSCAFT00845047056 ENTREZGENE
  ENSCAFT00845047056.1 UniProtKB/TrEMBL
  ENSCAFT00845047153.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K-type_C2_dom UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  PIK3CG_ABD UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene PIK3CG ENTREZGENE
PANTHER PTHR10048 UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PIK3CG_ABD UniProtKB/TrEMBL
PROSITE C2_PI3K UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0NVL6_CANLF UniProtKB/TrEMBL
  A0A8C0RPI8_CANLF UniProtKB/TrEMBL
  A0A8I3PQH2_CANLF UniProtKB/TrEMBL
  A0A8I3S601_CANLF UniProtKB/TrEMBL
  E2RCV1 ENTREZGENE
VGNC ID VGNC:44558 ENTREZGENE