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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-histidine
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Accession:CHEBI:15971 term browser browse the term
Definition:The L-enantiomer of the amino acid histidine.
Synonyms:exact_synonym: (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid
 related_synonym: (S)-4-(2-Amino-2-carboxyethyl)imidazole;   (S)-alpha-Amino-1H-imidazole-4-propionic acid;   (S)-alpha-amino-1H-Imidazole-4-propanoic acid;   Formula=C6H9N3O2;   H;   HISTIDINE;   His;   InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1;   InChIKey=HNDVDQJCIGZPNO-YFKPBYRVSA-N;   L-Histidin;   SMILES=N[C@@H](Cc1c[nH]cn1)C(O)=O
 alt_id: CHEBI:13117;   CHEBI:21324;   CHEBI:43048;   CHEBI:43114;   CHEBI:43190;   CHEBI:43239;   CHEBI:6240
 xref: Beilstein:84088;   CAS:71-00-1;   DrugBank:DB00117;   ECMDB:ECMDB00177;   Gmelin:83042;   HMDB:HMDB0000177;   KEGG:C00135;   KEGG:D00032;   KNApSAcK:C00001363
 xref_mesh: MESH:D006639
 xref: MetaCyc:HIS;   PDBeChem:HIS;   PMID:15206581;   PMID:21608102;   PMID:21719207;   PMID:22324399;   PMID:22415677;   PMID:22517640;   Reaxys:84088;   Wikipedia:L-histidine;   YMDB:YMDB00369
 cyclic_relationship: is_conjugate_acid_of CHEBI:32510;   is_conjugate_base_of CHEBI:32513;   is_enantiomer_of CHEBI:27947;   is_tautomer_of CHEBI:57595


show annotations for term's descendants           Sort by:
L-histidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdc histidine decarboxylase multiple interactions ISO [HDC protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Histidine CTD PMID:35151785 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
ergothioneine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Ergothioneine inhibits the reaction [Cisplatin results in decreased activity of ACHE protein] CTD PMID:20932872 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] CTD PMID:33580994 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein] CTD PMID:33580994 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein] CTD PMID:33580994 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:33580994 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] CTD PMID:33580994 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] CTD PMID:33580994 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein] CTD PMID:33580994 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein] CTD PMID:33580994 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein] CTD PMID:33580994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          metabolite 19486
            histidine 11
              L-histidine 11
                Ala-Gly-His 0
                Ala-Leu-Leu-His 0
                Ala-Val-Asp-His 0
                Asn-Gly-Pro-His 0
                Asn-His 0
                Asn-Lys-His-His 0
                Asn-Trp-Cys-His 0
                Asp-His 0
                Cys-Cys-His-His 0
                Cys-Met-Phe-His 0
                Gly-His 0
                His-His 0
                His-Ile 0
                His-Phe 0
                Ile-His 0
                L-histidine derivative + 10
                L-histidine residue + 0
                L-histidyl group 0
                Leu-Asn-His 0
                N(2)-L-histidino group 0
                N(alpha)-(L-gamma-glutamyl)-hercynyl-L-cysteine sulfoxide 0
                N(alpha)-(L-gamma-glutamyl)-hercynyl-L-selenocysteine 0
                N(pros)-L-histidino group 0
                N(tele)-L-histidino group 0
                Phe-His 0
                Ser-His 0
                Thr-Ala-His 0
                Thr-His 0
                Tyr-His 0
                Val-His 0
                alpha-methyl-L-histidine 0
                cyclo(L-His-L-Pro) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        amino acid 15541
                                          alpha-amino acid 13675
                                            L-alpha-amino acid 12607
                                              L-histidine 11
                                                Ala-Gly-His 0
                                                Ala-Leu-Leu-His 0
                                                Ala-Val-Asp-His 0
                                                Asn-Gly-Pro-His 0
                                                Asn-His 0
                                                Asn-Lys-His-His 0
                                                Asn-Trp-Cys-His 0
                                                Asp-His 0
                                                Cys-Cys-His-His 0
                                                Cys-Met-Phe-His 0
                                                Gly-His 0
                                                His-His 0
                                                His-Ile 0
                                                His-Phe 0
                                                Ile-His 0
                                                L-histidine derivative + 10
                                                L-histidine residue + 0
                                                L-histidyl group 0
                                                Leu-Asn-His 0
                                                N(2)-L-histidino group 0
                                                N(alpha)-(L-gamma-glutamyl)-hercynyl-L-cysteine sulfoxide 0
                                                N(alpha)-(L-gamma-glutamyl)-hercynyl-L-selenocysteine 0
                                                N(pros)-L-histidino group 0
                                                N(tele)-L-histidino group 0
                                                Phe-His 0
                                                Ser-His 0
                                                Thr-Ala-His 0
                                                Thr-His 0
                                                Tyr-His 0
                                                Val-His 0
                                                alpha-methyl-L-histidine 0
                                                cyclo(L-His-L-Pro) 0
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