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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:D-glucitol
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Accession:CHEBI:17924 term browser browse the term
Definition:The D-enantiomer of glucitol (also known as D-sorbitol).
Synonyms:related_synonym: (-)-sorbitol;   (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol;   D-Sorbit;   D-sorbitol;   E-420;   E420;   Formula=C6H14O6;   G-ol;   Glc-ol;   InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1;   InChIKey=FBPFZTCFMRRESA-JGWLITMVSA-N;   L-Gulitol;   SMILES=OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
 alt_id: CHEBI:12954;   CHEBI:13020;   CHEBI:21091;   CHEBI:4246;   CHEBI:45559
 xref: Beilstein:1721899;   Beilstein:4656395;   CAS:50-70-4;   DrugBank:DB01638;   Drug_Central:2462;   Gmelin:83162;   HMDB:HMDB0000247;   KEGG:C00794;   KEGG:D00096;   KNApSAcK:C00001173
 xref_mesh: MESH:D013012
 xref: PDBeChem:SOR;   PMID:16901854;   PMID:17336832;   PMID:17979222;   PMID:19443021;   PMID:19695255;   PMID:22735334;   PMID:22878210;   PMID:23683321;   PMID:24643482;   PMID:25108762;   PMID:25568069;   PMID:31537530;   PPDB:1320;   Reaxys:1721899;   Wikipedia:Sorbitol
 cyclic_relationship: is_enantiomer_of CHEBI:28789



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D-glucitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions
increases abundance
ISO AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]
AKR1B1 protein results in increased abundance of Sorbitol
CTD PMID:25451566 PMID:25541468 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO [Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein CTD PMID:10779545 PMID:11698504 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Aqp9 aquaporin 9 multiple interactions
increases uptake
ISO
EXP
Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite]
AQP9 protein results in increased uptake of Sorbitol
CTD PMID:9733774 PMID:19341753 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Caprin1 cell cycle associated protein 1 multiple interactions ISO Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] CTD PMID:33939924 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP Sorbitol results in increased activity of CASP3 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]
CTD PMID:20609311 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
EXP Sorbitol results in increased activity of CASP8 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]
CTD PMID:20609311 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
EXP Sorbitol results in increased activity of CASP9 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]
CTD PMID:20609311 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases phosphorylation EXP Sorbitol results in increased phosphorylation of CRK protein CTD PMID:16187300 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:9545260 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:9545260 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 increases abundance ISO FMR1 5' UTR mutant form results in increased abundance of Sorbitol CTD PMID:27385396 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Ins1 insulin 1 multiple interactions EXP Sorbitol promotes the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:10221768 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
ISO JNK-IN-8 inhibits the reaction [Sorbitol results in increased phosphorylation of JUN protein] CTD PMID:24184208 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
increases activity
ISO Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK12 protein CTD PMID:15362974 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK14 protein CTD PMID:15362974 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 increases activity ISO Sorbitol results in increased activity of MAPK7 protein CTD PMID:11163183 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK8 protein CTD PMID:24184208 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK9 protein CTD PMID:24184208 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases activity
multiple interactions
increases phosphorylation
ISO Sorbitol results in increased activity of MAPKAPK2 protein
SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein]
CTD PMID:9545260 PMID:15362974 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 increases activity ISO Sorbitol results in increased activity of MKNK1 protein CTD PMID:9545260 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Sorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Pten phosphatase and tensin homolog affects localization ISO
EXP
Sorbitol affects the localization of PTEN protein CTD PMID:16807353 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 multiple interactions ISO Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] CTD PMID:33939924 NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases metabolic processing
increases abundance
ISO [SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose; epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]; ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] CTD PMID:32367058 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Tardbp TAR DNA binding protein increases ubiquitination ISO Sorbitol results in increased ubiquitination of TARDBP protein CTD PMID:31780563 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Ubxn1 UBX domain protein 1 increases phosphorylation ISO Sorbitol results in increased phosphorylation of UBXN1 protein CTD PMID:15362974 NCBI chr 1:205,765,212...205,769,236
Ensembl chr 1:205,745,120...205,816,520
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        biophysical role 13830
          cathartic 28
            D-glucitol 27
              1,5-anhydro-D-glucitol 0
              6-O-alpha-D-glucopyranosyl-D-glucitol + 0
              D-glucitol 3-phosphate 0
              D-glucitol 6-phosphate 0
              D-sorbitol-(13)C6 0
              alpha-D-Galp-(1->6)-D-Glc-OH 0
              alpha-L-Fucp-(1->2)-D-Glc-OH 0
              alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-D-Glc-OH 0
              alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-D-Glu-OH 0
              alpha-L-Fucp-(1->3)-[beta-D-Galp-(1->4)]-D-Glc-ol 0
              alpha-L-Fucp-(1->4)-[beta-D-Galp-(1->3)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-D-Glc-ol 0
              alpha-L-Rhap-(1->2)-[alpha-L-Rhap-(1->2)-alpha-D-Galp-(1->3)-beta-D-GlcpNAc-(1->4)]-alpha-L-Rhap-(1->2)-alpha-L-Rhap-(1->1')-[alpha-L-Rhap-(1->3')]-D-glucitol 0
              alpha-L-Rhap-(1->3)-D-glucitol 0
              beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-D-Glc-ol 0
              beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-Glc-ol 0
              beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-D-Glc-ol 0
              beta-D-Glcp-(1->2)-D-Glc-OH 0
              beta-D-Glcp-(1->3)-D-Glc-OH 0
              cellobiotol 0
              gentiobiitol 0
              maltitol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            heteroorganic entity 19450
                              organochalcogen compound 19236
                                organooxygen compound 19149
                                  carbohydrates and carbohydrate derivatives 14948
                                    carbohydrate 14948
                                      alditol 1915
                                        hexitol 118
                                          glucitol 32
                                            D-glucitol 27
                                              1,5-anhydro-D-glucitol 0
                                              6-O-alpha-D-glucopyranosyl-D-glucitol + 0
                                              D-glucitol 3-phosphate 0
                                              D-glucitol 6-phosphate 0
                                              D-sorbitol-(13)C6 0
                                              alpha-D-Galp-(1->6)-D-Glc-OH 0
                                              alpha-L-Fucp-(1->2)-D-Glc-OH 0
                                              alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-D-Glc-OH 0
                                              alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-D-Glu-OH 0
                                              alpha-L-Fucp-(1->3)-[beta-D-Galp-(1->4)]-D-Glc-ol 0
                                              alpha-L-Fucp-(1->4)-[beta-D-Galp-(1->3)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-D-Glc-ol 0
                                              alpha-L-Rhap-(1->2)-[alpha-L-Rhap-(1->2)-alpha-D-Galp-(1->3)-beta-D-GlcpNAc-(1->4)]-alpha-L-Rhap-(1->2)-alpha-L-Rhap-(1->1')-[alpha-L-Rhap-(1->3')]-D-glucitol 0
                                              alpha-L-Rhap-(1->3)-D-glucitol 0
                                              beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-D-Glc-ol 0
                                              beta-D-Galp-(1->3)-[alpha-L-Fucp-(1->4)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-Glc-ol 0
                                              beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-D-Glc-ol 0
                                              beta-D-Glcp-(1->2)-D-Glc-OH 0
                                              beta-D-Glcp-(1->3)-D-Glc-OH 0
                                              cellobiotol 0
                                              gentiobiitol 0
                                              maltitol 0
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