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Term:kynurenic acid
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Accession:CHEBI:18344 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Synonyms:related_synonym: 4-Hydroxy-2-chinolincarbonsaeure;   4-Hydroxy-2-quinolinecarboxylic acid;   4-Hydroxyquinoline-2-carboxylic acid;   4-hydroxyquinaldic acid;   4-hydroxyquinaldinic acid;   Formula=C10H7NO3;   InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14);   InChIKey=HCZHHEIFKROPDY-UHFFFAOYSA-N;   Kynurenate;   Kynurensaeure;   SMILES=OC(=O)c1cc(O)c2ccccc2n1
 alt_id: CHEBI:14495;   CHEBI:1841;   CHEBI:20378
 xref: Beilstein:147451 "Beilstein";   CAS:492-27-3 "ChemIDplus";   CAS:492-27-3 "KEGG COMPOUND";   HMDB:HMDB0000715;   KEGG:C01717;   KNApSAcK:C00026453;   KNApSAcK:C00026494;   LINCS:LSM-24962
 xref_mesh: MESH:D007736
 xref: MetaCyc:KYNURENATE;   PDBeChem:KYA;   PMID:10088651 "Europe PMC";   PMID:10867830 "Europe PMC";   PMID:10881031 "Europe PMC";   PMID:11051465 "Europe PMC";   PMID:11129102 "Europe PMC";   PMID:11191832 "Europe PMC";   PMID:11244357 "Europe PMC";   PMID:11334243 "Europe PMC";   PMID:11452979 "Europe PMC";   PMID:11521749 "Europe PMC";   PMID:11982504 "Europe PMC";   PMID:12503245 "Europe PMC";   PMID:12757473 "Europe PMC";   PMID:12926536 "Europe PMC";   PMID:14724046 "Europe PMC";   PMID:14770276 "Europe PMC";   PMID:15206728 "Europe PMC";   PMID:15364012 "Europe PMC";   PMID:15517427 "Europe PMC";   PMID:15605380 "Europe PMC";   PMID:15961072 "Europe PMC";   PMID:16088227 "Europe PMC";   PMID:16220290 "Europe PMC";   PMID:16388784 "Europe PMC";   PMID:16416446 "Europe PMC";   PMID:16457470 "Europe PMC";   PMID:16603336 "Europe PMC";   PMID:16644124 "Europe PMC";   PMID:16845213 "Europe PMC";   PMID:16888405 "Europe PMC";   PMID:16920787 "Europe PMC";   PMID:17023091 "Europe PMC";   PMID:17364732 "Europe PMC";   PMID:17573079 "Europe PMC";   PMID:17959203 "Europe PMC";   PMID:18231708 "Europe PMC";   PMID:18235993 "Europe PMC";   PMID:18346850 "Europe PMC";   PMID:18462830 "Europe PMC";   PMID:18836681 "Europe PMC";   PMID:18950711 "Europe PMC";   PMID:19187269 "Europe PMC";   PMID:19523966 "Europe PMC";   PMID:19616570 "Europe PMC";   PMID:19815960 "Europe PMC";   PMID:19816853 "Europe PMC";   PMID:22065206 "Europe PMC";   PMID:22108572 "Europe PMC";   PMID:22224417 "Europe PMC";   PMID:22732505 "Europe PMC";   PMID:22770225 "Europe PMC";   PMID:22814028 "Europe PMC";   PMID:22915278 "Europe PMC";   PMID:23030614 "Europe PMC";   PMID:7882580 "Europe PMC";   PMID:8579218 "Europe PMC";   PMID:8637415 "Europe PMC";   PMID:9078543 "Europe PMC";   Reaxys:147451 "Reaxys";   Wikipedia:Kynurenic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58454

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kynurenic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:6480464
G Gpr35 G protein-coupled receptor 35 JBrowse link 9 100,129,428 100,141,269 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Slc2a3 solute carrier family 2 member 3 JBrowse link 4 155,549,991 155,626,018 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19617
    role 19560
      biological role 19553
        pharmacological role 18673
          agonist 17982
            G-protein-coupled receptor agonist 13
              kynurenic acid 12
                4-hydroxy-8-methoxyquinaldic acid 0
                7,8-dihydro-7,8-dihydroxykynurenic acid 0
                7,8-dihydroxykynurenic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19617
    subatomic particle 19613
      composite particle 19613
        hadron 19613
          baryon 19613
            nucleon 19613
              atomic nucleus 19613
                atom 19613
                  main group element atom 19491
                    p-block element atom 19491
                      carbon group element atom 19363
                        carbon atom 19355
                          organic molecular entity 19355
                            organic group 18311
                              organic divalent group 18301
                                organodiyl group 18301
                                  carbonyl group 18186
                                    carbonyl compound 18186
                                      carboxylic acid 17852
                                        aromatic carboxylic acid 10067
                                          quinolinemonocarboxylic acid 89
                                            kynurenic acid 12
                                              4-hydroxy-8-methoxyquinaldic acid 0
                                              7,8-dihydro-7,8-dihydroxykynurenic acid 0
                                              7,8-dihydroxykynurenic acid 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.