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Term:kynurenic acid
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Accession:CHEBI:18344 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Synonyms:related_synonym: 4-Hydroxy-2-chinolincarbonsaeure;   4-Hydroxy-2-quinolinecarboxylic acid;   4-Hydroxyquinoline-2-carboxylic acid;   4-hydroxyquinaldic acid;   4-hydroxyquinaldinic acid;   Formula=C10H7NO3;   InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14);   InChIKey=HCZHHEIFKROPDY-UHFFFAOYSA-N;   Kynurenate;   Kynurensaeure;   SMILES=OC(=O)c1cc(O)c2ccccc2n1
 alt_id: CHEBI:14495;   CHEBI:1841;   CHEBI:20378
 xref: Beilstein:147451;   CAS:492-27-3;   HMDB:HMDB0000715;   KEGG:C01717;   KNApSAcK:C00026453;   KNApSAcK:C00026494;   LINCS:LSM-24962
 xref_mesh: MESH:D007736
 xref: MetaCyc:KYNURENATE;   PDBeChem:KYA;   PMID:10088651;   PMID:10867830;   PMID:10881031;   PMID:11051465;   PMID:11129102;   PMID:11191832;   PMID:11244357;   PMID:11334243;   PMID:11452979;   PMID:11521749;   PMID:11982504;   PMID:12503245;   PMID:12757473;   PMID:12926536;   PMID:14724046;   PMID:14770276;   PMID:15206728;   PMID:15364012;   PMID:15517427;   PMID:15605380;   PMID:15961072;   PMID:16088227;   PMID:16220290;   PMID:16388784;   PMID:16416446;   PMID:16457470;   PMID:16603336;   PMID:16644124;   PMID:16845213;   PMID:16888405;   PMID:16920787;   PMID:17023091;   PMID:17364732;   PMID:17573079;   PMID:17959203;   PMID:18231708;   PMID:18235993;   PMID:18346850;   PMID:18462830;   PMID:18836681;   PMID:18950711;   PMID:19187269;   PMID:19523966;   PMID:19616570;   PMID:19815960;   PMID:19816853;   PMID:22065206;   PMID:22108572;   PMID:22224417;   PMID:22732505;   PMID:22770225;   PMID:22814028;   PMID:22915278;   PMID:23030614;   PMID:7882580;   PMID:8579218;   PMID:8637415;   PMID:9078543;   Reaxys:147451;   Wikipedia:Kynurenic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58454

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kynurenic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:6480464
G Gpr35 G protein-coupled receptor 35 JBrowse link 9 100,129,428 100,141,269 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Slc2a3 solute carrier family 2 member 3 JBrowse link 4 155,549,991 155,626,018 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      biological role 19737
        pharmacological role 18817
          agonist 18201
            G-protein-coupled receptor agonist 13
              kynurenic acid 12
                4-hydroxy-8-methoxyquinaldic acid 0
                7,8-dihydro-7,8-dihydroxykynurenic acid 0
                7,8-dihydroxykynurenic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18475
                              organic divalent group 18468
                                organodiyl group 18468
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      carboxylic acid 18034
                                        aromatic carboxylic acid 10892
                                          quinolinemonocarboxylic acid 93
                                            kynurenic acid 12
                                              4-hydroxy-8-methoxyquinaldic acid 0
                                              7,8-dihydro-7,8-dihydroxykynurenic acid 0
                                              7,8-dihydroxykynurenic acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.