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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kynurenic acid
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Accession:CHEBI:18344 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
Synonyms:related_synonym: 4-Hydroxy-2-chinolincarbonsaeure;   4-Hydroxy-2-quinolinecarboxylic acid;   4-Hydroxyquinoline-2-carboxylic acid;   4-hydroxyquinaldic acid;   4-hydroxyquinaldinic acid;   Formula=C10H7NO3;   InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14);   InChIKey=HCZHHEIFKROPDY-UHFFFAOYSA-N;   Kynurenate;   Kynurensaeure;   SMILES=OC(=O)c1cc(O)c2ccccc2n1
 alt_id: CHEBI:14495;   CHEBI:1841;   CHEBI:20378
 xref: Beilstein:147451;   CAS:492-27-3;   HMDB:HMDB0000715;   KEGG:C01717;   KNApSAcK:C00026453;   KNApSAcK:C00026494;   LINCS:LSM-24962
 xref_mesh: MESH:D007736
 xref: MetaCyc:KYNURENATE;   PDBeChem:KYA;   PMID:10088651;   PMID:10867830;   PMID:10881031;   PMID:11051465;   PMID:11129102;   PMID:11191832;   PMID:11244357;   PMID:11334243;   PMID:11452979;   PMID:11521749;   PMID:11982504;   PMID:12503245;   PMID:12757473;   PMID:12926536;   PMID:14724046;   PMID:14770276;   PMID:15206728;   PMID:15364012;   PMID:15517427;   PMID:15605380;   PMID:15961072;   PMID:16088227;   PMID:16220290;   PMID:16388784;   PMID:16416446;   PMID:16457470;   PMID:16603336;   PMID:16644124;   PMID:16845213;   PMID:16888405;   PMID:16920787;   PMID:17023091;   PMID:17364732;   PMID:17573079;   PMID:17959203;   PMID:18231708;   PMID:18235993;   PMID:18346850;   PMID:18462830;   PMID:18836681;   PMID:18950711;   PMID:19187269;   PMID:19523966;   PMID:19616570;   PMID:19815960;   PMID:19816853;   PMID:22065206;   PMID:22108572;   PMID:22224417;   PMID:22732505;   PMID:22770225;   PMID:22814028;   PMID:22915278;   PMID:23030614;   PMID:7882580;   PMID:8579218;   PMID:8637415;   PMID:9078543;   Reaxys:147451;   Wikipedia:Kynurenic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:58454


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kynurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCB11 protein results in increased uptake of Taurocholic Acid] CTD PMID:30639138 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate] CTD PMID:21483698 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate] CTD PMID:21483698 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Kynurenic Acid binds to and results in increased activity of AHR protein
Kynurenic Acid analog results in increased activity of AHR protein; Kynurenic Acid results in increased activity of AHR protein
CTD PMID:20106948 PMID:27020609 PMID:28336214 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Kynurenic Acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
ISO [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]
Kynurenic Acid results in increased activity of CYP1A1 protein
Kynurenic Acid results in increased expression of CYP1A1 mRNA
CTD PMID:20106948 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO Kynurenic Acid results in decreased secretion of FGF1 protein CTD PMID:16392031 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO Kynurenic Acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,526,691...93,539,302
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA] CTD PMID:20106948 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA] CTD PMID:20106948 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein] CTD PMID:28951307 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [Ro 61-8048 results in decreased activity of KMO protein] which results in increased abundance of Kynurenic Acid CTD PMID:30151725 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions ISO Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein] CTD PMID:28951307 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          agonist 18266
            G-protein-coupled receptor agonist 14
              kynurenic acid 13
                4-hydroxy-8-methoxyquinaldic acid 0
                7,8-dihydro-7,8-dihydroxykynurenic acid 0
                7,8-dihydroxykynurenic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        aromatic carboxylic acid 11710
                                          quinolinemonocarboxylic acid 98
                                            kynurenic acid 13
                                              4-hydroxy-8-methoxyquinaldic acid 0
                                              7,8-dihydro-7,8-dihydroxykynurenic acid 0
                                              7,8-dihydroxykynurenic acid 0
paths to the root