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ONTOLOGY REPORT - ANNOTATIONS
Term:5-aminolevulinic acid
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Accession:CHEBI:17549 term browser browse the term
Definition:The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Synonyms:related_synonym: 5-ALA;   5-Amino-4-oxopentanoate;   5-Amino-4-oxopentanoic acid;   5-Amino-4-oxovaleric acid;   5-Aminolevulinate;   Formula=C5H9NO3;   InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9);   InChIKey=ZGXJTSGNIOSYLO-UHFFFAOYSA-N;   SMILES=NCC(=O)CCC(O)=O;   aminolevulinic acid;   dALA;   delta-ALA;   delta-aminolevulinic acid
 alt_id: CHEBI:2034;   CHEBI:20547
 xref: Beilstein:1759139 "Beilstein";   CAS:106-60-5 "ChemIDplus";   CAS:106-60-5 "KEGG COMPOUND";   DrugBank:DB00855;   Drug_Central:166 "DrugCentral";   HMDB:HMDB0001149;   KEGG:C00430;   KEGG:D07567;   KNApSAcK:C00007378;   LINCS:LSM-5677
 xref_mesh: MESH:D000622
 xref: PMID:11303952 "Europe PMC";   PMID:15756058 "Europe PMC";   PMID:15996585 "Europe PMC";   PMID:18982627 "Europe PMC";   PMID:19378778 "Europe PMC";   PMID:22378066 "Europe PMC";   PMID:22700502 "Europe PMC";   PMID:23242333 "Europe PMC";   PMID:23291627 "Europe PMC";   PMID:23299429 "Europe PMC";   PMID:23307195 "Europe PMC";   PMID:23339045 "Europe PMC";   PMID:23360321 "Europe PMC";   PMID:7890117 "Europe PMC";   Reaxys:1759139 "Reaxys";   Wikipedia:Aminolevulinic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:12109;   is_conjugate_base_of CHEBI:132970;   is_tautomer_of CHEBI:356416

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5-aminolevulinic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:6480464
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:6480464
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:6480464
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Mag myelin-associated glycoprotein JBrowse link 1 89,345,325 89,360,905 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:6480464
G Mpz myelin protein zero JBrowse link 13 89,524,204 89,530,070 RGD:6480464
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 1 264,298,671 264,303,712 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pmp22 peripheral myelin protein 22 JBrowse link 10 49,538,588 49,568,583 RGD:6480464
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Urod uroporphyrinogen decarboxylase JBrowse link 5 135,855,429 135,859,515 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        pro-agent 8768
          prodrug 8565
            5-aminolevulinic acid 26
              methyl 5-aminolevulinate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        monocarboxylic acid 17254
                                          fatty acid 15818
                                            saturated fatty acid 15785
                                              straight-chain saturated fatty acid 15181
                                                valeric acid 14347
                                                  oxopentanoic acid 26
                                                    4-oxopentanoic acid 26
                                                      5-aminolevulinic acid 26
                                                        methyl 5-aminolevulinate + 0
paths to the root

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