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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dihydroxyacetone
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Accession:CHEBI:16016 term browser browse the term
Definition:A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones.
Synonyms:related_synonym: 1,3-Dihydroxy-2-propanone;   1,3-Dihydroxyacetone;   1,3-Dihydroxydimethyl ketone;   1,3-Dihydroxypropan-2-one;   1,3-Dihydroxypropanone;   1,3-propanediol-2-one;   Bis(hydroxymethyl) ketone;   DHA;   Formula=C3H6O3;   Glycerone;   InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2;   InChIKey=RXKJFZQQPQGTFL-UHFFFAOYSA-N;   SMILES=C(CO)(CO)=O;   alpha,alpha'-dihydroxyacetone
 alt_id: CHEBI:14340;   CHEBI:24354;   CHEBI:39809;   CHEBI:5453
 xref: CAS:96-26-4;   DrugBank:DB01775;   HMDB:HMDB0001882;   KEGG:C00184;   KEGG:D07841
 xref_mesh: MESH:D004098
 xref: MetaCyc:DIHYDROXYACETONE;   PDBeChem:2HA;   PMID:20936361;   PMID:21549029;   PMID:21598406;   PMID:23543734;   PMID:23554234;   PMID:23748086;   PMID:24209782;   Reaxys:1740268;   Wikipedia:Dihydroxyacetone


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dihydroxyacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase decreases expression ISO Dihydroxyacetone results in decreased expression of ATM mRNA CTD PMID:32506039 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Dihydroxyacetone results in increased cleavage of CASP3 protein CTD PMID:29193605 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL21 mRNA CTD PMID:32506039 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL3 mRNA CTD PMID:32506039 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL4 mRNA CTD PMID:32506039 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccnc cyclin C increases expression ISO Dihydroxyacetone results in increased expression of CCNC mRNA CTD PMID:32506039 NCBI chr 5:40,063,589...40,081,731
Ensembl chr 5:35,266,823...35,296,584 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Dihydroxyacetone results in decreased expression of CDKN1A mRNA CTD PMID:32506039 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression EXP Dihydroxyacetone results in increased expression of CDKN2A protein CTD PMID:38582340 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cel carboxyl ester lipase increases expression ISO Dihydroxyacetone results in increased expression of CEL protein CTD PMID:32506039 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of CHEK2 mRNA CTD PMID:32506039 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO Dihydroxyacetone results in increased expression of CRYAB mRNA; Dihydroxyacetone results in increased expression of CRYAB protein CTD PMID:32506039 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Dihydroxyacetone results in increased expression of CSF2 mRNA CTD PMID:32506039 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP1A1 mRNA CTD PMID:32506039 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP2E1 mRNA CTD PMID:32506039 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP7A1 mRNA CTD PMID:32506039 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Dihydroxyacetone results in increased expression of DDIT3 mRNA CTD PMID:32506039 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Dihydroxyacetone results in increased expression of DNAJB4 mRNA CTD PMID:32506039 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Dnm1l dynamin 1-like decreases phosphorylation EXP Dihydroxyacetone results in decreased phosphorylation of DNM1L protein CTD PMID:38582340 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Dihydroxyacetone results in increased expression of E2F1 mRNA CTD PMID:32506039 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Egr1 early growth response 1 affects expression ISO Dihydroxyacetone affects the expression of EGR1 mRNA CTD PMID:32506039 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of EIF2S1 protein CTD PMID:32506039 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of EPHX2 mRNA CTD PMID:32506039 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit increases expression ISO Dihydroxyacetone results in increased expression of ERCC3 mRNA CTD PMID:32506039 NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329 		JBrowse link
G Faslg Fas ligand affects expression ISO Dihydroxyacetone affects the expression of FASLG mRNA CTD PMID:32506039 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase increases expression EXP Dihydroxyacetone results in increased expression of FASN protein CTD PMID:38582340 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression ISO Dihydroxyacetone results in decreased expression of FMO1 mRNA CTD PMID:32506039 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Dihydroxyacetone results in decreased expression of GDF15 mRNA CTD PMID:32506039 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Glb1 galactosidase, beta 1 increases activity EXP Dihydroxyacetone results in increased activity of GLB1 protein CTD PMID:38582340 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Glo1 glyoxalase 1 affects response to substance ISO GLO1 protein affects the susceptibility to Dihydroxyacetone CTD PMID:32506039 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO GPD2 protein inhibits the reaction [Dihydroxyacetone results in increased abundance of alpha-glycerophosphoric acid]; GPD2 protein inhibits the reaction [Dihydroxyacetone results in increased abundance of Glucose-6-Phosphate] CTD PMID:31974165 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Dihydroxyacetone results in increased expression of H2AX protein CTD PMID:32506039 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Dihydroxyacetone results in increased expression of HMOX1 mRNA; Dihydroxyacetone results in increased expression of HMOX1 protein CTD PMID:32506039 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Dihydroxyacetone results in increased expression of HSPA1A mRNA CTD PMID:32506039 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO Dihydroxyacetone results in increased expression of HSPA2 mRNA CTD PMID:32506039 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO Dihydroxyacetone results in increased expression of HSPA6 protein CTD PMID:32506039 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of HSPB1 protein CTD PMID:32506039 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Dihydroxyacetone results in increased expression of HSPD1 mRNA CTD PMID:32506039 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression ISO Dihydroxyacetone results in increased expression of HSPE1 mRNA CTD PMID:32506039 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Il6 interleukin 6 increases expression ISO Dihydroxyacetone results in increased expression of IL6 mRNA CTD PMID:32506039 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression EXP Dihydroxyacetone results in decreased expression of LDHA protein CTD PMID:38582340 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldhb lactate dehydrogenase B decreases expression EXP Dihydroxyacetone results in decreased expression of LDHB protein CTD PMID:38582340 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of MAPK1 protein CTD PMID:32506039 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of MAPK3 protein CTD PMID:32506039 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mfn2 mitofusin 2 decreases expression EXP Dihydroxyacetone results in decreased expression of MFN2 protein CTD PMID:38582340 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP10 protein CTD PMID:30959092 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP13 protein CTD PMID:30959092 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mt2 metallothionein 2 decreases expression ISO Dihydroxyacetone results in decreased expression of MT2A mRNA CTD PMID:32506039 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases secretion ISO Dihydroxyacetone results in decreased secretion of MUC5AC protein CTD PMID:30959092 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 increases expression EXP Dihydroxyacetone results in increased expression of NDUFS1 protein CTD PMID:38582340 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Dihydroxyacetone results in increased expression of NFE2L2 protein CTD PMID:32506039 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO Dihydroxyacetone results in decreased expression of NFKB1 mRNA CTD PMID:32506039 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of NOS2 mRNA CTD PMID:32506039 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO
EXP 		Dihydroxyacetone results in increased cleavage of PARP1 protein CTD PMID:29193605 PMID:38582340 PMID:38867704 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Dihydroxyacetone results in increased expression of PCNA mRNA CTD PMID:32506039 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pklr pyruvate kinase L/R multiple interactions EXP 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile inhibits the reaction [Dihydroxyacetone results in increased expression of PKLR mRNA] CTD PMID:31974165 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048] CTD PMID:31974165 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048] CTD PMID:31974165 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Dihydroxyacetone results in increased expression of TNF mRNA CTD PMID:32506039 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression ISO Dihydroxyacetone affects the expression of TNFRSF1A mRNA CTD PMID:32506039 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO Dihydroxyacetone results in decreased expression of TNFSF10 mRNA CTD PMID:32506039 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 increases expression EXP Dihydroxyacetone results in increased expression of TOMM20 protein CTD PMID:38582340 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Dihydroxyacetone results in increased expression of TPI protein CTD PMID:38582340 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO Dihydroxyacetone results in decreased expression of UNG mRNA CTD PMID:32506039 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Xrcc2 X-ray repair cross complementing 2 increases expression ISO Dihydroxyacetone results in increased expression of XRCC2 mRNA; Dihydroxyacetone results in increased expression of XRCC2 protein CTD PMID:32506039 NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482 		JBrowse link
dihydroxyacetone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions 		ISO IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate] 		CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Tpi1 triosephosphate isomerase 1 affects metabolic processing EXP TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate CTD PMID:14762718 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        biochemical role 20250
          metabolite 20231
            dihydroxyacetone 66
              1-hydroxy-3-methoxyacetone 0
              1-palmitoylglycerone 3-phosphate 0
              1-stearoylglycerone 3-phosphate 0
              dihydroxyacetone phosphate 2
              glycerone derivative + 2
              glycerone phosphate(2-) 0
              glycerone sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      carbon group element atom 20699
                        carbon atom 20693
                          organic molecular entity 20693
                            heteroorganic entity 20202
                              organochalcogen compound 19890
                                organooxygen compound 19792
                                  carbohydrates and carbohydrate derivatives 15420
                                    carbohydrate 15420
                                      monosaccharide 4896
                                        ketose 1035
                                          ketotriose 66
                                            dihydroxyacetone 66
                                              1-hydroxy-3-methoxyacetone 0
                                              1-palmitoylglycerone 3-phosphate 0
                                              1-stearoylglycerone 3-phosphate 0
                                              dihydroxyacetone phosphate 2
                                              glycerone derivative + 2
                                              glycerone phosphate(2-) 0
                                              glycerone sulfate 0
paths to the root