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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dihydroxyacetone
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Accession:CHEBI:16016 term browser browse the term
Definition:A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones.
Synonyms:related_synonym: 1,3-Dihydroxy-2-propanone;   1,3-Dihydroxyacetone;   1,3-Dihydroxydimethyl ketone;   1,3-Dihydroxypropan-2-one;   1,3-Dihydroxypropanone;   1,3-propanediol-2-one;   Bis(hydroxymethyl) ketone;   DHA;   Formula=C3H6O3;   Glycerone;   InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2;   InChIKey=RXKJFZQQPQGTFL-UHFFFAOYSA-N;   SMILES=C(CO)(CO)=O;   alpha,alpha'-dihydroxyacetone
 alt_id: CHEBI:14340;   CHEBI:24354;   CHEBI:39809;   CHEBI:5453
 xref: Beilstein:1740268;   CAS:96-26-4;   DrugBank:DB01775;   HMDB:HMDB0001882;   KEGG:C00184;   KEGG:D07841
 xref_mesh: MESH:D004098
 xref: MetaCyc:DIHYDROXYACETONE;   PDBeChem:2HA;   PMID:20936361;   PMID:21549029;   PMID:21598406;   PMID:23543734;   PMID:23554234;   PMID:23748086;   PMID:24209782;   Reaxys:1740268;   Wikipedia:Dihydroxyacetone


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dihydroxyacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase decreases expression ISO Dihydroxyacetone results in decreased expression of ATM mRNA CTD PMID:32506039 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Dihydroxyacetone results in increased cleavage of CASP3 protein CTD PMID:29193605 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL21 mRNA CTD PMID:32506039 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL3 mRNA CTD PMID:32506039 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Dihydroxyacetone results in decreased expression of CCL4 mRNA CTD PMID:32506039 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccnc cyclin C increases expression ISO Dihydroxyacetone results in increased expression of CCNC mRNA CTD PMID:32506039 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Dihydroxyacetone results in decreased expression of CDKN1A mRNA CTD PMID:32506039 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cel carboxyl ester lipase increases expression ISO Dihydroxyacetone results in increased expression of CEL protein CTD PMID:32506039 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of CHEK2 mRNA CTD PMID:32506039 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO Dihydroxyacetone results in increased expression of CRYAB mRNA; Dihydroxyacetone results in increased expression of CRYAB protein CTD PMID:32506039 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Dihydroxyacetone results in increased expression of CSF2 mRNA CTD PMID:32506039 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP1A1 mRNA CTD PMID:32506039 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP2E1 mRNA CTD PMID:32506039 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Dihydroxyacetone results in decreased expression of CYP7A1 mRNA CTD PMID:32506039 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Dihydroxyacetone results in increased expression of DDIT3 mRNA CTD PMID:32506039 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Dihydroxyacetone results in increased expression of DNAJB4 mRNA CTD PMID:32506039 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Dihydroxyacetone results in increased expression of E2F1 mRNA CTD PMID:32506039 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Egr1 early growth response 1 affects expression ISO Dihydroxyacetone affects the expression of EGR1 mRNA CTD PMID:32506039 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of EIF2S1 protein CTD PMID:32506039 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of EPHX2 mRNA CTD PMID:32506039 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit increases expression ISO Dihydroxyacetone results in increased expression of ERCC3 mRNA CTD PMID:32506039 NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329 		JBrowse link
G Faslg Fas ligand affects expression ISO Dihydroxyacetone affects the expression of FASLG mRNA CTD PMID:32506039 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression ISO Dihydroxyacetone results in decreased expression of FMO1 mRNA CTD PMID:32506039 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Dihydroxyacetone results in decreased expression of GDF15 mRNA CTD PMID:32506039 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Glo1 glyoxalase 1 affects response to substance ISO GLO1 protein affects the susceptibility to Dihydroxyacetone CTD PMID:32506039 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO GPD2 protein inhibits the reaction [Dihydroxyacetone results in increased abundance of alpha-glycerophosphoric acid]; GPD2 protein inhibits the reaction [Dihydroxyacetone results in increased abundance of Glucose-6-Phosphate] CTD PMID:31974165 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Dihydroxyacetone results in increased expression of H2AX protein CTD PMID:32506039 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Dihydroxyacetone results in increased expression of HMOX1 mRNA; Dihydroxyacetone results in increased expression of HMOX1 protein CTD PMID:32506039 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Dihydroxyacetone results in increased expression of HSPA1A mRNA CTD PMID:32506039 NCBI chr20:3,870,765...3,873,221 JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO Dihydroxyacetone results in increased expression of HSPA2 mRNA CTD PMID:32506039 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO Dihydroxyacetone results in increased expression of HSPA6 protein CTD PMID:32506039 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of HSPB1 protein CTD PMID:32506039 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Dihydroxyacetone results in increased expression of HSPD1 mRNA CTD PMID:32506039 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression ISO Dihydroxyacetone results in increased expression of HSPE1 mRNA CTD PMID:32506039 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Il6 interleukin 6 increases expression ISO Dihydroxyacetone results in increased expression of IL6 mRNA CTD PMID:32506039 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of MAPK1 protein CTD PMID:32506039 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Dihydroxyacetone results in increased phosphorylation of MAPK3 protein CTD PMID:32506039 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP10 protein CTD PMID:30959092 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP13 protein CTD PMID:30959092 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mt2A metallothionein 2A decreases expression ISO Dihydroxyacetone results in decreased expression of MT2A mRNA CTD PMID:32506039 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases secretion ISO Dihydroxyacetone results in decreased secretion of MUC5AC protein CTD PMID:30959092 NCBI chr 1:196,864,375...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Dihydroxyacetone results in increased expression of NFE2L2 protein CTD PMID:32506039 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO Dihydroxyacetone results in decreased expression of NFKB1 mRNA CTD PMID:32506039 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Dihydroxyacetone results in decreased expression of NOS2 mRNA CTD PMID:32506039 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Dihydroxyacetone results in increased cleavage of PARP1 protein CTD PMID:29193605 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Dihydroxyacetone results in increased expression of PCNA mRNA CTD PMID:32506039 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pklr pyruvate kinase L/R multiple interactions EXP 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile inhibits the reaction [Dihydroxyacetone results in increased expression of PKLR mRNA] CTD PMID:31974165 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048] CTD PMID:31974165 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048]] which results in decreased abundance of Adenosine Triphosphate; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to [Dihydroxyacetone co-treated with S 4048] CTD PMID:31974165 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Dihydroxyacetone results in increased expression of TNF mRNA CTD PMID:32506039 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression ISO Dihydroxyacetone affects the expression of TNFRSF1A mRNA CTD PMID:32506039 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO Dihydroxyacetone results in decreased expression of TNFSF10 mRNA CTD PMID:32506039 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO Dihydroxyacetone results in decreased expression of UNG mRNA CTD PMID:32506039 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Xrcc2 X-ray repair cross complementing 2 increases expression ISO Dihydroxyacetone results in increased expression of XRCC2 mRNA; Dihydroxyacetone results in increased expression of XRCC2 protein CTD PMID:32506039 NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482 		JBrowse link
dihydroxyacetone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]		 CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Tpi1 triosephosphate isomerase 1 affects metabolic processing EXP TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate CTD PMID:14762718 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          metabolite 19486
            dihydroxyacetone 57
              1-hydroxy-3-methoxyacetone 0
              1-palmitoylglycerone 3-phosphate 0
              1-stearoylglycerone 3-phosphate 0
              dihydroxyacetone phosphate 2
              glycerone derivative + 2
              glycerone phosphate(2-) 0
              glycerone sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      ketone 17140
                                        oxyketone 8803
                                          alpha-oxyketone 8803
                                            alpha-hydroxy ketone 8803
                                              primary alpha-hydroxy ketone 7680
                                                dihydroxyacetone 57
                                                  1-hydroxy-3-methoxyacetone 0
                                                  1-palmitoylglycerone 3-phosphate 0
                                                  1-stearoylglycerone 3-phosphate 0
                                                  dihydroxyacetone phosphate 2
                                                  glycerone derivative + 2
                                                  glycerone phosphate(2-) 0
                                                  glycerone sulfate 0
paths to the root