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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydroxyacetone
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Accession:CHEBI:16016 term browser browse the term
Definition:A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones.
Synonyms:related_synonym: 1,3-Dihydroxy-2-propanone;   1,3-Dihydroxyacetone;   1,3-Dihydroxydimethyl ketone;   1,3-Dihydroxypropan-2-one;   1,3-Dihydroxypropanone;   1,3-propanediol-2-one;   Bis(hydroxymethyl) ketone;   DHA;   Formula=C3H6O3;   Glycerone;   InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2;   InChIKey=RXKJFZQQPQGTFL-UHFFFAOYSA-N;   SMILES=C(CO)(CO)=O;   alpha,alpha'-dihydroxyacetone
 alt_id: CHEBI:14340;   CHEBI:24354;   CHEBI:39809;   CHEBI:5453
 xref: Beilstein:1740268;   CAS:96-26-4;   DrugBank:DB01775;   HMDB:HMDB0001882;   KEGG:C00184;   KEGG:D07841
 xref_mesh: MESH:D004098
 xref: MetaCyc:DIHYDROXYACETONE;   PDBeChem:2HA;   PMID:20936361;   PMID:21549029;   PMID:21598406;   PMID:23543734;   PMID:23554234;   PMID:23748086;   PMID:24209782;   Reaxys:1740268;   Wikipedia:Dihydroxyacetone


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dihydroxyacetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO Dihydroxyacetone results in increased cleavage of CASP3 protein CTD PMID:29193605 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP10 protein CTD PMID:30959092 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases secretion ISO Dihydroxyacetone results in decreased secretion of MMP13 protein CTD PMID:30959092 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming decreases secretion ISO Dihydroxyacetone results in decreased secretion of MUC5AC protein CTD PMID:30959092 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Dihydroxyacetone inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Dihydroxyacetone results in increased cleavage of PARP1 protein CTD PMID:29193605 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
dihydroxyacetone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]
CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects metabolic processing EXP TPI1 protein affects the metabolism of Dihydroxyacetone Phosphate CTD PMID:14762718 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            dihydroxyacetone 8
              1-hydroxy-3-methoxyacetone 0
              1-palmitoylglycerone 3-phosphate 0
              1-stearoylglycerone 3-phosphate 0
              dihydroxyacetone phosphate 2
              glycerone derivative + 2
              glycerone phosphate(2-) 0
              glycerone sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxyketone 8629
                                          alpha-oxyketone 8629
                                            alpha-hydroxy ketone 8629
                                              primary alpha-hydroxy ketone 7514
                                                dihydroxyacetone 8
                                                  1-hydroxy-3-methoxyacetone 0
                                                  1-palmitoylglycerone 3-phosphate 0
                                                  1-stearoylglycerone 3-phosphate 0
                                                  dihydroxyacetone phosphate 2
                                                  glycerone derivative + 2
                                                  glycerone phosphate(2-) 0
                                                  glycerone sulfate 0
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