INS (insulin) - Rat Genome Database

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Gene: INS (insulin) Canis lupus familiaris
Analyze
Symbol: INS
Name: insulin
RGD ID: 12370161
Description: ENCODES a protein that exhibits insulin receptor binding (ortholog); zinc ion binding (ortholog); INVOLVED IN ER overload response (ortholog); glucose homeostasis (ortholog); glucose metabolic process (ortholog); PARTICIPATES IN altered insulin signaling pathway; forkhead class A signaling pathway; gliclazide pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); adenoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog); INTERACTS WITH aldehydo-D-glucose; colforsin daropate hydrochloride; corticotropin
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,324,047 - 46,324,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,324,041 - 46,325,122 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,933,843 - 44,934,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,003,520 - 47,004,406 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,003,520 - 47,004,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,452,280 - 46,453,156 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,032,597 - 46,033,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,779,045 - 46,779,926 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
bipolar disorder  (ISO)
bladder disease  (ISO)
cardiac arrest  (ISO)
cholangiocarcinoma  (ISO)
cognitive disorder  (ISO)
congestive heart failure  (ISO)
cystic kidney disease  (ISO)
delta beta-thalassemia  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic ketoacidosis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease of metabolism  (ISO)
early infantile epileptic encephalopathy  (ISO)
Edema  (ISO)
Experimental Liver Cirrhosis  (ISO)
fatty liver disease  (ISO)
generalized dystonia  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperkalemia  (ISO)
Hyperproinsulinemia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hyperuricemia  (ISO)
hypoglycemia  (ISO)
Hypoinsulinemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
immunodeficiency 39  (ISO)
Insulin Resistance  (ISO)
insulinoma  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Lewy body dementia  (ISO)
liver disease  (ISO)
maturity-onset diabetes of the young  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 10  (ISO)
Memory Disorders  (ISO)
Metabolic Syndrome  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
MPTP Poisoning  (ISO)
muscular disease  (ISO)
neonatal diabetes  (ISO)
Neoplasm Invasiveness  (ISO)
neural tube defect  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
panic disorder  (ISO)
Paralysis  (ISO)
Paresthesia  (ISO)
Parkinson's disease  (ISO)
permanent neonatal diabetes mellitus  (ISO)
Permanent Neonatal Diabetes Mellitus 4  (ISO)
Phelan-McDermid syndrome  (ISO)
polycystic ovary syndrome  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Rhabdomyolysis  (ISO)
Segawa Syndrome, Autosomal Recessive  (ISO)
Tachycardia  (ISO)
transient neonatal diabetes mellitus  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 2  (ISO)
type 2 diabetes mellitus  (ISO)
Type 2 Diabetes Mellitus 1  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Outflow Obstruction  (ISO)
visual epilepsy  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IEA)
acute-phase response  (IEA)
alpha-beta T cell activation  (IEA)
carbohydrate metabolic process  (IEA)
ER overload response  (ISO)
fatty acid homeostasis  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
glucose homeostasis  (IBA,IEA,ISO)
glucose metabolic process  (IEA,ISO)
glycoprotein biosynthetic process  (ISO)
insulin processing  (ISO)
insulin receptor signaling pathway  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
lactate biosynthetic process  (ISO)
lipid biosynthetic process  (ISO)
lipid catabolic process  (ISO)
lipoprotein biosynthetic process  (ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of acute inflammatory response  (IEA)
negative regulation of fatty acid metabolic process  (IEA)
negative regulation of feeding behavior  (IEA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glycogen catabolic process  (IEA)
negative regulation of lipid catabolic process  (IEA)
negative regulation of NAD(P)H oxidase activity  (IEA)
negative regulation of protein catabolic process  (IEA)
negative regulation of protein secretion  (IEA)
negative regulation of proteolysis  (IEA)
negative regulation of reactive oxygen species biosynthetic process  (IEA)
negative regulation of respiratory burst involved in inflammatory response  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron projection maintenance  (IEA)
nitric oxide-cGMP-mediated signaling pathway  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of cytokine production  (IEA)
positive regulation of dendritic spine maintenance  (IEA)
positive regulation of DNA replication  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of glucose import  (IEA)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (IEA)
positive regulation of glycolytic process  (IEA)
positive regulation of insulin receptor signaling pathway  (IEA)
positive regulation of lipoprotein lipase activity  (ISO)
positive regulation of MAPK cascade  (IEA)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of nitric oxide mediated signal transduction  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein kinase B signaling  (IEA)
positive regulation of protein localization to nucleus  (IEA)
positive regulation of protein metabolic process  (IEA)
positive regulation of protein secretion  (IBA)
positive regulation of respiratory burst  (IEA)
protein hexamerization  (ISO)
receptor internalization  (ISO)
regulation of cellular amino acid metabolic process  (IEA)
regulation of gene expression  (ISO)
regulation of phosphorylation  (ISO)
regulation of protein binding  (ISO)
regulation of protein localization  (IEA)
regulation of protein localization to plasma membrane  (IEA)
regulation of protein secretion  (IEA)
regulation of transmembrane transporter activity  (IEA)
signal transduction  (IEA)
vasodilation  (IEA)
wound healing  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:5949593   PMID:6296142   PMID:19755527   PMID:22381588  


Genomics

Comparative Map Data
INS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,324,047 - 46,324,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,324,041 - 46,325,122 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,933,843 - 44,934,720 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,003,520 - 47,004,406 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,003,520 - 47,004,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,452,280 - 46,453,156 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,032,597 - 46,033,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,779,045 - 46,779,926 (-)NCBIUU_Cfam_GSD_1.0
INS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,159,779 - 2,161,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl112,159,779 - 2,161,221 (-)EnsemblGRCh38hg38GRCh38
GRCh37112,181,009 - 2,182,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,137,585 - 2,139,015 (-)NCBINCBI36Build 36hg18NCBI36
Build 34112,137,584 - 2,139,000NCBI
Celera112,217,516 - 2,218,946 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,971,272 - 1,972,702 (-)NCBIHuRef
CHM1_1112,179,957 - 2,181,387 (-)NCBICHM1_1
T2T-CHM13v2.0112,247,427 - 2,248,857 (-)NCBIT2T-CHM13v2.0
Ins2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,232,393 - 142,233,463 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,232,393 - 142,297,118 (-)EnsemblGRCm39 Ensembl
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,678,656 - 142,743,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBIMGSCv36mm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.0NCBI
Ins2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21197,843,277 - 197,992,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,843,281 - 197,864,775 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,216,147 - 206,217,214 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01213,302,063 - 213,303,130 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01205,976,222 - 205,977,289 (-)NCBIRnor_WKY
Rnor_6.01215,856,967 - 215,858,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,856,971 - 215,858,034 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,751,786 - 222,756,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,935,548 - 202,936,379 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,123,613 - 203,124,445 (-)NCBI
Celera1195,461,309 - 195,462,376 (-)NCBICelera
Cytogenetic Map1q41NCBI
Ins
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,909,407 - 13,910,419 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542213,909,408 - 13,910,419 (-)NCBIChiLan1.0ChiLan1.0
INS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,230,309 - 2,231,666 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,218,117 - 2,231,666 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0112,200,785 - 2,202,579 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Ins
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,748,017 - 1,749,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368161,002,137 - 1,003,357 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049368161,002,137 - 1,003,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,496,842 - 1,497,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,496,842 - 1,498,052 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
INS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,965,128 - 1,969,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603899,163,059 - 99,164,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ins
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,999,088 - 15,000,035 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476714,999,088 - 15,000,035 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in INS
8 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system respiratory system
High
Medium
Low 2 1
Below cutoff 8 6 4 6 3 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016041   ⟹   ENSCAFP00000014836
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1846,324,047 - 46,324,938 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000083211   ⟹   ENSCAFP00000051648
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1846,324,041 - 46,325,122 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845019762   ⟹   ENSCAFP00845015468
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1847,003,520 - 47,004,411 (-)Ensembl
RefSeq Acc Id: NM_001130093   ⟹   NP_001123565
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11846,324,047 - 46,324,933 (-)NCBI
Dog10K_Boxer_Tasha1844,933,843 - 44,934,720 (-)NCBI
ROS_Cfam_1.01847,003,520 - 47,004,406 (-)NCBI
UMICH_Zoey_3.11846,452,280 - 46,453,156 (-)NCBI
UNSW_CanFamBas_1.01846,032,597 - 46,033,483 (-)NCBI
UU_Cfam_GSD_1.01846,779,045 - 46,779,926 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001123565 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein P01321 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001123565   ⟸   NM_001130093
- Peptide Label: precursor
- UniProtKB: P01321 (UniProtKB/Swiss-Prot),   A0A8C0R307 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000051648   ⟸   ENSCAFT00000083211
RefSeq Acc Id: ENSCAFP00000014836   ⟸   ENSCAFT00000016041
RefSeq Acc Id: ENSCAFP00845015468   ⟸   ENSCAFT00845019762
Protein Domains
IlGF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010092 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030017808 UniProtKB/TrEMBL
  ENSCAFG00805009726 UniProtKB/Swiss-Prot
  ENSCAFG00845011141 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00000014836 UniProtKB/Swiss-Prot
  ENSCAFP00030028655.1 UniProtKB/TrEMBL
  ENSCAFP00030028701.1 UniProtKB/TrEMBL
  ENSCAFP00805014034 UniProtKB/Swiss-Prot
  ENSCAFP00845015468 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000016041 UniProtKB/Swiss-Prot
  ENSCAFT00030032848.1 UniProtKB/TrEMBL
  ENSCAFT00030032901.1 UniProtKB/TrEMBL
  ENSCAFT00805017844 UniProtKB/Swiss-Prot
  ENSCAFT00845019762 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Insulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:483665 UniProtKB/Swiss-Prot
NCBI Gene INS ENTREZGENE
PANTHER PTHR11454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Insulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INSULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSULINFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IlGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0NNU2_CANLF UniProtKB/TrEMBL
  A0A8C0NTT6_CANLF UniProtKB/TrEMBL
  A0A8C0R307 ENTREZGENE
  INS_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:97204 ENTREZGENE