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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5,6,7,8-tetrahydrofolic acid
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Accession:CHEBI:20506 term browser browse the term
Definition:A tetrahydrofolic acid that has formula C19H23N7O6.
Synonyms:exact_synonym: N-[4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl]-L-glutamic acid
 related_synonym: (6S)-THFA;   (6S)-Tetrahydrofolate;   (6S)-Tetrahydrofolic acid;   5,6,7,8-Tetrahydrofolate;   Formula=C19H23N7O6;   InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1;   InChIKey=MSTNYGQPCMXVAQ-KIYNQFGBSA-N;   SMILES=Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Nc2c(=O)[nH]1;   THF;   tetrahydrofolate;   tetrahydrofolic acid
 xref: Beilstein:101189;   CAS:135-16-0;   DrugBank:DB00116;   KEGG:C00101;   KNApSAcK:C00007249
 xref_mesh: MESH:C030371
 cyclic_relationship: is_conjugate_acid_of CHEBI:68437


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5,6,7,8-tetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases chemical synthesis ISO ALDH1L2 protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acid CTD PMID:21238436 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO 5,6,7,8-tetrahydrofolic acid results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP 5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
5,6,7,8-tetrahydrofolic acid results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Tyms thymidylate synthetase increases activity EXP 5,6,7,8-tetrahydrofolic acid results in increased activity of TYMS protein CTD PMID:187325 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              fungal metabolite 17444
                Saccharomyces cerevisiae metabolite 16509
                  5,6,7,8-tetrahydrofolic acid 6
                    (6S)-5,6,7,8-tetrahydrofolic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        amino acid 14879
                                          alpha-amino acid 12854
                                            L-alpha-amino acid 11559
                                              glutamine family amino acid 10263
                                                L-glutamic acid 10208
                                                  L-glutamic acid derivative 9369
                                                    folic acids 9369
                                                      tetrahydrofolic acid 66
                                                        5,6,7,8-tetrahydrofolic acid 6
                                                          (6S)-5,6,7,8-tetrahydrofolic acid 0
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