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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,6,7,8-tetrahydrofolic acid
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Accession:CHEBI:20506 term browser browse the term
Definition:A tetrahydrofolic acid that has formula C19H23N7O6.
Synonyms:exact_synonym: N-[4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl]-L-glutamic acid
 related_synonym: (6S)-THFA;   (6S)-Tetrahydrofolate;   (6S)-Tetrahydrofolic acid;   5,6,7,8-Tetrahydrofolate;   Formula=C19H23N7O6;   InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1;   InChIKey=MSTNYGQPCMXVAQ-KIYNQFGBSA-N;   SMILES=Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Nc2c(=O)[nH]1;   THF;   Tetrahydrofolic acid;   tetrahydrofolate
 xref: Beilstein:101189;   CAS:135-16-0;   DrugBank:DB00116;   KEGG:C00101;   KNApSAcK:C00007249
 xref_mesh: MESH:C030371
 cyclic_relationship: is_conjugate_acid_of CHEBI:68437


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5,6,7,8-tetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases chemical synthesis ISO ALDH1L2 protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acid CTD PMID:21238436 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:22,141,842...22,193,398 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:95,221,314...95,224,780 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO 5,6,7,8-tetrahydrofolic acid results in decreased expression of IGF1R mRNA CTD PMID:16728583 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO 5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr17:62,911,705...62,996,544
Ensembl chr17:62,911,771...62,996,541 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity 		EXP 5,6,7,8-tetrahydrofolic acid inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
5,6,7,8-tetrahydrofolic acid results in decreased activity of SLC19A1 protein 		CTD PMID:14612385 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,583,929...11,601,488 		JBrowse link
G Tyms thymidylate synthetase increases activity EXP 5,6,7,8-tetrahydrofolic acid results in increased activity of TYMS protein CTD PMID:187325 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097 		JBrowse link
5-methyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 decreases abundance ISO ALDH1L1 protein results in decreased abundance of 5-methyltetrahydrofolate CTD PMID:16627483 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:124,617,217...124,664,704 		JBrowse link
G Folr1 folate receptor alpha increases uptake ISO FOLR1 protein results in increased uptake of 5-methyltetrahydrofolate CTD PMID:17473184 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:165,631,462...165,642,669 		JBrowse link
G Gnmt glycine N-methyltransferase affects binding EXP GNMT protein binds to 5-methyltetrahydrofolate CTD PMID:17158459 NCBI chr 9:21,752,235...21,756,368
Ensembl chr 9:21,752,266...21,755,692 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases chemical synthesis ISO MTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate CTD PMID:7647779 PMID:9719624 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding ISO 5-methyltetrahydrofolate binds to MTR protein CTD PMID:17477549 NCBI chr17:62,911,705...62,996,544
Ensembl chr17:62,911,771...62,996,541 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance ISO MTRR protein affects the abundance of 5-methyltetrahydrofolate CTD PMID:17369066 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:36,695,460...36,727,807 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [Docosahexaenoic Acids co-treated with 5-methyltetrahydrofolate] results in increased expression of PCNA protein CTD PMID:16870008 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity 		ISO
EXP 		[5-methyltetrahydrofolate results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid
5-methyltetrahydrofolate inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate] 		CTD PMID:14612385 PMID:17034785 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,583,929...11,601,488 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity 		ISO 5-methyltetrahydrofolate inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
5-methyltetrahydrofolate results in decreased activity of SLC46A1 protein 		CTD PMID:17475902 NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO 5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]; dorsomorphin inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]] CTD PMID:26400185 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            eukaryotic metabolite 19958
              fungal metabolite 18288
                Saccharomyces cerevisiae metabolite 17831
                  5,6,7,8-tetrahydrofolic acid 14
                    (6S)-5,6,7,8-tetrahydrofolic acid 0
                    5-methyltetrahydrofolic acid + 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino acid 16340
                                          alpha-amino acid 14255
                                            L-alpha-amino acid 12393
                                              glutamine family amino acid 10355
                                                L-glutamic acid 10288
                                                  L-glutamic acid derivative 9440
                                                    folic acids 9440
                                                      tetrahydrofolic acid 69
                                                        5,6,7,8-tetrahydrofolic acid 14
                                                          (6S)-5,6,7,8-tetrahydrofolic acid 0
                                                          5-methyltetrahydrofolic acid + 10
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