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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-furoic acid
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Accession:CHEBI:30845 term browser browse the term
Definition:A furoic acid having the carboxylic acid group located at position 2.
Synonyms:exact_synonym: furan-2-carboxylic acid
 related_synonym: 2-Furancarboxylic acid;   2-carboxyfuran;   2-furanoic acid;   Formula=C5H4O3;   Furan-2-carbonsaeure;   InChI=1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7);   InChIKey=SMNDYUVBFMFKNZ-UHFFFAOYSA-N;   Pyromucic acid;   SMILES=OC(=O)C1=CC=CO1;   acide 2-furoique;   acido 2-furoico;   alpha-furancarboxylic acid;   alpha-furoic acid
 alt_id: CHEBI:1101;   CHEBI:19583;   CHEBI:42470
 xref: CAS:88-14-2;   Chemspider:10251740;   FooDB:FDB000951;   Gmelin:3056;   HMDB:HMDB0000617;   KEGG:C01546;   KNApSAcK:C00000151;   PDBeChem:FOA;   PMID:12587683;   PMID:16306695;   PMID:18492059;   PMID:19938546;   PMID:20393580;   PMID:22031465;   PMID:23421908;   PMID:26378464;   PMID:29097752;   Reaxys:110149;   Wikipedia:2-Furoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:16739



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5-(tetradecyloxy)-2-furoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO 5-(tetradecyloxy)-2-furancarboxylic acid inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:55,164,721...55,170,289 JBrowse link
mometasone furoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon] CTD PMID:16442095 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mometasone Furoate results in increased activity of ABCG2 protein
CTD PMID:16442095 NCBI chr 4:89,006,056...89,132,915 JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr10:38,887,692...38,889,673 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mometasone Furoate results in decreased activity of CYP2C8 protein CTD PMID:15601807
G F3 coagulation factor III, tissue factor increases expression ISO Mometasone Furoate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:212,511,675...212,523,375 JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Mometasone Furoate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:110,076,710...110,103,665 JBrowse link
G Il10 interleukin 10 decreases secretion ISO Mometasone Furoate results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein] CTD PMID:19422381 NCBI chr10:29,390,300...29,405,194 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP
ISO
Mometasone Furoate binds to NR3C1 protein CTD PMID:16507850 PMID:19422381 NCBI chr18:31,522,783...31,644,508 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding ISO Mometasone Furoate binds to NR3C2 protein CTD PMID:19422381 NCBI chr19:47,619,853...47,964,089 JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding
ISO Mometasone Furoate binds to and results in increased activity of PGR protein
Mometasone Furoate binds to PGR protein
CTD PMID:15189034 PMID:19422381 NCBI chr 8:14,354,398...14,413,271 JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr14:5,613,569...5,620,695 JBrowse link
G Tat tyrosine aminotransferase increases activity ISO Mometasone Furoate results in increased activity of TAT protein CTD PMID:19422381 NCBI chr19:37,947,153...37,957,717 JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO Mometasone Furoate results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr 3:167,192,612...167,221,845 JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Mometasone Furoate results in decreased secretion of TNF protein
CTD PMID:9819297 PMID:10100995 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:206,723,050...206,742,783 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        inhibitor 18949
          2-furoic acid 18
            2-Phenylethyl 2-furancarboxylate 0
            2-Propenyl 2-furancarboxylate 0
            2-furancarboxylic acid (2-acetyl-1-benzothiophen-3-yl) ester 0
            2-furoate ester + 17
            2-furoyl-CoA + 0
            4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (5-methoxycarbonyl-2-furanyl)methyl ester 0
            5-(tetradecyloxy)-2-furoic acid 1
            5-Bromopyridin-3-yl furan-2-carboxylate 0
            5-Chloro-3-pyridinyl 2-furoate 0
            5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate 0
            5-[[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]methyl]-2-furancarboxylic acid methyl ester 0
            5-[[[(5-tert-butyl-2-methyl-3-furanyl)-oxomethyl]amino]methyl]-2-furancarboxylic acid ethyl ester 0
            5-bromo-2-furancarboxylic acid [2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester 0
            5-nitro-2-furancarboxylic acid (5-phenyl-1,3,4-oxadiazol-2-yl)methyl ester 0
            Amyl 2-furoate 0
            Asperfuran A 0
            Dimethyl 3,4-dihydroxyfuran-2,5-dicarboxylate 0
            Epoxydine B 0
            Ethyl 2-phenyl-3-furancarboxylate 0
            Ethyl 3-furoate 0
            Ethyl furoate 0
            GNF5343 0
            HS071 0
            Hexyl 2-furoate 0
            Isoamyl 2-furoate 0
            LSM-26546 0
            Methyl 2-Furancarboxylate 0
            Methyl 5-nitro-2-furoate 0
            N-(2-furoyl)glycine 0
            N-2-furoyl-L-leucine 0
            Octyl 2-furoate 0
            Propyl 2-furoate 0
            Robillafuran 0
            [(1R)-1-\{[N-(furan-2-ylcarbonyl)-L-leucyl]amino\}-2-(1H-indol-3-yl)ethyl]phosphonic acid 0
            methyl 5-(hydroxymethyl) furan-2-carboxylate 0
            methyl 5-\{[2-(ethoxycarbonyl)-3-oxohex-1-enyl]amino\}-2-furoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      monocarboxylic acid 18028
                                        furoic acid 18
                                          2-furoic acid 18
                                            2-Phenylethyl 2-furancarboxylate 0
                                            2-Propenyl 2-furancarboxylate 0
                                            2-furancarboxylic acid (2-acetyl-1-benzothiophen-3-yl) ester 0
                                            2-furoate ester + 17
                                            2-furoyl-CoA + 0
                                            4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (5-methoxycarbonyl-2-furanyl)methyl ester 0
                                            5-(tetradecyloxy)-2-furoic acid 1
                                            5-Bromopyridin-3-yl furan-2-carboxylate 0
                                            5-Chloro-3-pyridinyl 2-furoate 0
                                            5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate 0
                                            5-[[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]methyl]-2-furancarboxylic acid methyl ester 0
                                            5-[[[(5-tert-butyl-2-methyl-3-furanyl)-oxomethyl]amino]methyl]-2-furancarboxylic acid ethyl ester 0
                                            5-bromo-2-furancarboxylic acid [2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester 0
                                            5-nitro-2-furancarboxylic acid (5-phenyl-1,3,4-oxadiazol-2-yl)methyl ester 0
                                            Amyl 2-furoate 0
                                            Asperfuran A 0
                                            Dimethyl 3,4-dihydroxyfuran-2,5-dicarboxylate 0
                                            Epoxydine B 0
                                            Ethyl 2-phenyl-3-furancarboxylate 0
                                            Ethyl 3-furoate 0
                                            Ethyl furoate 0
                                            GNF5343 0
                                            HS071 0
                                            Hexyl 2-furoate 0
                                            Isoamyl 2-furoate 0
                                            LSM-26546 0
                                            Methyl 2-Furancarboxylate 0
                                            Methyl 5-nitro-2-furoate 0
                                            N-(2-furoyl)glycine 0
                                            N-2-furoyl-L-leucine 0
                                            Octyl 2-furoate 0
                                            Propyl 2-furoate 0
                                            Robillafuran 0
                                            [(1R)-1-\{[N-(furan-2-ylcarbonyl)-L-leucyl]amino\}-2-(1H-indol-3-yl)ethyl]phosphonic acid 0
                                            methyl 5-(hydroxymethyl) furan-2-carboxylate 0
                                            methyl 5-\{[2-(ethoxycarbonyl)-3-oxohex-1-enyl]amino\}-2-furoate 0
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