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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-furoic acid
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Accession:CHEBI:30845 term browser browse the term
Definition:A furoic acid having the carboxylic acid group located at position 2.
Synonyms:exact_synonym: furan-2-carboxylic acid
 related_synonym: 2-Furancarboxylic acid;   2-carboxyfuran;   2-furanoic acid;   Formula=C5H4O3;   Furan-2-carbonsaeure;   InChI=1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7);   InChIKey=SMNDYUVBFMFKNZ-UHFFFAOYSA-N;   Pyromucic acid;   SMILES=OC(=O)C1=CC=CO1;   acide 2-furoique;   acido 2-furoico;   alpha-furancarboxylic acid;   alpha-furoic acid
 alt_id: CHEBI:1101;   CHEBI:19583;   CHEBI:42470
 xref: Beilstein:110149;   CAS:88-14-2;   Chemspider:10251740;   FooDB:FDB000951;   Gmelin:3056;   HMDB:HMDB0000617;   KEGG:C01546;   KNApSAcK:C00000151;   PDBeChem:FOA;   PMID:12587683;   PMID:16306695;   PMID:18492059;   PMID:19938546;   PMID:20393580;   PMID:22031465;   PMID:23421908;   PMID:26378464;   PMID:29097752;   Reaxys:110149;   Wikipedia:2-Furoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:16739


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5-(tetradecyloxy)-2-furoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO 5-(tetradecyloxy)-2-furancarboxylic acid inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
mometasone furoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon] CTD PMID:16442095 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mometasone Furoate results in increased activity of ABCG2 protein
CTD PMID:16442095 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Mometasone Furoate results in decreased activity of CYP2C8 protein CTD PMID:15601807
G F3 coagulation factor III, tissue factor increases expression ISO Mometasone Furoate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Mometasone Furoate results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Mometasone Furoate inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL12B protein] CTD PMID:19422381 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Mometasone Furoate inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein] CTD PMID:10460758 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding EXP
ISO
Mometasone Furoate binds to NR3C1 protein CTD PMID:16507850 PMID:19422381 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding ISO Mometasone Furoate binds to NR3C2 protein CTD PMID:19422381 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pgr progesterone receptor multiple interactions
affects binding
ISO Mometasone Furoate binds to and results in increased activity of PGR protein
Mometasone Furoate binds to PGR protein
CTD PMID:15189034 PMID:19422381 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Mometasone Furoate results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tat tyrosine aminotransferase increases activity ISO Mometasone Furoate results in increased activity of TAT protein CTD PMID:19422381 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO Mometasone Furoate results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Mometasone Furoate results in decreased secretion of TNF protein
CTD PMID:9819297 PMID:10100995 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mometasone Furoate inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        inhibitor 18592
          2-furoic acid 17
            2-Phenylethyl 2-furancarboxylate 0
            2-Propenyl 2-furancarboxylate 0
            2-furancarboxylic acid (2-acetyl-1-benzothiophen-3-yl) ester 0
            2-furoate ester + 16
            2-furoyl-CoA + 0
            4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (5-methoxycarbonyl-2-furanyl)methyl ester 0
            5-(tetradecyloxy)-2-furoic acid 1
            5-Bromopyridin-3-yl furan-2-carboxylate 0
            5-Chloro-3-pyridinyl 2-furoate 0
            5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate 0
            5-[[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]methyl]-2-furancarboxylic acid methyl ester 0
            5-[[[(5-tert-butyl-2-methyl-3-furanyl)-oxomethyl]amino]methyl]-2-furancarboxylic acid ethyl ester 0
            5-bromo-2-furancarboxylic acid [2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester 0
            5-nitro-2-furancarboxylic acid (5-phenyl-1,3,4-oxadiazol-2-yl)methyl ester 0
            Amyl 2-furoate 0
            Ethyl 2-phenyl-3-furancarboxylate 0
            Ethyl furoate 0
            GNF5343 0
            Hexyl 2-furoate 0
            LSM-26546 0
            Methyl 2-Furancarboxylate 0
            N-(2-furoyl)glycine 0
            N-2-furoyl-L-leucine 0
            Octyl 2-furoate 0
            Propyl 2-furoate 0
            [(1R)-1-\{[N-(furan-2-ylcarbonyl)-L-leucyl]amino\}-2-(1H-indol-3-yl)ethyl]phosphonic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          furoic acid 17
                                            2-furoic acid 17
                                              2-Phenylethyl 2-furancarboxylate 0
                                              2-Propenyl 2-furancarboxylate 0
                                              2-furancarboxylic acid (2-acetyl-1-benzothiophen-3-yl) ester 0
                                              2-furoate ester + 16
                                              2-furoyl-CoA + 0
                                              4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (5-methoxycarbonyl-2-furanyl)methyl ester 0
                                              5-(tetradecyloxy)-2-furoic acid 1
                                              5-Bromopyridin-3-yl furan-2-carboxylate 0
                                              5-Chloro-3-pyridinyl 2-furoate 0
                                              5-Chloropyridin-3-yl 5-(4-chlorophenyl)furan-2-carboxylate 0
                                              5-[[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]methyl]-2-furancarboxylic acid methyl ester 0
                                              5-[[[(5-tert-butyl-2-methyl-3-furanyl)-oxomethyl]amino]methyl]-2-furancarboxylic acid ethyl ester 0
                                              5-bromo-2-furancarboxylic acid [2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester 0
                                              5-nitro-2-furancarboxylic acid (5-phenyl-1,3,4-oxadiazol-2-yl)methyl ester 0
                                              Amyl 2-furoate 0
                                              Ethyl 2-phenyl-3-furancarboxylate 0
                                              Ethyl furoate 0
                                              GNF5343 0
                                              Hexyl 2-furoate 0
                                              LSM-26546 0
                                              Methyl 2-Furancarboxylate 0
                                              N-(2-furoyl)glycine 0
                                              N-2-furoyl-L-leucine 0
                                              Octyl 2-furoate 0
                                              Propyl 2-furoate 0
                                              [(1R)-1-\{[N-(furan-2-ylcarbonyl)-L-leucyl]amino\}-2-(1H-indol-3-yl)ethyl]phosphonic acid 0
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