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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metamizole sodium
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Accession:CHEBI:59033 term browser browse the term
Definition:An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.
Synonyms:exact_synonym: sodium [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
 related_synonym: Algocalmin;   Analgin;   Analgin (sodium salt);   Dipyrone;   Formula=C13H16N3NaO4S;   InChI=1S/C13H17N3O4S.Na/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h4-8H,9H2,1-3H3,(H,18,19,20);/q;+1/p-1;   InChIKey=DJGAAPFSPWAYTJ-UHFFFAOYSA-M;   Methampyrone;   Methylmelubrin;   Mexican aspirin;   Neomelurbrin;   Noraminophenazone methanesulfonate sodium salt;   Noraminophenazone sodium mesylate;   Novalgin;   SMILES=[Na+].CN(CS([O-])(=O)=O)c1c(C)n(C)n(-c2ccccc2)c1=O;   Sodium (antipyrinylmethylamino)methanesulfonate;   Sodium methylaminoantipyrine methanesulfonate;   Sodium noramidopyrine methanesulfonate;   Sulpyrine;   Vetalgin;   aminopyrine sodium sulfonate;   dipyrone [anhydrous];   meamizol sodico;   metamizole sodique;   metamizolum natricum
 xref: CAS:68-89-3;   DrugBank:DB04817;   KEGG:D08190
 xref_mesh: MESH:D004177
 xref: PMID:15012736;   PMID:15137974;   PMID:15595715;   PMID:15851637;   PMID:16752674;   PMID:17435797;   PMID:21446784;   PMID:25776531;   PMID:25789542;   PMID:3044874;   PMID:3425858;   Reaxys:3643594;   Wikipedia:Metamizole


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Dipyrone results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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  CHEBI ontology 221
    role 221
      application 189
        pro-agent 17
          prodrug 17
            metamizole sodium 1
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  CHEBI ontology 221
    subatomic particle 221
      composite particle 221
        hadron 221
          baryon 221
            nucleon 221
              atomic nucleus 221
                atom 221
                  main group element atom 214
                    p-block element atom 214
                      chalcogen 183
                        oxygen atom 181
                          oxygen molecular entity 181
                            oxide 15
                              oxoanion 6
                                chalcogen oxoanion 1
                                  sulfur oxoanion 1
                                    sulfonate 1
                                      organosulfonate oxoanion 1
                                        metamizole(1-) 1
                                          metamizole sodium 1
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