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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methanethiol
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Accession:CHEBI:16007 term browser browse the term
Definition:An alkanethiol that has formula CH4S.
Synonyms:related_synonym: Formula=CH4S;   InChI=1S/CH4S/c1-2/h2H,1H3;   InChIKey=LSDPWZHWYPCBBB-UHFFFAOYSA-N;   Methylmercaptan;   SMILES=CS
 alt_id: CHEBI:14586;   CHEBI:25225;   CHEBI:6814
 xref: CAS:74-93-1;   KEGG:C00409;   KNApSAcK:C00001258
 xref_mesh: MESH:C005231
 xref: PDBeChem:MEE;   UM-BBD_compID:c0238


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methanethiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Selenbp1 selenium binding protein 1 increases metabolic processing
decreases metabolic processing 		ISO SELENBP1 protein results in increased metabolism of methylmercaptan
SELENBP1 gene mutant form results in decreased metabolism of methylmercaptan 		CTD PMID:29255262 NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594 		JBrowse link
S-methyl methanethiosulfonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]; methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]; methyl methanethiosulfonate inhibits the reaction [NR3C1 protein binds to dexamethasone oxetanone] CTD PMID:1597467 PMID:2226332 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP methyl methanethiosulfonate inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]] CTD PMID:19793987 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891 		JBrowse link
G Pgr progesterone receptor decreases activity ISO methyl methanethiosulfonate results in decreased activity of PGR protein CTD PMID:9879984 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
thioridazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Thioridazine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Thioridazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Thioridazine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Casp3 caspase 3 increases activity ISO Thioridazine results in increased activity of CASP3 protein CTD PMID:21035837 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Thioridazine results in decreased expression of CCND1 protein CTD PMID:21035837 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdc25a cell division cycle 25A increases phosphorylation ISO Thioridazine results in increased phosphorylation of CDC25A protein CTD PMID:21035837 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Thioridazine results in decreased expression of CDK4 protein CTD PMID:21035837 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Thioridazine results in increased expression of CDKN1A protein CTD PMID:21035837 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Thioridazine results in increased expression of CDKN2A protein CTD PMID:21035837 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Thioridazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 PMID:23397584 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases activity 		ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP2C19 protein 		CTD PMID:15135088 PMID:23397584 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 PMID:23397584 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Thioridazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity 		ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP3A4 protein 		CTD PMID:15135088 PMID:23397584 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Thioridazine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Thioridazine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:21035837 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Thioridazine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Thioridazine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Thioridazine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063 		JBrowse link
G Hpn hepsin increases expression ISO Thioridazine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Thioridazine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity 		ISO Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Thioridazine results in decreased activity of KCNH2 protein 		CTD PMID:15671647 PMID:16278312 PMID:21158687 PMID:24052561 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lss lanosterol synthase increases expression ISO Thioridazine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Thioridazine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Thioridazine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Thioridazine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Prl prolactin increases expression ISO Thioridazine results in increased expression of PRL protein CTD PMID:4065553 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Thioridazine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Thioridazine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Tagln transgelin decreases expression ISO Thioridazine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Thioridazine affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Thioridazine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    chemical entity 20843
      group 20786
        inorganic group 20285
          thiol group 2342
            thiol 2342
              alkanethiol 114
                methanethiol 39
                  S-methyl methanethiosulfonate 3
                  methylsulfanyl group + 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    main group molecular entity 20766
                      s-block molecular entity 20561
                        hydrogen molecular entity 20545
                          hydrides 19679
                            inorganic hydride 18572
                              chalcogen hydride 2933
                                sulfur hydride 2458
                                  hydrogen sulfide 2458
                                    thiol group 2342
                                      thiol 2342
                                        alkanethiol 114
                                          methanethiol 39
                                            S-methyl methanethiosulfonate 3
                                            methylsulfanyl group + 35
paths to the root