PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial) - Rat Genome Database

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Gene: PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial) Canis lupus familiaris
Analyze
Symbol: PCK2
Name: phosphoenolpyruvate carboxykinase 2, mitochondrial
RGD ID: 12110037
Description: ENCODES a protein that exhibits phosphoenolpyruvate carboxykinase (GTP) activity (ortholog); phosphoenolpyruvate carboxykinase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to tumor necrosis factor (ortholog); gluconeogenesis (ortholog); PARTICIPATES IN gluconeogenesis pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); COVID-19 (ortholog); Endotoxemia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH clofibrate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphoenolpyruvate carboxykinase [GTP], mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,099,016 - 4,107,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,098,671 - 4,107,865 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,020,846 - 4,030,924 (+)NCBI
ROS_Cfam_1.084,209,738 - 4,219,816 (+)NCBI
ROS_Cfam_1.0 Ensembl84,209,258 - 4,220,128 (+)Ensembl
UMICH_Zoey_3.183,900,384 - 3,910,462 (+)NCBI
UNSW_CanFamBas_1.083,962,137 - 3,972,205 (+)NCBI
UU_Cfam_GSD_1.084,224,247 - 4,234,326 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
clofibrate  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PCK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,099,016 - 4,107,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,098,671 - 4,107,865 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,020,846 - 4,030,924 (+)NCBI
ROS_Cfam_1.084,209,738 - 4,219,816 (+)NCBI
ROS_Cfam_1.0 Ensembl84,209,258 - 4,220,128 (+)Ensembl
UMICH_Zoey_3.183,900,384 - 3,910,462 (+)NCBI
UNSW_CanFamBas_1.083,962,137 - 3,972,205 (+)NCBI
UU_Cfam_GSD_1.084,224,247 - 4,234,326 (+)NCBI
PCK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,094,171 - 24,104,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1424,094,053 - 24,110,598 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,563,520 - 24,573,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,633,323 - 23,643,179 (+)NCBINCBI36hg18NCBI36
Build 341423,633,388 - 23,643,173NCBI
Celera144,427,958 - 4,437,809 (+)NCBI
Cytogenetic Map14q11.2-q12NCBI
HuRef144,678,408 - 4,688,558 (+)NCBIHuRef
CHM1_11424,562,148 - 24,571,997 (+)NCBICHM1_1
T2T-CHM13v2.01418,292,625 - 18,302,437 (+)NCBI
Pck2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,777,721 - 55,787,477 (+)NCBIGRCm39mm39
GRCm39 Ensembl1455,777,723 - 55,788,699 (+)Ensembl
GRCm381455,540,263 - 55,550,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,540,266 - 55,551,242 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,159,103 - 56,168,854 (+)NCBIGRCm37mm9NCBIm37
MGSCv361454,494,337 - 54,504,088 (+)NCBImm8
Celera1453,345,110 - 53,354,861 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Pck2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21529,027,891 - 29,036,729 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1529,027,894 - 29,037,283 (+)Ensembl
Rnor_6.01534,216,735 - 34,224,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,216,833 - 34,224,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,106,930 - 38,114,552 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,671,834 - 33,680,613 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11533,677,328 - 33,696,192 (+)NCBI
Celera1528,603,811 - 28,612,649 (+)NCBICelera
Cytogenetic Map15p13NCBI
Pck2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,288,568 - 36,296,828 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,288,402 - 36,296,761 (-)NCBIChiLan1.0ChiLan1.0
PCK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11422,996,813 - 23,006,775 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,996,813 - 23,006,775 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0144,872,276 - 4,882,118 (+)NCBIMhudiblu_PPA_v0panPan3
Pck2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,951,769 - 35,960,519 (+)NCBI
SpeTri2.0NW_004936722428,473 - 450,452 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,187,197 - 75,197,733 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,187,195 - 75,197,613 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,458,494 - 80,468,914 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,077,206 - 1,087,306 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl241,077,447 - 1,087,607 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603612,759,325 - 12,769,341 (+)NCBIVero_WHO_p1.0
Pck2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,426,606 - 8,436,284 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248208,426,456 - 8,436,484 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 6 6 6 6 5
Low 4 16 6 12 8 10 1
Below cutoff 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018871   ⟹   ENSCAFP00000017488
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,098,671 - 4,107,865 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063491   ⟹   ENSCAFP00000060662
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,099,504 - 4,107,865 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000068059   ⟹   ENSCAFP00000056594
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,099,055 - 4,103,846 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000073916   ⟹   ENSCAFP00000046413
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,099,504 - 4,107,678 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845008058   ⟹   ENSCAFP00845006338
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,209,258 - 4,220,128 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845008075   ⟹   ENSCAFP00845006347
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,209,658 - 4,214,635 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845008085   ⟹   ENSCAFP00845006354
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,209,661 - 4,218,468 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845008092   ⟹   ENSCAFP00845006358
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,210,882 - 4,220,128 (+)Ensembl
RefSeq Acc Id: XM_038482830   ⟹   XP_038338758
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.183,900,384 - 3,910,462 (+)NCBI
RefSeq Acc Id: XM_038544264   ⟹   XP_038400192
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.084,224,247 - 4,234,326 (+)NCBI
RefSeq Acc Id: XM_038608381   ⟹   XP_038464309
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.083,962,137 - 3,972,205 (+)NCBI
RefSeq Acc Id: XM_038673188   ⟹   XP_038529116
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,209,738 - 4,219,816 (+)NCBI
RefSeq Acc Id: XM_537379   ⟹   XP_537379
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,099,016 - 4,107,870 (+)NCBI
Dog10K_Boxer_Tasha84,020,846 - 4,030,924 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038338758 (Get FASTA)   NCBI Sequence Viewer  
  XP_038400192 (Get FASTA)   NCBI Sequence Viewer  
  XP_038464309 (Get FASTA)   NCBI Sequence Viewer  
  XP_038529116 (Get FASTA)   NCBI Sequence Viewer  
  XP_537379 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_537379   ⟸   XM_537379
- Sequence:
RefSeq Acc Id: ENSCAFP00000017488   ⟸   ENSCAFT00000018871
RefSeq Acc Id: ENSCAFP00000060662   ⟸   ENSCAFT00000063491
RefSeq Acc Id: ENSCAFP00000046413   ⟸   ENSCAFT00000073916
RefSeq Acc Id: ENSCAFP00000056594   ⟸   ENSCAFT00000068059
RefSeq Acc Id: XP_038338758   ⟸   XM_038482830
RefSeq Acc Id: XP_038464309   ⟸   XM_038608381
RefSeq Acc Id: XP_038529116   ⟸   XM_038673188
RefSeq Acc Id: XP_038400192   ⟸   XM_038544264
RefSeq Acc Id: ENSCAFP00845006347   ⟸   ENSCAFT00845008075
RefSeq Acc Id: ENSCAFP00845006358   ⟸   ENSCAFT00845008092
RefSeq Acc Id: ENSCAFP00845006338   ⟸   ENSCAFT00845008058
RefSeq Acc Id: ENSCAFP00845006354   ⟸   ENSCAFT00845008085
Protein Domains
PEPCK_GTP   PEPCK_N

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 4102155 4102156 C T snv Labrador Retriever (LA882)
8 4107413 4107414 G A snv Shetland Sheepdog (SS004)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011868 Ensembl
  ENSCAFG00030012761 UniProtKB/TrEMBL
  ENSCAFG00040003321 UniProtKB/TrEMBL
  ENSCAFG00845004487 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030020799.1 UniProtKB/TrEMBL
  ENSCAFP00030020885.1 UniProtKB/TrEMBL
  ENSCAFP00030020979.1 UniProtKB/TrEMBL
  ENSCAFP00030021035.1 UniProtKB/TrEMBL
  ENSCAFP00040005550 UniProtKB/TrEMBL
  ENSCAFP00040005562 UniProtKB/TrEMBL
  ENSCAFP00845006338.1 UniProtKB/TrEMBL
  ENSCAFP00845006347.1 UniProtKB/TrEMBL
  ENSCAFP00845006354.1 UniProtKB/TrEMBL
  ENSCAFP00845006358 ENTREZGENE
  ENSCAFP00845006358.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030023863.1 UniProtKB/TrEMBL
  ENSCAFT00030023961.1 UniProtKB/TrEMBL
  ENSCAFT00030024066.1 UniProtKB/TrEMBL
  ENSCAFT00030024125.1 UniProtKB/TrEMBL
  ENSCAFT00040006410 UniProtKB/TrEMBL
  ENSCAFT00040006422 UniProtKB/TrEMBL
  ENSCAFT00845008058.1 UniProtKB/TrEMBL
  ENSCAFT00845008075.1 UniProtKB/TrEMBL
  ENSCAFT00845008085.1 UniProtKB/TrEMBL
  ENSCAFT00845008092 ENTREZGENE
  ENSCAFT00845008092.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.449.10 UniProtKB/TrEMBL
  3.90.228.20 UniProtKB/TrEMBL
InterPro PEP_carboxykin_GTP_CS UniProtKB/TrEMBL
  PEP_carboxykinase_C UniProtKB/TrEMBL
  PEP_carboxykinase_GTP UniProtKB/TrEMBL
  PEP_carboxykinase_GTP_C UniProtKB/TrEMBL
  PEP_carboxykinase_GTP_N UniProtKB/TrEMBL
  PEP_carboxykinase_N UniProtKB/TrEMBL
NCBI Gene PCK2 ENTREZGENE
PANTHER PTHR11561 UniProtKB/TrEMBL
Pfam PEPCK_GTP UniProtKB/TrEMBL
  PEPCK_N UniProtKB/TrEMBL
PIRSF PEP_carboxykinase_GTP UniProtKB/TrEMBL
PROSITE PEPCK_GTP UniProtKB/TrEMBL
Superfamily-SCOP SSF68923 UniProtKB/TrEMBL
UniProt A0A8C0N6J4_CANLF UniProtKB/TrEMBL
  A0A8C0Q1I9_CANLF UniProtKB/TrEMBL
  A0A8C0RJ08_CANLF UniProtKB/TrEMBL
  A0A8C0RJ38_CANLF UniProtKB/TrEMBL
  A0A8I3MN02_CANLF UniProtKB/TrEMBL
  A0A8I3MT45_CANLF UniProtKB/TrEMBL
  A0A8I3MTV2_CANLF UniProtKB/TrEMBL
  A0A8I3RTJ7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44308 ENTREZGENE