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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:inosine
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Accession:CHEBI:17596 term browser browse the term
Definition:A purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Synonyms:exact_synonym: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-3,4-diol
 related_synonym: 9-beta-D-ribofuranosyl-9H-purin-6-ol;   9-beta-D-ribofuranosylhypoxanthine;   Formula=C10H12N4O5;   InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1;   InChIKey=UGQMRVRMYYASKQ-KQYNXXCUSA-N;   Inosin;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(O)ncnc12;   hypoxanthine D-riboside;   hypoxanthosine;   i;   inosina;   inosinum
 alt_id: CHEBI:14456;   CHEBI:24841;   CHEBI:44407;   CHEBI:5927
 xref: CAS:58-63-9;   Drug_Central:3301;   ECMDB:ECMDB00195;   Gmelin:489332;   HMDB:HMDB0000195;   KEGG:C00294;   KEGG:D00054;   KNApSAcK:C00019692
 xref_mesh: MESH:D007288
 xref: MetaCyc:INOSINE;   PDBeChem:NOS;   PMID:22770225;   Reaxys:624889;   Wikipedia:Inosine;   YMDB:YMDB00510


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inosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase decreases abundance
increases abundance		 ISO ADA alternative form results in decreased abundance of Inosine
ADA protein results in increased abundance of Inosine		 CTD PMID:16221767 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Inosine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Inosine] CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Faslg Fas ligand increases expression ISO Inosine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Inosine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Inosine] CTD PMID:39172838 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP		 Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Inosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          metabolite 19561
            fundamental metabolite 14543
              hypoxanthine 38
                inosine 8
                  1-methylinosine 0
                  2'-O-methylinosine 0
                  2'-deoxyinosine 0
                  3',5'-cyclic IMP 0
                  5'-S-methyl-5'-thioinosine 0
                  5'-deoxyinosine 0
                  6-O-methylinosine 0
                  6-deoxyinosine 5'-phosphate 0
                  7-methylinosine 0
                  Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbohydrates and carbohydrate derivatives 15308
                                    carbohydrate 15308
                                      carbohydrate derivative 14322
                                        glycosyl compound 13083
                                          N-glycosyl compound 5882
                                            nucleoside 5740
                                              ribonucleoside 1165
                                                purine ribonucleoside 822
                                                  purines D-ribonucleoside 420
                                                    inosine 8
                                                      1-methylinosine 0
                                                      2'-O-methylinosine 0
                                                      2'-deoxyinosine 0
                                                      3',5'-cyclic IMP 0
                                                      5'-S-methyl-5'-thioinosine 0
                                                      5'-deoxyinosine 0
                                                      6-O-methylinosine 0
                                                      6-deoxyinosine 5'-phosphate 0
                                                      7-methylinosine 0
                                                      Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester 0
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