CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: inosine
Accession: CHEBI:17596
browse the term
Definition: A purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Synonyms: exact_synonym: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-3,4-diol
related_synonym: 9-beta-D-ribofuranosyl-9H-purin-6-ol; 9-beta-D-ribofuranosylhypoxanthine; Formula=C10H12N4O5; InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1; InChIKey=UGQMRVRMYYASKQ-KQYNXXCUSA-N; Inosin; SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(O)ncnc12; hypoxanthine D-riboside; hypoxanthosine; i; inosina; inosinum
alt_id: CHEBI:14456; CHEBI:24841; CHEBI:44407; CHEBI:5927
xref: Beilstein:624889; CAS:58-63-9; Drug_Central:3301; ECMDB:ECMDB00195; Gmelin:489332; HMDB:HMDB0000195; KEGG:C00294; KEGG:D00054; KNApSAcK:C00019692
xref_mesh: MESH:D007288
xref: MetaCyc:INOSINE; PDBeChem:NOS; PMID:22770225; Reaxys:624889; Wikipedia:Inosine; YMDB:YMDB00510
G
Ada
adenosine deaminase
decreases abundance increases abundance
ISO
ADA alternative form results in decreased abundance of Inosine ADA protein results in increased abundance of Inosine
CTD
PMID:16221767
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
G
Faslg
Fas ligand
increases expression
ISO
Inosine results in increased expression of FASLG protein
CTD
PMID:16419169
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
H2ax
H2A.X variant histone
multiple interactions
ISO
Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]
CTD
PMID:32941855
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
G
Slc29a1
solute carrier family 29 member 1
multiple interactions
ISO EXP
Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]
CTD
PMID:9353301 PMID:11085929
NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
G
Slc29a2
solute carrier family 29 member 2
multiple interactions
ISO
Inosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]
CTD
PMID:11085929
NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
G
Tp53bp1
tumor protein p53 binding protein 1
multiple interactions
ISO
Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]
CTD
PMID:32941855
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20056
role
20008
biological role
20007
biochemical role
19640
metabolite
19623
fundamental metabolite
12801
hypoxanthine
23
inosine
6
1-methylinosine
0
2'-O-methylinosine
0
2'-deoxyinosine
0
3',5'-cyclic IMP
0
5'-S-methyl-5'-thioinosine
0
5'-deoxyinosine
0
6-O-methylinosine
0
6-deoxyinosine 5'-phosphate
0
7-methylinosine
0
Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester
0
Path 2
CHEBI ontology
20056
subatomic particle
20054
composite particle
20054
hadron
20054
baryon
20054
nucleon
20054
atomic nucleus
20054
atom
20054
main group element atom
19956
p-block element atom
19956
carbon group element atom
19882
carbon atom
19875
organic molecular entity
19875
heteroorganic entity
19561
organochalcogen compound
19310
organooxygen compound
19243
carbohydrates and carbohydrate derivatives
13928
carbohydrate
13928
carbohydrate derivative
13657
glycosyl compound
12913
N-glycosyl compound
5592
nucleoside
5451
ribonucleoside
699
purine ribonucleoside
587
purines D-ribonucleoside
372
inosine
6
1-methylinosine
0
2'-O-methylinosine
0
2'-deoxyinosine
0
3',5'-cyclic IMP
0
5'-S-methyl-5'-thioinosine
0
5'-deoxyinosine
0
6-O-methylinosine
0
6-deoxyinosine 5'-phosphate
0
7-methylinosine
0
Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester
0