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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:inosine
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Accession:CHEBI:17596 term browser browse the term
Definition:A purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Synonyms:exact_synonym: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-3,4-diol
 related_synonym: 9-beta-D-ribofuranosyl-9H-purin-6-ol;   9-beta-D-ribofuranosylhypoxanthine;   Formula=C10H12N4O5;   InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1;   InChIKey=UGQMRVRMYYASKQ-KQYNXXCUSA-N;   Inosin;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(O)ncnc12;   hypoxanthine D-riboside;   hypoxanthosine;   i;   inosina;   inosinum
 alt_id: CHEBI:14456;   CHEBI:24841;   CHEBI:44407;   CHEBI:5927
 xref: Beilstein:624889;   CAS:58-63-9;   Drug_Central:3301;   ECMDB:ECMDB00195;   Gmelin:489332;   HMDB:HMDB0000195;   KEGG:C00294;   KEGG:D00054;   KNApSAcK:C00019692
 xref_mesh: MESH:D007288
 xref: MetaCyc:INOSINE;   PDBeChem:NOS;   PMID:22770225;   Reaxys:624889;   Wikipedia:Inosine;   YMDB:YMDB00510

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inosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase decreases abundance
increases abundance		 ISO ADA alternative form results in decreased abundance of Inosine
ADA protein results in increased abundance of Inosine		 CTD PMID:16221767 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947 		JBrowse link
G Faslg Fas ligand increases expression ISO Inosine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP		 Inosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301, PMID:11085929 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Inosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            fundamental metabolite 12621
              hypoxanthine 12
                inosine 4
                  1-methylinosine 0
                  2'-O-methylinosine 0
                  2'-deoxyinosine 0
                  3',5'-cyclic IMP 0
                  5'-S-methyl-5'-thioinosine 0
                  5'-deoxyinosine 0
                  6-O-methylinosine 0
                  6-deoxyinosine 5'-phosphate 0
                  7-methylinosine 0
                  Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organooxygen compound 18816
                                  carbohydrates and carbohydrate derivatives 12191
                                    carbohydrate 12191
                                      carbohydrate derivative 11814
                                        glycosyl compound 10856
                                          N-glycosyl compound 5340
                                            nucleoside 5200
                                              ribonucleoside 699
                                                purine ribonucleoside 592
                                                  purines D-ribonucleoside 334
                                                    inosine 4
                                                      1-methylinosine 0
                                                      2'-O-methylinosine 0
                                                      2'-deoxyinosine 0
                                                      3',5'-cyclic IMP 0
                                                      5'-S-methyl-5'-thioinosine 0
                                                      5'-deoxyinosine 0
                                                      6-O-methylinosine 0
                                                      6-deoxyinosine 5'-phosphate 0
                                                      7-methylinosine 0
                                                      Phosphoric acid mono-[(2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester 0
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