Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chitosan
go back to main search page
Accession:CHEBI:16261 term browser browse the term
Definition:An aminoglycan consisting of beta-(1->4)-linked D-glucosamine residues.
Synonyms:exact_synonym: (1->4)-2-amino-2-deoxy-beta-D-glucan
 related_synonym: Deacetylchitin;   Formula=H2O(C6H11NO4)n;   [4)-beta-D-GlcpN(1->]n;   beta-1,4-Poly-D-glucosamine;   poliglusam
 alt_id: CHEBI:13964;   CHEBI:3599
 xref: CAS:9012-76-4;   KEGG:C00734;   KEGG:G10536
 xref_mesh: MESH:D048271
 cyclic_relationship: is_conjugate_base_of CHEBI:57704


show annotations for term's descendants           Sort by:
 
chitosan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions EXP [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA] CTD PMID:28987369 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein] CTD PMID:28732690 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions EXP [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein] CTD PMID:22704994 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Chitosan results in increased expression of ALPL mRNA; Chitosan results in increased expression of ALPL protein CTD PMID:25246786 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions EXP [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA] CTD PMID:28987369 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
[Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in increased expression of BAX protein
Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
CTD PMID:18567086 PMID:30928397 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
[Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in decreased expression of BCL2 protein
[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
CTD PMID:18567086 PMID:28732690 PMID:30928397 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Chitosan results in increased expression of BGLAP mRNA CTD PMID:25246786 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Chitosan metabolite inhibits the reaction [Copper results in increased activity of CASP3 protein]
Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
CTD PMID:25542178 PMID:30928397 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein] CTD PMID:30928397 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP [Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; Chitosan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:12679053 PMID:22704994 PMID:27923682 PMID:30928397 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Clec7a C-type lectin domain containing 7A multiple interactions
decreases expression
ISO Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of CLEC7A mRNA]
Chitosan results in decreased expression of CLEC7A mRNA
CTD PMID:21329777 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein] CTD PMID:28732690 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases activity ISO Chitosan analog results in increased activity of CYP3A4 protein CTD PMID:20831879 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Fish Oils promotes the reaction [Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]] CTD PMID:28987369 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions EXP [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA] CTD PMID:28987369 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] CTD PMID:28987369 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gcg glucagon increases expression
increases secretion
multiple interactions
ISO Chitosan results in increased expression of GCG mRNA
Chitosan results in increased secretion of GCG protein
SB 203580 inhibits the reaction [Chitosan results in increased expression of GCG mRNA]; SB 203580 inhibits the reaction [Chitosan results in increased secretion of GCG protein]
CTD PMID:23611362 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
EXP Chitosan analog results in increased expression of GPX1 mRNA
[Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]; [Chitosan analog co-treated with Quercetin] results in increased expression of GPX1 mRNA; Chitosan analog inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]
CTD PMID:27923682 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein] CTD PMID:28732690 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA] CTD PMID:30928397 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA] CTD PMID:28987369 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
[Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 mRNA; [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 protein
Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]
CTD PMID:25542178 PMID:30928397 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il10 interleukin 10 multiple interactions
increases secretion
ISO Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Chitosan results in increased secretion of IL10 protein
CTD PMID:21329777 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
ISO Chitosan results in increased secretion of IL6 protein
Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:21329777 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein] CTD PMID:28732690 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Chitosan inhibits the reaction [Aminolevulinic Acid analog results in increased activity of MMP2 protein] CTD PMID:18806744 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
ISO
EXP
[Chitosan metabolite results in decreased susceptibility to Copper] which results in increased phosphorylation of NFE2L2 protein
Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]; pyrazolanthrone inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; SB 203580 inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]
Chitosan analog affects the localization of NFE2L2 protein
CTD PMID:25542178 PMID:30928397 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA] CTD PMID:30928397 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in increased expression of NR1H3 protein] CTD PMID:28987369 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein] CTD PMID:28987369 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein] CTD PMID:28732690 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Chitosan results in increased expression of RUNX2 mRNA; Chitosan results in increased expression of RUNX2 protein CTD PMID:25246786 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
EXP [Chitosan analog co-treated with Quercetin] results in increased expression of SOD1 mRNA; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of SOD1 mRNA]
Chitosan analog results in increased expression of SOD1 mRNA
CTD PMID:27923682 PMID:30928397 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Chitosan results in increased expression of SPP1 mRNA CTD PMID:25246786 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:28987369 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein] CTD PMID:22704994 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
decreases expression
ISO Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]
Chitosan results in decreased expression of TLR2 mRNA
CTD PMID:21329777 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression
multiple interactions
ISO Chitosan results in decreased expression of TLR4 mRNA
Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA]
CTD PMID:21329777 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Chitosan results in increased secretion of TNF protein
CTD PMID:21329777 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein] CTD PMID:22704994 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        agrochemical 14675
          plant activator 674
            chitosan 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            heteroorganic entity 19199
                              organochalcogen compound 18946
                                organooxygen compound 18873
                                  carbohydrates and carbohydrate derivatives 12285
                                    carbohydrate 12285
                                      polysaccharide 3063
                                        polysaccharide derivative 3045
                                          aminoglycan 394
                                            chitosan 41
paths to the root