UROC1 (urocanate hydratase 1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: UROC1 (urocanate hydratase 1) Canis lupus familiaris
Analyze
Symbol: UROC1
Name: urocanate hydratase 1
RGD ID: 12228377
Description: ENCODES a protein that exhibits urocanate hydratase activity (inferred); INVOLVED IN histidine catabolic process to glutamate and formamide (inferred); histidine catabolic process to glutamate and formate (inferred); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH Ataxia (ortholog); hepatocellular carcinoma (ortholog); intellectual disability (ortholog); FOUND IN cytosol (inferred); INTERACTS WITH clofibrate; phenobarbital
Type: protein-coding
RefSeq Status: MODEL
Also known as: urocanase domain containing 1; urocanate hydratase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl20678,073 - 717,141 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.120676,624 - 717,109 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
UROC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl20678,073 - 717,141 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.120676,624 - 717,109 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
UROC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3126,481,166 - 126,517,773 (-)EnsemblGRCh38hg38GRCh38
GRCh383126,481,166 - 126,517,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373126,200,008 - 126,236,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363127,682,814 - 127,719,284 (-)NCBINCBI36hg18NCBI36
Build 343127,682,821 - 127,719,292NCBI
Celera3124,624,832 - 124,661,450 (-)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3123,580,466 - 123,616,232 (-)NCBIHuRef
CHM1_13126,163,023 - 126,199,631 (-)NCBICHM1_1
Uroc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39690,310,221 - 90,341,533 (+)NCBIGRCm39mm39
GRCm38690,333,239 - 90,364,551 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl690,333,284 - 90,364,551 (+)EnsemblGRCm38mm10GRCm38
MGSCv37690,283,283 - 90,314,545 (+)NCBIGRCm37mm9NCBIm37
MGSCv36690,298,810 - 90,330,055 (+)NCBImm8
Celera692,226,993 - 92,258,298 (+)NCBICelera
Cytogenetic Map6D1NCBI
Uroc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04122,244,744 - 122,276,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,244,711 - 122,276,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04186,786,121 - 186,817,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44124,591,873 - 124,622,726 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4111,769,716 - 111,800,721 (+)NCBICelera
Cytogenetic Map4q34NCBI
Uroc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542121,732,262 - 21,765,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542121,734,910 - 21,765,754 (-)NCBIChiLan1.0ChiLan1.0
UROC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13130,845,588 - 130,882,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3130,846,775 - 130,882,119 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03123,530,644 - 123,569,337 (-)NCBIMhudiblu_PPA_v0panPan3
Uroc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936898583,802 - 600,305 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UROC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,590,776 - 53,637,714 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,592,763 - 53,634,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,628,304 - 58,665,410 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UROC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12254,497,373 - 54,536,295 (+)NCBI
ChlSab1.1 Ensembl2254,499,487 - 54,535,862 (+)Ensembl
Uroc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477372,871 - 107,686 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6
Low 1
Below cutoff 5 5 16 6 5 6 12 8 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006209   ⟹   ENSCAFP00000005751
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl20678,073 - 717,141 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000073426   ⟹   ENSCAFP00000052997
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl20678,073 - 717,141 (-)Ensembl
RefSeq Acc Id: XM_005632061   ⟹   XP_005632118
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.120676,624 - 715,698 (-)NCBI
Sequence:
RefSeq Acc Id: XM_533714   ⟹   XP_533714
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.120676,624 - 717,109 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_533714   ⟸   XM_533714
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005632118   ⟸   XM_005632061
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000005751   ⟸   ENSCAFT00000006209
RefSeq Acc Id: ENSCAFP00000052997   ⟸   ENSCAFT00000073426
Protein Domains
Urocanase   Urocanase_C   Urocanase_N

Promoters
RGD ID:13686748
Promoter ID:EPDNEW_C4815
Type:initiation region
Name:UROC1_1
Description:urocanate hydratase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.120717,080 - 717,140EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003843 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000005751 UniProtKB/TrEMBL
  ENSCAFP00000052997 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006209 UniProtKB/TrEMBL
  ENSCAFT00000073426 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10730 UniProtKB/TrEMBL
InterPro Urocanase UniProtKB/TrEMBL
  Urocanase_C UniProtKB/TrEMBL
  Urocanase_central_sf UniProtKB/TrEMBL
  Urocanase_CS UniProtKB/TrEMBL
  Urocanase_N UniProtKB/TrEMBL
  Urocanase_Rossmann-like UniProtKB/TrEMBL
  Urocanase_sf UniProtKB/TrEMBL
NCBI Gene UROC1 ENTREZGENE
PANTHER PTHR12216 UniProtKB/TrEMBL
Pfam Urocanase UniProtKB/TrEMBL
  Urocanase_C UniProtKB/TrEMBL
  Urocanase_N UniProtKB/TrEMBL
PROSITE UROCANASE UniProtKB/TrEMBL
Superfamily-SCOP SSF111326 UniProtKB/TrEMBL
TIGRFAMs hutU UniProtKB/TrEMBL
UniProt A0A5F4CJJ2_CANLF UniProtKB/TrEMBL
  E2RT03_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48168 ENTREZGENE