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RGD ID: 12252833
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: ALOX5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:10112
Term: zileuton
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
Chemical ID: MESH:C063449
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ALOX5decreases activityEXP 6480464CTDzileuton results in decreased activity of ALOX5 proteinPMID:1618819
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