HADH (hydroxyacyl-CoA dehydrogenase) - Rat Genome Database

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Gene: HADH (hydroxyacyl-CoA dehydrogenase) Canis lupus familiaris
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Symbol: HADH
Name: hydroxyacyl-CoA dehydrogenase
RGD ID: 12299714
Description: ENCODES a protein that exhibits 3-hydroxyacyl-CoA dehydrogenase activity (ortholog); identical protein binding (ortholog); INVOLVED IN fatty acid beta-oxidation (ortholog); negative regulation of insulin secretion (ortholog); positive regulation of cold-induced thermogenesis (ortholog); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; butanoate metabolic pathway; ASSOCIATED WITH 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (ortholog); Congenital Hyperinsulinism (ortholog); diabetes mellitus (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); nucleoplasm (ortholog); INTERACTS WITH clofibrate; phenobarbital
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hydroxyacyl-Coenzyme A dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,460,445 - 28,506,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,460,193 - 28,531,280 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,516,288 - 13,562,132 (-)NCBI
ROS_Cfam_1.03228,689,480 - 28,735,351 (+)NCBI
ROS_Cfam_1.0 Ensembl3228,689,484 - 28,780,497 (+)Ensembl
UMICH_Zoey_3.13228,682,743 - 28,728,360 (+)NCBI
UNSW_CanFamBas_1.03228,427,283 - 28,473,178 (+)NCBI
UU_Cfam_GSD_1.03211,383,587 - 11,429,427 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
mitochondrion  (IBA,ISO)
nucleoplasm  (ISO)

References

Genomics

Comparative Map Data
HADH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,460,445 - 28,506,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,460,193 - 28,531,280 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,516,288 - 13,562,132 (-)NCBI
ROS_Cfam_1.03228,689,480 - 28,735,351 (+)NCBI
ROS_Cfam_1.0 Ensembl3228,689,484 - 28,780,497 (+)Ensembl
UMICH_Zoey_3.13228,682,743 - 28,728,360 (+)NCBI
UNSW_CanFamBas_1.03228,427,283 - 28,473,178 (+)NCBI
UU_Cfam_GSD_1.03211,383,587 - 11,429,427 (-)NCBI
HADH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384107,989,889 - 108,035,171 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4107,989,714 - 108,035,241 (+)EnsemblGRCh38hg38GRCh38
GRCh374108,911,045 - 108,956,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,130,389 - 109,175,780 (+)NCBINCBI36hg18NCBI36
Celera4106,205,689 - 106,251,144 (+)NCBI
Cytogenetic Map4q25NCBI
HuRef4104,642,283 - 104,687,973 (+)NCBIHuRef
CHM1_14108,887,327 - 108,932,780 (+)NCBICHM1_1
T2T-CHM13v2.04111,292,223 - 111,337,508 (+)NCBI
Hadh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393131,027,068 - 131,065,750 (-)NCBIGRCm39mm39
GRCm39 Ensembl3131,027,068 - 131,065,750 (-)Ensembl
GRCm383131,233,419 - 131,272,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,233,419 - 131,272,101 (-)EnsemblGRCm38mm10GRCm38
MGSCv373130,936,342 - 130,974,955 (-)NCBIGRCm37mm9NCBIm37
MGSCv363131,222,610 - 131,261,182 (-)NCBImm8
Celera3137,754,696 - 137,793,253 (-)NCBICelera
Cytogenetic Map3G3NCBI
Hadh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22219,787,935 - 219,830,335 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)Ensembl
Rnor_6.02236,353,445 - 236,395,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,902,140 - 254,944,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,698,545 - 228,751,691 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12228,685,284 - 228,738,431 (-)NCBI
Celera2212,044,254 - 212,086,368 (-)NCBICelera
Cytogenetic Map2q43NCBI
Hadh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,835,034 - 1,861,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,835,034 - 1,861,410 (-)NCBIChiLan1.0ChiLan1.0
HADH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14111,067,537 - 111,112,945 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,067,336 - 111,113,868 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04100,495,205 - 100,540,589 (+)NCBIMhudiblu_PPA_v0panPan3
Hadh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,605,927 - 12,654,203 (-)NCBI
SpeTri2.0NW_004936818575,272 - 623,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,950,034 - 114,005,511 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,952,561 - 114,005,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,212,898 - 122,265,850 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HADH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,919,499 - 55,965,074 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl755,919,623 - 55,964,857 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603734,546,087 - 34,591,597 (+)NCBIVero_WHO_p1.0
Hadh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,426,775 - 1,451,440 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248301,429,989 - 1,451,447 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017829   ⟹   ENSCAFP00000016506
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3228,479,059 - 28,505,548 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060061   ⟹   ENSCAFP00000059870
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3228,460,459 - 28,531,280 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000069445   ⟹   ENSCAFP00000048279
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3228,460,784 - 28,504,548 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000076696   ⟹   ENSCAFP00000050176
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3228,460,193 - 28,523,826 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078213   ⟹   ENSCAFP00000058385
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3228,460,459 - 28,505,548 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000085322   ⟹   ENSCAFP00000059345
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3228,460,538 - 28,505,548 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845051565   ⟹   ENSCAFP00845040458
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3228,689,484 - 28,780,497 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845051583   ⟹   ENSCAFP00845040475
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3228,689,494 - 28,735,357 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845051606   ⟹   ENSCAFP00845040493
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3228,689,494 - 28,734,493 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845051639   ⟹   ENSCAFP00845040517
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3228,689,581 - 28,735,430 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845051653   ⟹   ENSCAFP00845040527
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3228,711,733 - 28,735,430 (+)Ensembl
RefSeq Acc Id: XM_038444332   ⟹   XP_038300260
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03228,689,480 - 28,735,351 (+)NCBI
RefSeq Acc Id: XM_038518720   ⟹   XP_038374648
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13228,682,743 - 28,728,360 (+)NCBI
RefSeq Acc Id: XM_038581946   ⟹   XP_038437874
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03211,383,587 - 11,429,427 (-)NCBI
RefSeq Acc Id: XM_038646669   ⟹   XP_038502597
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03228,427,283 - 28,473,178 (+)NCBI
RefSeq Acc Id: XM_535685   ⟹   XP_535685
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13228,460,445 - 28,506,141 (+)NCBI
Dog10K_Boxer_Tasha3213,516,288 - 13,562,132 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038300260 (Get FASTA)   NCBI Sequence Viewer  
  XP_038374648 (Get FASTA)   NCBI Sequence Viewer  
  XP_038437874 (Get FASTA)   NCBI Sequence Viewer  
  XP_038502597 (Get FASTA)   NCBI Sequence Viewer  
  XP_535685 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_535685   ⟸   XM_535685
- Sequence:
RefSeq Acc Id: ENSCAFP00000058385   ⟸   ENSCAFT00000078213
RefSeq Acc Id: ENSCAFP00000059870   ⟸   ENSCAFT00000060061
RefSeq Acc Id: ENSCAFP00000048279   ⟸   ENSCAFT00000069445
RefSeq Acc Id: ENSCAFP00000016506   ⟸   ENSCAFT00000017829
RefSeq Acc Id: ENSCAFP00000050176   ⟸   ENSCAFT00000076696
RefSeq Acc Id: ENSCAFP00000059345   ⟸   ENSCAFT00000085322
RefSeq Acc Id: XP_038374648   ⟸   XM_038518720
RefSeq Acc Id: XP_038502597   ⟸   XM_038646669
RefSeq Acc Id: XP_038300260   ⟸   XM_038444332
RefSeq Acc Id: XP_038437874   ⟸   XM_038581946
RefSeq Acc Id: ENSCAFP00845040475   ⟸   ENSCAFT00845051583
RefSeq Acc Id: ENSCAFP00845040458   ⟸   ENSCAFT00845051565
RefSeq Acc Id: ENSCAFP00845040493   ⟸   ENSCAFT00845051606
RefSeq Acc Id: ENSCAFP00845040517   ⟸   ENSCAFT00845051639
RefSeq Acc Id: ENSCAFP00845040527   ⟸   ENSCAFT00845051653


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011216 Ensembl
  ENSCAFG00845029127 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845040458.1 UniProtKB/TrEMBL
  ENSCAFP00845040475.1 UniProtKB/TrEMBL
  ENSCAFP00845040493.1 UniProtKB/TrEMBL
  ENSCAFP00845040517.1 UniProtKB/TrEMBL
  ENSCAFP00845040527 ENTREZGENE
  ENSCAFP00845040527.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845051565.1 UniProtKB/TrEMBL
  ENSCAFT00845051583.1 UniProtKB/TrEMBL
  ENSCAFT00845051606.1 UniProtKB/TrEMBL
  ENSCAFT00845051639.1 UniProtKB/TrEMBL
  ENSCAFT00845051653 ENTREZGENE
  ENSCAFT00845051653.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1040.10 UniProtKB/TrEMBL
InterPro 3-OHacyl-CoA_DH UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_CS UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/TrEMBL
  3HC_DH_C UniProtKB/TrEMBL
  6-PGluconate_DH-like_C_sf UniProtKB/TrEMBL
  6PGD_dom2 UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene HADH ENTREZGENE
Pfam 3HCDH UniProtKB/TrEMBL
  3HCDH_N UniProtKB/TrEMBL
PIRSF HCDH UniProtKB/TrEMBL
PROSITE 3HCDH UniProtKB/TrEMBL
Superfamily-SCOP SSF48179 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8I3Q031_CANLF UniProtKB/TrEMBL
  A0A8I3Q6J5_CANLF UniProtKB/TrEMBL
  A0A8I3QIU7_CANLF UniProtKB/TrEMBL
  A0A8I3QIW6_CANLF UniProtKB/TrEMBL
  A0A8I3SC35_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41584 ENTREZGENE