|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases expression |
EXP |
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of AKT1 protein] |
CTD |
PMID:37661366 |
|
NCBI chr 6:137,534,810...137,555,131
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
EXP |
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of BCL2 protein] |
CTD |
PMID:37661366 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] |
CTD |
PMID:24718106 |
|
NCBI chr 3:116,619,633...116,670,212
|
|
G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions increases secretion |
EXP |
Carbon Dioxide inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]; Carbon Dioxide inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein] Carbon Dioxide results in increased secretion of CALCA protein |
CTD |
PMID:18052948 |
|
NCBI chr 1:178,312,636...178,317,588
|
|
G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] |
CTD |
PMID:24718106 |
|
NCBI chr14:85,059,166...85,148,121
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:24718106 |
|
NCBI chr 9:73,397,333...73,466,339
|
|
G |
Crh |
corticotropin releasing hormone |
increases response to substance |
ISO |
CRH protein results in increased susceptibility to Carbon Dioxide |
CTD |
PMID:8957205 |
|
NCBI chr 2:104,059,184...104,061,048
|
|
G |
Dlg3 |
discs large MAGUK scaffold protein 3 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] |
CTD |
PMID:24718106 |
|
NCBI chr X:65,859,653...65,911,887
|
|
G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein] |
CTD |
PMID:24718106 |
|
NCBI chr 4:170,297,811...170,775,420
|
|
G |
Il2 |
interleukin 2 |
multiple interactions increases expression |
EXP ISO |
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of IL2 mRNA]; 3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of IL2 protein] Carbon Dioxide results in increased expression of IL2 mRNA; Carbon Dioxide results in increased expression of IL2 protein |
CTD |
PMID:37661366 |
|
NCBI chr 2:121,932,968...121,937,672
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24718106 PMID:25004876 |
|
NCBI chr11:97,462,025...97,529,193
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24718106 PMID:25004876 |
|
NCBI chr 1:190,797,189...190,803,411
|
|
G |
Mir29a |
microRNA 29a |
multiple interactions |
ISO |
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Dioxide] which results in increased expression of MIR29A mRNA |
CTD |
PMID:29980036 |
|
NCBI chr 4:60,617,955...60,618,042
|
|
G |
Neil1 |
nei-like DNA glycosylase 1 |
affects abundance |
ISO |
NEIL1 affects the abundance of Carbon Dioxide |
CTD |
PMID:21285402 |
|
NCBI chr 8:57,550,142...57,556,884
|
|
G |
Ngb |
neuroglobin |
affects binding |
ISO |
Carbon Dioxide binds to [Heme binds to NGB protein] |
CTD |
PMID:16684569 |
|
NCBI chr 6:106,744,378...106,749,830
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
PPARA protein promotes the reaction [[GW 7647 results in increased oxidation of Palmitic Acid] which results in increased abundance of Carbon Dioxide] |
CTD |
PMID:21324916 |
|
NCBI chr 7:118,712,261...118,780,723
|
|
G |
Rapgef3 |
Rap guanine nucleotide exchange factor 3 |
multiple interactions |
ISO |
[RAPGEF3 protein affects the susceptibility to Dietary Fats] which affects the chemical synthesis of Carbon Dioxide |
CTD |
PMID:27381457 |
|
NCBI chr 7:128,875,772...128,898,203
|
|
G |
Slc9a1 |
solute carrier family 9 member A1 |
affects response to substance |
EXP |
SLC9A1 protein affects the susceptibility to Carbon Dioxide |
CTD |
PMID:16831598 |
|
NCBI chr 5:145,576,341...145,629,630
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
[[[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid] which results in increased chemical synthesis of Carbonates; [[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid; [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]] which results in increased chemical synthesis of Carbonates; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide]; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide] |
CTD |
PMID:19243126 |
|
NCBI chr11:42,942,742...42,948,399
|
|
G |
Syncrip |
synaptotagmin binding, cytoplasmic RNA interacting protein |
multiple interactions |
ISO |
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Dioxide] which affects the expression of SYNCRIP mRNA |
CTD |
PMID:29980036 |
|
NCBI chr 8:98,282,358...98,315,412
|
|
G |
Syngap1 |
synaptic Ras GTPase activating protein 1 |
multiple interactions |
EXP |
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] |
CTD |
PMID:24718106 |
|
NCBI chr20:5,026,366...5,056,659
|
|
G |
Tpi1 |
triosephosphate isomerase 1 |
increases expression |
EXP |
Carbon Dioxide results in increased expression of TPI1 mRNA |
CTD |
PMID:14762718 |
|
NCBI chr 4:159,301,558...159,305,088
|
|
G |
Trh |
thyrotropin releasing hormone |
increases response to substance |
ISO |
TRH protein results in increased susceptibility to Carbon Dioxide |
CTD |
PMID:8957205 |
|
NCBI chr 4:124,742,111...124,777,094
|
|
G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
increases activity |
EXP |
Carbon Dioxide results in increased activity of TRPA1 protein |
CTD |
PMID:20881114 |
|
NCBI chr 5:9,163,060...9,217,325
|
|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
affects response to substance |
EXP |
TRPV1 protein affects the susceptibility to Carbon Dioxide |
CTD |
PMID:16831598 |
|
NCBI chr10:58,349,936...58,375,021
|
|