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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:squalene
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Accession:CHEBI:15440 term browser browse the term
Definition:A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration.
Synonyms:exact_synonym: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
 related_synonym: (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene;   Formula=C30H50;   InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+;   InChIKey=YYGNTYWPHWGJRM-AAJYLUCBSA-N;   SMILES=CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C=C(/C)CC\\C=C(/C)CCC=C(C)C;   Spinacene;   Supraene
 alt_id: CHEBI:10795;   CHEBI:10843;   CHEBI:15104;   CHEBI:26746;   CHEBI:9245
 xref: Beilstein:1728920;   CAS:111-02-4;   HMDB:HMDB0000256;   KEGG:C00751;   KNApSAcK:C00003755;   LIPID_MAPS_instance:LMPR0106010002
 xref_mesh: MESH:D013185
 xref: MetaCyc:SQUALENE;   PDBeChem:SQL;   PMID:16341241;   PMID:23625688;   PMID:24362891;   PMID:25286851;   PMID:25286853;   PMID:25987292;   Wikipedia:Squalene


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squalene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Squalene inhibits the reaction [potassium bromate results in increased phosphorylation of AKT1 protein] CTD PMID:33219891 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Squalene promotes the reaction [potassium bromate results in increased expression of BAX protein] CTD PMID:33219891 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Squalene inhibits the reaction [potassium bromate results in increased expression of BCL2 protein] CTD PMID:33219891 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP Squalene promotes the reaction [potassium bromate results in increased expression of CASP3 protein] CTD PMID:33219891 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Squalene inhibits the reaction [potassium bromate results in decreased activity of CAT protein] CTD PMID:33219891 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO Squalene results in decreased expression of EPAS1 mRNA; Squalene results in decreased expression of EPAS1 protein CTD PMID:33219891 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Squalene inhibits the reaction [potassium bromate results in increased activity of GPT protein] CTD PMID:33219891 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Squalene inhibits the reaction [potassium bromate results in decreased activity of GSR protein] CTD PMID:33219891 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Squalene results in decreased expression of HIF1A mRNA; Squalene results in decreased expression of HIF1A protein CTD PMID:33219891 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Squalene inhibits the reaction [potassium bromate results in increased expression of MMP2 protein] CTD PMID:33219891 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Squalene inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Squalene inhibits the reaction [potassium bromate results in increased expression of RELA protein] CTD PMID:33219891 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Squalene results in decreased expression of TNF mRNA CTD PMID:33219891 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
EXP
ISO
Squalene inhibits the reaction [potassium bromate results in increased expression of VEGFA protein]
Squalene results in decreased expression of VEGFA mRNA
CTD PMID:33219891 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            eukaryotic metabolite 19052
              plant metabolite 17458
                squalene 14
                  (R)-12-hydroxysqualene 0
                  (S)-2,3-epoxysqualene 0
                  2,3-epoxysqualene + 0
                  3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene 0
                  3-methyl-1,2-didehydro-2,3-dihydrosqualene 0
                  squalene triterpenoid + 0
                  tetrahydroxysqualene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  terpene 12711
                                    triterpene 737
                                      squalene 14
                                        (R)-12-hydroxysqualene 0
                                        (S)-2,3-epoxysqualene 0
                                        2,3-epoxysqualene + 0
                                        3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene 0
                                        3-methyl-1,2-didehydro-2,3-dihydrosqualene 0
                                        squalene triterpenoid + 0
                                        tetrahydroxysqualene 0
paths to the root