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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridoxamine
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Accession:CHEBI:16410 term browser browse the term
Definition:A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 3, an aminomethyl group at position 4, a hydroxymethyl group at position 5 and a methyl group at position 2. The 4-aminomethyl form of vitamin B6, it is used (in the form of the hydrochloride salt) for treatment of diabetic nephropathy.
Synonyms:related_synonym: 4-(AMINOMETHYL)-5-(HYDROXYMETHYL)-2-METHYLPYRIDIN-3-OL;   Formula=C8H12N2O2;   InChI=1S/C8H12N2O2/c1-5-8(12)7(2-9)6(4-11)3-10-5/h3,11-12H,2,4,9H2,1H3;   InChIKey=NHZMQXZHNVQTQA-UHFFFAOYSA-N;   PM;   SMILES=Cc1ncc(CO)c(CN)c1O
 alt_id: CHEBI:14978;   CHEBI:26426;   CHEBI:45228;   CHEBI:8669
 xref: Beilstein:6993;   CAS:85-87-0;   Chemspider:1023;   FooDB:FDB021819;   Gmelin:774473;   HMDB:HMDB0001431;   KEGG:C00534;   KNApSAcK:C00007504
 xref_mesh: MESH:D011733
 xref: MetaCyc:PYRIDOXAMINE;   PDBeChem:PXM;   PMID:1400785;   PMID:15369738;   PMID:18434162;   PMID:19212411;   PMID:23504149;   PMID:23841818;   PMID:24094054;   PMID:2580028;   PMID:33535220;   PMID:33665688;   PMID:7710125;   PMID:8054960;   Reaxys:6993;   Wikipedia:Pyridoxamine
 cyclic_relationship: is_conjugate_base_of CHEBI:57761


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pyridoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase decreases activity EXP Pyridoxamine results in decreased activity of GSR protein CTD PMID:24831520 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO Pyridoxamine results in decreased activity of PTGS2 protein CTD PMID:20041722 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sod2 superoxide dismutase 2 increases activity EXP Pyridoxamine results in increased activity of SOD2 protein CTD PMID:24831520 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] CTD PMID:15309289 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Pyridoxamine inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:15309289 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      chemical role 19418
        ligand 6121
          chelator 6108
            iron chelator 1253
              pyridoxamine 6
                pyridoxamine 5'-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic molecule 19651
                              organic cyclic compound 19457
                                organic heterocyclic compound 18816
                                  organic heteromonocyclic compound 17581
                                    pyridines 9413
                                      hydroxypyridine 86
                                        monohydroxypyridine 55
                                          pyridoxamine 6
                                            pyridoxamine 5'-phosphate 0
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