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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(R)-carnitine
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Accession:CHEBI:16347 term browser browse the term
Definition:The (R)-enantiomer of carnitine.
Synonyms:exact_synonym: (3R)-3-hydroxy-4-(trimethylammonio)butanoate
 related_synonym: 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt;   Carnicor;   Carnitene;   Carnitine;   Carnitor;   Formula=C7H15NO3;   InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1;   InChIKey=PHIQHXFUZVPYII-ZCFIWIBFSA-N;   L-Carnitine;   Levocarnitine;   SMILES=C[N+](C)(C)C[C@H](O)CC([O-])=O;   Vitamin BT
 alt_id: CHEBI:13091;   CHEBI:21256;   CHEBI:6202
 xref: Beilstein:4292315;   Beilstein:5732837;   CAS:541-15-1;   DrugBank:DB00583;   Drug_Central:513;   Gmelin:1782973;   HMDB:HMDB0000062;   KEGG:C00318;   KEGG:D02176
 xref_mesh: MESH:D002331
 xref: MetaCyc:CARNITINE;   PDBeChem:152
 cyclic_relationship: is_conjugate_base_of CHEBI:39547;   is_enantiomer_of CHEBI:11060


show annotations for term's descendants           Sort by:
(R)-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression EXP Carnitine results in decreased expression of ACACA protein CTD PMID:25669660 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acacb acetyl-CoA carboxylase beta decreases expression EXP Carnitine results in decreased expression of ACACB protein CTD PMID:25669660 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:48,026,394...48,138,214 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP Carnitine results in increased expression of ADIPOQ protein CTD PMID:30256492 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation 		EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein] CTD PMID:29186614 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein binds to APP protein]]] CTD PMID:33290254 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions 		EXP Carnitine results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in decreased expression of BAX protein]; Carnitine inhibits the reaction [Atrazine results in increased expression of BAX mRNA]; Carnitine inhibits the reaction [Methotrexate results in increased expression of BAX protein] 		CTD PMID:29186614 PMID:36282381 PMID:37312617 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 multiple interactions
increases chemical synthesis 		ISO Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]]; Ketoglutaric Acids inhibits the reaction [Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] CTD PMID:21439360 NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:117,277,226...117,326,064 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases phosphorylation 		EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of BCL2 protein]; Carnitine inhibits the reaction [Atrazine results in decreased expression of BCL2 mRNA]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA]; Carnitine inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein] CTD PMID:23213347 PMID:29186614 PMID:36282381 PMID:37312617 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Carnitine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein] CTD PMID:19491382 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression 		EXP
ISO 		Carnitine inhibits the reaction [Atrazine results in increased expression of CASP3 mRNA]; Carnitine inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP3 mRNA]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]; Carnitine inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]
Carnitine results in increased expression of CASP3 protein
Carnitine inhibits the reaction [quinone results in increased activity of CASP3 protein] 		CTD PMID:19491382 PMID:23213347 PMID:25669660 PMID:26562095 PMID:32478940 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein] CTD PMID:32478940 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO 		Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP9 mRNA]
Carnitine inhibits the reaction [quinone results in increased activity of CASP9 protein] 		CTD PMID:23213347 PMID:32478940 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP Carnitine inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of CAT mRNA] CTD PMID:16889571 PMID:19294768 PMID:23213347 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Carnitine inhibits the reaction [Sunitinib results in increased expression of CCN2 mRNA] CTD PMID:26581635 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CDH1 protein] CTD PMID:28973641 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of COL1A1 mRNA]; Carnitine inhibits the reaction [Sunitinib results in increased expression of COL1A1 mRNA] CTD PMID:26581635 PMID:28973641 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] affects the abundance of Carnitine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine] CTD PMID:24709313 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP
ISO 		valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Carnitine]
[Doxorubicin co-treated with Carnitine] results in increased expression of CPT1A mRNA; [Genistein co-treated with Carnitine] results in increased expression of CPT1A protein; Carnitine inhibits the reaction [quinone results in decreased expression of CPT1A protein] 		CTD PMID:16283381 PMID:16362726 PMID:19854160 PMID:32478940 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions
increases expression 		ISO
EXP 		Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate]
Carnitine results in increased expression of CPT2 protein 		CTD PMID:21816645 PMID:25669660 NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Carnitine inhibits the reaction [Sunitinib results in increased expression of CYBB mRNA]; Carnitine inhibits the reaction [Sunitinib results in increased expression of CYBB protein] CTD PMID:26581635 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP Carnitine inhibits the reaction [Atrazine results in decreased expression of CYP17A1 mRNA] CTD PMID:29710542 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein] CTD PMID:8130774 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions EXP Carnitine inhibits the reaction [Doxorubicin results in decreased expression of FABP3 mRNA] CTD PMID:20470772 NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881 		JBrowse link
G Fabp9 fatty acid binding protein 9 multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in decreased expression of FABP9 mRNA]; Carnitine inhibits the reaction [carbendazim results in decreased expression of FABP9 protein] CTD PMID:33965443 NCBI chr 2:93,499,136...93,503,267
Ensembl chr 2:93,499,134...93,503,260 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Carnitine results in decreased expression of FASN protein CTD PMID:25669660 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in decreased expression of FSHB protein] CTD PMID:33965443 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G Gdf9 growth differentiation factor 9 multiple interactions
increases expression 		ISO Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of GDF9 mRNA]
Carnitine results in increased expression of GDF9 mRNA 		CTD PMID:37863343 NCBI chr10:38,090,021...38,100,801
Ensembl chr10:38,089,878...38,100,797 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Carnitine inhibits the reaction [Atrazine results in increased expression of GFAP protein] CTD PMID:36282381 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression 		ISO Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of GJA1 mRNA]
Carnitine results in increased expression of GJA1 mRNA 		CTD PMID:37863343 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression
multiple interactions 		ISO Carnitine results in increased expression of GJA4 mRNA
Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of GJA4 mRNA] 		CTD PMID:37863343 NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:144,914,147...144,921,216 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Carnitine inhibits the reaction [Atrazine results in increased activity of GPT protein] CTD PMID:36282381 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA] CTD PMID:23213347 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein] CTD PMID:32478940 NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698 		JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions
increases expression 		ISO Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of HAS2 mRNA]
Carnitine results in increased expression of HAS2 mRNA 		CTD PMID:37863343 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Carnitine inhibits the reaction [Methotrexate results in decreased expression of HMOX1 protein] CTD PMID:37312617 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions ISO Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK mRNA]; Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK protein] CTD PMID:16239342 NCBI chr12:44,048,402...44,070,561
Ensembl chr12:44,048,402...44,070,561 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions EXP Carnitine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA2 protein] CTD PMID:22359436 NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance 		ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Carnitine] CTD PMID:27469509 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in decreased expression of IL10 protein]; Carnitine inhibits the reaction [Sunitinib results in decreased expression of IL10 mRNA] CTD PMID:26581635 PMID:33965443 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il18 interleukin 18 increases expression EXP Carnitine results in increased expression of IL18 protein CTD PMID:25669660 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Carnitine inhibits the reaction [sunitinib results in increased expression of IL1B mRNA]
Carnitine results in increased expression of IL1B protein 		CTD PMID:25669660 PMID:26562095 PMID:26581635 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in increased expression of IL6 protein]; Carnitine inhibits the reaction [Methotrexate results in increased expression of IL6 protein]; Carnitine inhibits the reaction [Sunitinib results in increased expression of IL6 mRNA] CTD PMID:26581635 PMID:33965443 PMID:37312617 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 decreases uptake
multiple interactions 		ISO
EXP 		INS1 protein results in decreased uptake of Carnitine
Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein] 		CTD PMID:28298333 PMID:30256492 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Carnitine inhibits the reaction [Doxorubicin results in increased activity of LDHA protein] CTD PMID:37453608 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Carnitine CTD PMID:20567778 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in decreased expression of LHB protein] CTD PMID:33965443 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Carnitine inhibits the reaction [sunitinib results in decreased expression of MMP9 mRNA] CTD PMID:26581635 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity 		EXP [Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased activity of MPO protein] CTD PMID:18597074 PMID:18852009 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA] CTD PMID:21419151 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853 		JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions ISO Carnitine inhibits the reaction [nickel chloride results in decreased expression of ND6 mRNA] CTD PMID:21419151 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,531...14,049 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA] CTD PMID:18299183 NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Carnitine inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein] CTD PMID:37312617 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression EXP Carnitine results in increased expression of NLRP3 protein CTD PMID:25669660 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in increased expression of NOS2 protein]; Carnitine inhibits the reaction [Ifosfamide results in increased expression of NOS2 mRNA] CTD PMID:23213347 PMID:33965443 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP Carnitine results in increased expression of NOS3 CTD PMID:20123095 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Ocln occludin multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in decreased expression of OCLN protein] CTD PMID:33965443 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
increases activity 		EXP [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [SLC22A21 protein results in increased uptake of Carnitine]; PPARA protein promotes the reaction [Carnitine results in decreased susceptibility to Gentamicins]
Carnitine results in increased expression of PPARA protein
Carnitine results in increased activity of PPARA protein 		CTD PMID:19491382 PMID:19735737 PMID:25669660 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions 		EXP Carnitine results in increased expression of PPARG protein
Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein] 		CTD PMID:30256492 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Carnitine inhibits the reaction [Methotrexate results in decreased expression of PPARGC1A protein] CTD PMID:37312617 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ptgis prostaglandin I2 synthase increases expression
increases response to substance
multiple interactions 		EXP Carnitine results in increased expression of PTGIS mRNA
PTGIS protein results in increased susceptibility to Carnitine
[Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha 		CTD PMID:19491382 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Pycard PYD and CARD domain containing increases expression EXP Carnitine results in increased expression of PYCARD protein CTD PMID:25669660 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in increased expression of RELA protein] CTD PMID:33965443 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Carnitine results in decreased expression of SCD protein CTD PMID:25669660 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Carnitine inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein] CTD PMID:37312617 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions ISO Carnitine inhibits the reaction [Cyclophosphamide results in increased expression of SIRT3 mRNA] CTD PMID:37863343 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression EXP Carnitine results in decreased expression of SLC22A1 protein CTD PMID:25669660 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases expression EXP Carnitine results in decreased expression of SLC22A2 protein CTD PMID:25669660 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc22a21 solute carrier family 22 (organic cation transporter), member 21 multiple interactions
increases uptake 		EXP [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [SLC22A21 protein results in increased uptake of Carnitine] CTD PMID:19735737 NCBI chr10:38,605,665...38,633,376
Ensembl chr10:38,604,886...38,631,209 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 increases uptake
decreases expression 		ISO
EXP 		SLC22A4 protein results in increased uptake of Carnitine
Carnitine results in decreased expression of SLC22A4 protein 		CTD PMID:21256917 PMID:25669660 PMID:33007874 NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,634,098...38,679,920 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions
affects expression
decreases expression
increases transport
increases uptake
increases expression
affects uptake
affects binding 		ISO
EXP 		[Doxorubicin co-treated with Carnitine] results in increased expression of SLC22A5 mRNA; Amiodarone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Atorvastatin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [SLC22A5 protein results in increased abundance of Doxorubicin]; Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; Choline inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ipratropium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Propranolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Quetiapine Fumarate inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; talinolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine affects the expression of SLC22A5 protein
Carnitine inhibits the reaction [SLC22A5 protein results in increased abundance of and results in increased localization of Doxorubicin]
Carnitine results in decreased expression of SLC22A5 mRNA; Carnitine results in decreased expression of SLC22A5 protein
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine deficiency results in increased expression of SLC22A5 mRNA
SLC22A5 protein results in increased uptake of Carnitine; SLC22A5 protein results in increased uptake of Carnitine analog
SLC22A5 protein affects the uptake of Carnitine
Carnitine binds to SLC22A5 protein 		CTD PMID:12644265 PMID:15486076 PMID:16283381 PMID:16928358 PMID:18762717 More... NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Carnitine CTD PMID:15100168 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions
increases transport 		EXP Ampicillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Carnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cefonicid inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Piperacillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 PMID:23402788 NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions 		EXP Carnitine results in increased expression of SLC2A4 protein
Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein] 		CTD PMID:30256492 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions EXP Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein] CTD PMID:28973641 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression 		EXP Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA]
Carnitine results in decreased expression of SREBF1 protein 		CTD PMID:18299183 PMID:25669660 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP Carnitine inhibits the reaction [carbendazim results in decreased expression of STAR mRNA]; Carnitine inhibits the reaction [carbendazim results in decreased expression of STAR protein] CTD PMID:33965443 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TGFB1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of TGFB1 mRNA] CTD PMID:26562095 PMID:26581635 PMID:28973641 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Carnitine inhibits the reaction [sunitinib results in increased expression of TIMP1 mRNA] CTD PMID:26581635 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein] CTD PMID:28973641 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression 		EXP Carnitine deficiency results in increased expression of TNF mRNA
[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased expression of TNF mRNA]; Carnitine inhibits the reaction [carbendazim results in increased expression of TNF protein]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Carnitine inhibits the reaction [Methotrexate results in increased expression of TNF protein]
Carnitine results in decreased expression of TNF protein 		CTD PMID:18597074 PMID:18629605 PMID:18852009 PMID:26562095 PMID:33965443 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vim vimentin multiple interactions EXP Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of VIM protein] CTD PMID:28973641 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Acetylcarnitine inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Acetylcarnitine inhibits the reaction [Dexamethasone results in increased activity of ACHE protein] CTD PMID:21986892 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Acetylcarnitine results in increased expression of APEX1 mRNA CTD PMID:14654561 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases expression EXP Acetylcarnitine results in increased expression of ATP6V1F mRNA CTD PMID:14654561 NCBI chr 4:59,033,020...59,035,980 JBrowse link
G C1qa complement C1q A chain decreases expression ISO Acetylcarnitine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732 		JBrowse link
G C4b complement C4B decreases expression ISO Acetylcarnitine results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of CASP3 mRNA] CTD PMID:20067779 PMID:29278859 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein] CTD PMID:29278859 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of CAT mRNA] CTD PMID:20067779 PMID:26349760 PMID:29278859 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Acetylcarnitine CTD PMID:24709313 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627 		JBrowse link
G Cs citrate synthase decreases activity EXP Acetylcarnitine results in decreased activity of CS protein CTD PMID:9821151 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938 		JBrowse link
G Ctss cathepsin S decreases expression ISO Acetylcarnitine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO Acetylcarnitine results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,323,143...8,331,172 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of EGR1 mRNA] CTD PMID:20067779 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Acetylcarnitine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Acetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein] CTD PMID:26265018 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA] CTD PMID:21986892 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA] CTD PMID:21986892 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA] CTD PMID:21986892 NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression EXP Acetylcarnitine results in decreased expression of HSPB1 mRNA CTD PMID:14654561 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions 		ISO IDH2 protein mutant form results in increased abundance of Acetylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine] 		CTD PMID:27469509 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:29278859 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:29278859 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression EXP Acetylcarnitine results in increased expression of MGST1 mRNA CTD PMID:14654561 NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions EXP Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of COX1 mRNA] CTD PMID:20067779 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Acetylcarnitine inhibits the reaction [Cisplatin results in decreased expression of NGF protein] CTD PMID:14654561 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA] CTD PMID:21986892 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA] CTD PMID:21986892 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Acetylcarnitine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions 		ISO Acetylcarnitine results in increased expression of PPARGC1A protein
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein 		CTD PMID:20414966 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304 		JBrowse link
G Psmb6 proteasome 20S subunit beta 6 increases expression EXP Acetylcarnitine results in increased expression of PSMB6 mRNA CTD PMID:14654561 NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,737,888...55,740,218 		JBrowse link
G Ptma prothymosin alpha increases expression EXP Acetylcarnitine results in increased expression of PTMA mRNA CTD PMID:14654561 NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of RELA protein] CTD PMID:29278859 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rps17 ribosomal protein S17 increases expression EXP Acetylcarnitine results in increased expression of RPS17 mRNA CTD PMID:14654561 NCBI chr 1:144,705,150...144,707,736
Ensembl chr 1:144,705,149...144,707,734
Ensembl chr 8:144,705,149...144,707,734 		JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO Acetylcarnitine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:82,281,221...82,431,664
Ensembl chr 4:82,263,709...82,432,886 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Acetylcarnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein] CTD PMID:23402788 NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027 		JBrowse link
G Snca synuclein alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Acetylcarnitine inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253 		JBrowse link
O-butanoyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance 		ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of butyrylcarnitine] CTD PMID:27469509 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
O-propanoyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases abundance
multiple interactions 		ISO APP protein mutant form results in increased abundance of propionylcarnitine
PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of propionylcarnitine]
[APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in decreased abundance of propionylcarnitine 		CTD PMID:39172838 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Mapt microtubule-associated protein tau decreases abundance
multiple interactions 		ISO MAPT protein mutant form results in decreased abundance of propionylcarnitine
PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased abundance of propionylcarnitine] 		CTD PMID:39172838 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in decreased abundance of propionylcarnitine CTD PMID:39172838 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      biological role 20799
        biochemical role 20250
          vitamin (role) 14061
            water-soluble vitamin (role) 9731
              (R)-carnitine 108
                (3R)-4-(dimethylammonio)-3-hydroxybutanoate 0
                (R)-carnitinamide + 0
                O-acyl-L-carnitine + 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    main group molecular entity 20762
                      s-block molecular entity 20556
                        hydrogen molecular entity 20540
                          hydrides 19681
                            inorganic hydride 18586
                              pnictogen hydride 18572
                                nitrogen hydride 18487
                                  ammonium 8449
                                    ammonium ion derivative 8444
                                      quaternary ammonium ion 5311
                                        quaternary nitrogen compound 884
                                          ammonium betaine 372
                                            amino-acid betaine 277
                                              carnitine 114
                                                (R)-carnitine 108
                                                  (3R)-4-(dimethylammonio)-3-hydroxybutanoate 0
                                                  (R)-carnitinamide + 0
                                                  O-acyl-L-carnitine + 42
paths to the root