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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:O-acetyl-L-carnitine
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Accession:CHEBI:57589 term browser browse the term
Definition:An O-acyl-L-carnitine where the acyl group specified is acetyl. It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids.
Synonyms:exact_synonym: (3R)-3-(acetyloxy)-4-(trimethylazaniumyl)butanoate
 related_synonym: (-)-Acetylcarnitine;   Acetyl-L-carnitine;   Formula=C9H17NO4;   InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1;   InChIKey=RDHQFKQIGNGIED-MRVPVSSYSA-N;   L-Acetylcarnitine;   L-Carnitine acetyl ester;   L-O-Acetylcarnitine;   O-acetyl-(R)-carnitine;   R-Acetylcarnitine;   SMILES=CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C
 alt_id: MESH:D000108
 xref: CAS:3040-38-8;   Drug_Central:64;   HMDB:HMDB0000201;   KEGG:C02571
 xref_mesh: MESH:D000108
 xref: MetaCyc:O-ACETYLCARNITINE;   PMID:22770225;   Reaxys:3667658;   Wikipedia:Acetyl-L-carnitine
 cyclic_relationship: is_enantiomer_of CHEBI:86045


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O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Acetylcarnitine inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Acetylcarnitine inhibits the reaction [Dexamethasone results in increased activity of ACHE protein] CTD PMID:21986892 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Acetylcarnitine results in increased expression of APEX1 mRNA CTD PMID:14654561 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F increases expression EXP Acetylcarnitine results in increased expression of ATP6V1F mRNA CTD PMID:14654561 NCBI chr 4:59,033,020...59,035,980 JBrowse link
G C1qa complement C1q A chain decreases expression ISO Acetylcarnitine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C4b complement C4B decreases expression ISO Acetylcarnitine results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of CASP3 mRNA] CTD PMID:20067779 PMID:29278859 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein] CTD PMID:29278859 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of CAT mRNA] CTD PMID:20067779 PMID:26349760 PMID:29278859 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Acetylcarnitine CTD PMID:24709313 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cs citrate synthase decreases activity EXP Acetylcarnitine results in decreased activity of CS protein CTD PMID:9821151 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421 		JBrowse link
G Ctss cathepsin S decreases expression ISO Acetylcarnitine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO Acetylcarnitine results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of EGR1 mRNA] CTD PMID:20067779 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Acetylcarnitine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Acetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein] CTD PMID:26265018 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA] CTD PMID:21986892 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA] CTD PMID:21986892 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA] CTD PMID:21986892 NCBI chr10:11,303,512...11,337,640
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression EXP Acetylcarnitine results in decreased expression of HSPB1 mRNA CTD PMID:14654561 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of Acetylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine]		 CTD PMID:27469509 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:29278859 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:29278859 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression EXP Acetylcarnitine results in increased expression of MGST1 mRNA CTD PMID:14654561 NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions EXP Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of COX1 mRNA] CTD PMID:20067779 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Acetylcarnitine inhibits the reaction [Cisplatin results in decreased expression of NGF protein] CTD PMID:14654561 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA] CTD PMID:21986892 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA] CTD PMID:21986892 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO Acetylcarnitine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:21,933,179...21,998,130 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions		 ISO Acetylcarnitine results in increased expression of PPARGC1A protein
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein		 CTD PMID:20414966 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Psmb6 proteasome 20S subunit beta 6 increases expression EXP Acetylcarnitine results in increased expression of PSMB6 mRNA CTD PMID:14654561 NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,239,241...55,241,586 		JBrowse link
G Ptma prothymosin alpha increases expression EXP Acetylcarnitine results in increased expression of PTMA mRNA CTD PMID:14654561 NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:87,176,230...87,180,333 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of RELA protein] CTD PMID:29278859 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps17 ribosomal protein S17 increases expression EXP Acetylcarnitine results in increased expression of RPS17 mRNA CTD PMID:14654561 NCBI chr 1:144,705,150...144,707,736
Ensembl chr 1:135,295,919...135,298,535
Ensembl chr 8:135,295,919...135,298,535 		JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO Acetylcarnitine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions EXP Acetylcarnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein] CTD PMID:23402788 NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
G Snca synuclein alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Acetylcarnitine inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    role 19850
      biological role 19848
        biochemical role 19562
          metabolite 19550
            butyrate 114
              carnitine 114
                O-acetyl-L-carnitine 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    main group molecular entity 19816
                      s-block molecular entity 19651
                        hydrogen molecular entity 19633
                          hydrides 19147
                            inorganic hydride 18160
                              pnictogen hydride 18150
                                nitrogen hydride 18063
                                  ammonium 8309
                                    ammonium ion derivative 8304
                                      quaternary ammonium ion 5294
                                        quaternary nitrogen compound 880
                                          ammonium betaine 370
                                            amino-acid betaine 275
                                              carnitine 114
                                                O-acylcarnitine 47
                                                  O-acyl-L-carnitine 42
                                                    fatty acyl-L-carnitine 42
                                                      saturated fatty acyl-L-carnitine 42
                                                        O-acetyl-L-carnitine 39
paths to the root