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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-methyl-2-oxobutanoic acid
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Accession:CHEBI:16530 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid.
Synonyms:related_synonym: 2-Keto-3-methylbutyric acid;   2-Ketoisovaleric acid;   2-Ketovaline;   2-Oxo-3-methylbutanoic acid;   2-Oxo-3-methylbutyric acid;   2-Oxoisovaleric acid;   3-Methyl-2-oxobutanoate;   3-Methyl-2-oxobutyric acid;   Dimethylpyruvic acid;   Formula=C5H8O3;   InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8);   InChIKey=QHKABHOOEWYVLI-UHFFFAOYSA-N;   Isopropylglyoxylic acid;   SMILES=CC(C)C(=O)C(O)=O;   alpha-Ketovaline;   alpha-keto-isovaleric acid;   alpha-oxo-beta-methylbutyricacid;   alpha-oxoisovaleric acid
 alt_id: CHEBI:1584;   CHEBI:20115;   CHEBI:43714
 xref: CAS:759-05-7;   DrugBank:DB04074;   HMDB:HMDB0000019;   KEGG:C00141;   KNApSAcK:C00007623;   LIPID_MAPS_instance:LMFA01020274
 xref_mesh: MESH:C001505
 xref: MetaCyc:2-KETO-ISOVALERATE;   PDBeChem:KIV;   PMID:17190852;   PMID:192504;   PMID:7021997;   Reaxys:1744951
 cyclic_relationship: is_conjugate_acid_of CHEBI:11851;   is_tautomer_of CHEBI:132177


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3-methyl-2-oxobutanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of alpha-ketoisovalerate CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of alpha-ketoisovalerate CTD PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        biochemical role 19310
          metabolite 19292
            eukaryotic metabolite 18963
              fungal metabolite 17440
                Saccharomyces cerevisiae metabolite 16496
                  3-methyl-2-oxobutanoic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        monocarboxylic acid 17526
                                          fatty acid 16004
                                            short-chain fatty acid 15694
                                              fatty acid 4:0 7848
                                                butyric acid 6198
                                                  3-methyl-2-oxobutanoic acid 2
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