CPS1 (carbamoyl-phosphate synthase 1) - Rat Genome Database

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Gene: CPS1 (carbamoyl-phosphate synthase 1) Canis lupus familiaris
Analyze
Symbol: CPS1
Name: carbamoyl-phosphate synthase 1
RGD ID: 12113445
Description: ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); carbamoyl-phosphate synthase (ammonia) activity (ortholog); INVOLVED IN anion homeostasis (ortholog); cellular response to cAMP (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; ASSOCIATED WITH Acidoses (ortholog); Animal Hepatitis (ortholog); carbamoyl phosphate synthetase I deficiency disease (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial inner membrane (ortholog); protein-containing complex (ortholog); INTERACTS WITH clofibrate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthetase 1, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13718,308,164 - 18,428,487 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3719,188,984 - 19,309,290 (+)NCBI
ROS_Cfam_1.03718,246,433 - 18,366,577 (+)NCBI
ROS_Cfam_1.0 Ensembl3718,082,221 - 18,366,572 (+)Ensembl
UMICH_Zoey_3.13718,198,783 - 18,319,066 (+)NCBI
UNSW_CanFamBas_1.03718,161,084 - 18,281,176 (+)NCBI
UU_Cfam_GSD_1.03718,175,864 - 18,296,018 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
clofibrate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
CPS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13718,308,164 - 18,428,487 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3719,188,984 - 19,309,290 (+)NCBI
ROS_Cfam_1.03718,246,433 - 18,366,577 (+)NCBI
ROS_Cfam_1.0 Ensembl3718,082,221 - 18,366,572 (+)Ensembl
UMICH_Zoey_3.13718,198,783 - 18,319,066 (+)NCBI
UNSW_CanFamBas_1.03718,161,084 - 18,281,176 (+)NCBI
UU_Cfam_GSD_1.03718,175,864 - 18,296,018 (+)NCBI
CPS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382210,477,685 - 210,679,107 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2210,477,682 - 210,679,107 (+)EnsemblGRCh38hg38GRCh38
GRCh372211,342,409 - 211,543,831 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362211,129,583 - 211,252,076 (+)NCBINCBI36hg18NCBI36
Build 342211,246,843 - 211,369,335NCBI
Celera2205,110,438 - 205,311,714 (+)NCBI
Cytogenetic Map2q34NCBI
HuRef2203,188,451 - 203,390,097 (+)NCBIHuRef
CHM1_12211,348,531 - 211,549,854 (+)NCBICHM1_1
T2T-CHM13v2.02210,958,482 - 211,159,839 (+)NCBI
Cps1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39167,151,294 - 67,270,426 (+)NCBIGRCm39mm39
GRCm39 Ensembl167,162,185 - 67,270,418 (+)Ensembl
GRCm38167,122,426 - 67,231,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl167,123,026 - 67,231,259 (+)EnsemblGRCm38mm10GRCm38
MGSCv37167,169,640 - 67,277,022 (+)NCBIGRCm37mm9NCBIm37
MGSCv36167,056,235 - 67,164,475 (+)NCBImm8
Celera167,649,362 - 67,756,702 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map133.75NCBI
Cps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2968,614,153 - 68,737,037 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl968,614,153 - 68,737,033 (+)Ensembl
Rnor_6.0974,113,437 - 74,236,274 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl974,124,016 - 74,236,274 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0973,072,857 - 73,183,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4965,907,211 - 66,017,942 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1966,054,192 - 66,164,924 (+)NCBI
Celera966,092,717 - 66,214,118 (+)NCBICelera
Cytogenetic Map9q32NCBI
Cps1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554574,844,152 - 4,961,246 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554574,848,116 - 4,961,384 (-)NCBIChiLan1.0ChiLan1.0
CPS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B216,136,857 - 216,337,728 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B216,136,857 - 216,337,728 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B97,735,486 - 97,936,623 (+)NCBIMhudiblu_PPA_v0panPan3
Cps1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303166,764,670 - 166,886,826 (+)NCBI
SpeTri2.0NW_0049365865,739,038 - 5,850,317 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15113,150,157 - 113,339,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115113,210,038 - 113,339,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215125,183,128 - 125,279,098 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11096,267,890 - 96,392,393 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1096,267,889 - 96,392,206 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040102,979,677 - 103,099,178 (-)NCBIVero_WHO_p1.0
Cps1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247655,528,112 - 5,651,415 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247655,527,029 - 5,652,343 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6
Low 3 5 1 2 11 8
Below cutoff 5 2 11 5 4 6 1 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000022222   ⟹   ENSCAFP00000020636
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,247,726 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000065057   ⟹   ENSCAFP00000063915
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000067245   ⟹   ENSCAFP00000056998
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075634   ⟹   ENSCAFP00000044374
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000076588   ⟹   ENSCAFP00000049536
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,269,478 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087977   ⟹   ENSCAFP00000055233
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000088539   ⟹   ENSCAFP00000063655
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089713   ⟹   ENSCAFP00000052359
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,144,007 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845031688   ⟹   ENSCAFP00845024805
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3718,082,221 - 18,366,572 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845032056   ⟹   ENSCAFP00845025064
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3718,185,935 - 18,366,572 (+)Ensembl
RefSeq Acc Id: XM_038447847   ⟹   XP_038303775
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03718,246,433 - 18,366,577 (+)NCBI
RefSeq Acc Id: XM_038521872   ⟹   XP_038377800
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13718,198,783 - 18,319,066 (+)NCBI
RefSeq Acc Id: XM_038585639   ⟹   XP_038441567
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03718,175,864 - 18,296,018 (+)NCBI
RefSeq Acc Id: XM_038650021   ⟹   XP_038505949
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03718,161,084 - 18,281,176 (+)NCBI
RefSeq Acc Id: XM_545627   ⟹   XP_545627
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13718,308,164 - 18,428,487 (+)NCBI
Dog10K_Boxer_Tasha3719,188,984 - 19,309,290 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038303775 (Get FASTA)   NCBI Sequence Viewer  
  XP_038377800 (Get FASTA)   NCBI Sequence Viewer  
  XP_038441567 (Get FASTA)   NCBI Sequence Viewer  
  XP_038505949 (Get FASTA)   NCBI Sequence Viewer  
  XP_545627 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_545627   ⟸   XM_545627
- UniProtKB: F1PJF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000063655   ⟸   ENSCAFT00000088539
RefSeq Acc Id: ENSCAFP00000055233   ⟸   ENSCAFT00000087977
RefSeq Acc Id: ENSCAFP00000049536   ⟸   ENSCAFT00000076588
RefSeq Acc Id: ENSCAFP00000056998   ⟸   ENSCAFT00000067245
RefSeq Acc Id: ENSCAFP00000063915   ⟸   ENSCAFT00000065057
RefSeq Acc Id: ENSCAFP00000052359   ⟸   ENSCAFT00000089713
RefSeq Acc Id: ENSCAFP00000044374   ⟸   ENSCAFT00000075634
RefSeq Acc Id: ENSCAFP00000020636   ⟸   ENSCAFT00000022222
RefSeq Acc Id: XP_038377800   ⟸   XM_038521872
RefSeq Acc Id: XP_038505949   ⟸   XM_038650021
RefSeq Acc Id: XP_038303775   ⟸   XM_038447847
RefSeq Acc Id: XP_038441567   ⟸   XM_038585639
RefSeq Acc Id: ENSCAFP00845024805   ⟸   ENSCAFT00845031688
RefSeq Acc Id: ENSCAFP00845025064   ⟸   ENSCAFT00845032056
Protein Domains
ATP-grasp   MGS-like

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
37 18329818 18329819 G A snv Wolf (WO002_732)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013966 Ensembl
  ENSCAFG00030015614 UniProtKB/TrEMBL
  ENSCAFG00040013121 UniProtKB/TrEMBL
  ENSCAFG00845017752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030025654.1 UniProtKB/TrEMBL
  ENSCAFP00030025891.1 UniProtKB/TrEMBL
  ENSCAFP00030025935.1 UniProtKB/TrEMBL
  ENSCAFP00040021969 UniProtKB/TrEMBL
  ENSCAFP00040022195 UniProtKB/TrEMBL
  ENSCAFP00040022446 UniProtKB/TrEMBL
  ENSCAFP00040022624 UniProtKB/TrEMBL
  ENSCAFP00845024805 ENTREZGENE
  ENSCAFP00845024805.1 UniProtKB/TrEMBL
  ENSCAFP00845025064.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030029438.1 UniProtKB/TrEMBL
  ENSCAFT00030029711.1 UniProtKB/TrEMBL
  ENSCAFT00030029766.1 UniProtKB/TrEMBL
  ENSCAFT00040025276 UniProtKB/TrEMBL
  ENSCAFT00040025524 UniProtKB/TrEMBL
  ENSCAFT00040025809 UniProtKB/TrEMBL
  ENSCAFT00040026015 UniProtKB/TrEMBL
  ENSCAFT00845031688 ENTREZGENE
  ENSCAFT00845031688.1 UniProtKB/TrEMBL
  ENSCAFT00845032056.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1030.10 UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/TrEMBL
  3.40.50.1380 UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/TrEMBL
  3.50.30.20 UniProtKB/TrEMBL
InterPro ATP-grasp UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/TrEMBL
  CarbamoylP_synth_lsu UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo_sf UniProtKB/TrEMBL
  CarbamoylP_synth_ssu UniProtKB/TrEMBL
  CarbamoylP_synth_ssu_N UniProtKB/TrEMBL
  CarbP_synth_ssu_N_sf UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/TrEMBL
  CbamoylP_synth_lsu_CPSase_dom UniProtKB/TrEMBL
  Class_I_gatase-like UniProtKB/TrEMBL
  CPSase_GATase1 UniProtKB/TrEMBL
  GATASE UniProtKB/TrEMBL
  MGS-like_dom UniProtKB/TrEMBL
  MGS-like_dom_sf UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/TrEMBL
NCBI Gene CPS1 ENTREZGENE
Pfam CPSase_L_D2 UniProtKB/TrEMBL
  CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  GATase UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
PRINTS CPSASE UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
SMART CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
Superfamily-SCOP SSF48108 UniProtKB/TrEMBL
  SSF52021 UniProtKB/TrEMBL
  SSF52317 UniProtKB/TrEMBL
  SSF52335 UniProtKB/TrEMBL
  SSF52440 UniProtKB/TrEMBL
TIGRFAMs CPSaseII_lrg UniProtKB/TrEMBL
  CPSaseIIsmall UniProtKB/TrEMBL
UniProt A0A8C0NKH0_CANLF UniProtKB/TrEMBL
  A0A8C0SJ79_CANLF UniProtKB/TrEMBL
  A0A8C0SJY9_CANLF UniProtKB/TrEMBL
  A0A8C0SKX7_CANLF UniProtKB/TrEMBL
  A0A8C0YY59_CANLF UniProtKB/TrEMBL
  A0A8I3P552_CANLF UniProtKB/TrEMBL
  A0A8I3P9N3_CANLF UniProtKB/TrEMBL
  F1PJF3 ENTREZGENE
VGNC ID VGNC:39572 ENTREZGENE