CPS1 (carbamoyl-phosphate synthase 1) - Rat Genome Database

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Gene: CPS1 (carbamoyl-phosphate synthase 1) Canis lupus familiaris
Analyze
Symbol: CPS1
Name: carbamoyl-phosphate synthase 1
RGD ID: 12113445
Description: ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); carbamoyl-phosphate synthase (ammonia) activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to glucagon stimulus (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; ASSOCIATED WITH Acidoses (ortholog); Animal Hepatitis (ortholog); brain disease (ortholog); FOUND IN mitochondrial inner membrane (ortholog); protein-containing complex (ortholog); INTERACTS WITH clofibrate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthetase 1, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13718,308,164 - 18,428,487 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3719,188,984 - 19,309,290 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03718,246,433 - 18,366,577 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3718,082,221 - 18,366,572 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13718,198,783 - 18,319,066 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03718,161,084 - 18,281,176 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03718,175,864 - 18,296,018 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
clofibrate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CPS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13718,308,164 - 18,428,487 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3719,188,984 - 19,309,290 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03718,246,433 - 18,366,577 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3718,082,221 - 18,366,572 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13718,198,783 - 18,319,066 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03718,161,084 - 18,281,176 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03718,175,864 - 18,296,018 (+)NCBIUU_Cfam_GSD_1.0
CPS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382210,477,685 - 210,679,107 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2210,477,682 - 210,679,107 (+)EnsemblGRCh38hg38GRCh38
GRCh372211,342,409 - 211,543,831 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362211,129,583 - 211,252,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 342211,246,843 - 211,369,335NCBI
Celera2205,110,438 - 205,311,714 (+)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2203,188,451 - 203,390,097 (+)NCBIHuRef
CHM1_12211,348,531 - 211,549,854 (+)NCBICHM1_1
T2T-CHM13v2.02210,958,482 - 211,159,839 (+)NCBIT2T-CHM13v2.0
Cps1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39167,151,294 - 67,270,426 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl167,162,185 - 67,270,418 (+)EnsemblGRCm39 Ensembl
GRCm38167,122,426 - 67,231,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl167,123,026 - 67,231,259 (+)EnsemblGRCm38mm10GRCm38
MGSCv37167,169,640 - 67,277,022 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36167,056,235 - 67,164,475 (+)NCBIMGSCv36mm8
Celera167,649,362 - 67,756,702 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map133.75NCBI
Cps1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8976,063,863 - 76,186,739 (+)NCBIGRCr8
mRatBN7.2968,614,153 - 68,737,037 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl968,614,153 - 68,737,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx977,103,116 - 77,225,425 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0982,232,050 - 82,354,355 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0980,638,581 - 80,759,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0974,113,437 - 74,236,274 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl974,124,016 - 74,236,274 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0973,072,857 - 73,183,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4965,907,211 - 66,017,942 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1966,054,192 - 66,164,924 (+)NCBI
Celera966,092,717 - 66,214,118 (+)NCBICelera
Cytogenetic Map9q32NCBI
Cps1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554574,844,152 - 4,961,246 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554574,848,116 - 4,961,384 (-)NCBIChiLan1.0ChiLan1.0
CPS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213113,101,056 - 113,302,208 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B113,116,036 - 113,318,192 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B97,735,486 - 97,936,623 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B216,136,857 - 216,337,728 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B216,136,857 - 216,337,728 (+)Ensemblpanpan1.1panPan2
Cps1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303166,764,670 - 166,886,826 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365865,739,337 - 5,850,312 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365865,739,038 - 5,850,317 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15113,150,157 - 113,339,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115113,210,038 - 113,339,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215125,183,128 - 125,279,098 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11096,267,890 - 96,392,393 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1096,267,889 - 96,392,206 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040102,979,677 - 103,099,178 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cps1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247655,528,112 - 5,651,415 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247655,527,029 - 5,652,343 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CPS1
1580 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6
Low 3 5 1 2 11 8
Below cutoff 5 2 11 5 4 6 1 10 6

Sequence


RefSeq Acc Id: ENSCAFT00000022222   ⟹   ENSCAFP00000020636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,247,726 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000065057   ⟹   ENSCAFP00000063915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000067245   ⟹   ENSCAFP00000056998
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075634   ⟹   ENSCAFP00000044374
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000076588   ⟹   ENSCAFP00000049536
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,269,478 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087977   ⟹   ENSCAFP00000055233
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000088539   ⟹   ENSCAFP00000063655
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,143,986 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089713   ⟹   ENSCAFP00000052359
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3718,144,007 - 18,427,697 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845031688   ⟹   ENSCAFP00845024805
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3718,082,221 - 18,366,572 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845032056   ⟹   ENSCAFP00845025064
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3718,185,935 - 18,366,572 (+)Ensembl
RefSeq Acc Id: XM_038447847   ⟹   XP_038303775
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03718,246,433 - 18,366,577 (+)NCBI
RefSeq Acc Id: XM_038521872   ⟹   XP_038377800
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13718,198,783 - 18,319,066 (+)NCBI
RefSeq Acc Id: XM_038585639   ⟹   XP_038441567
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03718,175,864 - 18,296,018 (+)NCBI
RefSeq Acc Id: XM_038650021   ⟹   XP_038505949
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03718,161,084 - 18,281,176 (+)NCBI
RefSeq Acc Id: XM_545627   ⟹   XP_545627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13718,308,164 - 18,428,487 (+)NCBI
Dog10K_Boxer_Tasha3719,188,984 - 19,309,290 (+)NCBI
Sequence:
RefSeq Acc Id: XP_545627   ⟸   XM_545627
- UniProtKB: A0A8C0LVT3 (UniProtKB/TrEMBL),   A0A8C0SJY9 (UniProtKB/TrEMBL),   A0A8I3P9N3 (UniProtKB/TrEMBL),   A0A8C0SJ79 (UniProtKB/TrEMBL),   A0A8I3P552 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000063655   ⟸   ENSCAFT00000088539
RefSeq Acc Id: ENSCAFP00000055233   ⟸   ENSCAFT00000087977
RefSeq Acc Id: ENSCAFP00000049536   ⟸   ENSCAFT00000076588
RefSeq Acc Id: ENSCAFP00000056998   ⟸   ENSCAFT00000067245
RefSeq Acc Id: ENSCAFP00000063915   ⟸   ENSCAFT00000065057
RefSeq Acc Id: ENSCAFP00000052359   ⟸   ENSCAFT00000089713
RefSeq Acc Id: ENSCAFP00000044374   ⟸   ENSCAFT00000075634
RefSeq Acc Id: ENSCAFP00000020636   ⟸   ENSCAFT00000022222
RefSeq Acc Id: XP_038377800   ⟸   XM_038521872
RefSeq Acc Id: XP_038505949   ⟸   XM_038650021
RefSeq Acc Id: XP_038303775   ⟸   XM_038447847
- UniProtKB: A0A8C0LVT3 (UniProtKB/TrEMBL),   A0A8C0SJY9 (UniProtKB/TrEMBL),   A0A8I3P9N3 (UniProtKB/TrEMBL),   A0A8C0SJ79 (UniProtKB/TrEMBL),   A0A8I3P552 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441567   ⟸   XM_038585639
- UniProtKB: A0A8C0LVT3 (UniProtKB/TrEMBL),   A0A8C0SJ79 (UniProtKB/TrEMBL),   A0A8C0SJY9 (UniProtKB/TrEMBL),   A0A8I3P552 (UniProtKB/TrEMBL),   A0A8I3P9N3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845024805   ⟸   ENSCAFT00845031688
RefSeq Acc Id: ENSCAFP00845025064   ⟸   ENSCAFT00845032056
Protein Domains
ATP-grasp   MGS-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013966 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015614 UniProtKB/TrEMBL
  ENSCAFG00040013121 UniProtKB/TrEMBL
  ENSCAFG00845017752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022222.5 UniProtKB/TrEMBL
  ENSCAFT00000087977.2 UniProtKB/TrEMBL
  ENSCAFT00030029438.1 UniProtKB/TrEMBL
  ENSCAFT00030029711.1 UniProtKB/TrEMBL
  ENSCAFT00030029766.1 UniProtKB/TrEMBL
  ENSCAFT00040025276.1 UniProtKB/TrEMBL
  ENSCAFT00040025524.1 UniProtKB/TrEMBL
  ENSCAFT00040025809.1 UniProtKB/TrEMBL
  ENSCAFT00040026015.1 UniProtKB/TrEMBL
  ENSCAFT00845031688 ENTREZGENE
  ENSCAFT00845031688.1 UniProtKB/TrEMBL
  ENSCAFT00845032056.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1030.10 UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/TrEMBL
  3.40.50.1380 UniProtKB/TrEMBL
  3.40.50.20 UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/TrEMBL
  3.50.30.20 UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro ATP-grasp UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/TrEMBL
  CarbamoylP_synth_lsu UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo_sf UniProtKB/TrEMBL
  CarbamoylP_synth_ssu UniProtKB/TrEMBL
  CarbamoylP_synth_ssu_N UniProtKB/TrEMBL
  CarbP_synth_ssu_N_sf UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/TrEMBL
  CbamoylP_synth_lsu_CPSase_dom UniProtKB/TrEMBL
  Class_I_gatase-like UniProtKB/TrEMBL
  CPSase_GATase1 UniProtKB/TrEMBL
  GATASE UniProtKB/TrEMBL
  MGS-like_dom UniProtKB/TrEMBL
  MGS-like_dom_sf UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:488506 UniProtKB/TrEMBL
NCBI Gene CPS1 ENTREZGENE
PANTHER CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN UniProtKB/TrEMBL
  CARBAMOYLTRANSFERASE FAMILY MEMBER UniProtKB/TrEMBL
Pfam CPSase_L_D2 UniProtKB/TrEMBL
  CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  GATase UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
PRINTS CPSASE UniProtKB/TrEMBL
  CPSGATASE UniProtKB/TrEMBL
  GATASE UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/TrEMBL
  GATASE_TYPE_1 UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
SMART CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
  SSF48108 UniProtKB/TrEMBL
  SSF52021 UniProtKB/TrEMBL
  SSF52317 UniProtKB/TrEMBL
  SSF52335 UniProtKB/TrEMBL
  SSF52440 UniProtKB/TrEMBL
UniProt A0A8C0LVT3 ENTREZGENE
  A0A8C0NKH0_CANLF UniProtKB/TrEMBL
  A0A8C0SJ79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SJY9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SKX7_CANLF UniProtKB/TrEMBL
  A0A8C0YY59_CANLF UniProtKB/TrEMBL
  A0A8I3P552 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P9N3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39572 ENTREZGENE