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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridoxine
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Accession:CHEBI:16709 term browser browse the term
Definition:A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.
Synonyms:exact_synonym: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
 related_synonym: 2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine;   3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine;   3-hydroxy-4,5-dimethylol-alpha-picoline;   5-hydroxy-6-methyl-3,4-pyridinedimethanol;   Formula=C8H11NO3;   InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3;   InChIKey=LXNHXLLTXMVWPM-UHFFFAOYSA-N;   Pyridoxol;   SMILES=Cc1ncc(CO)c(CO)c1O;   vitamin B6
 alt_id: CHEBI:14981;   CHEBI:26429;   CHEBI:8671
 xref: Beilstein:139854;   CAS:65-23-6;   DrugBank:DB00165;   Drug_Central:2836;   Gmelin:563676;   HMDB:HMDB0000239;   KEGG:C00314;   KEGG:D08454;   KNApSAcK:C00001551;   LINCS:LSM-5324
 xref_mesh: MESH:D011736
 xref: PMID:24035968;   PMID:2580028;   Reaxys:139854;   Wikipedia:Pyridoxine

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pyridoxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Pyridoxine results in increased expression of BAX mRNA CTD PMID:28716455 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Casp8 caspase 8 increases expression ISO Pyridoxine results in increased expression of CASP8 mRNA CTD PMID:28716455 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO
EXP		 Pyridoxine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 multiple interactions ISO Pyridoxine affects the expression of and affects the activity of SHMT1 protein CTD PMID:17482557 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        biochemical role 19328
          cofactor 15557
            pyridoxine 4
              5'-O-beta-D-glucosylpyridoxine 0
              pyridoxine 5'-phosphate 0
              pyridoxine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organic heteromonocyclic compound 16595
                                    pyridines 8397
                                      hydroxypyridine 66
                                        monohydroxypyridine 50
                                          pyridoxine 4
                                            5'-O-beta-D-glucosylpyridoxine 0
                                            pyridoxine 5'-phosphate 0
                                            pyridoxine hydrochloride 0
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