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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyridoxine
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Accession:CHEBI:16709 term browser browse the term
Definition:A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2. The 4-methanol form of vitamin B6, it is converted intoto pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters, sphingolipids and aminolevulinic acid.
Synonyms:exact_synonym: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
 related_synonym: 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin;   2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine;   2-methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine;   2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine;   2-methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine;   2-methyl-4,5-dimethylol-pyridin-3-ol;   3-hydroxy-2-picoline-4,5-dimethanol;   3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine;   3-hydroxy-4,5-dimethylol-alpha-picoline;   4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol;   5-hydroxy-6-methyl-3,4-pyridinedimethanol;   Formula=C8H11NO3;   InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3;   InChIKey=LXNHXLLTXMVWPM-UHFFFAOYSA-N;   Pyridoxol;   SMILES=CC1=C(O)C(CO)=C(CO)C=N1;   piridossina;   pyridoxina;   pyridoxinum;   pyridoxolum;   vitamin B6
 alt_id: CHEBI:14981;   CHEBI:26429;   CHEBI:8671
 xref: AGR:IND607198670;   CAS:65-23-6;   Chemspider:1025;   DrugBank:DB00165;   Drug_Central:2836;   FooDB:FDB000574;   Gmelin:563676;   HMDB:HMDB0000239;   KEGG:C00314;   KEGG:D08454;   KNApSAcK:C00001551;   LINCS:LSM-5324
 xref_mesh: MESH:D011736
 xref: MetaCyc:PYRIDOXINE;   PDBeChem:UEG;   PMID:10687314;   PMID:10894227;   PMID:11562405;   PMID:12640345;   PMID:12768081;   PMID:13046427;   PMID:15132238;   PMID:15369738;   PMID:15756083;   PMID:16236150;   PMID:16277693;   PMID:16690736;   PMID:17044573;   PMID:22932811;   PMID:24035968;   PMID:24601602;   PMID:2580028;   PMID:27113583;   PMID:2885064;   PMID:31093449;   PMID:32105687;   PMID:33549283;   PMID:33665688;   PMID:3710434;   PMID:559690;   PMID:6624427;   PMID:6801073;   PMID:9625217;   Reaxys:139854;   Wikipedia:Pyridoxine


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pyridoxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Pyridoxine results in increased expression of BAX mRNA CTD PMID:28716455 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp8 caspase 8 increases expression ISO Pyridoxine results in increased expression of CASP8 mRNA CTD PMID:28716455 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Nefl neurofilament light chain increases secretion EXP Pyridoxine results in increased secretion of NEFL protein CTD PMID:34677616 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO
EXP 		Pyridoxine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 multiple interactions ISO Pyridoxine affects the expression of and affects the activity of SHMT1 protein CTD PMID:17482557 NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        biochemical role 20261
          cofactor 16912
            pyridoxine 5
              5'-O-beta-D-glucosylpyridoxine 0
              pyridoxine 5'-phosphate 0
              pyridoxine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            organic molecule 20649
                              organic cyclic compound 20400
                                organic heterocyclic compound 19383
                                  organic heteromonocyclic compound 18207
                                    pyridines 12208
                                      hydroxypyridine 89
                                        monohydroxypyridine 58
                                          pyridoxine 5
                                            5'-O-beta-D-glucosylpyridoxine 0
                                            pyridoxine 5'-phosphate 0
                                            pyridoxine hydrochloride 0
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