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ONTOLOGY REPORT - ANNOTATIONS


Term:3',5'-cyclic GMP
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Accession:CHEBI:16356 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.
Synonyms:exact_synonym: guanosine 3',5'-(hydrogen phosphate)
 related_synonym: Cyclic GMP;   Formula=C10H12N5O7P;   Guanosine 3',5'-cyclic monophosphate;   Guanosine 3',5'-cyclic phosphate;   Guanosine cyclic monophosphate;   InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1;   InChIKey=ZOOGRGPOEVQQDX-UUOKFMHZSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O;   cGMP
 alt_id: CHEBI:11675;   CHEBI:1327;   CHEBI:14377;   CHEBI:19829;   CHEBI:39915;   CHEBI:44955;   CHEBI:44957
 xref: CAS:7665-99-8 "ChemIDplus";   CAS:7665-99-8 "KEGG COMPOUND";   DrugBank:DB02315;   HMDB:HMDB0001314;   KEGG:C00942;   KNApSAcK:C00019673
 xref_mesh: MESH:D006152
 xref: PDBeChem:35G;   PDBeChem:PCG;   PMID:24591051 "Europe PMC";   PMID:24705918 "Europe PMC";   Reaxys:586222 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:57746


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3',5'-cyclic GMP term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Aldh2 aldehyde dehydrogenase 2 family member JBrowse link 12 40,466,418 40,498,813 RGD:6480464
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:6480464
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:6480464
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cct7 chaperonin containing TCP1 subunit 7 JBrowse link 4 117,235,023 117,252,265 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Edn3 endothelin 3 JBrowse link 3 172,856,730 172,879,276 RGD:6480464
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6480464
G Gch1 GTP cyclohydrolase 1 JBrowse link 15 23,935,011 23,968,971 RGD:6480464
G Gnrh1 gonadotropin releasing hormone 1 JBrowse link 15 44,441,856 44,446,064 RGD:6480464
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 JBrowse link 2 181,045,694 181,103,321 RGD:6480464
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 2 180,976,939 181,026,001 RGD:6480464
G Hmox2 heme oxygenase 2 JBrowse link 10 10,990,034 11,035,493 RGD:6480464
G Il12rb2 interleukin 12 receptor subunit beta 2 JBrowse link 4 98,049,195 98,141,562 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6480464
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Nppc natriuretic peptide C JBrowse link 9 93,731,436 93,735,636 RGD:6480464
G Pde10a phosphodiesterase 10A JBrowse link 1 52,360,296 52,544,448 RGD:6480464
G Pde11a phosphodiesterase 11A JBrowse link 3 62,818,502 63,211,843 RGD:6480464
G Pde1a phosphodiesterase 1A JBrowse link 3 66,803,247 67,263,658 RGD:6480464
G Pde5a phosphodiesterase 5A JBrowse link 2 226,899,604 227,044,916 RGD:6480464
G Pde9a phosphodiesterase 9A JBrowse link 20 10,123,624 10,216,325 RGD:6480464
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:6480464
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 JBrowse link 4 10,631,129 10,702,390 RGD:6480464
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:6480464
8-(4-chlorophenylthio)-cGMP term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:6480464
G Arhgef17 Rho guanine nucleotide exchange factor 17 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:6480464
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6480464
G Scnn1a sodium channel epithelial 1 alpha subunit JBrowse link 4 157,834,339 157,860,472 RGD:6480464
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:6480464
G Scnn1g sodium channel epithelial 1 gamma subunit JBrowse link 1 191,704,397 191,738,271 RGD:6480464
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:6480464
G Vasp vasodilator-stimulated phosphoprotein JBrowse link 1 80,170,608 80,185,882 RGD:6480464
8-bromo-3',5'-cyclic GMP term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgef17 Rho guanine nucleotide exchange factor 17 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cox4i1 cytochrome c oxidase subunit 4i1 JBrowse link 19 54,245,958 54,252,198 RGD:6480464
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Edn3 endothelin 3 JBrowse link 3 172,856,730 172,879,276 RGD:6480464
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 1 264,298,671 264,303,712 RGD:6480464
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:6480464
G Nrf1 nuclear respiratory factor 1 JBrowse link 4 57,335,732 57,445,317 RGD:6480464
G Pde5a phosphodiesterase 5A JBrowse link 2 226,899,604 227,044,916 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:6480464
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6480464
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:6480464
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6480464
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 JBrowse link 8 117,679,328 117,691,073 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          metabolite 19101
            eukaryotic metabolite 18744
              plant metabolite 17049
                3',5'-cyclic GMP 74
                  (Rp)-cGMPS 0
                  (Sp)-8-Br-cGMPS 0
                  (Sp)-cGMPS 0
                  8-(4-chlorophenylthio)-cGMP 13
                  8-(6-aminohexylthio)-cGMP 0
                  8-bromo-3',5'-cyclic GMP 33
                  8-nitroguanosine 3',5'-cyclic monophosphate 0
                  N(1)-methyl-cGMP 0
                  N(2),3-etheno-cGMP 0
                  N(2),N(2)-dimethyl-cGMP 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      chalcogen 19228
                        oxygen atom 19182
                          oxygen molecular entity 19182
                            hydroxides 18964
                              oxoacid 18075
                                pnictogen oxoacid 8543
                                  phosphorus oxoacid 8436
                                    phosphoric acids 7318
                                      phosphoric acid 7318
                                        phosphoric acid derivative 6968
                                          phosphate 6968
                                            organic phosphate 6967
                                              carbohydrate phosphate 1498
                                                phospho sugar 1433
                                                  aldose phosphate 1431
                                                    aldopentose phosphate 1425
                                                      ribose phosphate 1419
                                                        ribonucleotide 1378
                                                          purine ribonucleotide 1351
                                                            guanyl ribonucleotide 123
                                                              3',5'-cyclic GMP 74
                                                                (Rp)-cGMPS 0
                                                                (Sp)-8-Br-cGMPS 0
                                                                (Sp)-cGMPS 0
                                                                8-(4-chlorophenylthio)-cGMP 13
                                                                8-(6-aminohexylthio)-cGMP 0
                                                                8-bromo-3',5'-cyclic GMP 33
                                                                8-nitroguanosine 3',5'-cyclic monophosphate 0
                                                                N(1)-methyl-cGMP 0
                                                                N(2),3-etheno-cGMP 0
                                                                N(2),N(2)-dimethyl-cGMP 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.