KCNJ6 (potassium inwardly rectifying channel subfamily J member 6) - Rat Genome Database

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Gene: KCNJ6 (potassium inwardly rectifying channel subfamily J member 6) Canis lupus familiaris
Analyze
Symbol: KCNJ6
Name: potassium inwardly rectifying channel subfamily J member 6
RGD ID: 12242625
Description: ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to morphine (ortholog); response to electrical stimulus (ortholog); thyroid hormone metabolic process (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); FOUND IN axon (ortholog); cell surface (ortholog); cytoplasm (ortholog); INTERACTS WITH acetylcholine; barium(0); potassium atom
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G protein-activated inward rectifier potassium channel 2; potassium inwardly-rectifying channel, subfamily J, member 6; potassium voltage-gated channel subfamily J member 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13132,752,585 - 33,010,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3132,755,899 - 32,934,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3131,821,629 - 32,081,491 (-)NCBI
ROS_Cfam_1.03132,062,846 - 32,322,567 (-)NCBI
ROS_Cfam_1.0 Ensembl3132,066,922 - 32,322,588 (-)Ensembl
UMICH_Zoey_3.13131,937,274 - 32,196,786 (-)NCBI
UNSW_CanFamBas_1.03131,945,083 - 32,204,244 (-)NCBI
UU_Cfam_GSD_1.03132,428,866 - 32,689,562 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
KCNJ6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13132,752,585 - 33,010,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3132,755,899 - 32,934,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3131,821,629 - 32,081,491 (-)NCBI
ROS_Cfam_1.03132,062,846 - 32,322,567 (-)NCBI
ROS_Cfam_1.0 Ensembl3132,066,922 - 32,322,588 (-)Ensembl
UMICH_Zoey_3.13131,937,274 - 32,196,786 (-)NCBI
UNSW_CanFamBas_1.03131,945,083 - 32,204,244 (-)NCBI
UU_Cfam_GSD_1.03132,428,866 - 32,689,562 (-)NCBI
KCNJ6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,607,373 - 37,916,457 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2137,607,373 - 38,121,345 (-)EnsemblGRCh38hg38GRCh38
GRCh372138,979,675 - 39,288,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,918,655 - 38,210,566 (-)NCBINCBI36hg18NCBI36
Build 342137,918,656 - 38,210,566NCBI
Celera2124,194,896 - 24,487,265 (-)NCBI
Cytogenetic Map21q22.13NCBI
HuRef2124,470,127 - 24,761,921 (-)NCBIHuRef
CHM1_12138,557,922 - 38,850,112 (-)NCBICHM1_1
T2T-CHM13v2.02135,989,771 - 36,299,971 (-)NCBI
Kcnj6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,545,839 - 94,798,719 (-)NCBIGRCm39mm39
GRCm39 Ensembl1694,549,495 - 94,798,560 (-)Ensembl
GRCm381694,744,980 - 94,997,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,748,636 - 94,997,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371694,970,290 - 95,219,303 (-)NCBIGRCm37mm9NCBIm37
MGSCv361694,857,497 - 95,106,494 (-)NCBImm8
Celera1695,836,339 - 96,085,607 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.44NCBI
Kcnj6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,061,705 - 34,309,128 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1134,061,708 - 34,308,758 (-)Ensembl
Rnor_6.01135,011,007 - 35,262,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1135,024,196 - 35,099,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,602,645 - 38,692,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,025,118 - 35,116,500 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11135,096,649 - 35,172,743NCBI
Celera1134,144,832 - 34,389,786 (+)NCBICelera
Cytogenetic Map11q11NCBI
Kcnj6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540736,659,627 - 36,924,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540736,670,824 - 36,923,960 (-)NCBIChiLan1.0ChiLan1.0
KCNJ6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12137,339,201 - 37,634,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2137,340,738 - 37,558,688 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02123,983,485 - 24,284,759 (-)NCBIMhudiblu_PPA_v0panPan3
Kcnj6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497132,225,573 - 32,465,141 (-)NCBI
SpeTri2.0NW_0049365005,002,668 - 5,164,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,243,609 - 201,525,820 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113201,231,803 - 201,525,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,406,250 - 211,613,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,569,659 - 81,878,047 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660549,424,667 - 9,732,757 (-)NCBIVero_WHO_p1.0
Kcnj6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474525,947,561 - 26,127,171 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474525,879,671 - 26,130,998 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 6 12
Below cutoff 3 1 7 4 6 1 7 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015581   ⟹   ENSCAFP00000014417
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3132,755,899 - 32,934,478 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000074267   ⟹   ENSCAFP00000053800
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3132,755,899 - 32,825,312 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845051108   ⟹   ENSCAFP00845040072
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3132,066,922 - 32,322,588 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845051121   ⟹   ENSCAFP00845040084
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3132,066,922 - 32,322,587 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845051134   ⟹   ENSCAFP00845040096
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3132,066,922 - 32,319,834 (-)Ensembl
RefSeq Acc Id: XM_038443498   ⟹   XP_038299426
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03132,062,846 - 32,322,567 (-)NCBI
RefSeq Acc Id: XM_038517911   ⟹   XP_038373839
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13131,937,274 - 32,196,786 (-)NCBI
RefSeq Acc Id: XM_038581478   ⟹   XP_038437406
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03132,428,866 - 32,689,562 (-)NCBI
RefSeq Acc Id: XM_038645861   ⟹   XP_038501789
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03131,945,083 - 32,204,244 (-)NCBI
RefSeq Acc Id: XM_544881   ⟹   XP_544881
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13132,752,585 - 33,010,999 (-)NCBI
Dog10K_Boxer_Tasha3131,821,629 - 32,081,491 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038299426 (Get FASTA)   NCBI Sequence Viewer  
  XP_038373839 (Get FASTA)   NCBI Sequence Viewer  
  XP_038437406 (Get FASTA)   NCBI Sequence Viewer  
  XP_038501789 (Get FASTA)   NCBI Sequence Viewer  
  XP_544881 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_544881   ⟸   XM_544881
- UniProtKB: E2RIA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014417   ⟸   ENSCAFT00000015581
RefSeq Acc Id: ENSCAFP00000053800   ⟸   ENSCAFT00000074267
RefSeq Acc Id: XP_038373839   ⟸   XM_038517911
RefSeq Acc Id: XP_038501789   ⟸   XM_038645861
RefSeq Acc Id: XP_038299426   ⟸   XM_038443498
RefSeq Acc Id: XP_038437406   ⟸   XM_038581478
RefSeq Acc Id: ENSCAFP00845040072   ⟸   ENSCAFT00845051108
RefSeq Acc Id: ENSCAFP00845040096   ⟸   ENSCAFT00845051134
RefSeq Acc Id: ENSCAFP00845040084   ⟸   ENSCAFT00845051121
Protein Domains
IRK   IRK_C


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009812 Ensembl
  ENSCAFG00030025481 UniProtKB/TrEMBL
  ENSCAFG00040021252 UniProtKB/TrEMBL
  ENSCAFG00845028925 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030041145.1 UniProtKB/TrEMBL
  ENSCAFP00040034403 UniProtKB/TrEMBL
  ENSCAFP00845040072 ENTREZGENE
  ENSCAFP00845040072.1 UniProtKB/TrEMBL
  ENSCAFP00845040084.1 UniProtKB/TrEMBL
  ENSCAFP00845040096.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030047064.1 UniProtKB/TrEMBL
  ENSCAFT00040039431 UniProtKB/TrEMBL
  ENSCAFT00845051108 ENTREZGENE
  ENSCAFT00845051108.1 UniProtKB/TrEMBL
  ENSCAFT00845051121.1 UniProtKB/TrEMBL
  ENSCAFT00845051134.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1400 UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir3.2 UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/TrEMBL
  Kir_TM UniProtKB/TrEMBL
NCBI Gene KCNJ6 ENTREZGENE
PANTHER PTHR11767 UniProtKB/TrEMBL
  PTHR11767:SF19 UniProtKB/TrEMBL
Pfam IRK UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
PIRSF GIRK_kir UniProtKB/TrEMBL
PRINTS KIR32CHANNEL UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
UniProt A0A8C0TE53_CANLF UniProtKB/TrEMBL
  A0A8I3PXZ9_CANLF UniProtKB/TrEMBL
  A0A8I3PY07_CANLF UniProtKB/TrEMBL
  A0A8I3QHZ6_CANLF UniProtKB/TrEMBL
  E2RIA0 ENTREZGENE
VGNC ID VGNC:42267 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-06 KCNJ6  potassium inwardly rectifying channel subfamily J member 6  KCNJ6  potassium voltage-gated channel subfamily J member 6  Symbol and/or name change 5135510 APPROVED