Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9H-xanthine
go back to main search page
Accession:CHEBI:17712 term browser browse the term
Definition:An oxopurine in which the purine ring is substituted by oxo groups at positions 2 and 6 and N-9 is protonated.
Synonyms:exact_synonym: 3,9-dihydro-1H-purine-2,6-dione
 related_synonym: 2,6-dihydroxypurine;   2,6-dioxo-1,2,3,6-tetrahydropurine;   9H-purine-2,6-(1H,3H)-dione;   Formula=C5H4N4O2;   InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11);   InChIKey=LRFVTYWOQMYALW-UHFFFAOYSA-N;   SMILES=O=c1[nH]c2[nH]cnc2c(=O)[nH]1;   XANTHINE;   Xan;   purine-2(3H),6(1H)-dione
 alt_id: CHEBI:10059;   CHEBI:27317;   CHEBI:46377
 xref: BPDB:2153;   Beilstein:609330;   CAS:69-89-6;   Gmelin:913730;   HMDB:HMDB0000292;   KEGG:C00385
 xref_mesh: MESH:D019820
 xref: PDBeChem:XAN;   PMID:22770225;   Reaxys:609330
 cyclic_relationship: is_tautomer_of CHEBI:48517


show annotations for term's descendants           Sort by:
 
9H-xanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of ACAT1 protein CTD PMID:19464573 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Aco2 aconitase 2 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of ACO2 protein CTD PMID:19464573 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Ak2 adenylate kinase 2 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein CTD PMID:19464573 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases activity ISO Xanthine analog results in decreased activity of ALDH1A1 protein CTD PMID:25450233 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of ATP5F1A protein CTD PMID:19464573 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G C1qbp complement C1q binding protein multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein CTD PMID:19464573 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein
3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]; [Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein; [Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]
CTD PMID:19135123 PMID:19268487 PMID:26374991 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein] CTD PMID:19268487 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of CKM protein CTD PMID:19464573 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of CRYAB protein CTD PMID:19464573 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Xanthine co-treated with XDH protein] results in increased expression of CYCS protein CTD PMID:19464573 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Des desmin multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Xanthine co-treated with XDH protein] results in decreased expression of DES protein CTD PMID:19464573 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein CTD PMID:19464573 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Ech1 enoyl-CoA hydratase 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of ECH1 protein CTD PMID:19464573 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ECHS1 protein CTD PMID:19464573 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Eno1 enolase 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of ENO1 protein CTD PMID:19464573 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Etfb electron transfer flavoprotein subunit beta multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein CTD PMID:19464573 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Xanthine co-treated with XDH protein] results in decreased expression of FABP3 protein CTD PMID:19464573 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fh fumarate hydratase multiple interactions EXP [Xanthine co-treated with XDH protein] results in increased expression of FH protein CTD PMID:19464573 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of GUCY1A1 protein CTD PMID:17339839 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of GUCY1B1 protein CTD PMID:17339839 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Xanthine co-treated with XDH protein] results in decreased expression of HADH protein CTD PMID:19464573 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Xanthine co-treated with XDH protein] inhibits the reaction [carbobenzoxy-leucyl-leucyl-leucine results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:12595275 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in increased expression of HMOX1 mRNA CTD PMID:7743507 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpse heparanase multiple interactions EXP [Xanthine co-treated with XDH protein] results in increased expression of HPSE mRNA; [Xanthine co-treated with XDH protein] results in increased expression of HPSE protein CTD PMID:19429930 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions EXP [Xanthine co-treated with XDH protein] affects the localization of HSF1 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein] CTD PMID:19135123 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSP90AB1 protein CTD PMID:19464573 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein CTD PMID:19464573 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of HSPA8 protein CTD PMID:19464573 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein CTD PMID:19464573 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Hspb2 heat shock protein family B (small) member 2 multiple interactions EXP 3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in decreased phosphorylation of HSPB2 protein]; [Xanthine co-treated with XDH protein] results in decreased phosphorylation of HSPB2 protein CTD PMID:26374991 NCBI chr 8:51,093,267...51,094,864 JBrowse link
G Hspb6 heat shock protein family B (small) member 6 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSPB6 protein CTD PMID:19464573 NCBI chr 1:85,806,898...85,809,072
Ensembl chr 1:85,806,146...85,809,071
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of HSPD1 protein CTD PMID:19464573 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Xanthine co-treated with XDH protein] results in decreased expression of IDH2 protein CTD PMID:19464573 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 3,4-dihydroxyphenylethanol promotes the reaction [[Xanthine co-treated with XDH protein] results in decreased phosphorylation of JUN protein]; [Xanthine co-treated with XDH protein] results in decreased phosphorylation of JUN protein CTD PMID:26374991 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO [Xanthine co-treated with XDH protein] results in decreased activity of KCNH2 protein CTD PMID:12531891 PMID:14973143 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of LDHB protein CTD PMID:19464573 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions EXP 3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein]; [Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein] CTD PMID:26374991 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mdh1 malate dehydrogenase 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of MDH1 protein CTD PMID:19464573 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mdh2 malate dehydrogenase 2 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of MDH2 protein CTD PMID:19464573 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Myl2 myosin light chain 2 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Xanthine co-treated with XDH protein] affects the expression of MYL2 protein CTD PMID:19464573 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
JBrowse link
G Myl3 myosin light chain 3 multiple interactions EXP [Xanthine co-treated with XDH protein] results in increased expression of MYL3 protein CTD PMID:19464573 NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:19135123 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of OXCT1 protein CTD PMID:19464573 NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714
JBrowse link
G Phb prohibitin multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein CTD PMID:19464573 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Xanthine co-treated with XDH protein] results in decreased expression of PKM protein CTD PMID:19464573 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein CTD PMID:19464573 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein CTD PMID:19464573 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:19135123 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein CTD PMID:19464573 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP
ISO
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Xanthine co-treated with XDH protein] results in increased expression of SOD2 mRNA
[Xanthine co-treated with XDH protein] results in increased expression of SOD2 protein
CTD PMID:7743507 PMID:19464573 PMID:22718889 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta multiple interactions EXP [Xanthine co-treated with XDH protein] results in decreased expression of SUCLG2 protein CTD PMID:19464573 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein] CTD PMID:19268487 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP [Xanthine co-treated with XDH protein] results in increased expression of TNNT2 protein CTD PMID:19464573 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP [Xanthine co-treated with XDH protein] promotes the reaction [myricetin results in decreased activity of TXNRD1 protein modified form] CTD PMID:16618767 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein CTD PMID:19464573 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO
EXP
[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; [Xanthine co-treated with XDH protein] results in decreased activity of KCNH2 protein; [Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]
3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in decreased phosphorylation of HSPB2 protein]; 3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]; 3,4-dihydroxyphenylethanol inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein]; 3,4-dihydroxyphenylethanol promotes the reaction [[Xanthine co-treated with XDH protein] results in decreased phosphorylation of JUN protein]; [2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Xanthine; [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein; [Xanthine co-treated with XDH protein] affects the expression of MYL2 protein; [Xanthine co-treated with XDH protein] affects the localization of HSF1 protein; [Xanthine co-treated with XDH protein] inhibits the reaction [carbobenzoxy-leucyl-leucyl-leucine results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] inhibits the reaction [Nitroprusside results in increased abundance of Cyclic GMP]; [Xanthine co-treated with XDH protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Xanthine co-treated with XDH protein] promotes the reaction [myricetin results in decreased activity of TXNRD1 protein modified form]; [Xanthine co-treated with XDH protein] results in decreased expression of ACAT1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ACO2 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ATP5F1A protein; [Xanthine co-treated with XDH protein] results in decreased expression of CKM protein; [Xanthine co-treated with XDH protein] results in decreased expression of CRYAB protein; [Xanthine co-treated with XDH protein] results in decreased expression of DES protein; [Xanthine co-treated with XDH protein] results in decreased expression of ECH1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ECHS1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of ENO1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of FABP3 protein; [Xanthine co-treated with XDH protein] results in decreased expression of GUCY1A1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of GUCY1B1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HADH protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSP90AB1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSPA8 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSPB6 protein; [Xanthine co-treated with XDH protein] results in decreased expression of HSPD1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of IDH2 protein; [Xanthine co-treated with XDH protein] results in decreased expression of LDHB protein; [Xanthine co-treated with XDH protein] results in decreased expression of MDH1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of MDH2 protein; [Xanthine co-treated with XDH protein] results in decreased expression of OXCT1 protein; [Xanthine co-treated with XDH protein] results in decreased expression of PKM protein; [Xanthine co-treated with XDH protein] results in decreased expression of SUCLG2 protein; [Xanthine co-treated with XDH protein] results in decreased phosphorylation of HSPB2 protein; [Xanthine co-treated with XDH protein] results in decreased phosphorylation of JUN protein; [Xanthine co-treated with XDH protein] results in increased abundance of Glutathione; [Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]; [Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein; [Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein; [Xanthine co-treated with XDH protein] results in increased expression of CYCS protein; [Xanthine co-treated with XDH protein] results in increased expression of FH protein; [Xanthine co-treated with XDH protein] results in increased expression of HMOX1 mRNA; [Xanthine co-treated with XDH protein] results in increased expression of HPSE mRNA; [Xanthine co-treated with XDH protein] results in increased expression of HPSE protein; [Xanthine co-treated with XDH protein] results in increased expression of MYL3 protein; [Xanthine co-treated with XDH protein] results in increased expression of SOD2 mRNA; [Xanthine co-treated with XDH protein] results in increased expression of TNNT2 protein; [Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [[Xanthine co-treated with XDH protein] results in increased phosphorylation of MAPKAPK2 protein]
[Xanthine co-treated with XDH protein] results in increased expression of SOD2 protein
CTD PMID:7743507 PMID:12531891 PMID:12595275 PMID:14973143 PMID:16618767 More... NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            fundamental metabolite 12766
              xanthine 3905
                9H-xanthine 57
                  3-isobutyl-1-methyl-9H-xanthine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterobicyclic compound 16868
                                      imidazopyrimidine 5610
                                        purines 5608
                                          aminopurine 4425
                                            2-aminopurines 4031
                                              guanine 3995
                                                xanthine 3905
                                                  9H-xanthine 57
                                                    3-isobutyl-1-methyl-9H-xanthine 0
paths to the root