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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-cystine
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Accession:CHEBI:16283 term browser browse the term
Definition:The L-enantiomer of the sulfur-containing amino acid cystine.
Synonyms:exact_synonym: (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoic acid)
 related_synonym: (R,R)-3,3'-dithiobis(2-aminopropanoic acid);   (R-(R*,R*))-3,3'-Dithiobis(2-aminopropanoic acid);   3,3'-Dithiobis-L-alanine;   E921;   Formula=C6H12N2O4S2;   InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1;   InChIKey=LEVWYRKDKASIDU-IMJSIDKUSA-N;   L-Dicysteine;   L-alpha-Diamino-beta-dithiolactic acid;   SMILES=N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O;   beta,beta'-diamino-beta,beta'-dicarboxydiethyl disulfide;   beta,beta'-dithiodialanine;   bis(beta-amino-beta-carboxyethyl) disulfide;   oxidized L-cysteine
 alt_id: CHEBI:13097;   CHEBI:21278;   CHEBI:6209
 xref: Beilstein:1728094;   CAS:56-89-3;   DrugBank:DB00138;   Drug_Central:4130;   Gmelin:397179;   HMDB:HMDB0000192;   KEGG:C00491;   KEGG:D03636;   KNApSAcK:C00001352
 xref_mesh: MESH:D003553
 xref: PMID:14726201;   PMID:24264736;   PMID:24327171;   Reaxys:1728094
 cyclic_relationship: is_conjugate_acid_of CHEBI:63163;   is_enantiomer_of CHEBI:35494;   is_tautomer_of CHEBI:35491



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L-cystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystine CTD PMID:22093698 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:19850060 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:19850060 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake
multiple interactions
ISO SLC3A1 protein results in increased uptake of Cystine
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine
CTD PMID:14978168 PMID:18845132 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933 PMID:22216172 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933 PMID:22216172 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slc7a9 solute carrier family 7 member 9 multiple interactions ISO [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine CTD PMID:14978168 NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    role 19832
      application 19675
        food additive 16155
          flour treatment agent 7553
            L-cystine 7
              L-cystine di-2-naphthylamide 0
              L-cystine mono-2-naphthylamide 0
              L-cystine residue 0
              L-cystinyl group 0
              L-cystyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    main group molecular entity 19804
                      s-block molecular entity 19637
                        hydrogen molecular entity 19618
                          hydrides 19124
                            inorganic hydride 18133
                              pnictogen hydride 18122
                                nitrogen hydride 18030
                                  azane 17837
                                    ammonia 17836
                                      organic amino compound 17836
                                        amino acid 15970
                                          alpha-amino acid 13875
                                            L-alpha-amino acid 12867
                                              serine family amino acid 5579
                                                L-cysteine 3416
                                                  L-cysteine derivative 3408
                                                    L-cystine 7
                                                      L-cystine di-2-naphthylamide 0
                                                      L-cystine mono-2-naphthylamide 0
                                                      L-cystine residue 0
                                                      L-cystinyl group 0
                                                      L-cystyl group 0
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