Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-cystine
go back to main search page
Accession:CHEBI:16283 term browser browse the term
Definition:The L-enantiomer of the sulfur-containing amino acid cystine.
Synonyms:exact_synonym: (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoic acid)
 related_synonym: (R,R)-3,3'-dithiobis(2-aminopropanoic acid);   (R-(R*,R*))-3,3'-Dithiobis(2-aminopropanoic acid);   3,3'-Dithiobis-L-alanine;   E921;   Formula=C6H12N2O4S2;   InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1;   InChIKey=LEVWYRKDKASIDU-IMJSIDKUSA-N;   L-Dicysteine;   L-alpha-Diamino-beta-dithiolactic acid;   SMILES=N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O;   beta,beta'-diamino-beta,beta'-dicarboxydiethyl disulfide;   beta,beta'-dithiodialanine;   bis(beta-amino-beta-carboxyethyl) disulfide;   oxidized L-cysteine
 alt_id: CHEBI:13097;   CHEBI:21278;   CHEBI:6209
 xref: Beilstein:1728094;   CAS:56-89-3;   DrugBank:DB00138;   Drug_Central:4130;   Gmelin:397179;   HMDB:HMDB0000192;   KEGG:C00491;   KEGG:D03636;   KNApSAcK:C00001352
 xref_mesh: MESH:D003553
 xref: PMID:14726201;   PMID:24264736;   PMID:24327171;   Reaxys:1728094
 cyclic_relationship: is_conjugate_acid_of CHEBI:63163;   is_enantiomer_of CHEBI:35494;   is_tautomer_of CHEBI:35491


show annotations for term's descendants           Sort by:
 
L-cystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystine CTD PMID:22093698 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:19850060 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:19850060 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Slc3a1 solute carrier family 3 member 1 increases uptake
multiple interactions
ISO SLC3A1 protein results in increased uptake of Cystine
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine
CTD PMID:14978168, PMID:18845132 NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933, PMID:22216172 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933, PMID:22216172 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc7a9 solute carrier family 7 member 9 multiple interactions ISO [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine CTD PMID:14978168 NCBI chr 1:91,709,034...91,738,492
Ensembl chr 1:91,716,383...91,738,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        food additive 14725
          flour treatment agent 5559
            L-cystine 7
              L-cystine di-2-naphthylamide 0
              L-cystine mono-2-naphthylamide 0
              L-cystine residue 0
              L-cystinyl group 0
              L-cystyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        amino acid 14085
                                          alpha-amino acid 11550
                                            L-alpha-amino acid 11385
                                              serine family amino acid 1878
                                                L-cysteine 1137
                                                  L-cysteine derivative 1126
                                                    L-cystine 7
                                                      L-cystine di-2-naphthylamide 0
                                                      L-cystine mono-2-naphthylamide 0
                                                      L-cystine residue 0
                                                      L-cystinyl group 0
                                                      L-cystyl group 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.