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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sucrose
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Accession:CHEBI:17992 term browser browse the term
Definition:A glycosyl glycoside formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose.
Synonyms:exact_synonym: beta-D-fructofuranosyl alpha-D-glucopyranoside
 related_synonym: 1-alpha-D-Glucopyranosyl-2-beta-D-fructofuranoside;   Cane sugar;   Formula=C12H22O11;   InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1;   InChIKey=CZMRCDWAGMRECN-UGDNZRGBSA-N;   SMILES=OC[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O;   Saccharose;   Sacharose;   White sugar;   beta-D-Fruf-(2<->1)-alpha-D-Glcp;   sacarosa;   table sugar
 alt_id: CHEBI:15128;   CHEBI:26812;   CHEBI:45795;   CHEBI:9314
 xref: Beilstein:90825;   CAS:57-50-1;   DrugBank:DB02772;   Drug_Central:4610;   Gmelin:97695;   HMDB:HMDB0000258;   KEGG:C00089;   KEGG:D00025;   KEGG:D06533;   KEGG:G00370;   KNApSAcK:C00001151
 xref_mesh: MESH:D013395
 xref: MetaCyc:SUCROSE;   PDBeChem:SUC;   PMID:11021636;   PMID:11093712;   PMID:11111003;   PMID:12065720;   PMID:12706980;   PMID:13508893;   PMID:15291457;   PMID:15660210;   PMID:15792978;   PMID:15845855;   PMID:16228482;   PMID:16304615;   PMID:16313996;   PMID:16525719;   PMID:16660545;   PMID:16663947;   PMID:16665852;   PMID:17233733;   PMID:17439666;   PMID:17597061;   PMID:18625236;   PMID:19199566;   PMID:19726178;   PMID:21703290;   PMID:21972845;   PMID:22085755;   PMID:22311778;   PMID:22404833;   PMID:22751876;   Reaxys:1435311;   Reaxys:90825;   Wikipedia:Sucrose


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sucrose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO
EXP
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of ACACA mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of ACACA mRNA
[Dietary Fats co-treated with Sucrose] results in increased expression of ACACA mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of ACACA mRNA]
CTD PMID:24440342 PMID:31175915 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACADM mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACADM mRNA] CTD PMID:24440342 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acly ATP citrate lyase multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of ACLY mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of ACLY mRNA CTD PMID:24440342 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA] CTD PMID:24440342 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Agt angiotensinogen multiple interactions EXP Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Sucrose inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Sucrose inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] CTD PMID:18267125 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO [Cadmium co-treated with Sucrose] affects the activity of ALAD protein CTD PMID:15454309 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Sucrose results in increased activity of CASP3 protein
EIF2AK2 protein affects the reaction [Sucrose results in increased activity of and results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased cleavage of CASP3 protein]; GW 506033X inhibits the reaction [Sucrose results in increased activity of CASP3 protein]; Sucrose results in increased activity of and results in increased cleavage of CASP3 protein
CTD PMID:15975986 PMID:27920257 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Sucrose co-treated with Palmitates] results in increased expression of CCL2 mRNA CTD PMID:26895660 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA; [Sucrose co-treated with Oleic Acid] results in increased expression of CPT1A mRNA; [Sucrose co-treated with Palmitates] results in increased expression of CPT1A mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA] CTD PMID:24440342 PMID:26895660 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation EXP Sucrose results in increased phosphorylation of CREB1 protein CTD PMID:12514263 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cs citrate synthase multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CS mRNA CTD PMID:24440342 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP Sucrose results in decreased expression of CYP1A1 protein CTD PMID:12680239 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A1 mRNA CTD PMID:15670589 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A2 mRNA CTD PMID:15670589 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of DGAT1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of DGAT1 mRNA CTD PMID:24440342 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA] CTD PMID:24440342 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions
increases phosphorylation
ISO EIF2AK2 protein affects the reaction [Sucrose results in increased activity of and results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; EIF2AK2 protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA]; EIF2AK2 protein affects the reaction [Sucrose results in increased phosphorylation of RELA protein]; GW 506033X inhibits the reaction [Sucrose results in increased phosphorylation of EIF2AK2 protein] CTD PMID:27920257 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Sucrose co-treated with Dietary Fats] results in decreased expression of FAS mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of FAS protein; Resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS mRNA]; Resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS protein] CTD PMID:23127599 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Sucrose co-treated with Oleic Acid] results in increased expression of FASN mRNA; [Sucrose co-treated with Palmitates] results in increased expression of FASN mRNA CTD PMID:26895660 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Sucrose results in increased expression of FGF2 mRNA CTD PMID:26800359 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression EXP Sucrose results in increased expression of G6PC1 mRNA CTD PMID:12514263 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects localization
multiple interactions
ISO Sucrose affects the localization of GAPDH protein
GW 506033X inhibits the reaction [Sucrose affects the localization of GAPDH protein]
CTD PMID:27920257 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gnat3 G protein subunit alpha transducin 3 affects response to substance ISO GNAT3 protein affects the susceptibility to Sucrose CTD PMID:16740645 NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of GPAM mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of GPAM mRNA CTD PMID:24440342 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of GPT protein] CTD PMID:31175915 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation EXP Sucrose results in decreased phosphorylation of GSK3A protein CTD PMID:12514263 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Sucrose results in increased expression of HBEGF mRNA CTD PMID:26800359 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR mRNA; [Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR protein; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR mRNA] CTD PMID:31175915 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions ISO IKBKE protein affects the reaction [Sucrose results in increased expression of NOS2 protein] CTD PMID:27920257 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Sucrose results in increased expression of IL6 mRNA
EIF2AK2 protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]
CTD PMID:27920257 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 increases expression ISO Sucrose results in increased expression of INS protein CTD PMID:1805284 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 mRNA]; Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 protein] CTD PMID:31181236 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Lct lactase increases expression EXP Sucrose results in increased expression of LCT mRNA CTD PMID:11242478 NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP [Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA]; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein] CTD PMID:23127599 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Sucrose CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Sucrose results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Sucrose results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD PMID:15975986 PMID:18267125 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Sucrose results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:15975986 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Sucrose results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Sucrose results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD PMID:15975986 PMID:18267125 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of MAPK8 mRNA] CTD PMID:31181236 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO [Oligosaccharides co-treated with Sucrose co-treated with Dietary Fats] affects the expression of MAPK9 mRNA CTD PMID:31181236 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression
ISO RELA protein affects the reaction [Sucrose results in increased expression of MCL1 mRNA] CTD PMID:27920257 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of MLXIPL mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of MLXIPL mRNA] CTD PMID:24440342 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO Sucrose results in increased expression of NFKBIA mRNA
RELA protein affects the reaction [Sucrose results in increased expression of NFKBIA mRNA]; Sucrose results in decreased expression of and results in increased phosphorylation of NFKBIA protein
CTD PMID:27920257 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Sucrose results in increased expression of NOS2 mRNA; Sucrose results in increased expression of NOS2 protein
EIF2AK2 protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA]; GW 506033X inhibits the reaction [Sucrose results in increased expression of NOS2 mRNA]; IKBKE protein affects the reaction [Sucrose results in increased expression of NOS2 protein]; RELA protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA]
CTD PMID:27920257 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP Chromium inhibits the reaction [Sucrose results in decreased expression of NOS3 protein] CTD PMID:17215582 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nts neurotensin multiple interactions
decreases activity
ISO Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein]; Sucrose promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]
Sucrose results in decreased activity of NTS protein
CTD PMID:18313772 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP [Dietary Fats co-treated with Sucrose] results in increased expression of PCK1 mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of PCK1 mRNA] CTD PMID:31175915 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of PIK3CA mRNA] CTD PMID:31181236 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of PKLR mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of PKLR mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of PKLR mRNA CTD PMID:24440342 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO
[Sucrose co-treated with Orotic Acid] results in decreased expression of PPARA protein
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]
CTD PMID:15670589 PMID:24440342 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARG mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARG mRNA] CTD PMID:24440342 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Dietary Fats co-treated with Sucrose] results in decreased expression of PRKAA2 mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased expression of PRKAA2 mRNA] CTD PMID:31175915 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression EXP Sucrose results in decreased expression of PRKG1 protein CTD PMID:17215582 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein] CTD PMID:18267125 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rac1 Rac family small GTPase 1 increases activity ISO Sucrose results in increased activity of RAC1 protein CTD PMID:15975986 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO EIF2AK2 protein affects the reaction [Sucrose results in increased phosphorylation of RELA protein]; RELA protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of MCL1 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of NFKBIA mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA] CTD PMID:27920257 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [Sucrose co-treated with Orotic Acid] results in decreased expression of RXRA protein CTD PMID:15670589 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions EXP [Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein] CTD PMID:23127599 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression
increases activity
ISO
EXP
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SCD1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of SCD1 mRNA; [Sucrose co-treated with Oleic Acid] results in increased expression of SCD1 mRNA; [Sucrose co-treated with Palmitates] results in increased expression of SCD1 mRNA
Sucrose results in increased expression of SCD1 mRNA
Sucrose results in increased activity of SCD1 protein
CTD PMID:22413010 PMID:24440342 PMID:26895660 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Si sucrase-isomaltase increases expression EXP Sucrose results in increased expression of SI mRNA CTD PMID:10222385 PMID:11242478 NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression
multiple interactions
EXP
ISO
Sucrose results in increased expression of SLC2A2 mRNA
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]
CTD PMID:10222385 PMID:24440342 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases localization
multiple interactions
ISO Sucrose results in decreased localization of SLC2A4 protein
Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of SLC2A4 mRNA]; Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of SLC2A4 protein]
Chromium inhibits the reaction [Sucrose results in decreased localization of SLC2A4 protein]
CTD PMID:18806091 PMID:31181236 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc2a5 solute carrier family 2 member 5 increases expression EXP Sucrose results in increased expression of SLC2A5 mRNA CTD PMID:9124564 PMID:10222385 NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
JBrowse link
G Slc39a4 solute carrier family 39 member 4 multiple interactions ISO Sucrose inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein] CTD PMID:17202136 NCBI chr 7:108,333,380...108,337,553
Ensembl chr 7:108,333,381...108,337,553
JBrowse link
G Slc5a1 solute carrier family 5 member 1 increases expression EXP Sucrose results in increased expression of SLC5A1 mRNA; Sucrose results in increased expression of SLC5A1 protein CTD PMID:8048533 PMID:10222385 NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Sucrose inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]] CTD PMID:22362149 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SREBF1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of SREBF1 mRNA
[Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 mRNA; [Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 protein; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 mRNA]; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 protein]
CTD PMID:24440342 PMID:31175915 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Sucrose inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP Sucrose inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] CTD PMID:7524481 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tas1r2 taste 1 receptor member 2 multiple interactions ISO Sucrose binds to and results in increased activity of TAS1R2 protein; Sucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein] CTD PMID:20173092 NCBI chr 5:151,909,648...151,925,345 JBrowse link
G Tas1r3 taste 1 receptor member 3 multiple interactions ISO Sucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein] CTD PMID:20173092 NCBI chr 5:166,469,589...166,472,742
Ensembl chr 5:166,469,589...166,472,742
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Sucrose results in increased phosphorylation of and affects the localization of TRP53 protein CTD PMID:15975986 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions
decreases phosphorylation
EXP Chromium inhibits the reaction [Sucrose results in decreased phosphorylation of VASP protein] CTD PMID:17215582 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        osmolyte 2050
          sucrose 74
            1,6-kestotetraose 0
            6,6-kestotetraose 0
            6-kestotriose 0
            agrocinopine A 0
            agrocinopine C 0
            beta-D-fructofuranosyl 6-O-octanoyl-alpha-D-glucopyranoside 0
            molasses 0
            stachyose + 0
            sucrose 6(F)-phosphate 0
            sucrose 6(G)-phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      oligosaccharide 572
                                        disaccharide 480
                                          glycosyl glycoside 117
                                            sucrose 74
                                              1,6-kestotetraose 0
                                              6,6-kestotetraose 0
                                              6-kestotriose 0
                                              agrocinopine A 0
                                              agrocinopine C 0
                                              beta-D-fructofuranosyl 6-O-octanoyl-alpha-D-glucopyranoside 0
                                              molasses 0
                                              stachyose + 0
                                              sucrose 6(F)-phosphate 0
                                              sucrose 6(G)-phosphate 0
paths to the root