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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methylglyoxal
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Accession:CHEBI:17158 term browser browse the term
Definition:A 2-oxo aldehyde derived from propanal.
Synonyms:related_synonym: 1,2-propanedione;   2-Ketopropionaldehyde;   2-Oxopropanal;   2-oxopropionaldehyde;   CH3COCHO;   Formula=C3H4O2;   InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3;   InChIKey=AIJULSRZWUXGPQ-UHFFFAOYSA-N;   Pyruvaldehyde;   Pyruvic aldehyde;   SMILES=[H]C(=O)C(C)=O;   acetylformaldehyde;   acetylformyl;   alpha-ketopropionaldehyde
 alt_id: CHEBI:11643;   CHEBI:14599;   CHEBI:25303;   CHEBI:6875
 xref: Beilstein:906750;   CAS:78-98-8;   KEGG:C00546;   KNApSAcK:C00007562
 xref_mesh: MESH:D011765
 xref: PMID:10373458;   PMID:10723098;   PMID:11504881;   PMID:15520007;   PMID:17103372;   PMID:19202315;   PMID:20096340;   PMID:22983866;   PMID:23543734;   PMID:23845007;   PMID:24040205;   PMID:24168114;   PMID:26861824;   PMID:9506998;   Reaxys:906750;   Wikipedia:Methylglyoxal


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methylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
increases expression
ISO
EXP
[TNFSF11 protein co-treated with Pyruvaldehyde] affects the activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of ACP5 mRNA]
Pyruvaldehyde results in increased expression of ACP5 mRNA; Pyruvaldehyde results in increased expression of ACP5 protein
CTD PMID:30217477, PMID:31103701, PMID:31369791 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Pyruvaldehyde results in increased expression of ACTA2 protein
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of ACTA2 protein]
CTD PMID:22101032 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of ADGRE1 protein] CTD PMID:22101032 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
increases expression
increases cleavage
ISO bergenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]; epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of AGER protein]; honokiol affects the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]
Pyruvaldehyde results in increased expression of AGER mRNA
CTD PMID:22101032, PMID:26723916, PMID:29148590, PMID:30447388 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agt angiotensinogen affects expression EXP Pyruvaldehyde affects the expression of AGT protein CTD PMID:24402234 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 increases expression ISO Pyruvaldehyde results in increased expression of AIFM2 mRNA CTD PMID:30447388 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO
EXP
AKR1A1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318, PMID:29763686 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of Pyruvaldehyde CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Pyruvaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:25451587 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 decreases response to substance
increases expression
ISO AKR7A5 protein results in decreased susceptibility to Pyruvaldehyde
Pyruvaldehyde results in increased expression of AKR7A2 mRNA; Pyruvaldehyde results in increased expression of AKR7A2 protein
AKR7A2 protein results in decreased susceptibility to Pyruvaldehyde
CTD PMID:22001351, PMID:24590062, PMID:25451587 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Pyruvaldehyde results in decreased phosphorylation of AKT1 protein
resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of AKT1 protein]
CTD PMID:22917016 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA] CTD PMID:31369791 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alb albumin affects binding
increases oxidation
multiple interactions
ISO Pyruvaldehyde binds to ALB protein
Pyruvaldehyde results in increased oxidation of ALB protein
[ALB protein binds to Myristic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to Oleic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to Palmitic Acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein binds to stearic acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [Pyruvaldehyde binds to ALB protein] which results in decreased metabolism of Prostaglandins; [Pyruvaldehyde results in increased oxidation of ALB protein] which results in decreased reduction of Dithionitrobenzoic Acid; Pyruvaldehyde inhibits the reaction [Warfarin binds to ALB protein]
CTD PMID:20934417, PMID:25451573 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde CTD PMID:21334317 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Pyruvaldehyde results in increased expression of BAD mRNA CTD PMID:30447388 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO naringenin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein] CTD PMID:26577515, PMID:31254498 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]
Pyruvaldehyde results in decreased expression of BCL2 mRNA; Pyruvaldehyde results in decreased expression of BCL2 protein
CTD PMID:26577515, PMID:30447388, PMID:31254498 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
ISO Pyruvaldehyde results in increased expression of BDNF protein
sulforafan promotes the reaction [Pyruvaldehyde results in increased expression of BDNF protein]
CTD PMID:25933243 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CAR2 mRNA CTD PMID:30217477 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
increases activity
multiple interactions
ISO
EXP
Pyruvaldehyde results in increased cleavage of CASP3 protein
Pyruvaldehyde results in increased expression of CASP3 protein
Pyruvaldehyde results in increased activity of CASP3 protein
resveratrol inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]
Pyruvaldehyde results in increased expression of CASP3 protein modified form
naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein]; sulforafan inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]
CTD PMID:18565324, PMID:20621070, PMID:21793156, PMID:25933243, PMID:26577515, PMID:31254498 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP9 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein] CTD PMID:26577515, PMID:31254498 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of CCL2 protein] CTD PMID:22101032 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CLCN7 mRNA CTD PMID:30217477 NCBI chr10:14,492,844...14,518,167
Ensembl chr10:14,492,844...14,516,894
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO Pyruvaldehyde results in increased expression of COL3A1 protein
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of COL3A1 protein]
CTD PMID:22101032 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cp ceruloplasmin multiple interactions
decreases activity
ISO bathocuproine inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; Ditiocarb inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; formic acid inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]; Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]; Sodium Azide inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]]
Pyruvaldehyde results in decreased activity of CP protein
CTD PMID:16756764 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Ctsk cathepsin K increases expression
multiple interactions
EXP
ISO
Pyruvaldehyde results in increased expression of CTSK mRNA
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of CTSK mRNA]
CTD PMID:31103701 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Ctss cathepsin S decreases activity ISO Pyruvaldehyde results in decreased activity of CTSS protein CTD PMID:16671891 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
EXP diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]; manumycin inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]; SB 203580 inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA] CTD PMID:17635749 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of FOS mRNA CTD PMID:30217477 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GAB2 mRNA CTD PMID:30217477 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Glo1 glyoxalase 1 affects response to substance
increases expression
multiple interactions
decreases activity
affects expression
decreases expression
ISO
EXP
GLO1 protein affects the susceptibility to Pyruvaldehyde
Pyruvaldehyde results in increased expression of GLO1 mRNA
magnolol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
Pyruvaldehyde affects the expression of GLO1 protein
[TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein; acetovanillone inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; honokiol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
Pyruvaldehyde results in decreased expression of GLO1 protein
GLO1 protein affects the reaction [Pyruvaldehyde binds to HSPB1 protein]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]; Resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]; Rosiglitazone affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]; sulforafan inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]
CTD PMID:20093988, PMID:22917016, PMID:25042521, PMID:25933243, PMID:26723916, PMID:28919305, PMID:28986142, PMID:29148590, PMID:30217477, PMID:30447388, PMID:30580027, PMID:31369791 NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
EXP magnolol promotes the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA] CTD PMID:28919305 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Pyruvaldehyde results in decreased activity of GSR protein CTD PMID:24831520 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases response to substance EXP GSTA5 protein results in increased susceptibility to Pyruvaldehyde CTD PMID:12076520 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Glucose co-treated with Oxygen deficiency] promotes the reaction [Pyruvaldehyde binds to and results in decreased activity of HIF1A protein]; Pyruvaldehyde binds to and results in decreased activity of HIF1A protein CTD PMID:18227068 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
affects expression
ISO Acetylcysteine affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; NFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]]; resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; rosiglitazone affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]
bergenin inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
CTD PMID:22917016, PMID:28986142, PMID:29148590 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hras HRas proto-oncogene, GTPase increases activity EXP Pyruvaldehyde results in increased activity of HRAS protein CTD PMID:17635749 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 affects binding
multiple interactions
ISO Pyruvaldehyde binds to HSPB1 protein
GLO1 protein affects the reaction [Pyruvaldehyde binds to HSPB1 protein]
CTD PMID:20093988 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
increases expression
EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]; monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]
Pyruvaldehyde results in increased expression of IL1B mRNA; Pyruvaldehyde results in increased expression of IL1B protein
CTD PMID:23954466, PMID:28919305, PMID:31103701 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 affects expression
increases expression
increases secretion
multiple interactions
ISO
EXP
Pyruvaldehyde analog affects the expression of IL6 mRNA
Pyruvaldehyde results in increased expression of IL6 mRNA
Pyruvaldehyde results in increased secretion of IL6 protein
Pyruvaldehyde results in increased expression of IL6 protein
acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; bergenin inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; honokiol affects the reaction [Pyruvaldehyde results in increased expression of IL6 protein]; Limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
CTD PMID:20200221, PMID:25042521, PMID:26723916, PMID:28986142, PMID:29148590, PMID:31103701 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of INS2 mRNA] CTD PMID:28919305 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein] CTD PMID:22917016 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation EXP Pyruvaldehyde results in decreased phosphorylation of IRS1 protein CTD PMID:23954466 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Pyruvaldehyde results in increased phosphorylation of MAPK1 protein
sulforafan inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK1 protein]
CTD PMID:25933243 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO sulforafan inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK3 protein]
[TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]
CTD PMID:25933243, PMID:30217477, PMID:31369791 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Pyruvaldehyde results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of ACP5 mRNA]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of CTSK mRNA]; MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of OSCAR mRNA]
sulforafan inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK8 protein]
CTD PMID:25933243, PMID:31103701 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Pyruvaldehyde results in increased phosphorylation of MAPK9 protein
sulforafan inhibits the reaction [Pyruvaldehyde results in increased phosphorylation of MAPK9 protein]
CTD PMID:25933243 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Pyruvaldehyde promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:17082178 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
ISO Pyruvaldehyde results in increased expression of MMP9 protein
[TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA
CTD PMID:28760545, PMID:31369791 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of NFATC1 mRNA CTD PMID:30217477 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects expression
decreases expression
affects response to substance
decreases phosphorylation
affects localization
ISO
EXP
[resveratrol results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Pyruvaldehyde; NFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]; NFE2L2 protein affects the reaction [resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]; resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of NFE2L2 protein]
bergenin affects the reaction [Pyruvaldehyde affects the expression of NFE2L2 protein]
Pyruvaldehyde results in decreased expression of NFE2L2 mRNA
NFE2L2 protein affects the susceptibility to Pyruvaldehyde
Pyruvaldehyde affects the localization of NFE2L2 protein
CTD PMID:22917016, PMID:23331247, PMID:23954466, PMID:25451587, PMID:28263721, PMID:29148590, PMID:30447388 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 affects response to substance
multiple interactions
increases expression
EXP NOS2 protein affects the susceptibility to Pyruvaldehyde
pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde results in increased expression of NOS2 protein]
CTD PMID:20621070 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Pyruvaldehyde results in increased expression of NQO1 mRNA CTD PMID:25451587 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
EXP monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Silymarin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]; Tretinoin inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of NRF1 mRNA]] CTD PMID:23331247 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases expression
multiple interactions
ISO Pyruvaldehyde results in decreased expression of NTRK2 protein
sulforafan inhibits the reaction [Pyruvaldehyde results in decreased expression of NTRK2 protein]
CTD PMID:25933243 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Oscar osteoclast associated Ig-like receptor increases expression
multiple interactions
ISO
EXP
Pyruvaldehyde results in increased expression of OSCAR mRNA
MAPK8 protein affects the reaction [Pyruvaldehyde results in increased expression of OSCAR mRNA]
CTD PMID:31103701 NCBI chr 1:64,182,174...64,188,658
Ensembl chr 1:64,182,422...64,188,658
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of OSTM1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA] CTD PMID:30217477, PMID:31369791 NCBI chr20:47,394,979...47,430,304
Ensembl chr20:47,395,014...47,430,284
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] CTD PMID:31254498 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of PDX1 mRNA CTD PMID:28919305 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of PECAM1 protein] CTD PMID:22101032 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity
ISO Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
Pyruvaldehyde results in decreased activity of PON1 protein
CTD PMID:15375178 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of IL1B protein]]; PPARG mutant form inhibits the reaction [Rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]] CTD PMID:23954466 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
[Limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein; [Pyruvaldehyde co-treated with honokiol] results in increased expression of PPARGC1A protein; [Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[magnolol co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein; [pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein
CTD PMID:26723916, PMID:28919305, PMID:28986142 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein] CTD PMID:22917016 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
affects localization
EXP pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Pyruvaldehyde results in increased activity of RELA protein] CTD PMID:20621070 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein; [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
affects localization
ISO Acetylcysteine inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]]; resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]; rosiglitazone inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein] CTD PMID:22917016 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Pyruvaldehyde results in decreased expression of SOD1 mRNA CTD PMID:30447388 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
increases expression
ISO Pyruvaldehyde results in decreased expression of SOD2 mRNA
Pyruvaldehyde results in increased expression of SOD2 mRNA
CTD PMID:30447388 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TCIRG1 mRNA CTD PMID:30217477 NCBI chr 1:219,126,687...219,139,466
Ensembl chr 1:219,127,602...219,139,464
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
EXP
ISO
diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 mRNA]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 protein]
epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 protein]
Pyruvaldehyde results in increased expression of TGFB1 mRNA; Pyruvaldehyde results in increased expression of TGFB1 protein
CTD PMID:17635749, PMID:22101032 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
EXP
ISO
monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; PPARG mutant form inhibits the reaction [monascin inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; PPARG mutant form inhibits the reaction [rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]]; rosiglitazone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]
Pyruvaldehyde results in increased secretion of TNF protein
acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; honokiol inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]
CTD PMID:23954466, PMID:25042521, PMID:26723916, PMID:28986142 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde co-treated with bergenin] results in decreased expression of MMP9 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CAR2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of CLCN7 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of FOS mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GAB2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of NFATC1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of OSTM1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TCIRG1 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TRAF6 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA; [TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of ACP5 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased expression of GLO1 protein]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of AKT2 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of MAPK3 mRNA]; bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein] CTD PMID:30217477, PMID:30580027, PMID:31369791 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of TRAF6 mRNA CTD PMID:30217477 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity
ISO [Pyruvaldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium CTD PMID:22863862 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP Silymarin inhibits the reaction [Pyruvaldehyde results in increased expression of VCAM1 mRNA] CTD PMID:23331247 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of VEGFA protein] CTD PMID:22101032 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        solvent 16489
          formic acid 7885
            formyl group 7851
              aldehyde 7851
                propanals 1800
                  methylglyoxal 78
                    mitoguazone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            formyl group 7851
                                              aldehyde 7851
                                                ketoaldehyde 78
                                                  2-oxo aldehyde 78
                                                    methylglyoxal 78
                                                      mitoguazone 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.