DLST (dihydrolipoamide S-succinyltransferase) - Rat Genome Database

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Gene: DLST (dihydrolipoamide S-succinyltransferase) Canis lupus familiaris
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Symbol: DLST
Name: dihydrolipoamide S-succinyltransferase
RGD ID: 12101396
Description: ENCODES a protein that exhibits chaperone binding (ortholog); dihydrolipoyllysine-residue succinyltransferase activity (ortholog); heat shock protein binding (ortholog); INVOLVED IN 2-oxoglutarate metabolic process (ortholog); NADH metabolic process (ortholog); succinyl-CoA metabolic process (ortholog); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; citric acid cycle pathway; fumaric aciduria pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); intellectual disability (ortholog); Paragangliomas 7 (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); mitochondrion (ortholog); nucleus (ortholog); INTERACTS WITH clofibrate
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,003,730 - 48,025,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,002,211 - 48,024,999 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,687,937 - 47,709,198 (+)NCBI
ROS_Cfam_1.0848,231,361 - 48,252,635 (+)NCBI
ROS_Cfam_1.0 Ensembl848,230,731 - 48,252,633 (+)Ensembl
UMICH_Zoey_3.1847,902,283 - 47,923,535 (+)NCBI
UNSW_CanFamBas_1.0847,923,602 - 47,944,852 (+)NCBI
UU_Cfam_GSD_1.0848,321,863 - 48,343,131 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
clofibrate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
DLST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,003,730 - 48,025,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,002,211 - 48,024,999 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,687,937 - 47,709,198 (+)NCBI
ROS_Cfam_1.0848,231,361 - 48,252,635 (+)NCBI
ROS_Cfam_1.0 Ensembl848,230,731 - 48,252,633 (+)Ensembl
UMICH_Zoey_3.1847,902,283 - 47,923,535 (+)NCBI
UNSW_CanFamBas_1.0847,923,602 - 47,944,852 (+)NCBI
UU_Cfam_GSD_1.0848,321,863 - 48,343,131 (+)NCBI
DLST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,881,916 - 74,903,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1474,881,891 - 74,903,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,348,619 - 75,370,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,418,372 - 74,440,199 (+)NCBINCBI36hg18NCBI36
Build 341474,418,371 - 74,440,196NCBI
Celera1455,386,967 - 55,408,821 (+)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1455,516,596 - 55,538,452 (+)NCBIHuRef
CHM1_11475,287,750 - 75,309,620 (+)NCBICHM1_1
T2T-CHM13v2.01469,091,016 - 69,112,843 (+)NCBI
Dlst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,157,597 - 85,180,865 (+)NCBIGRCm39mm39
GRCm39 Ensembl1285,157,607 - 85,181,619 (+)Ensembl
GRCm381285,110,822 - 85,134,091 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,110,833 - 85,134,845 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,451,783 - 86,475,041 (+)NCBIGRCm37mm9NCBIm37
MGSCv361285,999,999 - 86,023,189 (+)NCBImm8
Celera1286,568,081 - 86,591,232 (+)NCBICelera
Cytogenetic Map12D1NCBI
Dlst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26104,758,511 - 104,783,296 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl6104,758,631 - 104,783,296 (+)Ensembl
Rnor_6.06108,936,534 - 108,961,322 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,936,664 - 108,959,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,595,654 - 116,620,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,156,751 - 109,180,537 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16109,160,220 - 109,183,992 (+)NCBI
Celera6102,581,378 - 102,605,253 (+)NCBICelera
Cytogenetic Map6q31NCBI
Dlst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523661,738 - 680,802 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523660,413 - 680,878 (-)NCBIChiLan1.0ChiLan1.0
DLST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11474,278,128 - 74,300,133 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,278,128 - 74,300,133 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01455,433,358 - 55,455,876 (+)NCBIMhudiblu_PPA_v0panPan3
Dlst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,007,904 - 28,030,206 (-)NCBI
SpeTri2.0NW_0049364884,038,985 - 4,061,071 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,091,124 - 98,111,572 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,091,161 - 98,111,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,935,074 - 103,955,180 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,098,270 - 52,121,560 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605340,330,079 - 40,352,940 (+)NCBIVero_WHO_p1.0
Dlst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,803,344 - 26,825,272 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473426,802,902 - 26,824,632 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000036723   ⟹   ENSCAFP00000032131
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl848,002,211 - 48,024,999 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063045   ⟹   ENSCAFP00000062308
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl848,002,211 - 48,024,999 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063325   ⟹   ENSCAFP00000055507
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl848,002,211 - 48,024,999 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000066148   ⟹   ENSCAFP00000061524
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl848,002,211 - 48,024,999 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000083237   ⟹   ENSCAFP00000055326
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl848,003,762 - 48,011,738 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845026355   ⟹   ENSCAFP00845020776
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl848,230,731 - 48,252,633 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845026424   ⟹   ENSCAFP00845020824
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl848,231,368 - 48,239,362 (+)Ensembl
RefSeq Acc Id: XM_003639204   ⟹   XP_003639252
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1848,003,730 - 48,025,001 (+)NCBI
Dog10K_Boxer_Tasha847,687,937 - 47,709,198 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038483797   ⟹   XP_038339725
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1847,902,283 - 47,923,535 (+)NCBI
RefSeq Acc Id: XM_038545278   ⟹   XP_038401206
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0848,321,863 - 48,343,131 (+)NCBI
RefSeq Acc Id: XM_038609374   ⟹   XP_038465302
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0847,923,602 - 47,944,852 (+)NCBI
RefSeq Acc Id: XM_038674199   ⟹   XP_038530127
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0848,231,361 - 48,252,635 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_003639252   ⟸   XM_003639204
- UniProtKB: E2R0H0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000062308   ⟸   ENSCAFT00000063045
RefSeq Acc Id: ENSCAFP00000055507   ⟸   ENSCAFT00000063325
RefSeq Acc Id: ENSCAFP00000055326   ⟸   ENSCAFT00000083237
RefSeq Acc Id: ENSCAFP00000032131   ⟸   ENSCAFT00000036723
RefSeq Acc Id: ENSCAFP00000061524   ⟸   ENSCAFT00000066148
RefSeq Acc Id: XP_038339725   ⟸   XM_038483797
RefSeq Acc Id: XP_038465302   ⟸   XM_038609374
RefSeq Acc Id: XP_038530127   ⟸   XM_038674199
RefSeq Acc Id: XP_038401206   ⟸   XM_038545278
RefSeq Acc Id: ENSCAFP00845020776   ⟸   ENSCAFT00845026355
RefSeq Acc Id: ENSCAFP00845020824   ⟸   ENSCAFT00845026424

Promoters
RGD ID:13684284
Promoter ID:EPDNEW_C2352
Type:initiation region
Name:DLST_1
Description:dihydrolipoamide S-succinyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1848,003,785 - 48,003,845EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 48003809 48003810 C G snv Dachshund (DH0117)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016989 Ensembl
  ENSCAFG00845014735 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845020776.1 UniProtKB/TrEMBL
  ENSCAFP00845020824.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845026355.1 UniProtKB/TrEMBL
  ENSCAFT00845026424.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.559.10 UniProtKB/TrEMBL
InterPro 2-oxoA_DH_lipoyl-BS UniProtKB/TrEMBL
  2-oxoacid_DH_actylTfrase UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
  CAT-like_dom_sf UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/TrEMBL
  SucB UniProtKB/TrEMBL
NCBI Gene DLST ENTREZGENE
Pfam 2-oxoacid_dh UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/TrEMBL
PROSITE BIOTINYL_LIPOYL UniProtKB/TrEMBL
  LIPOYL UniProtKB/TrEMBL
Superfamily-SCOP SSF51230 UniProtKB/TrEMBL
TIGRFAMs sucB UniProtKB/TrEMBL
UniProt A0A8I3NPZ1_CANLF UniProtKB/TrEMBL
  A0A8I3NVG0_CANLF UniProtKB/TrEMBL
  E2R0H0 ENTREZGENE
VGNC ID VGNC:39988 ENTREZGENE