Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:zileuton
go back to main search page
Accession:CHEBI:10112 term browser browse the term
Definition:A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
Synonyms:exact_synonym: 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
 related_synonym: (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea;   Formula=C11H12N2O2S;   InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14);   InChIKey=MWLSOWXNZPKENC-UHFFFAOYSA-N;   Leutrol;   N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea;   N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea;   SMILES=CC(N(O)C(N)=O)c1cc2ccccc2s1;   Zyflo;   zileutonum
 xref: CAS:111406-87-2;   DrugBank:DB00744;   Drug_Central:2862;   KEGG:D00414;   LINCS:LSM-5084
 xref_mesh: MESH:C063449
 xref: PMID:19309543;   PMID:19645854;   PMID:20204486;   PMID:20436887;   Reaxys:4869674;   Wikipedia:Zileuton



show annotations for term's descendants           Sort by:
 
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:1618819 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 397
    role 397
      biological role 397
        inhibitor 272
          ferroptosis inhibitor 10
            zileuton 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 397
    subatomic particle 397
      composite particle 397
        hadron 397
          baryon 397
            nucleon 397
              atomic nucleus 397
                atom 397
                  main group element atom 390
                    p-block element atom 390
                      carbon group element atom 379
                        carbon atom 378
                          organic molecular entity 378
                            organic group 313
                              organic divalent group 312
                                organodiyl group 312
                                  carbonyl group 312
                                    carbonyl compound 312
                                      carboxylic acid 276
                                        carboacyl group 215
                                          univalent carboacyl group 215
                                            carbamoyl group 213
                                              carboxamide 213
                                                monocarboxylic acid amide 184
                                                  urea 9
                                                    ureas 7
                                                      zileuton 1
paths to the root