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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:keto-D-fructose 1,6-bisphosphate
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Accession:CHEBI:16905 term browser browse the term
Definition:A ketohexose bisphosphate that is D-fructose substituted by phosphate groups at positions 1 and 6.
Synonyms:exact_synonym: D-fructose 1,6-bis(dihydrogen phosphate)
 related_synonym: 1,6-di-O-phosphono-D-fructose;   D-Fructose 1,6-bisphosphate;   D-fructose-1,6-diphosphate;   Formula=C6H14O12P2;   Harden-Young ester;   InChI=1S/C6H14O12P2/c7-3(1-17-19(11,12)13)5(9)6(10)4(8)2-18-20(14,15)16/h3,5-7,9-10H,1-2H2,(H2,11,12,13)(H2,14,15,16)/t3-,5-,6-/m1/s1;   InChIKey=XPYBSIWDXQFNMH-UYFOZJQFSA-N;   SMILES=O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)C(=O)COP(O)(O)=O;   fructose-1,6-diphosphate
 alt_id: CHEBI:12924;   CHEBI:4120
 xref: CAS:488-69-7;   Chemspider:76632;   DrugBank:DB13863;   HMDB:HMDB0001058;   KEGG:C00354;   KNApSAcK:C00007386
 xref_mesh: MESH:C029063
 xref: MetaCyc:FRUCTOSE-16-DIPHOSPHATE;   PDBeChem:P6F;   PMID:13150027;   PMID:16233003;   PMID:19049602;   PMID:19236002;   PMID:21983965;   PMID:25206915;   PMID:26011931;   PMID:28972169;   PMID:29593097;   PMID:4610358;   Reaxys:1729954



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keto-D-fructose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        biochemical role 19390
          metabolite 19367
            fundamental metabolite 12783
              D-fructose 1,6-bisphosphate 5
                keto-D-fructose 1,6-bisphosphate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      chalcogen 19471
                        oxygen atom 19447
                          oxygen molecular entity 19447
                            hydroxides 19175
                              oxoacid 18500
                                pnictogen oxoacid 10692
                                  phosphorus oxoacid 9674
                                    phosphoric acids 8475
                                      phosphoric acid 8475
                                        phosphoric acid derivative 8181
                                          phosphate 8181
                                            organic phosphate 8180
                                              carbohydrate phosphate 1737
                                                phospho sugar 1662
                                                  ketose phosphate 10
                                                    ketohexose phosphate 8
                                                      ketohexose bisphosphate 8
                                                        D-fructose 1,6-bisphosphate 5
                                                          keto-D-fructose 1,6-bisphosphate 5
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