ABCC1 (ATP binding cassette subfamily C member 1) - Rat Genome Database

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Gene: ABCC1 (ATP binding cassette subfamily C member 1) Canis lupus familiaris
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Symbol: ABCC1
Name: ATP binding cassette subfamily C member 1
RGD ID: 12050846
Description: ENCODES a protein that exhibits ABC-type glutathione S-conjugate transporter activity (ortholog); ABC-type transporter activity (ortholog); ABC-type vitamin B12 transporter activity (ortholog); INVOLVED IN carboxylic acid transmembrane transport (ortholog); cell chemotaxis (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); asthma (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH calcein am; etoposide; leukotriene C4
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-binding cassette sub-family C member 1; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; LTC4 transporter; MRP1; multidrug resistance protein 1; multidrug resistance-associated protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1627,855,702 - 27,950,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,219,306 - 29,353,121 (-)NCBI
ROS_Cfam_1.0628,018,483 - 28,152,589 (-)NCBI
ROS_Cfam_1.0 Ensembl628,010,824 - 28,152,766 (-)Ensembl
UMICH_Zoey_3.1627,821,973 - 27,955,836 (-)NCBI
UNSW_CanFamBas_1.0627,711,967 - 27,845,729 (-)NCBI
UU_Cfam_GSD_1.0628,117,166 - 28,251,282 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:12429346   PMID:12516967   PMID:15459206   PMID:23373631   PMID:23773525   PMID:26560472  


Genomics

Comparative Map Data
ABCC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1627,855,702 - 27,950,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,219,306 - 29,353,121 (-)NCBI
ROS_Cfam_1.0628,018,483 - 28,152,589 (-)NCBI
ROS_Cfam_1.0 Ensembl628,010,824 - 28,152,766 (-)Ensembl
UMICH_Zoey_3.1627,821,973 - 27,955,836 (-)NCBI
UNSW_CanFamBas_1.0627,711,967 - 27,845,729 (-)NCBI
UU_Cfam_GSD_1.0628,117,166 - 28,251,282 (-)NCBI
ABCC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1615,949,138 - 16,143,257 (+)EnsemblGRCh38hg38GRCh38
GRCh381615,949,616 - 16,143,062 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371616,043,473 - 16,236,910 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,950,935 - 16,144,432 (+)NCBINCBI36hg18NCBI36
Build 341615,950,934 - 16,143,774NCBI
Celera1615,781,784 - 15,917,085 (+)NCBI
Cytogenetic Map16p13.11NCBI
HuRef1615,436,705 - 15,630,893 (+)NCBIHuRef
CHM1_11616,185,916 - 16,321,192 (+)NCBICHM1_1
Abcc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,179,317 - 14,292,743 (+)NCBIGRCm39mm39
GRCm39 Ensembl1614,179,422 - 14,293,601 (+)Ensembl
GRCm381614,361,453 - 14,474,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,361,558 - 14,475,737 (+)EnsemblGRCm38mm10GRCm38
MGSCv371614,361,653 - 14,474,968 (+)NCBIGRCm37mm9NCBIm37
MGSCv361614,275,138 - 14,388,453 (+)NCBImm8
Celera1614,966,079 - 15,077,783 (+)NCBICelera
Cytogenetic Map16A1NCBI
Abcc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210528,961 - 655,179 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl10531,812 - 655,114 (-)Ensembl
Rnor_6.010549,537 - 672,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10549,883 - 672,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01011,232,233 - 11,354,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410452,239 - 575,705 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110452,238 - 575,705 (-)NCBI
Celera1011,130,945 - 11,246,232 (-)NCBICelera
Cytogenetic Map10q11NCBI
Abcc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442729,316 - 860,290 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955442729,322 - 858,826 (+)NCBIChiLan1.0ChiLan1.0
ABCC1
(Pan paniscus - bonobo/pygmy chimpanzee)
No map positions available.
Abcc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344115,297,821 - 115,369,238 (+)NCBI
SpeTri2.0NW_0049365013,400,971 - 3,467,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl328,360,868 - 28,485,477 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1328,360,868 - 28,472,940 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2329,082,788 - 29,172,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,972,589 - 15,164,594 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl514,972,646 - 15,164,567 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606814,816,018 - 14,953,501 (-)NCBIVero_WHO_p1.0
Abcc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624782449,217 - 590,306 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 3 6 6 5 2
Low 3 5 19 6 6 6 12 8 5 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000027269   ⟹   ENSCAFP00000025361
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000028933   ⟹   ENSCAFP00000026911
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,855,702 - 27,970,580 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000067722   ⟹   ENSCAFP00000066267
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,857,049 - 27,989,331 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013516   ⟹   ENSCAFP00845010489
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,010,824 - 28,152,766 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013662   ⟹   ENSCAFP00845010609
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,017,221 - 28,152,766 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013903   ⟹   ENSCAFP00845010777
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,017,221 - 28,152,586 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845014070   ⟹   ENSCAFP00845010905
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,020,094 - 28,152,586 (-)Ensembl
RefSeq Acc Id: NM_001002971   ⟹   NP_001002971
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1627,855,702 - 27,950,140 (-)NCBI
Dog10K_Boxer_Tasha629,219,306 - 29,353,121 (-)NCBI
ROS_Cfam_1.0628,018,757 - 28,152,547 (-)NCBI
UMICH_Zoey_3.1627,821,973 - 27,955,836 (-)NCBI
UNSW_CanFamBas_1.0627,711,967 - 27,845,729 (-)NCBI
UU_Cfam_GSD_1.0628,117,166 - 28,251,282 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038667549   ⟹   XP_038523477
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0628,019,591 - 28,152,589 (-)NCBI
RefSeq Acc Id: XR_005427955
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0628,018,483 - 28,152,589 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001002971 (Get FASTA)   NCBI Sequence Viewer  
  XP_038523477 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO17310 (Get FASTA)   NCBI Sequence Viewer  
  AAQ23148 (Get FASTA)   NCBI Sequence Viewer  
  Q6UR05 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001002971   ⟸   NM_001002971
- UniProtKB: Q6UR05 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000066267   ⟸   ENSCAFT00000067722
RefSeq Acc Id: ENSCAFP00000026911   ⟸   ENSCAFT00000028933
RefSeq Acc Id: ENSCAFP00000025361   ⟸   ENSCAFT00000027269
RefSeq Acc Id: XP_038523477   ⟸   XM_038667549
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845010905   ⟸   ENSCAFT00845014070
RefSeq Acc Id: ENSCAFP00845010489   ⟸   ENSCAFT00845013516
RefSeq Acc Id: ENSCAFP00845010609   ⟸   ENSCAFT00845013662
RefSeq Acc Id: ENSCAFP00845010777   ⟸   ENSCAFT00845013903
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
6 27857661 27857662 G A snv Border Collie (BC555), Border Collie (BC518)
6 27866283 27866284 C G snv Australian Shepherd (AU178)
6 27870798 27870799 C T snv Tibetan Mastiff (TM6), Chinese indigenous dogs (YJ1)
6 27887892 27887893 G A snv Siberian Husky (SY046), Alaskan Husky (SY001)
6 27896618 27896619 C A snv Chow Chow (CW011)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018208 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040002016 UniProtKB/Swiss-Prot
  ENSCAFG00845007668 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000025361 UniProtKB/TrEMBL
  ENSCAFP00000026911 UniProtKB/TrEMBL
  ENSCAFP00000066267 UniProtKB/TrEMBL
  ENSCAFP00040003340 UniProtKB/Swiss-Prot
  ENSCAFP00845010609 ENTREZGENE
  ENSCAFP00845010905 ENTREZGENE
Ensembl Transcript ENSCAFT00000027269 UniProtKB/TrEMBL
  ENSCAFT00000028933 UniProtKB/TrEMBL
  ENSCAFT00000067722 UniProtKB/TrEMBL
  ENSCAFT00040003892 UniProtKB/Swiss-Prot
  ENSCAFT00845013662 ENTREZGENE
  ENSCAFT00845013903 ENTREZGENE
  ENSCAFT00845014070 ENTREZGENE
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403453 UniProtKB/Swiss-Prot
NCBI Gene ABCC1 ENTREZGENE
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MRP_assoc_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F4DHW2_CANLF UniProtKB/TrEMBL
  F1P9H1_CANLF UniProtKB/TrEMBL
  F1PRX6_CANLF UniProtKB/TrEMBL
  MRP1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:54275 ENTREZGENE