ABCC1 (ATP binding cassette subfamily C member 1) - Rat Genome Database
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Gene: ABCC1 (ATP binding cassette subfamily C member 1) Canis lupus familiaris
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Symbol: ABCC1
Name: ATP binding cassette subfamily C member 1
RGD ID: 12050846
Description: ENCODES a protein that exhibits ABC-type transmembrane transporter activity (ortholog); amide transmembrane transporter activity (ortholog); ATPase-coupled glutathione S-conjugate transmembrane transporter activity (ortholog); INVOLVED IN cell chemotaxis (ortholog); leukotriene transport (ortholog); long-chain fatty acid import across plasma membrane (ortholog); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); asthma (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH calcein am; etoposide; leukotriene C4
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-binding cassette sub-family C member 1; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; LTC4 transporter; MRP1; multidrug resistance protein 1; multidrug resistance-associated protein 1
Orthologs:
Homo sapiens (human) : ABCC1 (ATP binding cassette subfamily C member 1)  HGNC  Alliance
Mus musculus (house mouse) : Abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Abcc1 (ATP binding cassette subfamily C member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abcc1 (ATP binding cassette subfamily C member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCC1 (ATP binding cassette subfamily C member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcc1 (ATP binding cassette subfamily C member 1)
Sus scrofa (pig) : ABCC1 (ATP binding cassette subfamily C member 1)
Chlorocebus sabaeus (African green monkey) : ABCC1 (ATP binding cassette subfamily C member 1)
Heterocephalus glaber (naked mole-rat) : Abcc1 (ATP binding cassette subfamily C member 1)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1627,855,702 - 27,950,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:12429346   PMID:12516967   PMID:15459206   PMID:23373631   PMID:23773525   PMID:26560472  


Genomics

Comparative Map Data
ABCC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1627,855,702 - 27,950,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ABCC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1615,949,577 - 16,143,074 (+)EnsemblGRCh38hg38GRCh38
GRCh381615,949,616 - 16,143,062 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371616,043,434 - 16,236,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,950,935 - 16,144,432 (+)NCBINCBI36hg18NCBI36
Build 341615,950,934 - 16,143,774NCBI
Celera1615,781,784 - 15,917,085 (+)NCBI
Cytogenetic Map16p13.11NCBI
HuRef1615,436,705 - 15,630,893 (+)NCBIHuRef
CHM1_11616,185,916 - 16,321,192 (+)NCBICHM1_1
Abcc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,179,317 - 14,292,743 (+)NCBI
GRCm381614,361,453 - 14,474,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,361,558 - 14,475,737 (+)EnsemblGRCm38mm10GRCm38
MGSCv371614,361,653 - 14,474,968 (+)NCBIGRCm37mm9NCBIm37
MGSCv361614,275,138 - 14,388,453 (+)NCBImm8
Celera1614,966,079 - 15,077,783 (+)NCBICelera
Cytogenetic Map16A1NCBI
Abcc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010549,537 - 672,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10549,883 - 672,196 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01011,232,233 - 11,354,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410452,239 - 575,705 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110452,238 - 575,705 (-)NCBI
Celera1011,130,945 - 11,246,232 (-)NCBICelera
Cytogenetic Map10q11NCBI
Abcc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442729,316 - 860,290 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955442729,322 - 858,826 (+)NCBIChiLan1.0ChiLan1.0
ABCC1
(Pan paniscus - bonobo/pygmy chimpanzee)
No map positions available.
Abcc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365013,400,971 - 3,467,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl328,360,868 - 28,485,477 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1328,360,868 - 28,472,940 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2329,082,788 - 29,172,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl514,972,646 - 15,164,567 (+)Ensembl
ChlSab1.1514,972,589 - 15,164,594 (+)NCBI
Abcc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624782449,217 - 590,306 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 3 6 6 5 2
Low 3 5 19 6 6 6 12 8 5 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000027269   ⟹   ENSCAFP00000025361
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,855,702 - 27,989,331 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000028933   ⟹   ENSCAFP00000026911
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,855,702 - 27,970,580 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000067722   ⟹   ENSCAFP00000066267
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl627,857,049 - 27,989,331 (-)Ensembl
RefSeq Acc Id: NM_001002971   ⟹   NP_001002971
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1627,855,702 - 27,950,140 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO17310 (Get FASTA)   NCBI Sequence Viewer  
  AAQ23148 (Get FASTA)   NCBI Sequence Viewer  
  Q6UR05 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001002971   ⟸   NM_001002971
- UniProtKB: Q6UR05 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000066267   ⟸   ENSCAFT00000067722
RefSeq Acc Id: ENSCAFP00000026911   ⟸   ENSCAFT00000028933
RefSeq Acc Id: ENSCAFP00000025361   ⟸   ENSCAFT00000027269

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018208 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFG00040002016 UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00000025361 UniProtKB/TrEMBL
  ENSCAFP00000026911 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000066267 UniProtKB/TrEMBL
  ENSCAFP00040003340 UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000027269 UniProtKB/TrEMBL
  ENSCAFT00000028933 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000067722 UniProtKB/TrEMBL
  ENSCAFT00040003892 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403453 UniProtKB/Swiss-Prot
NCBI Gene ABCC1 ENTREZGENE
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MRP_assoc_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Cfa.3224 ENTREZGENE
UniProt A0A5F4DHW2_CANLF UniProtKB/TrEMBL
  F1P9H1_CANLF UniProtKB/TrEMBL
  F1PRX6_CANLF UniProtKB/TrEMBL
  MRP1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:54275 ENTREZGENE