ABCC2 (ATP binding cassette subfamily C member 2) - Rat Genome Database

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Gene: ABCC2 (ATP binding cassette subfamily C member 2) Canis lupus familiaris
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Symbol: ABCC2
Name: ATP binding cassette subfamily C member 2
RGD ID: 12050879
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN antibiotic metabolic process (ortholog); benzylpenicillin metabolic process (ortholog); bile acid and bile salt transport (ortholog); PARTICIPATES IN bile acid signaling pathway; docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); acute lymphoblastic leukemia (ortholog); alopecia (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; leukotriene C4; mercury atom
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family C member 2; canalicular multispecific organic anion transporter 1; MRP2; multidrug resistance associated protein 2; multidrug resistance protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,670,885 - 12,740,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,670,885 - 12,740,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2812,854,192 - 12,923,368 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,138,667 - 13,208,016 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,138,667 - 13,208,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,685,440 - 12,754,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02812,716,120 - 12,786,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02812,857,984 - 12,927,300 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibiotic metabolic process  (ISO)
benzylpenicillin metabolic process  (ISO)
bile acid and bile salt transport  (IEA,ISO)
bile acid signaling pathway  (ISO)
bilirubin transport  (IEA)
canalicular bile acid transport  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to xenobiotic stimulus  (ISO)
detoxification of mercury ion  (ISO)
female pregnancy  (ISO)
inflammatory response  (ISO)
intracellular chloride ion homeostasis  (ISO)
leukotriene transport  (IEA,ISO)
mercury ion transport  (ISO)
negative regulation of gene expression  (ISO)
organic anion transport  (IEA,ISO)
prostaglandin transport  (ISO)
regulation of bile acid secretion  (ISO)
regulation of gene expression  (ISO)
response to antineoplastic agent  (ISO)
response to arsenic-containing substance  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucagon  (ISO)
response to heat  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
thyroid hormone transport  (ISO)
transepithelial transport  (ISO)
transmembrane transport  (IBA,IEA)
xenobiotic catabolic process  (ISO)
xenobiotic detoxification by transmembrane export across the plasma membrane  (ISO)
xenobiotic export from cell  (IEA)
xenobiotic transmembrane transport  (IEA)
xenobiotic transport across blood-brain barrier  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:11164610   PMID:12429346  


Genomics

Comparative Map Data
ABCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,670,885 - 12,740,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,670,885 - 12,740,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2812,854,192 - 12,923,368 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,138,667 - 13,208,016 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,138,667 - 13,208,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,685,440 - 12,754,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02812,716,120 - 12,786,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02812,857,984 - 12,927,300 (+)NCBIUU_Cfam_GSD_1.0
ABCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381099,782,640 - 99,852,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1099,782,640 - 99,852,594 (+)EnsemblGRCh38hg38GRCh38
GRCh3710101,542,397 - 101,612,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,532,493 - 101,601,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410101,532,562 - 101,601,571NCBI
Celera1095,279,806 - 95,349,643 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1095,169,835 - 95,239,503 (+)NCBIHuRef
CHM1_110101,824,911 - 101,894,368 (+)NCBICHM1_1
T2T-CHM13v2.010100,665,562 - 100,736,331 (+)NCBIT2T-CHM13v2.0
Abcc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,770,747 - 43,826,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1943,770,631 - 43,829,179 (+)EnsemblGRCm39 Ensembl
GRCm381943,782,308 - 43,838,332 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,782,192 - 43,840,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv371943,856,798 - 43,912,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361943,835,715 - 43,891,248 (+)NCBIMGSCv36mm8
Celera1944,567,463 - 44,621,438 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
Abcc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,664,657 - 242,723,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,664,657 - 242,723,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,813,581 - 250,872,198 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01257,510,469 - 257,569,198 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01250,163,726 - 250,222,340 (+)NCBIRnor_WKY
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
Abcc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555075,724,762 - 5,790,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555075,724,788 - 5,791,281 (+)NCBIChiLan1.0ChiLan1.0
ABCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11099,889,021 - 99,947,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1099,889,160 - 99,947,270 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01096,385,534 - 96,458,571 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Abcc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,253,163 - 34,302,933 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636292,709 - 340,393 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936636292,631 - 341,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,955,633 - 111,037,537 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114110,955,698 - 111,038,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,400,787 - 120,484,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1992,826,423 - 92,902,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl992,841,818 - 92,902,265 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604853,844,985 - 53,909,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473711,593,864 - 11,688,460 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473711,593,701 - 11,686,790 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABCC2
776 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 4 4
Low 2 2 2 7
Below cutoff 5 5 16 6 6 6 12 1 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015149   ⟹   ENSCAFP00000014021
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2812,670,885 - 12,740,740 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000059980   ⟹   ENSCAFP00000050283
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2812,670,885 - 12,740,126 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000065466   ⟹   ENSCAFP00000054503
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2812,670,885 - 12,740,740 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000074719   ⟹   ENSCAFP00000049464
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2812,672,322 - 12,740,126 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054933   ⟹   ENSCAFP00845043200
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2813,138,667 - 13,208,633 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054981   ⟹   ENSCAFP00845043230
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2813,138,667 - 13,208,018 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054988   ⟹   ENSCAFP00845043235
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2813,140,098 - 13,208,018 (+)Ensembl
RefSeq Acc Id: NM_001003081   ⟹   NP_001003081
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12812,670,885 - 12,740,124 (+)NCBI
Dog10K_Boxer_Tasha2812,854,192 - 12,923,368 (+)NCBI
ROS_Cfam_1.02813,138,667 - 13,208,016 (+)NCBI
UMICH_Zoey_3.12812,685,440 - 12,754,683 (+)NCBI
UNSW_CanFamBas_1.02812,716,120 - 12,786,599 (+)NCBI
UU_Cfam_GSD_1.02812,857,984 - 12,927,300 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003081 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO17311 (Get FASTA)   NCBI Sequence Viewer  
  AAS91646 (Get FASTA)   NCBI Sequence Viewer  
  CAC17701 (Get FASTA)   NCBI Sequence Viewer  
  CAC48162 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003081   ⟸   NM_001003081
- UniProtKB: Q9GK09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014021   ⟸   ENSCAFT00000015149
RefSeq Acc Id: ENSCAFP00000049464   ⟸   ENSCAFT00000074719
RefSeq Acc Id: ENSCAFP00000050283   ⟸   ENSCAFT00000059980
RefSeq Acc Id: ENSCAFP00000054503   ⟸   ENSCAFT00000065466
RefSeq Acc Id: ENSCAFP00845043235   ⟸   ENSCAFT00845054988
RefSeq Acc Id: ENSCAFP00845043200   ⟸   ENSCAFT00845054933
RefSeq Acc Id: ENSCAFP00845043230   ⟸   ENSCAFT00845054981
Promoters
RGD ID:13688289
Promoter ID:EPDNEW_C6358
Type:multiple initiation site
Name:ABCC2_1
Description:ATP binding cassette subfamily C member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12812,670,777 - 12,670,837EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009536 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018738 UniProtKB/TrEMBL
  ENSCAFG00040018357 UniProtKB/TrEMBL
  ENSCAFG00845030901 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000014021.4 UniProtKB/TrEMBL
  ENSCAFP00000049464.2 UniProtKB/TrEMBL
  ENSCAFP00000050283.2 UniProtKB/TrEMBL
  ENSCAFP00030030520.1 UniProtKB/TrEMBL
  ENSCAFP00030030601.1 UniProtKB/TrEMBL
  ENSCAFP00030030687.1 UniProtKB/TrEMBL
  ENSCAFP00040029546 UniProtKB/TrEMBL
  ENSCAFP00040029606 UniProtKB/TrEMBL
  ENSCAFP00040029806 UniProtKB/TrEMBL
  ENSCAFP00040029885 UniProtKB/TrEMBL
  ENSCAFP00845043200.1 UniProtKB/TrEMBL
  ENSCAFP00845043230 ENTREZGENE
  ENSCAFP00845043230.1 UniProtKB/TrEMBL
  ENSCAFP00845043235.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015149.5 UniProtKB/TrEMBL
  ENSCAFT00000059980.2 UniProtKB/TrEMBL
  ENSCAFT00000074719.2 UniProtKB/TrEMBL
  ENSCAFT00030035000.1 UniProtKB/TrEMBL
  ENSCAFT00030035096.1 UniProtKB/TrEMBL
  ENSCAFT00030035193.1 UniProtKB/TrEMBL
  ENSCAFT00040033952 UniProtKB/TrEMBL
  ENSCAFT00040034014 UniProtKB/TrEMBL
  ENSCAFT00040034241 UniProtKB/TrEMBL
  ENSCAFT00040034328 UniProtKB/TrEMBL
  ENSCAFT00845054933.1 UniProtKB/TrEMBL
  ENSCAFT00845054981 ENTREZGENE
  ENSCAFT00845054981.1 UniProtKB/TrEMBL
  ENSCAFT00845054988.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABCC2 UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:403632 UniProtKB/TrEMBL
NCBI Gene ABCC2 ENTREZGENE
PANTHER PTHR24223:SF176 UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
TIGRFAMs MRP_assoc_pro UniProtKB/TrEMBL
UniProt A0A8C0NR86_CANLF UniProtKB/TrEMBL
  A0A8C0P713_CANLF UniProtKB/TrEMBL
  A0A8C0T222_CANLF UniProtKB/TrEMBL
  A0A8C0T271_CANLF UniProtKB/TrEMBL
  A0A8C0T2V2_CANLF UniProtKB/TrEMBL
  A0A8I3Q5P1_CANLF UniProtKB/TrEMBL
  A0A8I3QZD7_CANLF UniProtKB/TrEMBL
  A0A8I3SCV5_CANLF UniProtKB/TrEMBL
  Q9GK09 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37440 ENTREZGENE